Acipimox-mediated plasma free fatty acid depression per se stimulates growth hormone (GH) secretion in normal subjects and potentiates the response to other GH-releasing stimuli

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 3, 1996, Pages 909-913

  Peino, Roberto ^a   Cordido, Fernando ^a   Peñalva, Angela ^a   Alvarez, Clara V ^a   Dieguez, Carlos ^a   Casanueva, Felipe F ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b NONE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACIPIMOX; FATTY ACID; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; PLACEBO; PYRIDOSTIGMINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FATTY ACID BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANTILIPEMIC AGENTS; DRUG SYNERGISM; FATTY ACIDS, NONESTERIFIED; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; MALE; OLIGOPEPTIDES; PYRAZINES; PYRIDOSTIGMINE BROMIDE; REFERENCE VALUES;

EID: 0029913476     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.3.909     Document Type: Article

References (40)

1. Dieguez C, Page MD, Scanlon MF. 1988 Growth hormone neuroregulation and its alterations in disease states. Clin Endocrinol (Oxf). 28:109-143.
2. Casanueva FF. 1992 Physiology of growth hormone secretion and action. Endocrinol Metab Clin North Am. 21:483-517.
3. Dieguez C, Casanueva FF. 1995 Influence of metabolic substrates and obesity on growth hormone secretion. Trends Endocrinol Metab. 6:55-59.
4. Mary Lee Vance. 1993 Metabolic status and growth hormone secretion in man. J Pediatr Endocrinol. 6:3-4.
5. Quabbe HJ, Bratzke B, Siegers U, Elban K. 1972 Studies on the relationship between plasma free fatty acids and growth hormone secretion in man. J Clin Invest. 51:2388-2398.
6. Blackard WG, Boyden CT, Hinson TC, Nelson NC. 1969 Effect of lipid and ketone infusions on insulin-induced growth hormone elevations in rhesus monkeys. Endocrinology. 85:1180-1185.
7. Blackard WG, Hull EW, Lopez A. 1971 Effects of lipids on growth hormone secretion in humans. J Clin Invest. 50:1439-1443.
8. Fineberg SE, Horland AA, Merimee TJ. 1972 Free fatty acid concentrations and growth hormone secretion in man. Metabolism. 21:491-498.
9. Lucke C, Adelman N, Glick SM. 1972 The effect of elevated free fatty acids on the sleep-induced human growth hormone peak. J Clin Endocrinol Metab. 35:407-412.
10. Imaki T, Shibasaki T, Shizume K, et al. 1985 The effect of free fatty acids on growth hormone-releasing hormone-mediated GH secretion in man. J Clin Endocrinol Metab. 60:290-294.
11. Casanueva FF, Villanueva L, Dieguez C, et al. 1987 Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. J Clin Endocrinol Metab. 65:634-642.
12. Alvarez CV, Mallo F, Burguera B, Cacicedo L, Dieguez C, Casanueva FF. 1991 Evidence for a direct pituitary inhibition by free fatty acids of in vivo growth hormone responses to growth hormone-releasing factor in the rat. Neuroendocrinology. 53:185-189.
13. Renier G, Abribat T, Brazeau P, Deslauriers N, Gaudreau P. 1990 Cellular mechanism of caprylic acid-induced growth hormone suppression. Metabolism. 39:1108-1112.
14. Irie M, Sakuma M, Tsushima T, Shizume K, Nakao K. 1967 Effect of nicotinic acid administration on plasma growth hormone concentrations. Proc Soc Exp Biol Med. 126:708-711.
15. Quabbe HJ, Luyckx AS, L'Age M, Schwarz C. 1983 Growth hormone, cortisol, and glucagon concentrations during plasma free fatty acid depression: different effects of nicotinic acid and an adenosine derivative (BM 11.189). J Clin Endocrinol Metab. 57:410-414.
16. Pontiroli AE, Lanzi R, Monti LD, Pozza G. 1990 Effect of acipimox, a lipid lowering drug on growth hormone (GH) response to GH-releasing hormone in normal subjects. J Endocrinol Invest. 13:539-542.
17. Pontiroli AE, Lanzi R, Monti LD, Sandoli E, Pozza G. 1991 Growth hormone (GH) auto feedback on GH response to GH-releasing hormone. Role of free fatty acids and somatostatin. J Clin Endocrinol Metab. 72:492-495.
18. Bowers CY, Momany FA, Chang D, Hong A, Chang K. 1980 Structure-activity relationships of a synthetic pentapeptide that specifically releases GH in vitro. Endocrinology. 106:663-667.
19. Momany FA, Bowers CY, Reynolds GA, Hong A, Newlander K. 1984 Conformational energy studies and in vitro activity data on active GH releasing peptides. Endocrinology. 114:1531-1536.
20. Bowers CY, Sartor AO, Reynolds GA, Badger TM. 1991 On the actions of the growth hormone-releasing hexapeptide, GHRP-6. Endocrinology. 128:2027-2035.
21. Bowers CY, Momany FA, Reynolds GA, Hong A. 1984 On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 114:1537-1545.
22. Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO. 1990 Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistic with GH-releasing hormone. J Clin Endocrinol Metab. 70:975-982.
23. Popovic V, Damjanovic S, Micic D, Petakov M, Dieguez C, Casanueva FF. 1994 Growth hormone (GH) secretion in active acromegaly after the combined administration of GH-releasing hormone and GH-releasing peptide. J Clin Endocrinol Metab. 79:456-460.
24. Popovic V, Damjanovic S, Micic D, Djurovic M, Dieguez C, Casanueva FF. 1995 Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level. J Clin Endocrinol Metab. 80:942-947.
25. Cordido F, Peñalva A, Dieguez C, Casanueva FF. 1993 Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity. J Clin Endocrinol Metab. 76:819-823.
26. 2), GH-releasing hormone, and thyrotropin-releasing hormone in acromegaly. J Clin Endocrinol Metab. 77:842-845.
27. Leal-Cerro A, Pumar A, Garcia E, Dieguez C, Casanueva FF. 1994 Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome. Clin Endocrinol (Oxf). 41:649-654.
28. Hochachka PW. 1986 Defense strategies against hypoxia and hypothermia. Science. 231:234-241.
29. Renaud G, Bouma ME, Foliot A, Infante R. 1985 Free fatty-acid uptake by isolated rat hepatocytes. Arch Int Physiol Biochim. 93:313-319.
30. Sanderman H. 1978 Regulation of membrane enzymes by lipids. Biochim Biophys Acta. 515:208-237.
31. Pjura WJ, Kleinfeld AM, Hoover RL, Karnovsky MJ. 1984 Partition of fatty acids and fluorescent fatty acids into membranes. Biochemistry. 23:2039-2043.
32. Klausner RD, Kleinfeld AM, Hoover RL, Karnovsky MJ. 1980 Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis. J Biol Chem. 255:1286-1295.
33. Karnovsky MJ. 1979 Lipid domains in biological membranes. Am J Pathol. 97:212-221.
34. Casabiell X, Pandiella A, Casanueva FF. 1991 Regulation of epidermal-growth-factor-receptor signal transduction by cis-unsaturated fatty acids. Biochem J. 278:679-687.
35. Casabiell X, Zugaza JL, Pombo CM, Pandiella A, Casanueva FF. 1993 Oleic acid blocks epidermal growth factor-activated early intracellular signals without altering the ensuing mitogenic response. Exp Cell Res. 205:365-373.
36. i release without altering cellular metabolism in fibroblast EGFR T17. Biochem Biophys Res Commun. 207:105-110.
37. Señaris RM, Lewis MD, Lago F, Dominguez F, Scanlon MF, Dieguez C. 1993 Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture. J Mol Endocrinol. 10:207-214.
38. Massara F, Ghigo E, Molinati P, et al. 1986 Potentiation of cholinergic tone by pyridostigmine bromide re-instates and potentiates the growth hormone responsiveness to intermittent administration of growth hormone releasing factor in man. Acta Endocrinol (Copenh). 113:12-6.
39. Klausner RD, Bhalla DK, Dragsten P, Hoover RL, Karnovsky JK. 1980 Model for capping derived from inhibition of surface receptor capping by free fatty acids. Proc Natl Acad Sci USA. 77:437-441.
40. Widmaier EP. 1992 Metabolic feedback in mamalian endocrine systems. Horm Metab Res. 24:147-153.