Nitric oxide synthase inhibition versus norepinephrine for the treatment of hyperdynamic sepsis in sheep

Critical Care Medicine

Volumn 24, Issue 5, 1996, Pages 835-844

  Booke, Michael ^a   Hinder, Frank ^a   McGuire, Roy ^a   Traber, Lillian D ^a   Traber, Daniel L ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

critical illness; hyperdynamic circulation; methyl arginine; nitric oxide; norepinephrine; oxygen consumption; oxygen transport; renal function; sepsis; vasoconstriction

Indexed keywords

CATECHOLAMINE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; RINGER LACTATE SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; HEART INDEX; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SEPSIS; SHEEP; SYSTEMIC VASCULAR RESISTANCE; VASOCONSTRICTION;

ANIMALS; ARGININE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; HEMODYNAMIC PROCESSES; NITRIC OXIDE SYNTHASE; NOREPINEPHRINE; OMEGA-N-METHYLARGININE; OXYGEN CONSUMPTION; PROSPECTIVE STUDIES; SEPSIS; SHEEP; TIME FACTORS; VASOCONSTRICTOR AGENTS;

EID: 0029931337     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199605000-00018     Document Type: Article

References (40)

1. Bone RC: Gram-negative sepsis: A dilemma of modern medicine. Clin Microbiol Rev 1993; 6:57-68
2. Hazinski MF, Iberti TJ, MacIntyre NR, et al: Epidemiology, pathophysiology and clinical presentation of Gram-negative sepsis. Am J Crit Care 1993; 2: 224-235
3. Increase in National Hospital Discharge Survey rates for septicemia-United States, 1979-1987. MMWR Morb Mortal Wkly Rep 1990; 39:31
4. Cerra FB: The multiple organ failure syndrome. Hosp Pract (Off Ed) 1990; 25:169-176
5. Jeremy JY, Nystrom ML, Barradas MA, et al: Eicosanoids and septicemia. Prostaglandins Leukot Essent Fatty Acids 1994; 50:287-297
6. Vincent J-L, Bihari D: Sepsis, severe sepsis or sepsis syndrome: Need for clarification. Intensive Care Med 1992; 18:255-257
7. Martich GD, Boujoukos AJ, Suffredini AF: Response of man to endotoxin. Immunobiology 1993; 187:403-416
8. Redl-Wenzl EM, Arbruster C, Edelmann G, et al: The effects of norepinephrine on hemodynamics and renal function in severe septic shock states. Intensive Care Med 1993; 19:151-154
9. Nelson S, Stewart RH, Traber L, et al: Endotoxin-induced alterations in contractility of isolated blood vessels from sheep. Am J Physiol 1991; 260: H1790-H1794
10. Nelson SH, Dehring DJ, Ehardt JS, et al: Regional variation in content of C-GMP and associated vascular reactivity in bacteremia. Abstr. Circ Shock 1993; 39:54
11. Nava E, Palmer RM, Moncada S: Inhibition of nitric oxide synthesis in septic shock: How much is beneficial? Lancet 1991; 338:1555-1557
12. Geller DA, Nussler AK, Di Silvio M, et al: Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA 1993; 90: 522-526
13. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329:2002-2012
14. Nicolson AG, Haites NE, McKay NG, et al: Induction of nitric oxide synthase in human mesangial cells. Biochem Biophys Res Commun 1993; 193:1269-1274
15. Kilbourn RG, Jubran A, Gross SS, et al: Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 1990; 172:1132-1138
16. Meyer J, Lentz CW, Stothert JC, et al: Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia. Crit Care Med 1994; 22:306-312
17. Jones SB, Romano FD: Myocardial beta adrenergic receptor coupling to adenylate cyclase during developing septic shock. Circ Shock 1990; 30:51-61
18. Carcillo JA, Litten RZ, Roth BL: Norepinephrine-induced phosphorylation of a 25 kD phosphoprotein in rat aorta is altered in intraperitoneal sepsis. Circ Shock 1989; 28:257-265
19. Hwang TL, Lau YT, Huang SF, et al: Changes of alpha 1-adrenergic receptors in human liver during intraabdominal sepsis. Hepatology 1994; 20:638-642
20. Hollenberg SM, Cunnion RE, Zimmerberg J: Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol 1993; 264: H660-H663
21. Booke M, Meyer J, Lingnau W, et al: Use of nitric oxide synthase inhibitors in animal models of sepsis. New Horiz 1995; 3:123-138
22. Landin L, Lorente JA, Renes E, et al: Inhibition of nitric oxide synthesis improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 1994; 106:250-256
23. Wolf YG, Cotev S, Perel A, et al: Dependence of oxygen consumption on cardiac output in sepsis. Crit Care Med 1987; 15:198-203
24. Palazzo MD, Suter PM: Delivery dependent oxygen consumption in patients with septic shock: Daily variations, relationship with outcome and the sick-euthyroid syndrome. Intensive Care Med 1991; 17:325-332
25. Schneider F, Lutun P, Couchot A, et al: Plasma cyclic guanosine 3′-5′ monophosphate concentrations and low vascular resistance in human septic shock. Intensive Care Med 1993; 19:99-104
26. Schuller F, Fleming I, Stoclet JC, et al: Effect of endotoxin on circulating cyclic GMP in the rat. Eur J Pharmacol 1992; 212:93-96
27. Shah AM: Nitric oxide synthase activities in human myocardium. Lancet 1993; 341:448
28. Smith JA, Shah AM, Lewis MJ: Factors released from endocardium of the ferret and pig modulate myocardial contraction. J Physiol (Lond) 1991; 439:1-14
29. 2+ in intact cardiac myocytes. Circ Res 1994; 74:970-978
30. Dasta JF: Norepinephrine in septic shock: Renewed interest in an old drug. DICP Ann Pharmacother 1990; 24: 153-156
31. Bersten AD, Hersch M, Cheung H, et al: The effect of various sympathomimetics on the regional circulations in hyperdynamic sepsis. Surgery 1992; 112:549-561
32. Suba EA, McKenna TM, Williams, TJ: Differential contractile responses of mesenteric and pulmonary artery segments to norepinephrine and phorbol ester in the septic pig. Circ Shock 1992; 37:164-168
33. Cronin RE, de Torrente A, Miller PD, et al: Pathogenic mechanisms in early norepinephrine-induced acute renal failure: Functional and histological correlates of protection. Kidney Int 1978; 14:115-125
34. Hoffend J, Cavarape A, Endlich K, et al: Influence of endothelium-derived relaxing factor on renal microvessels and pressure-dependent vasodilation. Am J Physiol 1993; 265:F285-F292
35. Mills LC, Moyer JF, Handley CA: Effects of various sympathomimetic drugs on renal hemodynamics in normotensive and hypotensive dogs. Am J Physiol 1960; 198:179-183
36. Yukimura T, Yamashita Y, Miura K, et al: Renal effects of the nitric oxide synthase inhibitor, L-NG-nitroarginine, in dogs. Am J Hypertens 1992; 5:484-487
37. Desjars P, Pinaud M, Potel G, et al: A reappraisal of norepinephrine therapy in human septic shock. Crit Care Med 1987; 15:134-137
38. Meadows D, Edwards JD, Wilkins RG, et al: Reversal of intractable septic shock with norepinephrine therapy. Crit Care Med 1988; 16:663-666
39. Hinder F, Booke M, Traber LD, et al: Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically increased atrial natriuretic peptide. Crit Care Med 1996; 24:131-136
40. Lingnau W, McGuire R, Traber LD, et al: Renal function after nitric oxide inhibition in ovine bacterial sepsis. Abstr. Crit Care Med 1994; 22:A122