Overexpressed Bcl-xL prevents bacterial superantigen-induced apoptosis of thymocytes in vitro

Cell Death and Differentiation

Volumn 4, Issue 2, 1997, Pages 159-165

  Takahashi, Takeshi ^a   Honda, Hiroaki ^b,c   Hirai, Hisamaru ^c   Tsujimoto, Yoshihide ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bcl xl; Clonal deletion; Superantigen; Thymocytes; Transgenic mouse

Indexed keywords

BACTERIAL ANTIGEN; PROTEIN BCL 2; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EMBRYO; IMMUNOLOGICAL TOLERANCE; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; SPLEEN CELL; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; THYMOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 0031052142     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400214     Document Type: Article

References (30)

1. Aiba Y, Mazda O, Davis MM, Muramatsu S and Katsura Y (1994) Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells. Int. Immunol. 6: 1475-1483
2. Blackman M, Kappler J and Marrack P (1990) The role of the T cell receptor in positive and negative selection of developing T cells. Science 248: 1335-1342
3. Boise LH, Garcia MG, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G and Thompson CB (1993) bcl-x, a bcl-2-related gene thatfunctions as adominant regulator of apoptotic cell death. Cell 74: 597-608
4. Cory S (1995) Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13: 513-543
5. L is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Dev. 120: 3033-3042
6. L displays restricted distribution during T cell development and inhibits multiple forms of apoptotis but not clonal deletion in transgenic mice. J. Exp. Med. 182: 1973-1983
7. + thymocytes. Nature 300: 170-173
8. Hockenbery DM, Zutter M, Hickey W, Nahm M and Korsmeyer SJ (1991) BCL-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA 88: 6961-6965
9. Hogan B, Constantini F and Lacy E (1986) Manipulating the mouse embryo (Cold Spring Harbor Laboratory Press)
10. Jenkinson EJ, Kingston R, Williams GT and Owen JJ (1989) Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire. Eur. J. Immunol. 19: 2175-2177
11. Kamada S, Shimono A, Shinto Y, Tsujimura T, Takahashi T, Noda T, Kitamura Y, Kondoh H and Tsujimoto Y (1995) bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res. 55: 354-359
12. Katsumata M, Siegel RM, Louie DC, Miyashita T, Tsujimoto Y, Nowell PC, Green MI and Reed JC (1992) Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc. Natl. Acad. Sci. USA 89: 11376-11380
13. Krajewski S, Krajewska M, Shabaik A, Wang HG, Irie S, Fong L and Reed JC (1994) Immunohistochemical analysis of in vivo patterns of Bcl-x expression. Cancer Res. 54: 5501-5507
14. Lagasse E and Weissman IL (1994) bcl-2 inhibits apoptosis of neutorophils but not their engulfment by macrophages. J. Exp. Med. 179: 1047-1052
15. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S and Loh DY (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267: 1506-1510
16. - thymocytes in vivo. Science 250: 1720-1723
17. Nakayama K, Nakayama K, Negishi I, Kuida K, Shinkai Y, Louie MC, Fields LE, Lucas PJ, Stewart V, Alt FW and Loh DY (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261: 1584-1588
18. Nakayama K, Nakayama K, Negishi I, Kuida K, Sawa H and Loh DY (1994) Targeted disruption of Bcl-2αβ in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. USA 91: 3700-3704
19. Nossal GJV (1994) Negative selection of lymphocytes. Cell 76: 229-239
20. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271-279
21. Pullen AM, Marrack P and Kappler JW (1988) The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335: 796-801
22. Rosenbaum H, Webb E, Adams JM, Cory S and Harris AW (1989) N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. EMBO J. 8: 749-755
23. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888
24. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H and Tsujimoto Y (1995) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374: 811-813
25. Siegel RM, Katsumata M, Miyashita T, Louie DC, Greene MI, Reed JC (1992) Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc. Natl. Acad. Sci. USA 89: 7003-7007
26. Strasser A, Harris A and Cory S (1991) bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889-899
27. Surh CD and Sprent J (1994) T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372: 100-103
28. - immature thymocytes into the CD4/CD8 development pathway is controlled by tyrosine kinase signals that can be provided through TCR components. Int. Immunol. 6: 1505-1514
29. Veis DJ, Sorenson CM, Shutter JR and Korsmeyer SJ (1993) Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229-240
30. White J, Herman A, Pullen AM, Kubo R, Kappler JW and Marrack P (1989) The Vβ specific antigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56: 27-35