Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection

Journal of Infectious Diseases

Volumn 178, Issue 1, 1998, Pages 191-199

  Palmer, K L ^b   Thornton, A C ^b   Fortney, K R ^b   Hood, A F ^b   Munson Jr , R S ^b   Spinola, S M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEMOLYSIN; MEMBRANE PROTEIN;

ADULT; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CELL INFILTRATION; CLINICAL ARTICLE; DOSE RESPONSE; EXPERIMENTAL INFECTION; FEMALE; HAEMOPHILUS DUCREYI; HISTOPATHOLOGY; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; PUSTULE; STRAIN DIFFERENCE; ULCUS MOLLE;

EID: 0031845347     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515617     Document Type: Article

References (29)

1. Jessamine PG, Ronald AR. Chancroid and the role of genital ulcer disease in the spread of human retroviruses. Med Clin North Am 1990;74: 1417-31.
2. Wasserheit JN. Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Se× Transm Dis 1992;19:61-77.
3. Telzak EE, Chiasson MA, Bevier PJ, Stoneburner RL, Castro KG, Jaffe HW. HIV-1 seroconversion in patients with and without genital ulcer disease. Ann Intern Med 1993;119:1181-6.
4. + T cells during experimental human infection. J Infect Dis 1996;173:394-402.
5. King R, Gough J, Ronald AR, et al. An immunohistochemical analysis of naturally occurring chancroid. J Infect Dis 1996;174:427-30.
6. Plummer FA, Wainberg P, Jessamine P, D'Costa LJ, Wamola IA, Ronald AR. Detection of human immunodeficiency virus type 1 (HIV-1) in genital ulcer exudates of HIV-1-infected men by culture and gene amplification. J Infect Dis 1990;161:810-1.
7. Kreiss JK, Coombs R, Plummer F, et al. Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes. J Infect Dis 1989; 160:380-4.
8. MacDonald KS, Cameron DW, D'Costa L, Ndinya-Achola JO, Plummer FA, Ronald AR. Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother 1989;33:612-4.
9. Tyndall MW, Plourde PJ, Agoki E, et al. Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1. Am J Med 1993;94(suppl):S85-8.
10. Campagnari AA, Wild LM, Griffiths GE, Karalus RJ, Wirth MA, Spinola SM. Role of lipooligosaccharides in experimental dermal lesions caused by Haemophilus ducreyi. Infect Immun 1991;59:2601-8.
11. Lagergard T. The role of Haemophilus ducreyi bacteria, cytotoxin, endotoxin, and antibodies in animal models for study of chancroid. Microb Pathog 1992;13:203-17.
12. Gibson BW, Campagnari AA, Melaugh W, et al. Characterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide biosynthesis. J Bacteriol 1997;179: 5062-71.
13. Elkins C. Identification and purification of a conserved heme-regulated hemoglobin-binding outer membrane protein from Haemophilus ducreyi. Infect Immun 1995;63:1241-5.
14. Brentjens RJ, Ketterer M, Apicella MA, Spinola SM. Fine tangled pili expressed by Haemophilus ducreyi are a novel class of pili. J Bacteriol 1996;178:808-16.
15. Cope LD, Lumbley S, Latimer JL, et al. A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci USA 1997;94:4056-61.
16. Palmer KL, Grass S, Munson RS Jr. Identification of a hemolytic activity elaborated by Haemophilus ducreyi. Infect Immun 1994;62:3041-3.
17. Totten PA, Norn DV, Stamm WE. Characterization of the hemolytic activity of Haemophilus ducreyi. Infect Immun 1995;63:4409-16.
18. Palmer KL, Munson RS Jr. Cloning and characterization of the genes encoding the hemolysin of Haemophilus ducreyi. Mol Microbiol 1995; 18:821-30.
19. Uphoff TS, Welch RA. Nucleotide sequencing of the Proteus mirabilis calcium-independent hemolysin genes (hpmA and hpmB) reveals sequence similarity with the Serratia marcescens hemolysin genes (shlA and shlB). J Bacteriol 1990;172:1206-16.
20. Poole K, Schiebel E, Braun V. Molecular characterization of the hemolysin determinant of Serratia marcescens. J Bacteriol 1988;170:3177-88.
21. Strauss EJ, Ghori N, Falkow S. Edwardsiella tarda strain containing a mutation in a gene with homology to shlB and hpmB is defective for entry into epithelial cells in culture. Infect Immun 1997;65: 3924-32.
22. Hirono I, Tange N, Aoki T. An iron-regulated haemolysin gene from Edwardsiella tarda. Mol Microbiol 1997;24:851-6.
23. Welch RA. Pore-forming cytolysins of gram-negative bacteria. Mol Microbiol 1991;5:521-8.
24. Palmer KL, Goldman WE, Munson RS Jr. An isogenic hemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effect on human foreskin fibroblasts. Mol Microbiol 1996;21:13-9.
25. Alfa MJ, DeGagne P, Totten, PA. Haemophilus ducreyi hemolysin acts as a contact cytotoxin and damages human foreskin fibroblasts in cell culture. Infect Immun 1996;64:2349-52.
26. Spinola SM, Wild LM, Apicella MA, Gaspari AA, Campagnari AA. Experimental human infection with Haemophilus ducreyi. J Infect Dis 1994; 169:1146-50.
27. Hobbs MM, San Mateo LR, Orndorff PE, Almond G, Kawula TH. Swine model of Haemophilus ducreyi infection. Infect Immun 1995;63:3094-100.
28. Totten PA, Morton WR, Knitter GH, Clark AM, Kiviat NB, Stamm WE. A primate model for chancroid. J Infect Dis 1994;169:1284-90.
29. Purcell BK, Richardson JA, Radolf JD, Hansen EJ. A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi. J Infect Dis 1991;164:359-67.