An isogenic haemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts

Molecular Microbiology

Volumn 21, Issue 1, 1996, Pages 13-19

  Palmer, Katherine L ^a   Goldman, William E ^a   Munson Jr , Robert S ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOLYSIN; VIRULENCE FACTOR;

ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; HAEMOPHILUS DUCREYI; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PREPUCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; ULCUS MOLLE;

EID: 0030035255     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.00615.x     Document Type: Article

References (17)

1. Boukamp, P., Petrussevska, R.T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N.E. (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Biochem 106: 761-771.
2. Campagnari, A.A., Wild, L.M., Griffiths, G.E., Karalus, R.J., Wirth, M.A., and Spinola, S.M. (1991) Role of lipooligosaccharides in experimental dermal lesions caused by Haemophilus ducreyi. Infect Immun 59: 2601-2608.
3. Freshney, R.I. (1987) Culture of Animal Cells: A Manual of Basic Techniques. New York: Alan R. Liss, Inc.
4. Hollyer, T.T., Degagne, P.A., and Alfa, M.J. (1994) Characterization of the cytopathic effect of Haemophilus ducreyi. Sex Trans Dis 21: 247-257.
5. Jessamine, P.G., and Ronald, A.R. (1990) Chancroid and the role of genital ulcer disease in the spread of human retroviruses. Med Clin North Am 74: 1417-1431.
6. Lagergard, T. (1992) The role of Haemophilus ducreyi bacteria, cytotoxin, endotoxin and antibodies in animal models for study of chancroid. Microb Pathogen 13: 203-217.
7. MacDonald, K.S., Cameron, D.W., D'Costa, L., Ndinya-Achola, J.O., Plummer, F.A., and Ronald, A.R. (1989) Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Ag Chemother 33: 612-614.
8. Palmer, K.L., and Munson, Jr, R.S. (1995) Cloning and characterization of the genes encoding the haemolysin of Haemophilus ducreyi. Mol Microbiol 18: 821-830.
9. Palmer, K.L., Grass, S., and Munson, Jr, R.S. (1994) Identification of a haemolytic activity elaborated by Haemophilus ducreyi. Infect Immun 62: 3041-3043.
10. Pepin, J., Plummer, F.A., Brunham, R.C., Piot, P., Cameron, D.W., and Ronald, A.R. (1989) The interaction of HIV infection and other sexually transmitted diseass: an opportunity for intervention. AIDS 3: 3-9.
11. Perez-Casal, J., Caparon, M.G., and Scott, J.R. (1991) Mry, a frans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. J Bacteriol 173: 2617-2624.
12. Purcell, B.K., Richardson, J.A., Radolf, J.D., and Hansen, E.J. (1991) A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi. J Inf Dis 164: 359-367.
13. Purven, M., and Lagergard, T. (1992) Haemophilus ducreyi, a cytotoxin-producing bacterium. Infect Immun 60: 1156-1162.
14. Totten, P.A., Norn, D.V., and Stamm, W.E. (1995) Characterization of the hemolytic activity of Haemophilus ducreyi. Infect Immun 63: 4409-4416.
15. Trees, D.L., and Morse, S.A. (1995) Chancroid and Haemophilus ducreyi: an update. Clin Microbiol Rev 8: 357-375.
16. Tyndall, M.W., Plourde, P.J., Agoki, E., Malisa, W., Ndinya-Achola, J.O., Plummer, F.A., and Ronald, A.R. (1993) Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1. Am J Med 94: 85S-88S.
17. Wasserheit, J.N. (1992) Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Trans Dis 19: 61-77.