Gene-based neurotransmitter modulation in cerebellar granule neurons

Journal of Neurochemistry

Volumn 68, Issue 1, 1997, Pages 204-212

  Fritz, Jeffery D ^a   Utz, Andrea L ^a   Hale, Nannette M ^a   Wu, Lan ^b   Powers, Alvin C ^b,c   Verdoorn, Todd A ^a   Robertson, David ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Adenovirus; GABA; Gene transfer; Glutamate; Neuron

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE;

4 AMINOBUTYRIC ACID RELEASE; ADENOVIRUS; ANIMAL CELL; ARTICLE; CEREBELLUM CORTEX; DEGENERATIVE DISEASE; GENE EXPRESSION; GENE TRANSFER; GRANULE CELL; IMMUNOBLOTTING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENE;

ADENOVIRIDAE; ANIMALIA;

EID: 0031018593     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68010204.x     Document Type: Article

References (37)

1. Akli S., Caillaud C., Vigne E., Stratford-Perricaudet L. D., Poenaru L., Perricaudet M., Kahn A., and Peschanski M. R. (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat. Genet. 3, 224-228.
2. Bajocchi G., Feldman S. H., Crystal R. G., and Mastrangeli A. (1993) Direct in vivo gene therapy to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nat. Genet. 3, 229-234.
3. Balazs R., Gallo V., and Kingsbury A. (1988) Effect of depolarization on the maturation of cerebellar granule cells in culture. Dev. Brain Res. 40, 269-276.
4. Barbour B. (1993) Synaptic currents evoked in Purkinje cells by stimulating individual granule cells. Neuron 11, 759-769.
5. Bett A. J., Haddara W., Prevec L., and Graham F. L. (1994) An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91, 8802-8806.
6. Bu D.-F., Erlander M. G., Hitz B. C., Tillakaratne N. J. K., Kaufman D. L., Wagner-McPherson C. B., Evans G. L., and Tobin A. J. (1992) Two human decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc. Natl. Acad. Sci. USA 89, 2115-2119.
7. Byrnes A. P., MacLaren R. E., and Charlton H. M. (1996) Immunological instability of persistent adenoviral vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J. Neurosci. 16, 3045-3055.
8. Caillaud C., Akli S., Vigne E., Koulakoff A., Perricaudet M., Poenaru L., Kahn A., and Berwald-Netter Y. (1993) Adenoviral vectors as a gene delivery system into cultured rat neuronal and glial cells. Eur. J. Neurosci. 5, 1287-1291.
9. Davidson B. L., Allen E. D., Kozarsky K. F., Wilson J. M., and Roessler B. J. (1993) A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat. Genet. 3, 219-223.
10. 2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 270, 2241-2246.
11. Dolphin A. C. and Prestwich S. A. (1985) Pertussis toxin reverses adenosine inhibition of neuronal glutamate release. Nature 316, 148-150.
12. Engelhardt J. F., Ye X. I., Doranz B., and Wilson J. M. (1994) Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196-6200.
13. Erdö S. L. and Wolff J. R. (1990) γ-Aminobutyric acid outside the mammalian brain. J. Neurochem. 54, 363-372.
14. Erlander M. G. and Tobin A. J. (1991) The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem. Res. 16, 215-226.
15. Erlander M. G., Tillakaratne N. J., Feldblum S., Patel N., and Tobin A. J. (1991) Two genes encode distinct glutamate decarboxylases. Neuron 7, 91-100.
16. Gallo V., Ciotti M. T., Coletti A., Aloisi F., and Levi G. (1982) Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc. Natl. Acad. Sci. USA 79, 7919-7923.
17. Houser C. R., Vaughn J. E., Barber R. P., and Roberts E. (1980) GABA neurons are the major cell type of the nucleus reticularis thalami. Brain Res. 200, 341-354.
18. Kaufman D. L., Houser C. R., and Tobin A. J. (1991) Two forms of the γ-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 56, 720-723.
19. Le Gal La Salle G., Robert J. J., Berrard S., Ridoux V., Strarford-Perricaudet L. D., Perricaudet M., and Mallet J. (1993) An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259, 988-990.
20. Levi G. and Gallo V. (1986) Release studies related to the neurotransmitter role of glutamate in the cerebellum: an overview. Neurochem. Res. 11, 1627-1642.
21. Levi G., Aloisi F., Ciotti M. T., and Gallo V. (1984) Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures. Brain Res. 290, 77-86.
22. Mayer M. L. and Westbrook G. L. (1987) The physiology of excitatory amino acids in vertebrate central nervous system. Prog. Neurobiol. 28, 197-276.
23. Moriyoshi K., Richards L. J., Akazawa C., O'Leary D. D. M., and Nakanishi S. (1996) Labeling neural cells using adenoviral gene transfer of membrane-targeted GFP. Neuron 16, 255-260.
24. Mugnaini E. and Dahl A. L. (1983) Zinc-aldehyde fixation for light-microscopic immunocytochemistry of nervous tissue. J. Histochem. Cytochem. 31, 1435.
25. Price J., Turner D., and Cepko C. (1987) Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA 84, 156-160.
26. Ridoux V., Robert J. J., Zhang X., Perricaudet M., Mallet J., and Le Gal La Salle G. (1994) Adenoviral vectors as functional retrograde neuronal tracers. Brain Res. 648, 171-175.
27. Shy M. E., Tani M., Shi Y. J., Whyatt S. A., Chbihi T., Scherer S. S., and Kamholz J. (1995) An adenoviral vector can transfer lacZ expression into Schwann cells in culture and in sciatic nerve. Ann. Neurol. 38, 429-436.
28. Silver R. A., Traynelis S. F., and Cull-Candy S. G. (1992) Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature 355, 163-166.
29. Solimena M., Dirkx R. Jr., Radzynski M., Mundigl O., and De Camilli P. (1993) Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region. Proc. Natl. Acad. Sci. USA 90, 3073-3077.
30. Stewart C., Tailor N. A., Docherty K., and Bailey C. J. (1993) Insulin delivery by somatic cell gene therapy. J. Mol. Endocrinol. 11, 335-341.
31. Stewart C., Tailor N. A., Green I. C., Docherty K., and Bailey C. J. (1994) Insulin-releasing pituitary cells as a model for somatic cell gene therapy in diabetes mellitus. J. Endocrinol. 142, 339-343.
32. Talman W. T. (1996) Amino acid neurotransmission, in Primer on the Autonomic Nervous System (Robertson D., Low P. A., and Polinsky R. J., eds), pp. 104-106. Academic Press, San Diego.
33. Thangnipon W., Kingsbury A., Webb M., and Balázs R. (1983) Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes. Dev. Brain Res. 11, 177-189.
34. Venkatakrishnan A., Abel M. J., Campbell R. A., Donahue E. P., Uselton T. C., and Flakoll P. J. (1996) Whole blood analysis of gluconeogenic amino acids for estimation of de novo gluconeogenesis using pre-column o-phthalaldehyde derivatization and high-performance liquid chromatography. J. Chromatogr. [B] 676, 1-6.
35. Watanabe T. and Orth D. N. (1987) Detailed kinetic analysis of adrenocorticotropin secretion by dispersed rat anterior pituitary cells in a microperifusion system: effects of ovine corticotropin releasing factor and arginine vasopressin. Endocrinology 121, 1133-1145.
36. Yang Y., Nunes F. A., Berencsi K., Furth E. E., Gonczol E., and Wilson J. M. (1994) Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91, 4407-4411.
37. Zhou F. C., Cheng C., and Bledsoe S. (1993) Establishment of a stable glutamate decarboxylase (GAD) expressing cell-line by transfection. Cell Transplant. 2, 193-205.