Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer

International Journal of Cancer

Volumn 72, Issue 4, 1997, Pages 608-613

  Ellis, Paul A ^a   Saccani Jotti, Gloria ^a,e   Clarke, Robert ^b   Johnston, Stephen R D ^a   Anderson, Elizabeth ^b   Howell, Anthony ^b   A'Hern, Roger ^a   Salter, Janine ^a   Detre, Simone ^a   Nicholson, Robert ^c   Robertson, John ^d   Smith, Ian E ^a   Dowsett, Mitchell ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c Tenovus Inst Cancer Res   (United Kingdom)

^d NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^e UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FULVESTRANT; TAMOXIFEN;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER HORMONE THERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; BIOPSY; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; HUMANS; LONGITUDINAL STUDIES; MIDDLE AGED; PARAFFIN EMBEDDING; PLACEBOS; RECEPTORS, ESTROGEN; TAMOXIFEN;

EID: 0030874172     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7     Document Type: Article

References (26)

1. BARDON, S., VIGNON, F., MONTCOURRIER, P. and ROCHEFORT, H., Steroid receptor-mediaated cytotoxicity of an anti-oestrogen and an anti-progestin in breast cancer cells. Cancer Res., 47, 1441-1448 (1987).
2. BERRY, M., METZGER, D. and CHAMBON, P., Role of the two activating domains on the oestrogen receptor in the cell type and promoter context agonist activity of the anti oestrogen 4-hydroxytamoxifen. EMBO J., 9, 2811-2818 (1990).
3. CLARKE, R.B., LAIDLAW, I.J., JONES, L.J., HOWELL, A. and ANDERSON, E., Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status. Brit. J. Cancer, 67, 606-611 (1993).
4. DEFRIEND, D.J. and 13 OTHERS, Investigation of a new pure antioestrogen (ICI 182780) in women with primary breast cancer. Cancer Res., 54, 408-414 (1994).
5. DOWSETT, M., JOHNSTON, S.R.D., NEWBY, J., GOLDING, M., SACKS, N. and SMITH, I.E., Mechanisms of hormone response: a role for apoptosis. Endocrine Related Cancer, 2, 1-7 (1995).
6. EARLY BREAST CANCER TRIALISTS GROUP (EBCTG), Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31000 recurrences and 24000 deaths among 75000 women. Lancet, 339, 1-15, 71-85 (1992).
7. FERGUSON, D.J.P. and ANDERSON, T.J., Morphological evaluation of cell turnover in relation to the menstrual cycle in the "resting" human breast. Brit. J. Cancer, 44, 177-181 (1981).
8. HICKMAN, J.A., Apoptosis induced by anticancer drugs. Cancer Metastasis Rev., 11, 121-139 (1992).
9. HOWELL, A., DEFRIEND, D., ROBERTSON, J., BLAMEY, R. and WALTON, P., Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Lancet, 345, 29-30 (1995).
10. HOWELL, A., HARLAND, R.N.L., BARNES, D.M., BAILDAM, A.D., WILKINSON, M.J.S., HAYWARD, E., SWINDELL, R. and SELLWOOD, R.A., Endocrine therapy for advanced carcinoma of the breast: relationship between the effect of tamoxifen upon concentrations of progesterone receptor and subsequent response to treatment. Cancer Res., 47, 300-304 (1987).
11. JOHNSTON, S.R.D., SACCANI-JOTTI, G., SMITH, I.E., SALTER, J., NEWBY, J., COPPEN, M., EBBS, S.R. and DOWSETT, M., Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer. Cancer Res., 55, 3331-3338 (1995).
12. KYPRIANOU, N., ENGLISH, H.F., DAVIDSON, N.E. and ISAACS, J.T., Programmed cell death during regression of the MCF human breast cancer following oestrogen ablation. Cancer Res., 51, 162-166 (1991).
13. LIPPONEN, P., AALTOMAA, S., KOSMA, V.M. and SYRJANEN, K., Apoptosis in breast cancer as related to histopathological characteristics and prognosis. Europ. J. Cancer, 30A, 2068-2073 (1994).
14. OSBORNE, C.K., CORONADO-HEINSOHN, E.B., HILSENBECK, S.G., MCCUE, B.L., WAKELING, A.E., MCCLELLAND, R.A., MANNING, D.L. and NICHOLSON, R.I., Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J. nat. Cancer Inst., 87, 747-750 (1995).
15. OSBORNE, C.K., HOBBS, K. and CLARK, G.M., Effect of oestrogens and antioestrogens on the growth of breast cancer cells in athymic nude mice. Cancer Res., 45, 584-590 (1985).
16. SHAFIE, S.M. and GRANTHAM, F.H., Role of hormones in the growth and regression of human breast cancer cells (MCF-7) transplanted into athymic nude mice. J. nat. Cancer Inst., 67, 51-56 (1981).
17. STRANGE, R., LI, F., SAURER, S., BURKHARDT, A. and FRIIS, R.R., Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development, 115, 49-58 (1992).
18. SUTHERLAND, R.L., HALL, R.E. and TAYLOR, I.W., Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentionally growing and plateau-phase cells. Cancer Res., 43, 3998-4006 (1983a).
19. SUTHERLAND, R.L., REDDEL, R.R. and GREEN, M.D., Effects of oestrogens on cell proliferation and cell cycle kinetics. A hypothesis on the cell cycle effects of anti-oestrogens. Europ. J. Cancer clin. Oncol., 19, 307-318 (1983b).
20. TAYLOR, I.W., HUDSON, P.J., GREEN, M.D. and SUTHERLAND, R.L., Effects of tamoxifen on cell cycle progression of synchronous MCF-7 human mammary carcinoma cells. Cancer Res., 43, 4007-4010 (1983).
21. TEIXEIRA, C., REED, J.C. and PRATT, M.A.C., Estrogen promotes chemotherapeutic drug resistance by a mechanism involving bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res., 55, 3902-3907 (1995).
22. WAKELING, A.E., DUKES, M. and BOWLER, J., A potent specific pure anti-oestrogen with clinical potential. Cancer Res., 51, 3867-3873 (1991).
23. WANG, T.T.Y. and PHANG, J.M., Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res., 55, 2487-2489 (1995).
24. WARRI, A.M., HUOVINEN, R.L., LAINE, A.M., MARTIKAINEN, P.M. and HARKONEN, K., Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro. J. nat. Cancer Inst., 85, 1412-1418 (1993).
25. WIJSMAN, J.H., JONKER, R.R., KEIJZER, R., VAN DE VELDE, C.J.H., CORNELISSE, C.J. and VAN DIERENDONCK, J.H., A new method to detect apoptosis in paraffin sections: in situ end-labelling of fragmented DNA. J. Histochem. Cytochem., 41, 7-12 (1993).
26. WILSON, J.W., WAKELING, A.E., MORRIS, I.D., HICKMAN, J.A. and DIVE, C., MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone-withdrawal and DNA damage. Int. J. Cancer, 61, 502-508 (1995).