Mechanisms of stroke in sickle cell disease: Sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition

Blood

Volumn 89, Issue 12, 1997, Pages 4591-4599

  French II, James A ^b   Kenny, Dermot ^b   Scott, J Paul ^b   Hoffmann, Raymond G ^b   Wood, James D ^b   Hudetz, Antal G ^b   Hillery, Cheryl A ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL MODEL; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN; BRAIN BLOOD FLOW; BRAIN MICROCIRCULATION; CONTROLLED STUDY; ENZYME INHIBITION; ERYTHROCYTE ADHESIVENESS; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SICKLE CELL; SICKLE CELL ANEMIA; STROKE; VASCULAR ENDOTHELIUM;

EID: 0030912619     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.12.4591     Document Type: Article

References (43)

1. Powars D, Wilson B, Imbus C, Pagalow C, Allen J: The natural history of stroke in sickle cell anemia. Am J Med 65:461, 1978
2. Balkaran B, Char G, Morris JS, Thomas PW, Serjeant BE, Serjeant GR: Stroke in a cohort of patients with homozygous sickle cell disease. J Pediatr 120:360, 1992
3. Pavlakis SG, Bello J, Prohovnik I, Sutton M, Ince C, Mohr JP, Piomelli S, Hilal S, De Vivo DC: Brain infarction in sickle cell anemia: Magnetic resonance imaging correlates. Ann Neurol 23:125, 1988
4. Armstrong FD, Thompson RJ, Wang W, Zimmerman R, Pegelow CH, Miller S, Moser F, Bello J, Hurtig A, Vass K, Neuropsychologist Committee of the Cooperative Study of Sickle Cell Disease: Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease. Pediatrics 97:864, 1996
5. Craft S, Schatz J, Glauser TA, Lee B, DeBaun MR: Neuropsychologic effects of stroke in children with sickle cell anemia. J Pediatr 123:712, 1993
6. Stockman JA, Nigro MA, Mishkin MM, Oski FA: Occlusion of large cerebral vessels in sickle cell anemia. N Engl J Med 287:847, 1972
7. Glauser TA, Siegel MJ, Lee BCP, DeBaun MR: Accuracy of neurologic examination and history in detecting evidence of MRI-diagnosed cerebral infarctions in children with sickle cell hemoglobinopathy. J Child Neurol 10:88, 1995
8. Rothman SM, Fulling KH, Nelson JS: Sickle cell anemia and central nervous system infarction: A neuropathological study. Ann Neurol 20:684, 1986
9. Merkel KHH, Ginsburg PL, Parker JC, Post MJD: Cerebrovascular disease in sickle cell anemia: A clinical, pathological and radiological correlation. Stroke 9:45, 1978
10. Koshy M, Thomas C, Goodwin J: Vascular lesions in the central nervous system in sickle cell disease (neuropathology). J Assoc Acad Minor Phys 1:71, 1990
11. Francis RB, Johnson CS: Vascular occlusion in sickle cell disease: Current concepts and unanswered questions. Blood 77:1405, 1991
12. Hebbel RP: Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology. Blood 77:214, 1991
13. + sickle reticulocytes to endothelial cells. Blood 80:2634, 1992
14. Barabino GA, McIntire LV, Eskin SG, Sears DA, Udden M: Endothelial cell interactions with sickle cell, sickle trait, and mechanically injured erythrocytes under controlled flow. Blood 70:152, 1987
15. Mohandas N, Evans E: Sickle erythrocyte adherence to vascular endothelium: Morphologic correlates and the requirement for divalent cations and collagen-binding plasma proteins. J Clin Invest 76:1605, 1985
16. Hebbel RP, Yamada O, Moldow CF, Jacob HS, White JG, Eaton JW: Abnormal adherence of sickle erythrocytes to cultured vascular endothelium. J Clin Invest 65:154, 1980
17. Wick TM, Moake JL, Udden MM, Eskin SG, Sears DA, Mclntire LV: Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. J Clin Invest 80:905, 1987
18. Hillery CA, Du MC, Montgomery RR, Scott JP: Increased adhesion of erythrocytes to components of the extracellular matrix: Isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin. Blood 87:4879, 1996
19. Kaul DK, Fabry ME, Nagel RL: Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proc Natl Acad Sci USA 86:3356, 1989
20. 1H magnetic resonance imaging changes. Proc Natl Acad Sci USA 86:3808, 1989
21. Kaul DK, Fabry ME, Constantini F, Rubin EM, Nagel RL: In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest 96:2845, 1995
22. 1 and glycoprotein IV (CD 36) are expressed on circulating reticulocytes in sickle cell anemia. Blood 82:3548, 1993
23. Brittain HA, Eckman JR, Wick TM: Sickle erythrocyte adherence to large vessel and microvascular endothelium under physiologic flow is qualitatively different. J Lab Clin Med 120:538, 1992
24. Faller DV: Vascular modulation, in Embury SH, Hebbel RP, Mohandas N, Steinberg MH (eds): Sickle Cell Disease: Basic Principles and Clinical Practice. New York, NY, Raven, 1994, p 235
25. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109, 1991
26. Phelan M, Perrine SP, Brauer M, Faller DV: Transcriptional regulation of vasoactive genes in human endothelial cells by sickled cell or plasma from patients in crisis. Blood 86:418a, 1995 (abstr, suppl 1)
27. Liao JK, Zulueta JJ, Peng H, Cote CG, Hassoun PM: Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest 96:2661, 1995
28. Phelan MW, Faller DV: Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J Cell Physiol 167:469, 1995
29. Lipowsky HH, Sheikh N, Katz DM: Intravital microscopy of capillary hemodynamics in sickle cell disease. J Clin Invest 80:117, 1987
30. Rodgers GP, Schechter AN, Noguchi CT, Klein HG, Nienhuis AW, Bonner RF: Periodic microcirculatory flow in patients with sickle cell disease. N Engl J Med 311:1534, 1984
31. Dirnagl U, Kaplan B, Jacewicz M, Pulsinelli W: Continuous measurement of cerebral cortical blood flow by laser-doppler flow-metry in rat stroke model. J Cereb Blood Flow Metab 9:589, 1989
32. Levasseur JE, Enoch PW, Raper AJ, Kontos HA, Patterson JL: Detailed description of a cranial window technique for acute and chronic experiments. Stroke 6:308, 1975
33. Hudetz AG, Feher G, Weigle CGM, Knuese DE, Kampine JP: Video microscopy of cerebrocortical capillary flow: Response to hypotension and intracranial hypertension. Am J Physiol 268:H2202, 1995
34. Hudetz AG, Roman RJ, Harder DR: Spontaneous flow oscillations in cerebral cortex during acute changes in mean arterial pressure. J Cereb Blood Flow Metab 12:491, 1992
35. Hudetz AG, Weigle CGM, Fenoy FJ, Roman RJ: Use of fluorescently labeled erythrocytes and digital cross-correlation for the measurement of flow velocity in the cerebral microcirculation. Microvasc Res 43:334, 1992
36. Cox DR: The rates of occurrence of short and long events were compared using a test of the homogeneity of two Poisson processes, in Cox DR, Lewis PA (eds): The Statistical Analysis of a Series of Events. London, UK, Chapman and Hall, 1966, p 229
37. Winder BJ: Statistical Principals in Experimental Design. New York, NY, McGraw-Hill, 1971
38. Prado R, Watson BD, Kuliz J, Dietrich WD: Endothelium-derived nitric oxide synthase inhibition. Effects on cerebral blood flow, pial artery diameter, and vascular morphology in rats. Stroke 23:1118, 1992
39. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA: Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 14:175, 1994
40. Moncada S, Higgs EA: Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 9:1319, 1995
41. Mosseri M, Bartlett-Pandite AN, Wend K, Isner JM, Weinstein R: Inhibition of endothelium-dependent vasorelaxation by sickle erythrocytes. Am Heart J 126:338, 1993
42. Dias-Da-Motta PM, Arruda VR, Muscara MN, Saad STO, De Nucci G, Costa FF: The release of nitric oxide and Superoxide anion by neutrophils and mononuclear cells from patients with sickle cell anaemia. Br J Haematol 93:333, 1996
43. Jia L, Bonaventura C, Bonaventura J, Stamler JS: S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control. Nature 380:221, 1996