메뉴 건너뛰기




Volumn 55, Issue 4, 1998, Pages 523-531

Inhibition of the membrane translocation and activation of protein kinase C, and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen

Author keywords

Apoptosis; Chemotherapy; Hepatocellular carcinoma; Protein kinase C; Tamoxifen

Indexed keywords

CARRIER PROTEIN; DOXORUBICIN; PROTEIN KINASE C; TAMOXIFEN; VERAPAMIL;

EID: 0032519653     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00594-7     Document Type: Article
Times cited : (69)

References (45)
  • 1
    • 0002656482 scopus 로고
    • Hepatobiliary system
    • (Eds. DeVita VT, Hellman S and Rosenberg SA), 4th Edn, J.B. Lippincott, Philadelphia
    • Lotze MT, Flickinger JC and Carr BJ, Hepatobiliary system. In: Cancer: Principles and Practice of Oncology (Eds. DeVita VT, Hellman S and Rosenberg SA), 4th Edn, pp. 883-914. J.B. Lippincott, Philadelphia, 1993.
    • (1993) Cancer: Principles and Practice of Oncology , pp. 883-914
    • Lotze, M.T.1    Flickinger, J.C.2    Carr, B.J.3
  • 2
    • 0023936352 scopus 로고
    • Clinical trials in primary hepatocellular carcinoma: Current status and future directions
    • Nerenstone SR, Ihde DC and Friedman MA, Clinical trials in primary hepatocellular carcinoma: Current status and future directions. Cancer Treat Rev 15: 1-31, 1988.
    • (1988) Cancer Treat Rev , vol.15 , pp. 1-31
    • Nerenstone, S.R.1    Ihde, D.C.2    Friedman, M.A.3
  • 3
    • 0026524781 scopus 로고
    • Overexpression of the MDR-1 gene and P-glycoprotein in human hepatocellular carcinoma
    • Huang C, Wu M, Xu G, Li D, Chen H, Tu Z, Jiang H and Gu J, Overexpression of the MDR-1 gene and P-glycoprotein in human hepatocellular carcinoma. J Natl Cancer Inst 84: 262-264, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 262-264
    • Huang, C.1    Wu, M.2    Xu, G.3    Li, D.4    Chen, H.5    Tu, Z.6    Jiang, H.7    Gu, J.8
  • 5
    • 0027172153 scopus 로고
    • Modulatory effects of tamoxifen and recombinant human α-interferon on doxorubicin resistance
    • Kang Y and Perry R, Modulatory effects of tamoxifen and recombinant human α-interferon on doxorubicin resistance. Cancer Res 53: 3040-3045, 1993.
    • (1993) Cancer Res , vol.53 , pp. 3040-3045
    • Kang, Y.1    Perry, R.2
  • 6
    • 0027243899 scopus 로고
    • Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites
    • Kirk J, Houlbrook S, Stuart NSA, Stratford IJ, Harris AL and Carmichael J, Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites. Br J Cancer 67: 1189-1195, 1993.
    • (1993) Br J Cancer , vol.67 , pp. 1189-1195
    • Kirk, J.1    Houlbrook, S.2    Nsa, S.3    Stratford, I.J.4    Harris, A.L.5    Carmichael, J.6
  • 9
    • 0023462787 scopus 로고
    • Controlled clinical trial of doxorubicin and tamoxifen versus doxorubicin alone in hepatocellular carcinoma
    • Melia WM, Jonhson PJ and Williams R, Controlled clinical trial of doxorubicin and tamoxifen versus doxorubicin alone in hepatocellular carcinoma. Cancer Treat Rep 71: 1213-1216, 1987.
    • (1987) Cancer Treat Rep , vol.71 , pp. 1213-1216
    • Melia, W.M.1    Jonhson, P.J.2    Williams, R.3
  • 11
    • 26844546353 scopus 로고
    • In vitro sensitivity to anticancer drugs and the expression of the pleiotropic drug resistant biochemical determinants of human hepatoma cell lines
    • Doong SL, Ho KG, Fisher MH and Cheng YC, In vitro sensitivity to anticancer drugs and the expression of the pleiotropic drug resistant biochemical determinants of human hepatoma cell lines. Proc Am Assoc Cancer Res 31: 365, 1990.
    • (1990) Proc Am Assoc Cancer Res , vol.31 , pp. 365
    • Doong, S.L.1    Ho, K.G.2    Fisher, M.H.3    Cheng, Y.C.4
  • 12
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
    • Carmichael J, DeGraff WG, Gazdar AF, Minna JD and Mitchell JB, Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res 47: 936-942, 1987.
    • (1987) Cancer Res , vol.47 , pp. 936-942
    • Carmichael, J.1    Degraff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5
  • 13
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC and Talalay P, Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55, 1984.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 15
    • 0027261147 scopus 로고
    • The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
    • Gorczyca W, Gong J, Ardelt B, Traganos F and Darzynkiewicz Z, The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 53: 3186-3192, 1993.
    • (1993) Cancer Res , vol.53 , pp. 3186-3192
    • Gorczyca, W.1    Gong, J.2    Ardelt, B.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 16
    • 0030071752 scopus 로고    scopus 로고
    • Combined cytotoxic effects of tamoxifen and chemotherapeutic agents on bladder cancer cells: A potential use in intravesical chemotherapy
    • Pu Y-S, Hsieh T-S, Cheng A-L, Tseng N-F, Su I-J, Hsieh C-Y, Lai M-K and Tsai T-C, Combined cytotoxic effects of tamoxifen and chemotherapeutic agents on bladder cancer cells: A potential use in intravesical chemotherapy. Br J Urol 77: 76-85, 1996.
    • (1996) Br J Urol , vol.77 , pp. 76-85
    • Pu, Y.-S.1    Hsieh, T.-S.2    Cheng, A.-L.3    Tseng, N.-F.4    Su, I.-J.5    Hsieh, C.-Y.6    Lai, M.-K.7    Tsai, T.-C.8
  • 17
    • 0027439693 scopus 로고
    • Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC α
    • Blobe GC, Sachs CW, Khan WA, Fabbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL and Hannun YA, Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC α. J Biol Chem 268: 658-664, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 658-664
    • Blobe, G.C.1    Sachs, C.W.2    Khan, W.A.3    Fabbro, D.4    Stabel, S.5    Wetsel, W.C.6    Obeid, L.M.7    Fine, R.L.8    Hannun, Y.A.9
  • 18
    • 0027942841 scopus 로고
    • Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinase Cα and Cδ in mouse keratinocytes
    • Szallasi Z, Smith CB and Blumberg PM, Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinase Cα and Cδ in mouse keratinocytes. J Biol Chem 269: 27159-27162, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 27159-27162
    • Szallasi, Z.1    Smith, C.B.2    Blumberg, P.M.3
  • 20
    • 0029086492 scopus 로고
    • Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells
    • Basu A and Weixel KM, Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells. Int J Cancer 62: 457-460, 1995.
    • (1995) Int J Cancer , vol.62 , pp. 457-460
    • Basu, A.1    Weixel, K.M.2
  • 21
    • 0021321610 scopus 로고
    • Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase
    • Lam HYP, Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase. Biochem Biophys Res Commun 118: 27-32, 1984.
    • (1984) Biochem Biophys Res Commun , vol.118 , pp. 27-32
    • Lam, H.Y.P.1
  • 22
    • 0027174116 scopus 로고
    • In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen
    • Huynh HT, Tetenes E, Wallace L and Pollak M, In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen. Cancer Res 53: 1727-1730, 1993.
    • (1993) Cancer Res , vol.53 , pp. 1727-1730
    • Huynh, H.T.1    Tetenes, E.2    Wallace, L.3    Pollak, M.4
  • 23
    • 0027325188 scopus 로고
    • Down-regulation of transforming growth factor-α by tamoxifen in human breast cancer
    • Noguchi S, Motomura K, Inaji H, Imalka S and Koyama H, Down-regulation of transforming growth factor-α by tamoxifen in human breast cancer. Cancer 72: 131-136, 1993.
    • (1993) Cancer , vol.72 , pp. 131-136
    • Noguchi, S.1    Motomura, K.2    Inaji, H.3    Imalka, S.4    Koyama, H.5
  • 25
    • 0028833039 scopus 로고
    • Modulation of natural killer cell-mediated cytotoxicity by tamoxifen and estradiol
    • Baral E, Nagy E and Berczi I, Modulation of natural killer cell-mediated cytotoxicity by tamoxifen and estradiol. Cancer 75: 591-599, 1995.
    • (1995) Cancer , vol.75 , pp. 591-599
    • Baral, E.1    Nagy, E.2    Berczi, I.3
  • 26
    • 0028242089 scopus 로고
    • Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines
    • Couldwell WT, Hinton DR, He S, Chen TC, Sebat I and Weiss MH, Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett 345: 43-46, 1994.
    • (1994) FEBS Lett , vol.345 , pp. 43-46
    • Couldwell, W.T.1    Hinton, D.R.2    He, S.3    Chen, T.C.4    Sebat, I.5    Weiss, M.H.6
  • 27
    • 0029980356 scopus 로고    scopus 로고
    • Tamoxifen induction of apoptosis in estrogen receptor-negative cancers: New tricks for an old dog
    • Gelmann EP, Tamoxifen induction of apoptosis in estrogen receptor-negative cancers: New tricks for an old dog. J Natl Cancer Inst 88: 224-226, 1996.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 224-226
    • Gelmann, E.P.1
  • 28
    • 0025696935 scopus 로고
    • Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17β-estradiol
    • Clarke R, Van den Berg HW and Murphy RF, Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17β-estradiol. J Natl Cancer Inst 82: 1702-1705, 1990.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1702-1705
    • Clarke, R.1    Van Den Berg, H.W.2    Murphy, R.F.3
  • 29
    • 0021702431 scopus 로고
    • Combination chemotherapy with cisplatin, carmustine, dacarbazine, and tamoxifen in metastatic melanoma
    • Del Prete SA, Maurer LH, O'Donnell J, Forcier RJ and LeMarbre P, Combination chemotherapy with cisplatin, carmustine, dacarbazine, and tamoxifen in metastatic melanoma. Cancer Treat Rep 68: 1403-1405, 1984.
    • (1984) Cancer Treat Rep , vol.68 , pp. 1403-1405
    • Del Prete, S.A.1    Maurer, L.H.2    O'Donnell, J.3    Forcier, R.J.4    Lemarbre, P.5
  • 31
    • 0026672032 scopus 로고
    • The treatment of intracranial malignant glioma using orally administered tamoxifen therapy: Preliminary results in a series of "failed" patients
    • Vertosick FT, Selker RG, Pollack IF and Arena V, The treatment of intracranial malignant glioma using orally administered tamoxifen therapy: Preliminary results in a series of "failed" patients. Neurosurgery 30: 897-903, 1992.
    • (1992) Neurosurgery , vol.30 , pp. 897-903
    • Vertosick, F.T.1    Selker, R.G.2    Pollack, I.F.3    Arena, V.4
  • 32
    • 0021172004 scopus 로고
    • Tamoxifen in the treatment of refractory lymphoma
    • Narasimhan P, Tamoxifen in the treatment of refractory lymphoma. N Engl J Med 311: 1258-1259, 1984.
    • (1984) N Engl J Med , vol.311 , pp. 1258-1259
    • Narasimhan, P.1
  • 33
    • 0029958760 scopus 로고    scopus 로고
    • Role of c-myc in tamoxifen-induced apoptosis in estrogen-independent breast cancer cells
    • Kang Y, Cortina R and Perry RR, Role of c-myc in tamoxifen-induced apoptosis in estrogen-independent breast cancer cells. J Natl Cancer Inst 88: 279-284, 1996.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 279-284
    • Kang, Y.1    Cortina, R.2    Perry, R.R.3
  • 34
    • 0028844643 scopus 로고
    • Phase I trial of high-dose tamoxifen as a modulator of drug resistance in combination with daunorubicin in patients with relapsed or refractory acute leukemia
    • Berman E, McBride M, Lin S, Menedeq-Bodet C and Tong W, Phase I trial of high-dose tamoxifen as a modulator of drug resistance in combination with daunorubicin in patients with relapsed or refractory acute leukemia. Leukemia 9: 1631-1637, 1995.
    • (1995) Leukemia , vol.9 , pp. 1631-1637
    • Berman, E.1    McBride, M.2    Lin, S.3    Menedeq-Bodet, C.4    Tong, W.5
  • 35
    • 0029587220 scopus 로고
    • Tamoxifen inhibits hepatoma cell growth through an estrogen receptor independent mechanism
    • Jiang SY, Shyu RY, Yeh MY and Jordan VC, Tamoxifen inhibits hepatoma cell growth through an estrogen receptor independent mechanism. J Hepatol 23: 712-719, 1995.
    • (1995) J Hepatol , vol.23 , pp. 712-719
    • Jiang, S.Y.1    Shyu, R.Y.2    Yeh, M.Y.3    Jordan, V.C.4
  • 36
    • 0023876867 scopus 로고
    • Comparison of protein kinase C functional assay to clarify mechanisms of inhibitor action
    • Nakadate T, Jeng AY and Blumberg PM, Comparison of protein kinase C functional assay to clarify mechanisms of inhibitor action. Biochem Pharmacol 37: 1541-1545, 1988.
    • (1988) Biochem Pharmacol , vol.37 , pp. 1541-1545
    • Nakadate, T.1    Jeng, A.Y.2    Blumberg, P.M.3
  • 37
    • 0023623755 scopus 로고
    • Nonsteroidal antiestrogens are estrogen-receptor-targeted growth inhibitors that can act in the absence of estrogens
    • Rochefort H, Nonsteroidal antiestrogens are estrogen-receptor-targeted growth inhibitors that can act in the absence of estrogens. Horm Res 28: 196-201, 1987.
    • (1987) Horm Res , vol.28 , pp. 196-201
    • Rochefort, H.1
  • 38
    • 0028285894 scopus 로고
    • Effect of the protein kinase C inhibitor staurosporine on chemosensitivity to daunorubicin of normal and leukemic fresh myeloid cells
    • Laredo J, Huynh A, Muller C, Jaffrézou JP, Bailly JD, Cassar G, Laurent G and Demur C, Effect of the protein kinase C inhibitor staurosporine on chemosensitivity to daunorubicin of normal and leukemic fresh myeloid cells. Blood 84: 229-237, 1994.
    • (1994) Blood , vol.84 , pp. 229-237
    • Laredo, J.1    Huynh, A.2    Muller, C.3    Jaffrézou, J.P.4    Bailly, J.D.5    Cassar, G.6    Laurent, G.7    Demur, C.8
  • 40
    • 0028818393 scopus 로고
    • Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C
    • Sachs CW, Safa AR, Harrison SD and Fine RL, Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J Biol Chem 270: 26639-26648, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 26639-26648
    • Sachs, C.W.1    Safa, A.R.2    Harrison, S.D.3    Fine, R.L.4
  • 41
    • 0028853493 scopus 로고
    • Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26Bcl-2 protein
    • Ponnathpur V, Ibrado AM, Reed JC, Ray Y, Huang Y, Self S, Bullock G, Nawabi A and Bhalla K, Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26Bcl-2 protein. Clin Cancer Res 1: 1399-1406, 1995.
    • (1995) Clin Cancer Res , vol.1 , pp. 1399-1406
    • Ponnathpur, V.1    Ibrado, A.M.2    Reed, J.C.3    Ray, Y.4    Huang, Y.5    Self, S.6    Bullock, G.7    Nawabi, A.8    Bhalla, K.9
  • 42
    • 0028181584 scopus 로고
    • Effects of bryostatin 1 and other pharmacological activators of protein kinase C on l-[β-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells
    • Jarvis WD, Povirk LF, Turner AJ, Traylor RS, Gewirtz DA, Pettit GR and Grant S, Effects of bryostatin 1 and other pharmacological activators of protein kinase C on l-[β-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. Biochem Pharmacol 47: 839-852, 1994.
    • (1994) Biochem Pharmacol , vol.47 , pp. 839-852
    • Jarvis, W.D.1    Povirk, L.F.2    Turner, A.J.3    Traylor, R.S.4    Gewirtz, D.A.5    Pettit, G.R.6    Grant, S.7
  • 44
    • 0002266414 scopus 로고
    • Protein kinase C and signal transduction: A role in cancer prevention and treatment?
    • Weinstein IB, Protein kinase C and signal transduction: A role in cancer prevention and treatment? Adv Oncol 9: 3-9, 1994.
    • (1994) Adv Oncol , vol.9 , pp. 3-9
    • Weinstein, I.B.1
  • 45
    • 0344519441 scopus 로고    scopus 로고
    • Tamoxifen and cisplatin induce BAX mRNA in human melanoma cells
    • Raffo AJ and Fine RL, Tamoxifen and cisplatin induce BAX mRNA in human melanoma cells. Proc Am Assoc Cancer Res 37: 414, 1996.
    • (1996) Proc Am Assoc Cancer Res , vol.37 , pp. 414
    • Raffo, A.J.1    Fine, R.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.