Defective expression of the μ3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine

Molecular and General Genetics

Volumn 262, Issue 3, 1999, Pages 401-412

  Mullins, C ^a   Hartnell, L M ^a   Wassarman, D A ^a   Bonifacino, J S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Clathrin; Hermansky Pudlak syndrome; Pigment; Sorting; Tyrosine based signal

Indexed keywords

ADAPTOR PROTEIN; MESSENGER RNA; ADAPTOR PROTEIN COMPLEX 1, MU 1 SUBUNIT; ADAPTOR PROTEIN COMPLEX 1, MU 2 SUBUNIT; ADAPTOR PROTEIN COMPLEX 2, MU 1 SUBUNIT; ADAPTOR PROTEIN COMPLEX 2, MU 2 SUBUNIT; ADAPTOR PROTEIN COMPLEX 3, MU 2 SUBUNIT; ALPHA ADAPTIN; AP3M2 PROTEIN, RAT; CLATHRIN ASSEMBLY PROTEIN; CLATHRIN ASSEMBLY PROTEIN AP180; COAT PROTEIN COMPLEX I; MEMBRANE PROTEIN; MU ADAPTIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ARTICLE; DROSOPHILA MELANOGASTER; EXPRESSED SEQUENCE TAG; GENE INSERTION; GENE LOCUS; MICROSCOPY; MUTANT; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; ANIMAL; CELL GRANULE; CHROMOSOME MAP; ENDOSOME; GENETICS; LYSOSOME; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; OCULAR ALBINISM; PHOTORECEPTOR; PIGMENTATION; PRENATAL DEVELOPMENT; RAT; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ADAPTOR PROTEIN COMPLEX 1; ADAPTOR PROTEIN COMPLEX 2; ADAPTOR PROTEIN COMPLEX 3; ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEIN COMPLEX MU SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ALBINISM, OCULOCUTANEOUS; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CHROMOSOME MAPPING; COAT PROTEIN COMPLEX I; CYTOPLASMIC GRANULES; DROSOPHILA MELANOGASTER; ENDOSOMES; EVOLUTION, MOLECULAR; EXPRESSED SEQUENCE TAGS; LYSOSOMES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; MUTATION; PHOTORECEPTORS, INVERTEBRATE; PIGMENTATION; RATS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032590055     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380051099     Document Type: Article

References (65)

1. Aguilar RC, Ohno H, Roche KC, Bonifacino JS (1997) Functional domain mapping of the clathrin-associated adaptor medium chains μ1 and μ2. J Biol Chem 272:2760-2766
2. Ahle S, Ungewickell E (1989) Identification of a clathrin binding subunit in the HA2 adaptor protein complex. J Biol Chem 264:20089-20093
3. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410
4. Andrews J, Smith M, Merakovsky J, Coulson M, Hannan F, Kelly LE (1996) The stoned locus of Drosophila melanogaster produces a dicistronic transcript and encodes two distinct polypeptides. Genetics 143:1699-1711
5. Benmerah A, Begue B, Dautry-Varsat A, Cerf-Bensussan N (1996) The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. J Biol Chem 271:12111-12116
6. Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T (1996) Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J 15:5789-5795
7. Bonifacino JS, Dell'Angelica EC (1999) Molecular bases for the recognition of tyrosine-based sorting signals. J Cell Biol 145:923-926
8. Cagan RL, Ready DF (1989) The emergence of order in the Drosophila pupal retina. Dev Biol 136:346-362
9. Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli PD (1998) Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature 394:793-797
10. Cowles CR, Odorizzi G, Payne GS, Emr SD (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91:109-118
11. Darsow T, Burd CG, Emr SD (1998) Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J Cell Biol 142:913-922
12. Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (1997) AP-3: an adaptor-like protein complex with ubiquitous expression. EMBO J 16:917-928
13. Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998) Association of the AP-3 adaptor complex with clathrin. Science 280:431-434
14. Dell'Angelica EC, Mullins C, Bonifacino JS (1999a) AP-4, a novel protein complex related to clathrin adaptors. J Biol Chem 274:7278-7285
15. Dell'Angelica EC, Shotelersuk V, Aguilar RC, Gahl WA, Bonifacino JS (1999b) Altered trafficking of lysosomal membrane proteins in Hermansky-Pudlak syndrome due to mutations in the β3A subunit of the AP-3 adaptor complex. Mol Cell 3:11-21
16. Dornan S, Jackson AP, Gay NJ (1997) Alpha-adaptin, a marker for endocytosis, is expressed in complex patterns during Drosophila development. Mol Biol Cell 8:1391-1403
17. Duden R, Griffiths G, Frank R, Argos P, Kreis TE (1991) Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell 64:649-665
18. Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (1996) Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex. J Cell Biol 135:53-61
19. Feng L, Seymour AB, Jiang S, To A, Peden AA, Novak EK, Zhen L, Rusiniak ME, Eicher EM, Robinson MS, Gorin MB, Swank RT (1999) The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness. Hum Mol Genet 8:323-330
20. Ferre J, Silva FJ, Real MD, Mensua JL (1986) Pigment patterns in mutants affecting the biosynthesis of pteridines and xanthommatin in Drosophila melanogaster. Biochem Genet 24:545-569
21. Gallusser A, Kirchhausen T (1993) The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. EMBO J 12:5237-5244
22. Gonnet GH, Cohen MA, Benner SA (1992) Exhaustive matching of the entire protein sequence database. Science 256:1443-1445
23. Gonzalez-Gaitan M, Jäckle H (1997) Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. Cell 88:767-776
24. Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T (1998) A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol 8:1239-1242
25. Hirst J, Robinson MS (1998) Clathrin and adaptors. Biochim Biophys Acta 1404:173-193
26. Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M (1998) Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. Neuron 21:111-122
27. Kirchhausen T, Bonifacino JS, Riezman H (1997) Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol 9:488-495
28. Kuge O, Hara Kuge S, Orci L, Ravazzola M, Amherdt M, Tanigawa G, Wieland FT, Rothman JE (1993) zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly. J Cell Biol 123:1727-1734
29. Le Borgne R, Alconada A, Bauer U, Hoflack B (1998) The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins. J Biol Chem 273:29451-29461
30. Lee J, Jongeward GD, Sternberg PW (1994) unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev 8:60-73
31. Lewin DA, Mellman I (1998) Sorting out adaptors. Biochim Biophys Acta 1401:129-145
32. Lindsley DL, Zimm GG (1992) The genome of Drosophila melanogaster. Academic Press, New York
33. Lloyd V, Ramaswami M, Krämer H (1998) Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery. Trends Cell Biol 8:257-259
34. Mohr OL (1927) Carmine, a new sex-linked eye color in Drosophila melanogaster. Z Indukt Abstamm Vererb Lehre 45:403-405
35. Nakayama Y, Goebl M, O'Brine Greco B, Lemmon S, Pingchang Chow E, Kirchhausen T (1991) The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem 202:569-574
36. Nolte DJ (1950) The eye pigmentary system of Drosophila: the pigment cells. J Genet 50:79-99
37. Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS (1995) Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269:1872-1875
38. Ohno H, Fournier MC, Poy G, Bonifacino JS (1996) Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chains. J Biol Chem 271:29009-29015
39. Ohno H, Aguilar RC, Yeh D, Taura D, Saito T, Bonifacino JS (1998) The medium subunits of adaptor complexes recognize distinct but overlapping sets of tyrosine-based sorting signals. J Biol Chem 273:25915-25921
40. Ooi CE, Moreira JE, Dell'Angelica EC, Poy G, Wassarman DA, Bonifacino JS (1997) Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet. EMBO J 16:4508-4518
41. Owen DJ, Evans PR (1998) A structural explanation for the recognition of tyrosine-based endocytotic signals. Science 282:1327-1332
42. Page LJ, Robinson MS (1995) Targeting signals and subunit interactions in coated vesicle adaptor complexes. J Cell Biol 131:619-630
43. Panek HR, Stepp JD, Engle HM, Marks KM, Tan PK, Lemmon SK, Robinson LC (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16:4194-4204
44. Pevsner J, Volknandt W, Wong BR, Scheller RH (1994) Two rat homologs of clathrin-associated adaptor proteins. Gene 146:279-283
45. Phan HL, Finlay JA, Chu DS, Tan PK, Kirchhausen T, Payne GS (1994) The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. EMBO J 7:1706-1717
46. Phillips JP, Forrest HS (1980) Ommochromes and pteridines. In: Ashburner M, Wright TRF (eds) Genetics and biology of Drosophila, vol 2d. Academic Press, New York, pp 541-617
47. Radice P, Pensotti V, Jones C, Perry H, Pierotti MA, Tunnacliffe A (1995) The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila. Genomics 26:101-106
48. Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T (1997) Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J 16:2240-2250
49. Rapoport I, Chen YC, Cupers P, Shoelson SE, Kirchhausen T (1998) Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J 17:2148-2155
50. Robinson MS (1993) Assembly and targeting of adaptin chimeras in transfected cells. J Cell Biol 123:67-77
51. Rothman JE, Wieland FT (1996) Protein sorting by transport vesicles. Science 272:227-234
52. Schekman R, Orci L (1996) Coat proteins and vesicle budding. Science 271:1526-1533
53. Schmid SL (1997) Clathrin-coated vesicle formation and protein sorting: an integrated process. Annu rev Biochem 66:511-548
54. Shestopal SA, Makunin IV, Belyaeva ES, Ashburner M, Zhimulev IF (1997) Molecular characterization of the deep orange (dor) gene of Drosophila melanogaster. Mol Gen Genet 253:642-648
55. Shih W, Gallusser A, Kirchhausen T (1995) A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes. J Biol Chem 270:31083-31090
56. Simpson F, Bright NA, West MA, Newman LS, Darnell RB, Robinson MS (1996) A novel adaptor-related protein complex. J Cell Biol 133:749-760
57. Simpson F, Peden AA, Christopoulou L, Robinson MS (1997) Characterization of the adaptor-related protein complex, AP-3. J Cell Biol 137:835-845
58. Stephens DJ, Crump CM, Clarke AR, Banting G (1997) Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the μ2 subunit of the AP2 clathrin adaptor complex. J Biol Chem 272:14104-14109
59. Stepp JD, Huang K, Lemmon SK (1997) The yeast AP-3 complex is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J Cell Biol 139:1761-1774
60. Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen (1996) Eps 15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem 271:28727-28730
61. Thurieau C, Brosius J, Burne C, Jolles P, Keen JH, Mattaliano RJ, Chow EP, Ramachandran KL, Kirchhausen T (1988) Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. DNA 7:663-669
62. Vowels JJ, Payne GS (1998) A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole. EMBO J 17:2482-2493
63. Warner TS, Sinclair DA, Fitzpatrick KA, Singh M, Devlin RH, Honda BM (1998) The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking. Genome 41:236-243
64. Wu MN, Bellen HJ (1997) Genetic dissection of synaptic transmission in Drosophila. Curr Opin Neurobiol 5:624-630
65. Zizioli D, Meyer C, Guhde G, Saftig P, von Figura K, Schu P (1999) Early embryonic death of mice deficient in gamma-adaptin. J Biol Chem 274:5385-5390