-
1
-
-
12044254839
-
From the basic science of B cells to biological missiles at the bedside
-
Vitetta, E. (1994) From the basic science of B cells to biological missiles at the bedside, J. Immunol. 153, 1407-1420
-
(1994)
J. Immunol.
, vol.153
, pp. 1407-1420
-
-
Vitetta, E.1
-
2
-
-
0026692120
-
Recombinant toxins as novel therapeutic agents
-
Pastan, I., Chaudhary, V. and FitzGerald, D.J. (1992) Recombinant toxins as novel therapeutic agents, Annu. Rev. Biochem. 61, 331-354
-
(1992)
Annu. Rev. Biochem.
, vol.61
, pp. 331-354
-
-
Pastan, I.1
Chaudhary, V.2
FitzGerald, D.J.3
-
4
-
-
0025119680
-
Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically cleavable spacer sequence
-
O'Hare, M. et al. (1990) Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically cleavable spacer sequence, FEBS Lett. 273, 200-204
-
(1990)
FEBS Lett.
, vol.273
, pp. 200-204
-
-
O'Hare, M.1
-
5
-
-
0028357390
-
Humanized immunotoxins
-
Gadina, M. et al. (1994) Humanized immunotoxins, Ther. Immunol. 1, 59-64
-
(1994)
Ther. Immunol.
, vol.1
, pp. 59-64
-
-
Gadina, M.1
-
6
-
-
0022540281
-
Structure of exotoxin A of pseudomonas aeruginosa at 3.0 Å
-
Allured, V.S., Collier, R.J., Carroll, S.F. and McKay, D.B. (1986) Structure of exotoxin A of Pseudomonas aeruginosa at 3.0 Å, Proc. Natl. Acad. Sci. U. S. A. 83, 1320-1324
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 1320-1324
-
-
Allured, V.S.1
Collier, R.J.2
Carroll, S.F.3
McKay, D.B.4
-
7
-
-
0023657391
-
Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli
-
Hwang, J., FitzGerald, D.J., Adhya, S. and Pastan, I. (1987) Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli, Cell 48, 129-136
-
(1987)
Cell
, vol.48
, pp. 129-136
-
-
Hwang, J.1
FitzGerald, D.J.2
Adhya, S.3
Pastan, I.4
-
8
-
-
0028090446
-
Selection of pseudomonas exotoxin-resistant cells with altered expression of α2MR/LRP
-
FitzGerald, D. et al. (1994) Selection of pseudomonas exotoxin-resistant cells with altered expression of α2MR/LRP, Ann. New York Acad. Sci. 737, 138-144
-
(1994)
Ann. New York Acad. Sci.
, vol.737
, pp. 138-144
-
-
FitzGerald, D.1
-
9
-
-
0028304478
-
Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver
-
Chiron, M.F., Fryling, CM. and FitzGerald, D.J. (1994) Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver, J. Biol. Chem. 269, 18167-18176
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18167-18176
-
-
Chiron, M.F.1
Fryling, C.M.2
FitzGerald, D.J.3
-
10
-
-
0042048435
-
Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of pseudomonas exotoxin
-
Batra, J.K. et al. (1989) Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of pseudomonas exotoxin, Proc. Natl. Acad. Sci. U. S. A. 86, 8545-8549
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 8545-8549
-
-
Batra, J.K.1
-
11
-
-
0026318613
-
Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of pseudomonas exotoxin
-
Pai, L.H. et al. (1991) Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of pseudomonas exotoxin, Proc. Natl. Acad. Sci. U. S. A. 88, 3358-3362
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 3358-3362
-
-
Pai, L.H.1
-
12
-
-
0024349836
-
A recombinant immunotoxin consisting of two antibody variable domains fused to pseudomonas exotoxin
-
Chaudhary, V.K. et al. (1989) A recombinant immunotoxin consisting of two antibody variable domains fused to pseudomonas exotoxin, Nature 339, 394-397
-
(1989)
Nature
, vol.339
, pp. 394-397
-
-
Chaudhary, V.K.1
-
13
-
-
0026005994
-
B3(Fv)-PE38KDEL, a single chain immunotoxin that causes complete regression of a human carcinoma in mice
-
Brinkmann, U. et al. (1991) B3(Fv)-PE38KDEL, a single chain immunotoxin that causes complete regression of a human carcinoma in mice, Proc. Natl. Acad. Sci. U. S. A. 88, 8616-8620
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 8616-8620
-
-
Brinkmann, U.1
-
14
-
-
0026755810
-
Recombinant anti-ErbB2 immunotoxins containing pseudomonas exotoxin
-
Batra, J.K. et al. (1992) Recombinant anti-ErbB2 immunotoxins containing pseudomonas exotoxin, Proc. Natl. Acad. Sci. U. S. A. 89, 5867-5871
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 5867-5871
-
-
Batra, J.K.1
-
15
-
-
0027473745
-
Immunotoxins made with a recombinant form of pseudomonas exotoxin A that do not require proteolysis for activity
-
Theuer, C.P., Kreitman, R.J., FitzGerald, D.J. and Pastan, I. (1993) Immunotoxins made with a recombinant form of pseudomonas exotoxin A that do not require proteolysis for activity, Cancer Res. 53, 340-347
-
(1993)
Cancer Res.
, vol.53
, pp. 340-347
-
-
Theuer, C.P.1
Kreitman, R.J.2
FitzGerald, D.J.3
Pastan, I.4
-
17
-
-
0028790796
-
Recombinant immunotoxins: From basic research to cancer therapy
-
Brinkmann, U. and Pastan, I. (1995) Recombinant immunotoxins: from basic research to cancer therapy, Methods Companion Methods Enzymol. 8, 143-158
-
(1995)
Methods Companion Methods Enzymol.
, vol.8
, pp. 143-158
-
-
Brinkmann, U.1
Pastan, I.2
-
18
-
-
0025162270
-
A comparison of strategies to stabilize immunoglobulin Fv-fragments
-
Glockshuber, R., Malia, M., Pfitzinger, I. and Pluckthun, A. (1990) A comparison of strategies to stabilize immunoglobulin Fv-fragments, Biochemistry 29, 1362-1367
-
(1990)
Biochemistry
, vol.29
, pp. 1362-1367
-
-
Glockshuber, R.1
Malia, M.2
Pfitzinger, I.3
Pluckthun, A.4
-
19
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analog produced in Escherichia coli
-
Huston, J.S. et al. (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analog produced in Escherichia coli, Proc. Natl. Acad. Sci. U. S. A. 85, 5879-5883
-
(1988)
Proc. Natl. Acad. Sci. U. S. A.
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
-
20
-
-
0024293979
-
Single-chain antigen binding proteins
-
Bird, R.E. et al. (1988) Single-chain antigen binding proteins, Science 242, 423-426
-
(1988)
Science
, vol.242
, pp. 423-426
-
-
Bird, R.E.1
-
21
-
-
0027183934
-
A recombinant immunotoxin containing a disulfide-stabilized Fv fragment
-
Brinkmann, U. et al. (1993) A recombinant immunotoxin containing a disulfide-stabilized Fv fragment, Proc. Natl. Acad. Sci. U. S. A. 90, 7538-7542
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 7538-7542
-
-
Brinkmann, U.1
-
22
-
-
0028285899
-
Improved binding and antitumor activity of a recombinant anti-ErbB2 immunotoxin by disulfide stabilization of the Fv fragment
-
Reiter, Y. et al. (1994) Improved binding and antitumor activity of a recombinant anti-ErbB2 immunotoxin by disulfide stabilization of the Fv fragment, J. Biol. Chem. 269, 18327-18331
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18327-18331
-
-
Reiter, Y.1
-
23
-
-
0026510381
-
Independent domain folding of pseudomonas exotoxin and single-chain immunotoxins: Influence of inter-domain connections
-
Brinkmann, U., Buchner, J. and Pastan, I. (1992) Independent domain folding of pseudomonas exotoxin and single-chain immunotoxins: influence of inter-domain connections, Proc. Natl. Acad. Sci. U. S. A. 89, 3075-3079
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 3075-3079
-
-
Brinkmann, U.1
Buchner, J.2
Pastan, I.3
-
24
-
-
0026792807
-
A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies
-
Buchner, J., Pastan, I. and Brinkmann, U. (1992) A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies, Anal. Biochem. 205, 263-270
-
(1992)
Anal. Biochem.
, vol.205
, pp. 263-270
-
-
Buchner, J.1
Pastan, I.2
Brinkmann, U.3
-
25
-
-
0028205130
-
Recombinant single-chain immunotoxins against T and B cell leukemias
-
Kreitman, R. and Pastan, I. (1994) Recombinant single-chain immunotoxins against T and B cell leukemias, Leukemia Lymphoma 13, 1-10
-
(1994)
Leukemia Lymphoma
, vol.13
, pp. 1-10
-
-
Kreitman, R.1
Pastan, I.2
-
26
-
-
0029383661
-
Targeting pseudomonas exotoxin to hematologic malignancies
-
Kreitman, R. and Pastan, I. (1995) Targeting pseudomonas exotoxin to hematologic malignancies, Semin. Cancer Biol. 6, 297-306
-
(1995)
Semin. Cancer Biol.
, vol.6
, pp. 297-306
-
-
Kreitman, R.1
Pastan, I.2
-
27
-
-
0029383734
-
Targeting diphtheria toxin to growth factor receptors
-
Murphy, J.R. and VanderSpek, J.C. (1995) Targeting diphtheria toxin to growth factor receptors, Semin. Cancer Biol. 6, 259-267
-
(1995)
Semin. Cancer Biol.
, vol.6
, pp. 259-267
-
-
Murphy, J.R.1
Vanderspek, J.C.2
-
28
-
-
0028230402
-
In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats
-
Siegall, C. et al. ( 1994) In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats, J. Immunol. 152, 2377-2384
-
(1994)
J. Immunol.
, vol.152
, pp. 2377-2384
-
-
Siegall, C.1
-
29
-
-
0029133184
-
Recombinant toxins: New therapeutic agents for cancer
-
Pastan, I., Pai, L., Brinkmann, U. and FitzGerald, D. (1995) Recombinant toxins: new therapeutic agents for cancer, Ann. New York Acad. Sci. 758, 345-354
-
(1995)
Ann. New York Acad. Sci.
, vol.758
, pp. 345-354
-
-
Pastan, I.1
Pai, L.2
Brinkmann, U.3
FitzGerald, D.4
-
30
-
-
0030051837
-
Recombinant immunotoxins
-
Pastan, I., Pai, L., Brinkmann, U. and FitzGerald, D. (1996) Recombinant immunotoxins, Breast Cancer Res. Treat. 38, 3-9
-
(1996)
Breast Cancer Res. Treat.
, vol.38
, pp. 3-9
-
-
Pastan, I.1
Pai, L.2
Brinkmann, U.3
FitzGerald, D.4
-
31
-
-
0028313090
-
Immunotoxins and recombinant toxins for cancer treatment
-
(DeVita, V., Hellman, S. and Rosenberg, S., eds), J.B. Lippincott
-
Pai, L. and Pastan, I. (1994) Immunotoxins and recombinant toxins for cancer treatment, in Important Advances in Oncology (DeVita, V., Hellman, S. and Rosenberg, S., eds), pp. 3-19, J.B. Lippincott
-
(1994)
Important Advances in Oncology
, pp. 3-19
-
-
Pai, L.1
Pastan, I.2
-
32
-
-
0027317693
-
The use of immunotoxins for cancer therapy
-
Pai, L.H. and Pastan, I. (1993) The use of immunotoxins for cancer therapy, Eur. J. Cancer 11, 1606-1609
-
(1993)
Eur. J. Cancer
, vol.11
, pp. 1606-1609
-
-
Pai, L.H.1
Pastan, I.2
-
33
-
-
0027441541
-
Immunotoxin therapy for cancer
-
Pai, L.H. and Pastan, I. (1993) Immunotoxin therapy for cancer, J. Am. Med. Assoc. 269, 78-81
-
(1993)
J. Am. Med. Assoc.
, vol.269
, pp. 78-81
-
-
Pai, L.H.1
Pastan, I.2
-
34
-
-
0028609356
-
Cloning, expression and characterization of the Fv fragments of the anticarbohydrate monoclonal antibodies B1 and B5 as single-chain immunotoxins
-
Benhar, I. and Pastan, I. (1994) Cloning, expression and characterization of the Fv fragments of the anticarbohydrate monoclonal antibodies B1 and B5 as single-chain immunotoxins, Protein Eng. 7, 1509-1515
-
(1994)
Protein Eng.
, vol.7
, pp. 1509-1515
-
-
Benhar, I.1
Pastan, I.2
-
35
-
-
0028275863
-
Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment
-
Reiter, Y. et al. (1994) Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment, Cancer Res. 54, 2714-2718
-
(1994)
Cancer Res.
, vol.54
, pp. 2714-2718
-
-
Reiter, Y.1
-
36
-
-
0029165134
-
Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice
-
Benhar, I., Reiter, Y., Pai, L.H. and Pastan, I. (1995) Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice, Int. J. Cancer 62, 351-355
-
(1995)
Int. J. Cancer
, vol.62
, pp. 351-355
-
-
Benhar, I.1
Reiter, Y.2
Pai, L.H.3
Pastan, I.4
-
37
-
-
0028928499
-
Intrathecal administration of single-chain immunotoxin, LMB-7 (B3(Fv)-PE38), produces cures of carcinomatous meningitis in a rat model
-
Pastan, I. et al. (1995) Intrathecal administration of single-chain immunotoxin, LMB-7 (B3(Fv)-PE38), produces cures of carcinomatous meningitis in a rat model, Proc. Natl. Acad. Sci. U. S. A. 92, 2765-2769
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 2765-2769
-
-
Pastan, I.1
-
38
-
-
0029925934
-
Treatment of advanced solid tumors with immunotoxin LMB-1: An antibody linked to pseudomonas exotoxin
-
Pai, L.H. et al. (1996) Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to pseudomonas exotoxin, Nat. Med. 1, 350-353
-
(1996)
Nat. Med.
, vol.1
, pp. 350-353
-
-
Pai, L.H.1
-
39
-
-
0024411071
-
Phase I study of an anti-breast cancer immunotoxin by continuous infusion: Report of a targeted toxic effect not predicted by animal studies
-
Gould, B.J. et al (1989) Phase I study of an anti-breast cancer immunotoxin by continuous infusion: report of a targeted toxic effect not predicted by animal studies, J. Natl. Cancer Inst. 81, 775-781
-
(1989)
J. Natl. Cancer Inst.
, vol.81
, pp. 775-781
-
-
Gould, B.J.1
-
40
-
-
0025826197
-
Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas
-
Pastan, I. et al. (1991) Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas, Cancer Res. 51, 3781-3787
-
(1991)
Cancer Res.
, vol.51
, pp. 3781-3787
-
-
Pastan, I.1
-
41
-
-
0026211630
-
Routes to active proteins from transformed microorganisms
-
Buchner, J. and Rudolph, R. (1991) Routes to active proteins from transformed microorganisms, Curr. Opin. Biotechnol. 2, 532-538
-
(1991)
Curr. Opin. Biotechnol.
, vol.2
, pp. 532-538
-
-
Buchner, J.1
Rudolph, R.2
-
42
-
-
0026486446
-
Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the ErbB-2 receptor
-
Wels, W. et al. (1992) Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the ErbB-2 receptor, Cancer Res. 52, 6310-6317
-
(1992)
Cancer Res.
, vol.52
, pp. 6310-6317
-
-
Wels, W.1
|