Effect of tumor necrosis factor α on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts

Clinical Cancer Research

Volumn 3, Issue 3, 1997, Pages 319-324

  Kristensen, Claus A ^a   Roberge, Sylvie ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE INTAKE; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MELANOMA; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TISSUE PERFUSION; VASCULAR RESISTANCE; XENOGRAFT;

ANIMALS; FEMALE; GLUCOSE; HUMANS; KINETICS; MELANOMA; MICE; MICE, NUDE; NITRIC OXIDE; OXYGEN CONSUMPTION; PERFUSION; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR RESISTANCE;

EID: 0030928861     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Asher, A., Mulé, J. J., Reichert, C. M., Shiloni, E., and Rosenberg, S. A. Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo. J. Immunol., 138: 963-974, 1987.
2. Fraker, D. L., and Alexander, H. R. The use of tumor necrosis factor in isolated limb perfusions for melanoma and sarcoma. Princ. Pract. Oncol., 7: 1-10, 1993.
3. Liénard, D., Ewalenko, P., Delmotte, J-J., Renard, N., and Lejeune, F. J. High-dose recombinant tumor necrosis factor α in combination with Interferon γ and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J. Clin. Oncol., 10: 52-60, 1992.
4. Posner, M. C., Liénard, D., Lejeune, F. J., Rosenfelder, D., and Kirkwood, J. Hyperthermic isolated limb perfusion with tumor necrosis factor alone for melanoma. Cancer J. Sci. Am., 1: 274-280, 1995.
5. Folli, S., Pèlegrin, A., Chalandon, Y., Yao, X., Buchegger, F., Liénard, D., Lejeune, F., and Mach, J-P. Tumor-necrosis factor can enhance radio-antibody uptake in human colon carcinoma xenografts by increasing vascular permeability. Int. J. Cancer, 53: 829-836, 1993.
6. Rowlinson-Busza, G., Maraveyas, A., and Epenetos, A. A. Effect of tumour necrosis factor on the uptake of specific and control monoclonal antibodies in a human tumour xenograft model. Br. J. Cancer, 71: 660-665, 1995.
7. Kristensen, C. A., Nozue, M., Boucher, Y., and Jain, R. K. Reduction of interstitial fluid pressure after TNF-α treatment of three human melanoma xenografts. Br. J. Cancer, 74: 533-536, 1996.
8. Kallinowski, F., Schaefer, C., Tyler, G., and Vaupel, P. In vivo targets of recombinant human tumour necrosis factor-α: blood flow, oxygen consumption and growth of isotransplanted rat tumours. Br. J. Cancer, 60: 555-560, 1989.
9. Baudry, N., and Vicaut, E. Role of nitric oxide in effects of tumor necrosis factor-α on microcirculation in rat. J. Appl. Physiol., 75: 2392-2399, 1993.
10. Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., and Cerami, A. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature (Lond.), 330: 662-664, 1987.
11. Lamas, S., Michel, T., Brenner, B. M., and Marsden, P. A. Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-α. Am. J. Physiol., 261: C634-C641, 1991.
12. Mitaka, C., Hirata, Y., Ichikawa, K., Yokoyama, K., Emori, T., Kanno, K., and Amaha, K. Effects of TNF-α on hemodynamic changes and circulating endothelium-derived vasoactive factors in dogs. Am. J. Physiol., 267: H1530-H1536, 1994.
13. G-Methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc. Natl. Acad. Sci. USA, 87: 3629-3632, 1990.
14. Jain, R. K. Determinants of tumor blood flow: a review. Cancer Res., 48: 2641-2658, 1988.
15. Gullino, P. M., and Grantham, F. Studies of the exchange of fluids between host and tumor. I. A method for growing tissue-isolated tumors in laboratory animals. J. Natl. Cancer Inst., 27: 679-693, 1961.
16. Kristjansen, P. E. G., Roberge, S., Lee, I., and Jain, R. K. Tissue- isolated human tumor xenografts in athymic nude mice. Microvasc. Res., 48: 389-402, 1994.
17. Kristjansen, P. E. G., Brown, T. J., Shipley, L. A., and Jain, R. K. Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer. Clin. Cancer Res., 2: 359-367, 1996.
18. 15N]nitrate in biological fluids. Anal. Biochem., 126: 131-138, 1982.
19. West J. B. Uptake and delivering of the respiratory gases. In; J. B. West (ed.), Best and Taylor's Physiological Basis of Medical Practice, pp. 546-571. Baltimore: Williams & Wilkins, 1985.
20. Fukumura, D., Salehi, H. A., Witwer, B., Tuma, R. F., Melder, R. J., and Jain, R. K. Tumor necrosis factor α-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain. Cancer Res., 55: 4824-4829, 1995.
21. Renard, N., Liénard, D., Lespagnard, L., Eggermont, A., Heimann, R., and Lejeune, F. Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor α (rTNFα). Int. J. Cancer, 57: 656-663, 1994.
22. Renard, N., Nooijen, P. T. G. A., Schalkwijk, L., de Waal, R. M. W., Eggermont, A. M. M., Liénard, D., Kroon, B. B. R., Lejeune, F. J., and Ruiter, D. J. VWF release and platelet aggregation in human melanoma after perfusion with TNFα. J. Pathol., 776: 279-287, 1995.
23. Xie, J., Wang, Y., Lippton, H., Cai, B., Nelson, S., Kolls, J., Summer, W. R., and Greenberg, S. S. Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide. Am. Rev. Resp. Dis., 148: 627-636, 1993.
24. Tureen, J. Effect of recombinant human tumor necrosis factor-α on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide. J. Clin. Invest., 95: 1086-1091, 1995.
25. Tozer, G. M., Prise, V. E., and Bell, K. M. The influence of nitric oxide on tumour vascular tone. Acta Oncol., 34: 373-377, 1995.
26. Fukumura, D., Yuan, F., Endo, M., and Jain, R. K. Role of nitric oxide in tumor microcirculation: blood flow, vascular permeability, and leukocyte-endothelial interactions. Am. J. Pathol., in press, 1997.
27. Murata, M., Corradin, S. B., Janzer, R. C, and Juillerat-Jeanneret, L. Tumor cells suppress cytokine-induced nitric-oxide (NO) production in cerebral endothelial cells. Int. J. Cancer, 59: 699-705, 1994.
28. Kluge, M., Elger, B., Engel, T., Schaefer, C., Seega, J., and Vaupel, P. Acute effects of tumor necrosis factor α or lymphotoxin on global blood flow, laser doppler flux, and bioenergetic status of subcutaneous rodent tumors. Cancer Res., 52: 2167-2173, 1992.
29. Naredi, P. L., Lindnär, P. G., Holmberg, S. B., Stenram, U., Peterson, A., and Hafström, L. R. The effect of tumour necrosis factor α on the vascular bed and blood flow in an experimental rat hepatoma. Int. J. Cancer, 54: 645-649, 1993.
30. Suzuki, M., Hori, K., Abe, I., Saito, S., and Sato, H. A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II. J. Natl. Cancer Inst., 67: 663-669, 1981.
31. Gullino, P. M., Grantham, F. H., and Courtney, A. H. Utilization of oxygen by transplanted tumors in vivo. Cancer Res., 27: 1020-1030, 1967.
32. Gullino, P. M., Grantham, F. H., and Courtney, A. H. Glucose consumption by transplanted tumors in vivo. Cancer Res., 27: 1031-1040, 1967.
33. Ohkouchi, K., Imoto, H., Takakura, Y., Hashida, M., and Sezaki, H. Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system. Cancer Res., 50: 1640-1644, 1990.
34. Sensky, P. L., Prise, V. E., Tozer, G. M., Shaffi, K. M., and Hirst, D. G. Resistance to flow through tissue-isolated transplanted rat tumours located in two different sites. Br. J. Cancer, 67: 1337-1341, 1993.
35. 31P NMR. Proc. Natl. Acad. Sci. USA, 90: 2646-2650, 1993.