Regulation of growth hormone secretion by signals produced by the adipose tissue

Journal of Endocrinological Investigation

Volumn 22, Issue 5 SUPPL., 1999, Pages 22-26

  Pombo, M ^a   Pombo, C M ^a   Astorga, R ^b   Cordido, F ^c   Popovic, V ^d   Garcia Mayor, R V ^e   Dieguez, C ^a   Casanueva, F F ^a,f  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^c HOSPITAL JUAN CANALEJO   (Spain)

^d CLINICAL CENTER OF SERBIA   (Serbia)

^e HOSPITAL XERAL CALDE   (Spain)

^f NONE   (Serbia)

Author keywords

Acipimox; Adipose tissue; Free fatty acids; Growth hormone; Leptin

Indexed keywords

FATTY ACID; HUMAN GROWTH HORMONE; LEPTIN; PROTEIN;

ADIPOSE TISSUE; ANIMAL; BLOOD; HUMAN; METABOLISM; OBESITY; PHYSIOLOGY; RAT; REVIEW; SECRETION; SIGNAL TRANSDUCTION;

ADIPOSE TISSUE; ANIMALS; FATTY ACIDS, NONESTERIFIED; HUMAN GROWTH HORMONE; HUMANS; LEPTIN; OBESITY; PROTEINS; RATS; SIGNAL TRANSDUCTION;

EID: 0032603721     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Casanueva F.F., Dieguez C. Growth hormone secretagogues: physiological role and clinical utility. Trends Endocrinol. Metab. 1999, 10: 30.
2. Casanueva F.F. Physiology of growth hormone secretion and action. Endocrinol. Metab. Clin. North Am. 1992, 21: 484.
3. Casanueva F.F., Villanueva L., Dieguez C., Diaz Y., Cabranes J.A., Szoke B., Scanlon M.F., Schally A.V., Fernandez-Cruz A. Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. J. Clin. Endocrinol. Metab. 1987, 65: 634.
4. Dieguez C., Casanueva F.F. Influence of metabolic substrates and obesity on growth hormone secretion. Trends Endocrinol. Metab. 1995, 6: 55.
5. Christiansen J.S. Growth hormone and body composition. J. Pediatr. Endocrinol. Metab. 1996, 3 (Suppl.): 365.
6. De Boer H., Blok G.-J., van der Veen E.A. Clinical aspects of growth hormone deficiency in adults. Endocr. Rev. 1995, 16: 63.
7. Salomon F., Cuneo R.C., Hesp R., Sönksen P.H. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N. Engl. J. Med. 1989, 321: 1797.
8. Alvarez C.V., Mallo F., Burguera B., Cacicedo L., Dieguez C., Casanueva F.F. Evidence for a direct pituitary inhibition by free fatty acids of in vivo growth hormone responses to growth hormone-releasing factor in the rat. Neuroendocrinology 1991, 53: 185.
9. Widmaier E.P., Rosen K., Abbot B. Free fatty acids activate the hypothalamic-pituitary-adrenocortical axis in rats. Endocrinology 1992, 131: 2313.
10. Casabiell X., Zugaza J.L., Pombo C.M., Pandiella A., Casanueva F.F. Oleic acid blocks epidermal growth factor-activated early intracellular signals without altering the ensuing mitogenic response. Exp. Cell Res. 1993, 205: 365.
11. Perez F., Camiña J., Menendez C., Beiras A., Casabiell X., Casanueva F.F. cis-unsaturated free fatty acids block VIP-mediated GH and PRL secretion by perturbing the cAMP/protein kinase A pathway. Pituitary 1998, 68: 187.
12. 2+ i release without altering cellular metabolism in fibroblast EGFR T17. Biochem. Biophys. Res. Commun. 1995, 207: 105.
13. Pontiroli A.E., Lanzi R., Monti L.D., Sandoli E., Pozza G. Growth hormone (GH) auto feedback on GH response to GH-releasing hormone. Role of free fatty acids and somatostatin. J. Clin. Endocrinol. Metab. 1991, 72: 492.
14. Peino R., Cordido F., Peñalva A., Alvarez C.V., Dieguez C., Casanueva F.F. Acipimox-mediated plasma free fatty acid depression per se stimulates growth hormone (GH) secretion in normal subjects and potentiates the response to other GH-releasing stimuli. J. Clin. Endocrinol. Metab. 1996, 81: 909.
15. Cordido F., Casanueva F.F., Dieguez C. Cholinergic receptor activation by pyridostigmine restores growth hormone (GH) responsiveness to GH releasing hormone administration in obese subjects. J. Clin. Endocrinol. Metab. 1989, 68: 290.
16. Leal A., Jimenez I.M., Astorga R., Fernandez-Lopez I., Dieguez C., Casanueva F.F. Acute pharmacological reduction of plasma free fatty acids enhances the growth hormone (GH)-releasing hormone-mediated GH secretion in patients with Cushing's syndrome. J. Clin. Endocrinol. Metab. 1997, 82: 3165.
17. Cordido F., Fernandez T., Martinez T., Peñalva A., Peino R., Casanueva F.F., Dieguez C. Effect of acute pharmacological reduction of plasma free fatty acids on growth hormone (GH) releasing hormone-induced GH secretion in obese adults with and without hypopituitarism. J. Clin. Endocrinol. Metab. 1999, 83: (in press).
18. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372: 425.
19. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995, 269: 546.
20. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., Mckee L.J., Baver T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 1996, 334: 292.
21. Tome M.A., Lage M., Camin̄a J.P., Garcia-Mayor R.V., Dieguez C., Casanueva F.F. Gender-based differences in serum leptin levels from umbilical cord blood at delivery. Eur. J. Endocrinol. 1997, 137: 655.
22. Ahima R.S., Dushay J., Flier S.N., Prabakaran K., Flier J.S. Leptin accelerates the timing of puberty in normal female mice. J. Clin. Invest. 1997, 99: 391.
23. Garcia-Mayor R.V., Andrade M.A., Rios M., Lage M., Dieguez C., Casanueva F.F. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J. Clin. Endocrinol. Metab. 1997, 82: 2849.
24. Leal A., Considine R.V., Peino R., Venegas E., Astorga R., Casanueva F.F., Dieguez C. Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. Horm. Metab. Res. 1996, 28: 711.
25. Ferron F., Considine R.V., Peino R., Lado I.G., Dieguez C., Casanueva F.F. Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease. Clin. Endocrinol. 1997, 46: 289.
26. Carro E., Senaris R., Considine R.V., Casanueva F.F, Dieguez C. Regulation of in vivo growth hormone secretion by leptin. Endocrinology 1997, 138: 2203.
27. Quintela M., Señaris R., Heiman M.L., Casanueva F.F., Dieguez C. Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels. Endocrinology 1997, 138: 5641.
28. Carro E., Seoane L.M., Señaris R., Considine R.V., Casanueva F.F., Dieguez C. Interaction between leptin and neuropeptide Y on in vivo growth hormone secretion. Neuroendocrinology 1998, 68: 187.