Involvement of Ca2+ influx in the mechanism of tamoxifen-induced apoptosis in HepG2 human hepatoblastoma cells

Cancer Letters

Volumn 147, Issue 1-2, 1999, Pages 115-123

  Kim, Jung Ae ^a   Kang, Young Shin ^b   Jung, Mi Wha ^a   Lee, Sun Hee ^b   Lee, Yong Soo ^b  

^a Yeungnam University   (South Korea)

^b Catholic Kwandong University   (South Korea)

Author keywords

Apoptosis; HepG2 cell; Intracellular calcium ion; Non selective cation channel; Tamoxifen

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHELATING AGENT; CALCIUM ION; CATION CHANNEL; DNA FRAGMENT; EGTAZIC ACID; ESTROGEN RECEPTOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUFENAMIC ACID; MANGANESE; NIFEDIPINE; TAMOXIFEN; TETRYLAMMONIUM; VERAPAMIL; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; CALCIUM; CHELATING AGENT; DRUG DERIVATIVE; FLUORESCENT DYE; FURA 2; ION CHANNEL;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG MECHANISM; FLOW CYTOMETRY; HEPATOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION; CELL CULTURE; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EXTRACELLULAR SPACE; INTRACELLULAR FLUID; LIVER TUMOR; METABOLISM; PATHOLOGY;

APOPTOSIS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL SURVIVAL; CHELATING AGENTS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; EXTRACELLULAR SPACE; FLUFENAMIC ACID; FLUORESCENT DYES; FURA-2; HEPATOBLASTOMA; HUMANS; INTRACELLULAR FLUID; ION CHANNELS; LIVER NEOPLASMS; MANGANESE; MEMBRANE POTENTIALS; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TAMOXIFEN; TUMOR CELLS, CULTURED;

EID: 0032585770     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00284-0     Document Type: Article

References (40)

1. Jordan V.C. Long-term adjuvant tamoxifen therapy for breast cancer. Breast Cancer Res. Treat. 15:1990;125-136.
2. Nayfield S.G., Karp J.E., Ford L.G., Dorr F.A., Kramer B.S. Potential role of tamoxifen in prevention of breast cancer. J. Natl. Cancer. Inst. 83:1991;1450-1459.
3. Kon O.L. Estrogens, antiestrogens and cell proliferation. Bioessays. 10:1989;210-214.
4. Kidd V.J. Proteolytic activities that mediate apoptosis. Annu. Rev. Physiol. 60:1998;533-573.
5. Keen J.C., Dixon J.M., Miller E.P., Cameron D.A., Chetty U., Hanby A., Bellamy C., Miller W.R. The expression of Ki-S1 and BCL-2 and the response to primary tamoxifen therapy in elderly patients with breast cancer. Breast Cancer Res. Treat. 44:1997;123-133.
6. Ellis P.A., Saccani-Jotti G., Clarke R., Johnston S.R., Anderson E., Howell A., A'Hern R., Salter J., Detre S., Nicholson R., Robertson J., Smith I.E., Dowsett M. Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer. Int. J. Cancer. 72:1997;608-613.
7. Ferlini C., Scambia G., Marone M., Distefano M., Gaggini C., Ferrandina G., Fattorossi A., Isola G., Benedetti Panici P., Mancuso S. Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines. Br. J. Cancer. 79:1999;257-263.
8. Kang Y., Cortina R., Perry R.R. Role of c-myc in tamoxifen-induced apoptosis estrogen-independent breast cancer cells. J. Natl. Cancer Inst. 88:1996;279-284.
9. McConkey D.J., Orrenius S. The role of calcium in the regulation of apoptosis. J. Leukocyte Biol. 59:1996;775-783.
10. Barkhem T., Andersson-Ross C., Hoglund M., Nilsson S. Characterization of the "estrogenicity" of tamoxifen and raloxifene in HepG2 cells: regulation of gene expression from an ERE controlled reporter vector versus regulation of the endogenous SHBG and PS2 genes. J. Steroid Biochem. Mol. Biol. 62:1997;53-64.
11. van de Loosdrecht A.A., Nennie E., Ossenkoppele G.J., Beelen R.H., Langenhuijsen M.M. Cell mediated cytotoxicity against U937 cells by human monocytes and macrophages in a modified colorimetric MTT assay. A methodological study. J. Immunol. Methods. 141:1991;15-22.
12. Hockenbery D., Nunez G., Milliman C., Schreiber R.D., Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 348:1990;334-336.
13. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
14. Seligmann B.E., Gallin J.I. Use of lipophilic probes of membrane potential to assess human neutrophil activation. Abnormality in chronic granulomatous disease. J. Clin. Invest. 66:1980;493-503.
15. Bombeli T., Karsan A., Tait J.F., Harlan J.M. Apoptotic vascular endothelial cells become procoagulant. Blood. 89:1997;2429-2442.
16. DiPolo R., Beauge L. The squid axon as a model for studying plasma membrane mechanisms for calcium regulation. Hypertension. 10:1987;I15-I19.
17. 2+ influx in human neutrophils. Biochem. J. 297:1994;595-601.
18. Katz A.M. Pharmacology and mechanisms of action of calcium-channel blockers. J. Clin. Hypertens. 2:1986;28S-37S.
19. Gogelein H., Dahlem D., Englert H.C., Lang H.J. Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS Lett. 268:1990;79-82.
20. + channels of neuroblastoma cells. Cell. Signal. 2:1990;387-393.
21. Nilius B., Prenen J., Szucs G., Wei L., Tanzi F., Voets T., Droogmans G. Calcium-activated chloride channels in bovine pulmonary artery endothelial cells. J. Physiol. (Lond.). 498:1997;381-396.
22. - currents inhibit endothelial cell proliferation. Pflugers Arch. 431:1995;132-134.
23. 2+- and voltage-dependent nonselective cation channels in human HepG2 cells. J. Formos. Med. Assoc. 96:1997;503-510.
24. Jordan V.C. Molecular mechanisms of antiestrogen action in breast cancer. Breast Cancer Res. Treat. 31:1994;41-52.
25. Ramkumar T., Adler S. Differential positive and negative transcriptional regulation by tamoxifen. Endocrinology. 136:1995;536-542.
26. Colletta A.A., Wakefield L.M., Howell F.V., van Roozendaal K.E., Danielpour D., Ebbs S.R., Sporn M.B., Baum M. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br. J. Cancer. 62:1990;405-409.
27. Hashimoto M., Inoue S., Muramatsu M., Masliah E. Estrogens stimulate tamoxifen-induced neuronal cell apoptosis in vitro: a possible nongenomic action. Biochem. Biophys. Res. Commun. 240:1997;464-470.
28. Rowlands M.G., Parr I.B., McCague R., Jarman M., Goddard P.M. Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen: correlations with cytotoxicity. Biochem. Pharmacol. 40:1990;283-289.
29. Cheng A.L., Chuang S.E., Fine R.L., Yeh K.H., Liao C.M., Lay J.D., Chen D.S. Inhibition of the membrane translocation and activation of protein kinase C, and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen. Biochem. Pharmacol. 55:1998;523-531.
30. Harman A.W., Maxwell M.J. An evaluation of the role of calcium in cell injury. Annu. Rev. Pharmacol. Toxicol. 35:1995;129-144.
31. Distelhorst C.W., Dubyak G. Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: resurrection of old theories by new findings. Blood. 91:1998;731-734.
32. i, and arterial smooth muscle relaxation. Am. J. Physiol. 263:1992;C468-C473.
33. 2+ as a tool to study calcium influx pathways. Int. J. Neurosci. 88:1996;215-241.
34. 2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells. Proc. Natl. Acad. Sci. USA. 90:1993;3068-3072.
35. 2+ influx through non-specific cation channels in endothelial cells. Eur. J. Pharmacol. 251:1994;119-125.
36. Bonnefoy-Berard N., Genestier L., Flacher M., Revillard J.P. The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines. Eur. J. Immunol. 24:1994;325-329.
37. Squier M.K.T., Cohen J.J. Calpain, an upstream regulator of thymocyte apoptosis. J. Immunol. 158:1997;3690-3697.
38. Fesus L., Thomazy V., Falus A. Induction and activation of tissue transglutaminase during programmed cell death. FEBS Lett. 224:1987;104-108.
39. Cohen J.J., Duke R.C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:1984;38-42.
40. Wyllie A.H., Morris R.G., Smith A.L., Dunlop D. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142:1984;67-67.