CSF N-CAM in neuroleptic-naive first-episode patients with schizophrenia

Schizophrenia Research

Volumn 34, Issue 3, 1998, Pages 123-131

  Vawter, Marquis P ^a   Hemperly, John J ^b   Freed, William J ^a   Garver, David L ^c  

^a NIDA Addiction Research Center   (United States)

^b BD Technologies   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cerebrospinal fluid; Neural cell adhesion molecule; Neuroleptic; Schizophrenia

Indexed keywords

HALOPERIDOL; NERVE CELL ADHESION MOLECULE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DRUG WITHDRAWAL; FEMALE; HUMAN; IMMUNOBLOTTING; MALE; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PSYCHIATRIC DIAGNOSIS; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; FEMALE; HUMANS; MALE; NEURAL CELL ADHESION MOLECULES; SCHIZOPHRENIA;

EID: 0032583089     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(98)00103-0     Document Type: Article

References (47)

1. Akbarian, S., Kim, J.J., Potkin, S.G., Hagman, J.O., Tafazzoli, A., Bunney, W.E., , Jr Jones, E.G., 1995. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch. Gen. Psychiatry 52 (4), 258-278.
2. Andreasen, N.C., 1989. The Scale for the Assessment of Negative Symptoms (SANS): conceptual and theoretical foundations. Br. J. Psychiatry Suppl. 7, 49-58.
3. Andreasen, N.C., Flaum, M., Arndt, S., 1992. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch. Gen. Psychiatry 49 (8), 615-623.
4. Arnold, S.E., Franz, B.R., Gur, R.C., Gur, R.E., Shapiro, R.M., Moberg, P.J., , TrojTrojanowski, J.Q., 1995. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am. J. Psychiatry 152 (5), 738-748.
5. Barbeau, D., Liang, J.J., Robitalille, Y., Quirion, R., Srivastava, L.K., 1995. Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains. Proc. Natl. Acad. Sci. USA 92 (7), 2785-2789.
6. Becker, T., Elmer, K., Schneider, F., Schneider, M., Grodd, W., Bartels, M., Heckers, S., Beckmann, H., 1996. Confirmation of reduced temporal limbic structure volume on magnetic resonance imaging in male patients with schizophrenia [published erratum appears in Psychiatry Res. 74(2) (1997) 127-128]. Psychiatry Res 67 (2), 135-143.
7. Breese, C.R., Freedman, R., Leonard, S.S., 1995. Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res. 674 (1), 82-90.
8. Cannon, T.D., Mednick, S.A., Parnas, J., Schulsinger, F., Praestholm, J., Vestergaard, A., 1993. Developmental brain abnormalities in the offspring of schizophrenic mothers. I. Contributions of genetic and perinatal factors [see comments]. Arch. Gen. Psychiatry 50 (7), 551-564.
9. Catts, S.V., Ward, P.B., Lloyd, A., Huang, X.F., Dixon, G., Chahl, L., Harper, C., Wakefield, D., 1997. Molecular biological investigations into the role of the NMDA receptor in the pathophysiology of schizophrenia. Aust. NZ J. Psychiatry 31 (1), 17-26.
10. Conrad, A.J., Scheibel, A.B., 1987. Schizophrenia and the hippocampus: the embryological hypothesis extended. Schizophr. Bull. 13 (4), 577-587.
11. Cremer, H., Chazal, G., Goridis, C., Represa, A., 1997. NCAM is essential for axonal growth and fasciculation in the hippocampus. Mol. Cell Neurosci. 8 (5), 323-335.
12. Davis, G.W., Schuster, C.M., Goodman, C.S., 1996. Genetic dissection of structural and functional components of synaptic plasticity. 3. Creb is necessary for presynaptic functional plasticity. Neuron 17 (4), 669-679.
13. Deakin, J.F., Simpson, M.D., 1997. A two-process theory of schizophrenia: evidence from studies in post-mortem brain. J. Psychiatr. Res. 31 (2), 277-295.
14. DeLisi, L.E., 1997. Is schizophrenia a lifetime disorder of brain plasticity, growth and aging? Schizophr. Res. 23 (2), 119-129.
15. DeLisi, L.E., Sakuma, M., Tew, W., Kushner, M., Hoff, A.L., Grimson, R., 1997. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Res. 74 (3), 129-140.
16. Eastwood, S.L., Burnet, P.W., Harrison, P.J., 1995. Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia. Neuroscience 66 (2), 309-319.
17. Edelman, G.M., Jones, F.S., 1997. Gene regulation of cell adhesion molecules in neural morphogenesis. Acta Paediatr. Suppl. 422, 12-19.
18. Garver, D.L., Steinberg, J.L., McDermott, B.E., Yao, J.K., Ramberg, J.E., Lewis, S., Kingsbury, S.J., 1997. Etiologic heterogeneity of the psychoses: is there a dopamine psychosis? Neuropsychopharmacology 16 (3), 191-201.
19. Glantz, L.A., Lewis, D.A., Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity [corrected and republished article originally appeared in Arch. Gen. Psychiatry 54(7) (1997) 660-669]. 1997. Arch. Gen. Psychiatry 54 (10), 943-952.
20. Gur, R.E., Cowell, P., Turetsky, B.I., Gallacher, F., Cannon, T., Bilker, W., Gur, R.C., 1998. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch. Gen. Psychiatry 55 (2), 145-152.
21. Harrison, P.J., 1995. On the neuropathology of schizophrenia and its dementia: neurodevelopmental, neurodegenerative, or both? Neurodegeneration 4 (1), 1-12.
22. Honer, W.G., Falkai, P., Young, C., Wang, T., Xie, J., Bonner, J., Hu, L., Boulianne, G.L., Luo, Z., Trimble, W.S., 1997. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience 78 (1), 99-110.
23. Issa, F., Kirch, D.G., Gerhardt, G.A., Bartko, J.J., Suddath, R.L., Freedman, R., Wyatt, R.J., 1994. A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: II. Correlations with psychopathology. Psychiatry Res. 52 (3), 251-258.
24. Jaskiw, G.E., Juliano, D.M., Goldberg, T.E., Hertzman, M., Urow-Hamell, E., Weinberger, D.R., 1994. Cerebral ventricular enlargement in schizophreniform disorder does not progress. A seven year follow-up study. Schizophr. Res. 14 (1), 23-28.
25. Kemali, D., Maj, M., Galderisi, S., Milici, N., Salvati, A., 1989. Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study. Biol. Psychiatry 26 (7), 756-759.
26. Kindermann, S.S., Karimi, A., Symonds, L., Brown, G.G., Jeste, D.V., 1997. Review of functional magnetic resonance imaging in schizophrenia. Schizophr. Res. 27 (2-3), 143-156.
27. Marsh, L., Harris, D., Lim, K.O., Beal, M., Hoff, A.L., Minn, K., Csernansky, J.G., DeMent, S., Faustman, W.O., Sullivan, E.V., Pfefferbaum, A., 1997. Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset. Arch. Gen. Psychiatry 54 (12), 1104-1112.
28. Martin, K.C., Kandel, E.R., 1996. Cell adhesion molecules, CREB and the formation of new synaptic connections [comment]. Neuron 17 (4), 567-570.
29. Nair, T.R., Christensen, J.D., Kingsbury, S.J., Kumar, N.G., Terry, W.M., Garver, D.L., 1997. Progression of cerebroventricular enlargement and the subtyping of schizophrenia. Psychiatry Res. 74 (3), 141-150.
30. Nasrallah, H.A., Olson, S.C., McCalley-Whitters, M., Chapman, S., Jacoby, C.G., 1986. Cerebral ventricular enlargement in schizophrenia. A preliminary follow-up study. Arch. Gen. Psychiatry 43 (2), 157-159.
31. Ohnuma, T., Kimura, M., Takahashi, T., Iwamoto, N., Arai, H., 1997. A magnetic resonance imaging study in first-episode disorganized-type patients with schizophrenia. Psychiatry. Clin. Neurosci. 51 (1), 9-15.
32. Poltorak, M., Frye, M., Wright, R., Hemperly, J., George, M., Pazzaglia, P., Jerrels, S., Post, R., Freed, W.J., 1996. Increased neural cell adhesion molecule in the CSF of patients with mood disorder. J. Neurochem. 66, 1532-1538.
33. Poltorak, M., Khoja, I., Hemperly, J.J., Williams, J.R., el-Mallakh, R., Freed, W.J., 1995. Disturbances in cell recognition molecules (N-CAM and L1 antigen) in the CSF of patients with schizophrenia. Exp. Neurol. 131 (2), 266-272.
34. Poltorak, M., Wright, R., Hemperly, J.J., Torrey, E.F., Issa, F., Wyatt, R.J., Freed, W.J., 1997. Monozygotic twins discordant for schizophrenia are discordant for N-CAM and L1 in CSF. Brain Res. 751, 152-154.
35. Porter, R.H., Eastwood, S.L., Harrison, P.J., 1997. Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Brain Res. 751 (2), 217-231.
36. Portin, P., Alanen, Y.O., 1997. A critical review of genetic studies of schizophrenia. I. Epidemiological and brain studies. Acta Psychiatr. Scand. 95 (1), 1-5.
37. Rajkowska, G., Selemon, L.D., Goldman-Rakic, P.S., 1998. Neuronal and glial somal size in the prefrontal cortex in schizophrenia and huntington disease. Arch. Gen. Psychiatry 55 (3), 215-224.
38. Smythies, J.R., 1997. Oxidative reactions and schizophrenia: a review-discussion. Schizophr. Res. 24 (3), 357-364.
39. Spitzer, R.L., Gibbon, M., Skodol, A.E., Williams, J.B.W., First, M.B., 1987. DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders (Revised Edition). American Psychiatric Press, Washington, DC.
40. Stevens, J.R., 1997. Anatomy of schizophrenia revisited. Schizophr. Bull. 23 (3), 373-383.
41. van Kammen, D.P., Poltorak, M., Kelley, M.E., Yao, J.K., Gurklis, J.A., Peters, J.L., Hemperly, J.J., Wright, R.D., Freed, W.J., 1998. Further studies of elevated cerebrospinal fluid neuronal cell adhesion molecule in schizophrenia. Biol. Psychiatry 43 (9), 680-686.
42. Vawter, M.P., Cannon-Spoor, H.E., Hemperly, J.J., Vander Putten, D., Hyde, T.M., Kleinman, J.E., Freed, W.J., 1998. Abnormal expression of cell recognition molecules in schizophrenia. Exp. Neurol. 149, 424-432.
43. Waddington, J.L., Scully, P.J., Youssef, H.A., 1997. Developmental trajectory and disease progression in schizophrenia: the conundrum and insights from a 12-year prospective study in the Monaghan 101. Schizophr. Res. 23 (2), 107-118.
44. Weinberger, D.R., 1997. The biological basis of schizophrenia: new directions. J. Clin. Psychiatry (Suppl.) 58 (10), 22-27.
45. Wood, G.K., Tomasiewicz, H., Rutishauser, U., Magnuson, T., Quirion, R., Rochford, J., Srivastava, L.K., 1998. NCAM-180 knockout mice display increased lateral ventricle size and reduced prepulse inhibition of startle. Neuroreport 9 (3), 461-466.
46. Woods, B.T., Yurgelun-Todd, D., Benes, F.M., Frankenburg, F.R., Pope, H.G., Jr, McSparren, J., 1990. Progressive ventricular enlargement in schizophrenia: comparison to bipolar affective disorder and correlation with clinical course. Biol. Psychiatry 27 (3), 341-352.
47. Zorrilla, L.T., Cannon, T.D., Kronenberg, S., Mednick, S.A., Schulsinger, F., Parnas, J., Praestholm, J., Vestergaard, A., 1997. Structural brain abnormalities in schizophrenia: a family study. Biol. Psychiatry 42 (12), 1080-1086.