Genetic dissection of synaptic transmission in Drosophila

Current Opinion in Neurobiology

Volumn 7, Issue 5, 1997, Pages 624-630

  Wu, Mark N ^a   Bellen, Hugo J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; SYNAPTOBREVIN; SYNTAXIN;

DROSOPHILA; ENDOCYTOSIS; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; REVIEW; SYNAPTIC TRANSMISSION;

EID: 0030729350     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(97)80081-5     Document Type: Article

References (71)

1. Kelly RB: Storage and release of neurotransmitters. Cell/Neuron 1993, 72/10 (suppl):43-53.
2. Jessell TM, Kandel ER: Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication. Cell 1993, 72:1-30.
3. Südhof TC: The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 1995, 375:645-653.
4. Broadie KS: Genetic dissection of the molecular mechanisms of transmitter vesicle release during synaptic transmission. J Physiol 1995, 89:59-70.
5. Littleton JT, Bellen HJ: Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis. Invertebr Neurosci 1995, 1:3-13.
6. Parfitt K, Reist JL, Burgess R, Deitcher D, DiAntonio A, Schwarz TL: Drosophila genetics and the functions of synaptic proteins. Cold Spring Harb Symp Quant Biol 1995, 60:371-377.
7. Keshishian H, Broadie K, Chiba A, Bate M: The Drosophila neuromuscular junction: a model system for studying synaptic development and function. Annu Rev Neurosci 1996, 19:545-575.
8. Jan LY, Jan YN: Properties of the larval neuromuscular junction in Drosophila melanogaster. J Physiol 1976, 262:189-214.
9. Broadie K, Bate M: Development of embryonic neuromuscular synapse of Drosophila melanogaster. J Neurosci 1993, 13:144-166.
10. Kidokoro Y, Nishikawa K: Miniature endplate currents at the newly formed neuromuscular junction in Drosophila embryos and larvae. Neurosci Res 1994, 19:143-154.
11. Söllner T, Whiteheart SW, Brunner M, Erdjument-Bromage H, Geromanos S, Tempst P, Rothman JE: SNAP receptors implicated in vesicle targeting and fusion. Nature 1993, 362:318-324.
12. Schiavo G, Stenbeck G, Rothman JE, Söllner TH: Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. Proc Natl Acad Sci USA 1997, 94:997-1001.
13. Holz RW, Bittner MA, Peppers SC, Senter RA, Eberhard DA: MgATP-independent and MgATP-dependent exocytosis. J Biol Chem 1989, 264:5412-5419.
14. Parsons TD, Coorssen JR, Horstmann H, Almers W: Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells. Neuron 1995, 15:1085-1096.
15. 2+-activated exocytosis. J Biol Chem 1996, 271:20223-20226.
16. Mayer A, Wickner W, Haas A: Sec18p (NSF)-driven release of Sec17p (α-SNAP) can precede docking and fusion of yeast vacuoles. Cell 1996, 85:83-94.
17. Nichols BJ, Ungermann C, Pelham HRB, Wickner WT, Haas A: Homotypic vacuolar fusion mediated by t- and v-SNAREs. Nature 1997, 387:199-202.
18. Schulze K, Broadie K, Perin M, Bellen HJ: Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 1995, 80:311-320.
19. Sweeney ST, Broadie K, Keane J, Niemann, O'Kane CJ: Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioural defects. Neuron 1995, 14:341-351.
20. Broadie K, Prokop A, Bellen HJ, O'Kane CJ, Schulze KL, Sweeney ST: Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron 1995, 15:663-673.
21. Hunt JM, Charlton MP, Kistner A, Habermann E, Augustine GJ, Betz H: A post-docking role for synaptobrevin in synaptic vesicle fusion. Neuron 1994, 12:1269-1279.
22. 2+-dependent exocytosis. J Biol Chem 1996, 271:20227-20230.
23. Ordway RW, Pallanck L, Ganetzky B: Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins. Proc Natl Acad Sci USA 1994, 91:5715-5719.
24. Pallanck L, Ordway RW, Ramaswami M, Chi WY, Krishnan KS, Ganetzky B: Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog. J Biol Chem 1995, 270:18742-18744.
25. Pallanck L, Ordway RW, Ganetzky B: A Drosophila NSF mutant Nature 1995, 376:25.
26. Wilson DW, Wilcox CA, Flynn GC, Chen E, Kuang W-J, Henzel WJ, Block MR, Ullrich A, Rothman JE: A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast Nature 1989, 339:355-359.
27. Rothman JE: Mechanisms of intracellular protein transport Nature 1994, 372:55-63.
28. Siddiqi O, Benzer S: Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster. Proc Natl Acad Sci USA 1976, 73:3253-3257.
29. Morgan A: Classic clues to NSF function. Nature 1996, 382:680.
30. Bennett MK, Calakos N, Scheller RH: Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 1992, 257:255-259.
31. Schulze KL, Bellen HJ: Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization. Genetics 1996, 144:1713-1724.
32. Garcia EP, McPherson PS, Chilcote TJ, Takei K, De Camilli P: rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. J Cell Biol 1995, 129:105-120.
33. Sesack SR, Snyder CL: Cellular and subcellular localization of syntaxin-like immunoreactivity in the rat striatum and cortex. Neuroscience 1995, 67:993-1007.
34. Stevens CF, Tsujimoto T: Estimates for the pool size of releasable quanta at a single central synapse and for the time required to refill the pool. Proc Natl Acad Sci USA 1995, 92:846-849.
35. Rosemund C, Stevens CF: Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 1996, 16:1197-1207.
36. Südhof TC, Baumert M, Perin MS, Jahn R: A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Neuron 1989, 2:1475-1481.
37. Chin AC, Burgess RW, Wong BR, Schwarz TL, Scheller RH: Differential expression of transcripts from syb, a Drosophila melanogaster gene encoding a VAMP (synaptobrevin) that is abundant in non-neuronal cells. Gene 1993, 131:175-181.
38. DiAntonio A, Burgess RW, Chin AC, Deitcher DL, Scheller RH, Schwarz TL: Identification and characterization of Drosophila genes for synaptic vesicle proteins. J Neurosci 1993, 13:4924-4935.
39. Harris AJ, Miledi R: The effect of type D botulinum toxin on frog neuromuscular junctions. J Physiol 1971, 217:497-515.
40. Sellin LC, Thesleff S, Dasgupta BR: Different effects of types A and B botulinum toxin on transmitter release at the rat neuromuscular junction. Acta Physiol Scand 1983, 119:127-133.
41. Dreyer F, Becker C, Bigalke H, Funk J, Penner R, Rosenberg F, Ziegler M: Action of botulinum A toxin and tetanus toxin on synaptic transmission. J Physiol 1984, 79:252-258.
42. Molgo J, Siegel LS, Tabti N, Thesleff S: A study of synchronization of quantal transmitter release from mammalian motor endings by the use of botulinal toxins type A and D. J Physiol 1989, 411:195-205.
43. Protopopov V, Govindan B, Novick P, Gerst JE: Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell 1993, 74:855-861.
44. Aalto MK, Ronne H, Keranen S: Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport EMBO J 1993, 12:4095-4104.
45. De Camilli P, Takei K: Molecular mechanisms in synaptic vesicle endocytosis and recycling. Neuron 1996, 16:481-486.
46. Matthews G: Neurotransmitter release. Annu Rev Neurosci 1996, 19:219-233.
47. Heuser JE, Reese TS: Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction. J Cell Biol 1973, 57:315-344.
48. Pfeffer SR, Kelly RB: The subpopulation of brain coated vesicles that carries synaptic vesicle proteins contains two unique polypeptides. Cell 1985, 40:949-957.
49. Maycox PR, Link E, Reetz A, Morris SA, Jahn R: Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling. J Cell Biol 1992, 118:1379-1388.
50. Pley U, Parham P: Clathrin: its role in receptor-mediated vesicular transport and specialized functions in neurons. Crit Rev Biochem Mol Biol 1993, 28:431-464.
51. Robinson MS: The role of clathrin, adaptors and dynamin in endocytosis. Curr Opin Cell Biol 1994, 6:538-544.
52. Fesce R, Grohovaz R, Valtorta F, Meldolesi J: Neurotransmitter release: fusion or "kiss-and-run". Trends Cell Biol 1994, 4:1-4.
53. Von Gersdorff H, Matthews G: Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals. Nature 1994, 367:735-739.
54. Henkel AW, Betz WJ: Staurosporine blocks evoked release of FM1-43 but not acetylcholine from frog motor nerve terminals. J Neurosci 1996, 15:8246-8258.
55. Valtorta F, Fesce R, Grohovaz F, Haimann C, Hurlbut WP, Iezzi N, Torri Tarelli F, Villa A, Ceccarelli B: Neurotransmitter release and synaptic vesicle recycling. Neuroscience 1990, 35:477-489.
56. González-Gaitán M, Jäckle H: Role of Drosophila α-adaptin in presynaptic vesicle recycling. Cell 1997, 88:767-776.
57. Estes PS, Roos J, van der Bliek A, Kelly RB, Krishnan KS, Ramaswami M: Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers. J Neurosci 1996, 16:5443-5456.
58. Koenig JH, Ikeda K: Synaptic vesicles have two distinct recycling pathways. J Cell Biol 1996, 135:797-808.
59. Wang L-H, Sudhof TC, Anderson RGW: The appendage domain of α-adaptin is a high affinity binding site for dynamin. J Biol Chem 1995, 270:10079-10083.
60. Koenig JH, Ikeda K: Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval. J Neurosci 1989, 9:3844-3860.
61. Takei K, McPherson PS, Schmid SL, De Camilli P: Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals. Nature 1995, 374:186-189.
62. Betz WJ, Mao F, Bewick GS: Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals. J Neurosci 1992, 12:363-375.
63. Heuser JE, Reese TS: Structural changes after transmitter release at the frog neuromuscular junction. J Cell Biol 1981, 88:564-580.
64. 2+, GTP, and dynamin but not clathrin. Proc Natl Acad Sci USA 1995, 92:8328-8332.
65. DiAntonio A, Parfitt KD, Schwartz TL: Synaptic transmission persists in synaptotagmin mutants of Drosophila. Cell 1993, 73:1281-1290.
66. 2+-activated neurotransmitter release. Cell 1993, 74:1125-1134.
67. Broadie K, Bellen HJ, DiAntonio A, Littleton JT, Schwarz TL: The absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proc Natl Acad Sci USA 1994, 91:10727-10731.
68. Harrison SD, Broadie K, van de Goor J, Rubin GM: Mutations in the Drosophila rop gene suggest a function in general secretion and synaptic transmission. Neuron 1994, 13:555-566.
69. Schulze KL, Littleton JT, Salzberg A, Halachmi N, Stern M, Lev Z, Bellen HJ: rop, a Drosophila homolog of the vertebrate n-Sec1/Munc-18 and yeast Sec1 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 1994, 13:1099-1108.
70. Zinsmaier KE, Eberle KK, Buchner E, Walter N, Benzer S: Paralysis and early death in cysteine string protein mutants of Drosophila. Science 1994, 263:977-980.
71. Umbach JA, Zinsmaier KE, Eberle KK, Buchner E, Benzer S, Gundersen CB: Presynaptic dysfunction in Drosophila csp mutants. Neuron 1994, 13:899-907.