Novel synthesis and release of GABA in cerebellar granule cell cultures after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase

Molecular Brain Research

Volumn 61, Issue 1-2, 1998, Pages 121-135

  New, Kent C ^a   Gale, Karen ^a   Martuza, Robert L ^a   Rabkin, Samuel D ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cerebellar granule cells; GABA; Glutamic acid decarboxylase; Herpes simplex virus; Neurotransmitter release; Virus vector

Indexed keywords

4 AMINOBUTYRIC ACID; COMPLEMENTARY DNA; GLUTAMATE DECARBOXYLASE; KAINIC ACID; VERATRIDINE; VIRUS VECTOR;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; CELL LEVEL; CONTROLLED STUDY; DEPOLARIZATION; DNA STRUCTURE; ESCHERICHIA COLI; GRANULE CELL; HERPES; HERPES SIMPLEX VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NEUROLOGIC DISEASE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CEREBELLUM; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION; GENETIC VECTORS; GLUTAMATE DECARBOXYLASE; KAINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SIMPLEXVIRUS; TIME FACTORS; TRANSFECTION; VERO CELLS;

EID: 0032582856     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00203-4     Document Type: Article

References (71)

1. 2+-independent release of neurotransmitters. J. Neurochem. 58:1992;395-405.
2. Albin R.L., Young A.B., Penney J.B. The functional anatomy of basal ganglia disorders. Trends Neurosci. 12:1989;366-375.
3. Aloisi F.M., Ciotti M.T., Levi G. Characterization of GABAergic neurons in cerebellar primary cultures and selective neurotoxic effects of a serum fraction. J. Neurosci. 5:1985;2001-2008.
4. Attwell D., Barbour B., Szatkowski M. Nonvesicular release of neurotransmitter. Neuron. 11:1993;401-407.
5. B receptors negatively regulate transcription in cerebellar granular neurons through cyclic AMP responsive element binding protein-dependent mechanisms. Neuroscience. 70:1996;417-427.
6. A receptor subunit mRNA expression in cultured cerebellar granule neurons. J. Neurosci. 13:1993;1784-1792.
7. Behar T.N., Li Y.X., Tran H.T., Ma W., Dunlap V., Scott C., Barker J.L. GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms. J. Neurosci. 16:1996;1808-1818.
8. + and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA. Neuroscience. 54:1993;1019-1034.
9. Bonanno G., Pittaluga A., Fedele E., Fontana G., Raiteri M. Glutamic acid and γ-aminobutyric acid modulate each other's release through heterocarriers sited on the axon terminals of rat brain. J. Neurochem. 61:1993;222-230.
10. Burgoyne R.D., Cambray-Deakin M.A. The cellular neurobiology of neuronal development: the cerebellar granule cell. Brain Res. Rev. 13:1988;77-101.
11. Cao Y., Wilcox K.S., Martin C.E., Rachinsky T.L., Eberwine J., Dichter M.A. Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons. Proc. Natl. Acad. Sci. USA. 93:1996;9844-9849.
12. Casu M., Gale K. Intracerebral injection of gamma vinyl GABA: method for measuring rates of GABA synthesis in specific brain regions in vivo. Life Sci. 29:1981;681-688.
13. Chang T.-C., Gottlieb D.I. Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase. J. Neurosci. 8:1988;2123-2130.
14. Cherubini E., Gaiarsa J., Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 14:1991;515-519.
15. Davanger S. Colocalization of amino acid signal molecules in neurons and endocrine cells. Anat. Embryol. (Berlin). 194:1996;1-12.
16. Davison M.-J., Preston V.G., McGeoch D.J. Determination of the sequence alteration in the DNA of the herpes simplex virus type 1 temperature-sensitive mutant tsK. J. Gen. Virol. 65:1984;859-863.
17. Delfs J.M., Ellison G.D., Mercugliano M., Chesselet M.F. Expression of glutamic acid decarboxylase mRNA in striatum and pallidum in an animal model of tardive dyskinesia. Exp. Neurol. 133:1995;175-188.
18. 2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 270:1995;2241-2246.
19. Drejer J., Schousboe A. Selection of pure cerebellar granule cell culture by kainate treatment. Neurochem. Res. 14:1989;751-754.
20. During M., Ryder K., Spencer D. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature. 376:1995;174-177.
21. Erecinska M., Nelson D., Daikhin Y., Yudkoff M. Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J. Neurochem. 67:1996;2325-2334.
22. Erlander M.G., Tillakaratne N.J.K., Feldblum S., Patel N., Tobin A.J. Two genes encode distinct glutamate decarboxylases. Neuron. 7:1991;91-100.
23. Esclapez M., Tillakaratne N.J.K., Kaufman D.L., Tobin A.J., Houser C.R. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J. Neurosci. 14:1994;1834-1855.
24. Feldblum S., Erlander M.G., Tobin A.J. The different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles. J. Neurosci. Res. 34:1993;689-706.
25. Fenwick M.L., Walker M.J. Suppression of the synthesis of cellular macromolecules by herpes simplex virus. J. Gen. Virol. 41:1978;37-51.
26. Fraefel C., Song S., Lim F., Lang P., Yu L., Wang Y.M., Wild P., Geller A.I. Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J. Virol. 70:1996;7190-7197.
27. French J.A., Mosier M., Walker S., Sommerville K., Sussman N. A double-blind, placebo-controlled study of vigabatrin three g/day in patients with uncontrolled complex partial seizures. Vigabatrin Protocol 024 Investigative Cohort. Neurology. 46:1996;54-61.
28. Fritz J.D., Utz A.L., Hale N.M., Wu L., Powers A.C., Verdoorn T.A., Robertson D. Gene-based neurotransmitter modulation in cerebellar granule neurons. J. Neurochem. 68:1997;204-212.
29. Gallo V., Ciotti M., Coletti A., Aloisi F., Levi G. Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc. Natl. Acad. Sci. USA. 79:1982;7919-7923.
30. Gallo V., Kingsbury A., Balazs R., Jorgensen O. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7:1987;2203-2213.
31. 3H ] GABA from hippocampal neurons in primary culture Brain Res. 482:1989;23-33.
32. Hendry S., Schwark H., Jones E., Yan J. Numbers and proportion of GABA-immunoreactive neurons in different areas of monkey cerebral cortex. J. Neurosci. 7:1987;1503-1519.
33. Hunninghake G.W., Monick M.M., Liu B., Stinski M.F. The promoter-regulatory region of the major immediate-early gene of the human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements. J. Virol. 63:1989;3026-3033.
34. Jessel T.M., Kandel E.R. Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication. Cell. 72:1993;1-30.
35. Jung M.J., Lippert B., Metcalf B.W., Bohlen P., Schechter P.J. Gamma-vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice. J. Neurochem. 29:1977;797-802.
36. Kalviainen R., Aikia M., Saukkonen A.M., Mervaala E., Riekkinen P.J. Vigabatrin versus carbamazepine monotherapy in newly diagnosed patients with epilepsy: a randomized controlled study. Arch. Neurol. 52:1995;989-996.
37. Kaplitt M.G., Pfaus J.G., Kleopoulos S.P., Hanlon B.A., Rabkin S.D., Pfaff D.W. Expression of a functional foreign gene in adult mammalian brain following in vivo transfer via a herpes simplex virus type 1 defective viral vector. Molecular and Cellular Neurosciences. 2:1991;320-330.
38. Kaufman D.L., Houser C.R., Tobin A.J. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 56:1991;720-723.
39. Kocsis J.D., Mattson R.H. GABA levels in the brain: a target for new antiepileptic drugs. The Neuroscientist. 2:1996;326-334.
40. Levi G., Aloisi M., Ciotti T., Gallo V. Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures. Brain Res. 290:1984;77-86.
41. Lindroth P., Mopper K. High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with o-pthaldialdehyde. Anal. Chem. 51:1979;1667-1674.
42. Loscher W., Honack D., Gramer M. Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: a reevaluation of aminooxyacetic acid. J. Neurochem. 53:1989;1737-1750.
43. Martin D.L., Rimvall K. Regulation of γ-aminobutyric acid synthesis in the brain. J. Neurochem. 60:1993;359-407.
44. McIntire S.L., Reimer R.J., Schuske K., Edwards R.H., Jorgensen E.M. Identification and characterization of the vesicular GABA transporter. Nature. 389:1997;870-876.
45. Meier E., Drejer J., Schousboe A. GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells. J. Neurochem. 43:1984;1737-1744.
46. Mineta T., Rabkin S.D., Yazaki T., Hunter W.D., Martuza R.L. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nature Medicine. 1:1995;938-943.
47. E. Mugnaini, W.H. Oertel, An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunohistochemistry, in: A. Bjorklund, T. Hokfelt (Eds.), Handbook of Chemical Neuroanatomy, Vol. 4, Elsevier, Amsterdam, 1985, pp. 436-608.
48. New K.C., Rabkin S.D. Co-expression of two gene products in the CNS using double-cassette defective herpes simplex virus vectors. Mol. Brain Res. 37:1996;317-323.
49. Novelli A., Nicoletti F., Wroblewski J.T., Alho H., Costa E., Guidotti A. Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells. J. Neurosci. 7:1987;40-47.
50. Oertel W.H., Schmechel d.E., Tappaz M.L., Kopin I.J. Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex. Neuroscience. 6:1981;2689-2700.
51. Owens D.F., Boyce L.H., Davis M.B.E., Kriegstein A.R. Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging. J. Neurosci. 16:1996;6414-6423.
52. Patrizio M., Gallo V., Levi G. Measurement of amino acid release from cultured cerebellar granule cells by an improved high performance liquid chromatography procedure. Neurochem. Res. 14:1989;627-633.
53. Pin J.-P., Bockaert J. Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture. J. Neurosci. 9:1989;548-656.
54. Richens A., Chadwick D.W., Duncan J.S., Dam M., Gram L., Mikkelsen M., Morrow J., Mengel H., Shu V., McKelvy J.F.et al. Adjunctive treatment of partial seizures with tiagabine: a placebo-controlled trial. Epilepsy Res. 21:1995;37-42.
55. Rimvall K., Martin D.L. The level of GAD67 protein is highly sensitive to small increases in intraneuronal γ-aminobutyric acid levels. J. Neurochem. 62:1994;1375-1381.
56. Robert J.J., Bouilleret V., Ridoux V., Valin A., Geoffroy M.C., Mallet J., Le Gal La Salle G. Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases. Gene Ther. 4:1997;1237-1245.
57. Roberts E. γ-Aminobutyric acid and nervous system function - a perspective. Biochem. Pharmacol. 23:1974;2637-2649.
58. Sagne C., El Mestikawy S., Isambert M.F., Hamon M., Henry J.P., Giros B., Gasnier B. Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett. 417:1997;177-183.
59. Salganicoff L., De Robertis E. Subcellular distribution of the enzymes of the glutamic acid, glutamine and γ-aminobutyric acid cycles in rat brain. J. Neurochem. 12:1965;287-309.
60. Sandler R., Smith A.D. Coexistence of GABA and glutamate in mossy fiber terminals of the primate hippocampus: an ultrastructural study. J. Comp. Neurol. 303:1991;177-192.
61. Silverstein S., Engelhardt E.L. Alterations in the protein synthetic apparatus of cells infected with herpes simplex virus. Virology. 95:1979;324-342.
62. Sitges M. Effect of organic and inorganic calcium channel blockers on σ-amino-n-butyric acid release induced by monesin and veratrine in the absence of external calcium. J. Neurochem. 53:1989;436-441.
63. Sloviter R.S., Dichter M.A., Rachinsky T.L., Dean E., Goodman J.H., Sollas A.L., Martin D.L. Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. J. Comp. Neurol. 373:1996;593-618.
64. Smith R.L., Geller A.I., Escudero K.W., Wilcox C.L. Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector. J. Virol. 69:1995;4593-4599.
65. Spaete R.R., Frenkel N. The herpes simplex virus amplicon: a new eukaryotic defective-virus cloning-amplifying vector. Cell. 30:1982;295-304.
66. N.D. Stow, E.C. McMonagle, Propagation of foreign DNA sequences linked to a herpes simplex virus origin of replication, in: Y. Gluzman (Ed.), Eukaryotic Viral Vectors, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1982, p. 199.
67. Thangnipon W., Kingsbury A., Webb M., Balazs R. Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes. Dev. Brain Res. 11:1983;177-189.
68. Vaccarino F.M., Alho H., Santi M.R., Guidotti A. Coexistence of GABA receptors and GABA-modulin in cultures of rat cerebellar granule cells. J. Neurosci. 7:1987;65-76.
69. van den Pol A.N., Obrietan K., Chen G. Excitatory actions of GABA after neuronal trauma. J. Neurosci. 16:1996;4283-4292.
70. 3H ] aminobutyric acid from striatal neurons in primary culture J. Neurochem. 51:1988;435-441.
71. White L.E., Hodges H.D., Carnes K.M., Price J.L., Dubinsky J.M. Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the rat. J. Comp. Neurol. 339:1994;328-340.