The tachykinin NK1 receptor antagonist GR205171 abolishes the retching activity of neurons comprising the central pattern generator for vomiting in dogs

Neuroscience Research

Volumn 33, Issue 1, 1999, Pages 25-32

  Fukuda, Hiroyuki ^a   Koga, Tomoshige ^a   Furukawa, Naohiro ^a   Nakamura, Emi ^a   Shiroshita, Yasuteru ^b  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b Section I   (Japan)

Author keywords

Central pattern generator; Emesis; GR205171; Medulla oblongata; NK1 receptor antagonist; Reticular formation; Vagus nerve; Vomiting

Indexed keywords

[2 METHOXY 5 (1 TETRAZOLYL)BENZYL](2 PHENYL 3 PIPERIDINYL)AMINE; APOMORPHINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; ANTIEMETIC AGENT; EMETIC AGENT; PIPERIDINE DERIVATIVE; TETRAZOLE DERIVATIVE; VOFOPITANT;

ABDOMINAL WALL MUSCULATURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIEMETIC ACTIVITY; ARTICLE; DOG; DRUG MECHANISM; FAST MUSCLE; FEMALE; MALE; MEDULLA OBLONGATA; NERVE CELL; NONHUMAN; PATTERN GENERATOR; PRIORITY JOURNAL; RETICULAR FORMATION; SLOW MUSCLE; SOLITARY TRACT NUCLEUS; VAGUS NERVE STIMULATION; VOMITING; ANIMAL; CYTOLOGY; DECEREBRATION; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; VAGUS NERVE;

ANIMALS; ANTIEMETICS; APOMORPHINE; DECEREBRATE STATE; DOGS; ELECTRIC STIMULATION; EMETICS; FEMALE; MALE; NEURONS; PIPERIDINES; RECEPTORS, NEUROKININ-1; RETICULAR FORMATION; TETRAZOLES; VAGUS NERVE; VOMITING;

EID: 0032589003     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(98)00106-0     Document Type: Article

References (36)

1. Baranauskas G., Nistri A. NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneurones. Brain Res. 738:1996;329-332.
2. 1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulation. Eur. J. Neurosci. 7:1995;2409-2417.
3. Bianchi A.L., Grélot L. Converse motor output to inspiratory bulbospinal premotorneurones during vomiting. Neurosci. Lett. 104:1989;298-302.
4. 1 receptor antagonist, CP-99,994, in ferrets. Eur. J. Pharmacol. 249:1993;R3-R4.
5. Chen Y., Saito H., Matsuki N. Ethanol-induced emesis in the house musk shrew, Suncus murinus. Life Sci. 60:1997;253-261.
6. Fukuda H., Koga T. The Bötzinger complex as the pattern generator for retching and vomiting in the dog. Neurosci. Res. 12:1991;471-485.
7. Fukuda H., Koga T. Non-respiratory neurons in the Bötzinger complex exhibiting appropriate firing patterns to generate the emetic act in dogs. Neurosci. Res. 14:1992;180-194.
8. Fukuda H., Koga T. Hypercapnia and hypoxia which developed during retching participate in the transition from retching to expulsion in dogs. Neurosci. Res. 17:1993;205-215.
9. Fukuda H., Koga T. Stimulation of glossopharyngeal and laryngeal nerve afferents induces expulsion only when it is applied during retching in paralyzed decerebrate dogs. Neurosci. Res. 23:1995;117-120.
10. Fukuda H., Koga T. Activation of peripheral and/or central chemoreceptors changes retching activities of Bötzinger complex neurons and induces expulsion in decerebrate dogs. Neurosci. Res. 23:1995;171-183.
11. Fukuda H., Koga T. Neuronal gagging activity patterns may be generated by neurons in the reticular area dorsomedial to the retrofacial nucleus in dogs. Exp. Brain Res. 113:1997;394-401.
12. Fukuda H., Koga T. Most inspiratory neurons in the pre-Bötzinger complex are suppressed during vomiting in dogs. Brain Res. 763:1997;30-38.
13. Fukuda H., Koga T., Furukawa N., Nakamura E., Shiroshita Y. The tachykinin NK1 receptor antagonist GR205171 prevents vagal stimulation-induced retching but not neuronal transmission from emetic vagal afferents to solitary nucleus neurons in dogs. Brain Res. 802:1998;221-231.
14. 1 receptor antagonist is mediated centrally in the ferret. Br. J. Pharmacol. 112:1994;516P.
15. 1 receptor antagonist, on motion-induced emesis in suncus murinus. Br. J. Pharmacol. 116:1995;250P.
16. 1 receptor antagonist GR203040. Br. J. Pharmacol. 116:1995;3158-3163.
17. 1 receptor, and potent broad-spectrum anti-emetic activity. Regul. Pept. 27:1996;45-53.
18. Grélot L., Barillot J.C., Bianchi A.L. Activity of respiratory-related oropharyngeal and laryngeal motorneurones during fictive vomiting in the decerebrate cat. Brain Res. 513:1990;101-105.
19. Koga T. Discharge patterns of bulbar respiratory neurons during retching and vomiting in decerebrate dogs. Jpn. J. Physiol. 41:1991;233-249.
20. Koga T., Fukuda H. Characteristic behavior of the respiratory muscles, esophagus, and external anal and urethral sphincters during straining, retching, and vomiting in the decerebrate dog. Jpn. J. Physiol. 40:1990;789-807.
21. Koga T., Fukuda H. Neurons in the nucleus of the solitary tract mediating inputs from emetic vagal afferents and the area postrema to the pattern generator for the emetic act in dogs. Neurosci. Res. 14:1992;166-179.
22. Koga T., Fukuda H. Bulbospinal augmenting inspiratory neurons may participate in contractions of the diaphragm during vomiting in decerebrate dogs. Neurosci. Lett. 180:1994;257-260.
23. Koga T., Fukuda H. Descending pathway from the central pattern generator of vomiting. Neuroreport. 28:1997;2587-2590.
24. Koga T., Qu R.-y., Fukuda H. The central pattern generator for vomiting may exist in the reticular area dorsomedial to the retrofacial nucleus in dogs. Exp. Brain Res. 118:1998;138-147.
25. Koninck Y.D., Henry J.L. Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation. Proc. Natl. Acad. Sci. USA. 88:1991;11344-11348.
26. Lucot J.B., Obach R.S., McLean S., Watson J.W. The effect of CP-99994 on the responses to provocative motion in the cat. Br. J. Pharmacol. 120:1997;116-120.
27. Miller A.D., Ezure K. Behavior of inhibitory and excitatory propriobulbar respiratory neurons during fictive vomiting. Brain Res. 578:1992;168-176.
28. Miller A.D., Tan L.K., Suzuki I. Control of abdominal and expiratory intercostal muscle activity during vomiting: role of ventral respiratory group expiratory neurons. J. Neurophysiol. 57:1987;1854-1866.
29. 1 tachykinin receptor antagonist, CP-99,994, in antagonizing the acute and delayed emesis induced by cisplatin in the ferret. Br. J. Pharmacol. 119:1996;931-936.
30. 1 receptor antagonists. Eur. J. Pharmacol. 326:1997;201-209.
31. Shiroshita Y., Koga T., Fukuda H. Capsaicin in the 4th ventricle abolishes retching and transmission of emetic vagal afferents to solitary nucleus neurons. Eur. J. Pharmacol. 339:1997;183-192.
32. 1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret. Eur. J. Pharmacol. 321:1997;209-216.
33. 1 receptor antagonist CP-99,994 attenuates cisplatin-induced emesis in the ferret. Eur. J. Pharmacol. 250:1993;R5-R6.
34. Tattersall F.D., Rycroft W., Hill R.G., Hargreaves R.J. Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994. Neuropharmacology. 33:1994;259-260.
35. 1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 35:1996;1121-1129.
36. 1 receptor. Br. J. Pharmacol. 115:1995;84-94.