A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine

Biochemistry

Volumn 37, Issue 10, 1998, Pages 3491-3498

  Lee, Christian C ^a   Craig III, Sydney P ^a   Eakin, Ann E ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME BINDING; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ESCHERICHIA COLI; GENES, BACTERIAL; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FELIS CATUS; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032502283     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9720179     Document Type: Article

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