Examination of p53 alterations and cytokeratin expression in sputa collected from patients prior to histological diagnosis of squamous cell carcinoma

Journal of Cellular Biochemistry

Volumn 63, Issue SUPPL. 25, 1996, Pages 185-190

  Anderson, Marshall ^a,b,d   Sladon, Sue ^a   Michels, Ruth ^a   Davidson, Lois ^a   Conwell II, Kenneth ^a   Lechner, John ^c   Franklin, Wilbur ^b   Saccomanno, Geno ^a   Wiest, Jonathan ^a,b  

^a St Mary's Hospital Grand Junction   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Inhalation Toxicology Research Institute   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

cytokeratins; lung cancer; p53 overexpression; sputum

Indexed keywords

CYTOKERATIN; CYTOKERATIN 18; CYTOKERATIN 8; DNA; PROTEIN P53; UNCLASSIFIED DRUG; KERATIN;

ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC VALUE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SPUTUM ANALYSIS; SQUAMOUS CELL CARCINOMA; ALLELE; CHEMISTRY; GENETICS; LUNG TUMOR; METABOLISM; MUTAGENESIS; RETROSPECTIVE STUDY; SPUTUM;

ALLELES; CARCINOMA, SQUAMOUS CELL; HUMANS; KERATINS; LUNG NEOPLASMS; MUTAGENESIS; RETROSPECTIVE STUDIES; SPUTUM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030337856     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4644(1996)25+<185::aid-jcb26>3.0.co;2-m     Document Type: Article

References (20)

1. Sozzi G, Miozzo M, Pastorino U, Pilotti S, Donghi R, Giarola M, De Gregorio L, Manenti G, Radice P, Minoletti F, Della Porta G, Pierotti MA (1995): Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions. Cancer Res 55:135-140.
2. Bennett WP, Colby TV, Travis WD, Borkowski A, Jones RT, Lane DP, Metcalf RA, Samet JM, Takeshima Y, Gu JR, Vähäkangas KH, Soini Y, Pääkkö P, Welsh JA, Trump BP, Harris CC (1993): p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res 53:4817-4822.
3. Sozzi G, Miozzo M, Donghi R, Pilotti S, Cariani CT, Pastorino U, Della Porta G, Pierotti MA (1992): Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. Cancer Res 52:6079-6082.
4. Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM, Rabbitts P (1992): p53 and Chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 7:1989-1997.
5. Ahomadegbe JC, Barrois M, Fogel S, Le Bihan ML, Douc-Rasy S, Duvillard P, Armand JP, Riou G (1995): High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesions. Oncogene 10:1217-1227.
6. Shin DM, Kim J, Ro JY, Hittelman J, Roth JA, Hong WK, Hittelman WN (1994): Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 54:321-326.
7. Boyle JO, Hakim J, Koch W, van der Riet P, Hruban RH, Roa RA, Correo R, Eby YJ, Ruppert JM, Sidransky D (1993): The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53:4477-4480.
8. Nees M, Homann N, Bischer H, Andl T, Enders C, Herold-Mende C, Schuhmann A, Bosch FX (1993): Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: A possible molecular basis for the development of multiple tumors. Cancer Res 53:4189-4196.
9. Gusterson BA, Anbazhagan R, Warren W, Midgely C, Lane DP, O'Hare M, Stamps A, Carter R, Jayatilake H (1991): Expression of p53 in premalignant and malignant squamous epithelium. Oncogene 6:1785-1789.
10. Wang L-D, Hong J-Y, Qiu S-L, Gao H, Yang CS (1993): Accumulation of p53 protein in human esophageal precancerous lesions: A possible early biomarker for carcinogensis. Cancer Res 53:1783-1787.
11. Bennett WP, Hollstein MC, Metcalf RA, Welsh JA, He A, Zhu S-M, Kusters I, Resau JH, Trump BF, Lane DP, Harris CC (1992): p53 Mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res 52:6092-6097.
12. Harris CC, Hollstein M (1993): Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329: 1318-1322.
13. Ferrell L, Saccomanno G (1988): Diagnostic cytology techniques including fine needle aspirations: Practical considerations. In Thurlbeck WM (ed): "Pathology of the Lung." New York: Thieme Medical Publishers, Inc., pp 105-114.
14. Sundberg JP, Erickson AA, Roop DR, Binder RL (1994): Ornithine decarboxylase expression in cutaneous papillomas in sencar mice is associated with altered expression of keratins 1 and 10. Cancer Res 54:1344-1351.
15. Smedts F, Ramaekers F, Troyanovsky S, Pruszczynski M, Robben H, Lane B, Leigh I, Plantema F, Vooijs P (1992): Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia. Am J Pathol 140:601-612.
16. Lindberg K, Rheinwald JG (1989): Suprabasal 40 kd keratin (k19) expression as an immunohistologic marker of premalignancy in oral epithelium. Am J Pathol 134:89-98.
17. Ivanyi D, Groeneveld E, van Doornewaard G, Mooi WJ, Hageman PC (1990): Keratin subtypes in carcinomas of the uterine cervix: Implications for histogenesis and differential diagnosis. Cancer Res 50:5143-5152.
18. Smedts F, Ramaekers F, Troyanovsky S, Pruszczynski M, Link M, Lane B, Leigh I, Schijf C, Vooijs P (1992): Keratin expression in cervical cancer. Am J Pathol 141:497-511.
19. Broers JLV, Ramaekers FCS, Rot MK, Oostendorp T, Huysmans A, van Muijen GNP, Wagenaar SS, Vooijs GP (1988): Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies. Cancer Res 48:3221-3229.
20. Bosch FX, Leube RE, Achtstätter T, Moll R, Franke WW (1988): Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ. J Cell Biol 106: 1635-1648.