Activator-sigma interaction: A hydrophobic segment mediates the interaction of a sigma family promoter recognition protein with a sliding clamp transcription activator

Journal of Molecular Biology

Volumn 284, Issue 2, 1998, Pages 195-203

  Wong, Kevin ^a   Geiduschek, E Peter ^a  

^a 9500 Gilman Drive 92093 0634 ^*  (United States)

Author keywords

Bacteriophage T4 late genes; Sigma proteins; Sliding clamps; T4 gp55; Transcriptional regulation

Indexed keywords

ALANINE; BINDING PROTEIN; DNA POLYMERASE; EPITOPE; RNA POLYMERASE; SIGMA FACTOR; TRANSCRIPTION FACTOR;

AFFINITY CHROMATOGRAPHY; ARTICLE; BACTERIOPHAGE T4; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0032573425     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2166     Document Type: Article

References (30)

1. Berdis A.J., Soumillion P., Benkovic S.J. The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation. Proc. Natl Acad. Sci. USA. 93:1996;12822-12827
2. Berthomme H., Monahan S.J., Parris D.S., Jacquemont B., Epstein A.L. Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme evidence for specificity of interaction. J. Virol. 69:1995;2811-2818
3. Digard P., Bebrin W.R., Weisshart K., Coen D.M. The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication. J. Virol. 67:1993;398-406
4. Fu T.-J., Sanders G.M., O'Donnell M., Geiduschek E.P. Dynamics of DNA tracking by two sliding-clamp proteins. EMBO J. 15:1996;4414-4422
5. Geiduschek E.P., Fu T.-J., Kassavetis G.A., Sanders G.M., Tinker-Kulberg R.L. Transcriptional activation by a topologically linkable protein forging a connection between replication and gene activity. Eckstein F., Lilley D.M.J. Nucleic Acids and Molecular Biology. vol. 11:1997;135-150 Springer-Verlag, Heidelberg
6. Grosschedl R. Higher-order nucleoprotein complexes in transcription analogies with site-specific recombination. Curr. Opin. Cell Biol. 7:1995;362-370
7. Harlow E., Lane D. Antibodies: A Laboratory Manual. 1988;Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY
8. Herendeen D.R., Kassavetis G.A., Barry J., Alberts B.M., Geiduschek E.P. Enhancement of bacteriophage T4 late transcription by components of the T4 DNA replication apparatus. Science. 245:1989;952-958
9. Herendeen D.R., Williams K.P., Kassavetis G.A., Geiduschek E.P. An RNA polymerase-binding protein that is required for communication between an enhancer and a promoter. Science. 248:1990;573-578
10. Herendeen D.R., Kassavetis G.A., Geiduschek E.P. A transcriptional enhancer whose function imposes a requirement that proteins track along DNA. Science. 256:1992;1298-1303
11. Hernandez T.R., Lehman I.R. Functional interaction between the herpes simplex-1 DNA polymerase and UL42 protein. J. Biol. Chem. 265:1990;11227-11232
12. Kassavetis G.A., Elliott T., Rabussay D.P., Geiduschek E.P. Initiation of transcription at phage T4 late promoters with purified RNA polymerase. Cell. 33:1983;887-897
13. Latham G.J., Bacheller D.J., Pietroni P., von Hippel P.H. Structural analyses of gp45 sliding clamp interactions during assembly of the bacteriophage T4 DNA polymerase holoenzyme. II. The Gp44/62 clamp loader interacts with a single defined face of the sliding clamp ring. J. Biol. Chem. 272:1997;31677-31684
14. Latham G.J., Bacheller D.J., Pietroni P., von Hippel P.H. Structural analyses of gp45 sliding clamp interactions during assembly of the bacteriophage T4 DNA polymerase holoenzyme. III. The Gp43 DNA polymerase binds to the same face of the sliding clamp as the clamp loader. J. Biol. Chem. 272:1997;31685-31692
15. Léonetti J.-P., Wong K., Geiduschek E.P. Core-sigma interaction probing the interaction of the bacteriophage T4 gene 55 promoter recognition protein with E. coli RNA polymerase core. EMBO J. 17:1998;1467-1475
16. Li M., Moyle H., Susskind M.M. Target of the transcriptional activation function of phage lambda cI protein. Science. 263:1994;75-77
17. Mencia M., Monsalve M., Rojo F., Salas M. Transcription activation by phage phi29 protein p4 is mediated by interaction with the alpha subunit of Bacillus subtilis RNA polymerase. Proc. Natl Acad. Sci. USA. 93:1996;6616-6620
18. Miller A., Wood D., Ebright R.H., Rothman-Denes L.B. RNA polymerase beta′ subunit a target of DNA binding-independent activation. Science. 275:1997;1655-1657
19. Murakami K., Owens J.T., Belyaeva T.A., Meares C.F., Busby S.J., Ishihama A. Positioning of two alpha subunit carboxy-terminal domains of RNA polymerase at promoters by two transcription factors. Proc Natl Acad Sci USA. 94:1997;11274-11278
20. Richardson R.W., Nossal N.G. Trypsin cleavage in the COOH terminus of the bacteriophage T4 gene 41 DNA helicase alters the primase-helicase activities of the T4 replication complex in vitro. J. Biol. Chem. 264:1989;4732-4739
21. Rippe K., von Hippel P.H., Langowski J. Action at a distance DNA-looping and initiation of transcription. Trends Biochem. Sci. 20:1995;500-506
22. Sanders G.M., Kassavetis G.A., Geiduschek E.P. Rules governing the efficiency and polarity of loading a tracking clamp protein onto DNA determinants of enhancement in bacteriophage T4 late transcription. EMBO J. 14:1995;3966-3976
23. Sanders G.M., Kassavetis G.A., Geiduschek E.P. Dual targets of a transcriptional activator that tracks on DNA. EMBO J. 16:1997;3124-3132
24. Stow N.D. Sequences at the C-terminus of the herpes simplex virus type 1 UL30 protein are dispensable for DNA polymerase activity but not for viral origin-dependent DNA replication. Nucl. Acids Res. 21:1993;87-92
25. Tinker R.L., Kassavetis G.A., Geiduschek E.P. Detecting the ability of viral, bacterial and eukaryotic replication proteins to track along DNA. EMBO J. 13:1994;5330-5337
26. Tinker R.L., Williams K.P., Kassavetis G.A., Geiduschek E.P. Transcriptional activation by a DNA-tracking protein structural consequences of enhancement at the T4 late promoter. Cell. 77:1994;225-237
27. Tinker-Kulberg R.L., Fu T.-J., Geiduschek E.P., Kassavetis G.A. A direct interaction between a DNA-tracking protein and a promoter-recognition protein implications for searching DNA sequence. EMBO J. 15:1996;5032-5039
28. Williams K.P., Kassavetis G.A., Geiduschek E.P. Interactions of the bacteriophage T4 gene 55 product with Escherichia coli RNA polymerase. Competition with Escherichia coli sigma 70 and release from late T4 transcription complexes following initiation. J. Biol. Chem. 262:1987;12365-12371
29. Williams K.P., Müller R., Rüger W., Geiduschek E.P. The overproduced bacteriophage T4 gene 33 protein binds RNA polymerase. J. Bacteriol. 171:1989;3579-3582
30. Winkelman J.W., Kassavetis G.A., Geiduschek E.P. Molecular genetic analysis of a prokaryotic transcriptional coactivator functional domains of the bacteriophage T4 gene33 protein. J. Bacteriol. 176:1994;1164-1171