Role of intron 1 in smooth muscle α-actin transcriptional regulation in activated mesangial cells in vivo

Kidney International

Volumn 55, Issue 6, 1999, Pages 2338-2348

  Kawada, Noritaka ^a,b,c   Moriyama, Toshiki ^a,b,c   Ando, Akio ^a,b,c   Koyama, Tohru ^a,b,c   Hori, Masatsugu ^a,b,c   Miwa, Takeshi ^a,b,c   Imai, Enyu ^a,b,c  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

CarG element; Habu venom glomerulonephritis; Myofibroblast; Phenotypic modulation; Progressive renal disease

Indexed keywords

ALPHA ACTIN; CHLORAMPHENICOL ACETYLTRANSFERASE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CELL DENSITY; DISEASE MARKER; DNA SEQUENCE; GLOMERULONEPHRITIS; GROWTH STIMULATION; INTRON; MESANGIUM; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0033033627     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00475.x     Document Type: Article

References (42)

1. 1. Mene P, Simonson MS, Dunn MJ: Physiology of the mesangial cell. Physiol Rev 69:1347-1424, 1989
2. 2. Schlondorff D: The glomerular mesangial cell: An expanding role for a specialized pericyte. FASEB J 1:272-281, 1987
3. 3. Striker LJ, Doi T, Elliott S, Striker GE: The contribution of mesangial cells to progressive glomerulosclerosis. Semin Nephrol 9:318-329, 1989
4. 4. Ando Y, Moriyama T, Miyazaki M, Akagi Y, Kawada N, Isaka Y, Izumi M, Yokoyama K, Yamauchi A, Horio M, Ando A, Ueda N, Sobue K, Imai E, Hori M: Enhanced glomerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy. Nephrol Dial Transplant 13:1168-1175, 1998
5. 5. Makino H, Kashihara N, Sugiyama H, Kanao K, Sekikawa T, Okamoto K, Maeshima Y, Ota Z, Nagai R: Phenotypic modulation of the mesangium reflected by contractile proteins in diabetes. Diabetes 45:488-495, 1996
6. 6. Hiroi J, Kimura K, Aikawa M, Tojo A, Suzuki Y, Nagamatsu T, Omata M, Yazaki Y, Nagai R: Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats. Kidney Int 49:1231-1241, 1996
7. 7. Mise N, Kimura K, Nagai R, Ohba S, Suzuki N, Miyashita K, Tojo A, Goto A, Omata M: Mesangial expression of a nonmuscle myosin heavy chain, SMemb, is associated with glomerular sclerosis and renal prognosis in IgA nephropathy. Nephron 78:284-289, 1998
8. 8. Johnson RJ, Iida H, Alpers CE, Majesky MW, Schwartz SM, Pritzl P, Gordon K, Gown AM: Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. J Clin Invest 87:847-858, 1991
9. 9. Johnson RJ, Floege J, Yoshimura A, Iida H, Couser WG, Alpers CE: The activated mesangial cell: A glomerular "myofibroblast"? J Am Soc Nephrol 2:S190-S197, 1992
10. 10. Owens GK: Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75:487-517, 1995
11. 11. Vandekerckhove J. Weber K: The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. Differentiation 14:123-133, 1979
12. 12. Vandekerckhove J, Weber K: Actin typing on total cellular extracts. Eur J Biochem 113:595-603, 1981
13. 13. Alpers CE, Hudkins KL, Gown AM, Johnson RJ: Enhanced expression of "muscle-specific" actin in glomerulonephritis. Kidney Int 41:1134-1142, 1992
14. 14. Floege J, Burns MW, Alpers CE, Yoshimura A, Pritzi, P, Gordon K, Seifert RA, Bowen-Pope DF, Couser WG, JOHNSON RJ: Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int 41:297-309, 1992
15. 15. MacPherson BR, Leslie KO, Lizaso KV, Schwarz JE: Contractile cells of the kidney in primary glomerular disorders. Hum Pathtol 24:710-716, 1993
16. 16. Min B, Foster DN, Strauch AR: The 5'-flanking region of the mouse vascular smooth muscle α-actin gene contains evolutionarily conserved sequence motif within a functional promoter. J Biol Chem 265:16667-16675, 1990
17. 17. Carrol SL, Bergsma DJ, Schwartz RJ: A 29-nucleotide DNA segment containing an evolutionarily conserved motif is required in cis for cell-type-restricted repression of the chicken α-smoolh muscle actin gene core promoter. Mol Cell Biol 8:241-250, 1988
18. 18. Nakano Y, Nishihara T, Sasayama S, Miwa T, Kamada S, Kakunaga T: Transcriptional regulatory elements in the 5' upstream and first intron regions of the human smooth muscle (aortic type) α-actin-encoding gene. Gene 99:285-289, 1991
19. 19. Blank RS, McQuinn TC, Yin KC, Tompson MM, Takeyasu K, Schwartz RJ, Owens GK: Elements of the smooth muscle α-actin promoter required in cis for transcriptional activation in smooth muscle. J Biol Chem 267:984-989, 1992
20. 20. Shimizu RT, Blank RS, Jervis R, Lawrenz-Smith SC, Owens GK: The smooth muscle α-actin gene promoter is differentially regulated in smooth muscle versus non-smooth muscle cells. J Biol Chem 270:7631-7643, 1994
21. 21. Simonson MS, Walsh K, Kumar CC, Bushel P, Herman WH: Two proximal CArG elements regulate SM α-actin promoter, a genetic marker of activated phenotype of mesangial cells. Am J Physiol 268:F760-F769, 1995
22. 22. Hautmann MB, Madsen CS, Owens GK: A transforming growth factor β (TGFβ) control element drives TGFβ-induced stimulation of smooth muscle α-actin gene expression in concert with two CArG elements. J Biol Chem 272:10948-10956, 1997
23. 23. Hautmann MB, Tompson MM, Swartz EA, Olson EN, Owens GK: Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox. Circ Rex 81:600-610, 1997
24. 24. Hautmann MB, Madsen CS, Mack CP, Owens GK: Substitution of the degenerate smooth muscle (SM) β-actin CC (A/T-rich) 6GG elements with c-fos serum response elements results in increased basal expression but relaxed SM cell specificity and reduced angiotensin II inducibility. J Biol Chem 273:8398-8406, 1998
25. 25. Comer K, Dennis PA, Armstrong L, Catino JJ, Kastan MB, Kumar CC: Human smooth muscle α-actin is a transcriptional target of the p53 tumor suppressor protein. Oncogene 16:1299-1308, 1998
26. 26. Sun S, Stoflet ES, Cogan JG, Strauch AR, Getz MJ: Negative regulation of the vascular smooth muscle α-actin gene in fibroblasts and myoblasts: Disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins. Mol Cell Biol 15:2429-2436, 1995
27. 27. McNamara CA,Thompson MM, Vernon SM, Shimizu RT, Blank RS, Owens GK: Nuclear proteins bind cis-acting element in the smooth muscle α-actin promoter. Am J Physiol 268:C1259-C1266, 1995
28. 28. Kaneko T, Takenaka M, Okabe M, Yoshimura Y, Yamauchi A, Horio M, Kwon HM, Handler JS, Imai L: Osmolarity in renal medulla of transgenic mice regulates transcription via 5'-flanking region of canine BGT1 gene. Am J Physiol 272:F610-F616, 1997
29. 29. Mokiyama T, Fujibayashi M, Fujiwara Y, Kaneko T, Chen X, Imai E, Kamada T, Ando A, Ueda N: Angiotensin II stimulates IL-6 release from cultured mouse mesangial cells. J Am Soc Nephrol 6:95-101, 1995
30. 30. Bradford MM: A rapid and sensitive method for the quantitation of micrograms quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-251, 1976
31. 31. Kaneko T, Moriyama T, Imai E, Akagi Y, Arai M, Inoue T, Xia C, Noguchi T, Kamada T, Ueda N: Expression of transmembrane-type tyrosine phosphatase mRNA along rat nephron segments. Am J Physiol 268:F1102-F1108, 1995
32. 32. Elger M, Drenckhahn D, Nobling R, Mundel P, Kriz W: Cultured rat mesangial cells contain smooth muscle α-actin not found in vivo. Am J Pathol 142:497-509, 1993
33. 33. Treisman R, Ammerer G: The SRF and MCM1 transcription factors. Curr Opin Genet Dev 2:221-226, 1992
34. 34. Sartorelli V, Kurabayashi M, Kedes L: Muscle-specific gene expression. A comparison of cardiac and skeletal muscle transcription strategies. Circ Res 72:925-931, 1993
35. 35. Mar JH, Ordahl CP: M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription. Mol Cell Biol 10:4271-4283, 1990
36. 36. Sappino AP, Schurch W, Gabbiani G: Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 63:144-161, 1990
37. 37. Border WA, Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 331:1286-1292, 1994
38. 38. Akagi Y, Isaka Y, Arai M, Kaneko T, Takenaka M, Moriyama T, Kaneda Y, Ando A, Orita Y, Kamada T, Ueda N, Imai E: Inhibition of TGF-β1 expression by antisense oligonucleotidcs suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 50:148-155, 1996
39. 39. Isaka Y, Brees DK, Ikegaya K, Kanada Y, Imai E, Noble NA, Border WA: Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nature Med 2:418-423, 1996
40. 40. Greenblatt MS, Bennett WP, Hollstein M, Harris CC: Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878, 1994
41. 41. Takemura T, Okada M, Akano N, Murakami K, Hino S, Yagi K, Takekoshi Y, Yoshioka K: Proto-oncogene expression in human glomerular diseases, J Pathol 178:343-351, 1996
42. 42. Wang JS, Tseng HH, Shih DF, Jou HS, Ger LP: Expression of inducible nitric oxide synthase and apoptosis in human lupus nephritis. Nephron 77:404-411, 1997