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Volumn 2, Issue 10, 1996, Pages 439-446

Recombinant immunotoxins: Protein engineering for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BACTERIAL TOXIN; EXOTOXIN; GROWTH PROMOTOR; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOTOXIN; IMMUNOTOXIN LMB 7; IMMUNOTOXIN LMB-7; MONOCLONAL ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TOXA PROTEIN, PSEUDOMONAS AERUGINOSA; VIRULENCE FACTOR;

EID: 0030255965     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-4310(96)84848-9     Document Type: Review
Times cited : (22)

References (42)
  • 1
    • 12044254839 scopus 로고
    • From the basic science of B cells to biological missiles at the bedside
    • Vitetta, E. (1994) From the basic science of B cells to biological missiles at the bedside, J. Immunol. 153, 1407-1420
    • (1994) J. Immunol. , vol.153 , pp. 1407-1420
    • Vitetta, E.1
  • 4
    • 0025119680 scopus 로고
    • Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically cleavable spacer sequence
    • O'Hare, M. et al. (1990) Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically cleavable spacer sequence, FEBS Lett. 273, 200-204
    • (1990) FEBS Lett. , vol.273 , pp. 200-204
    • O'Hare, M.1
  • 5
    • 0028357390 scopus 로고
    • Humanized immunotoxins
    • Gadina, M. et al. (1994) Humanized immunotoxins, Ther. Immunol. 1, 59-64
    • (1994) Ther. Immunol. , vol.1 , pp. 59-64
    • Gadina, M.1
  • 7
    • 0023657391 scopus 로고
    • Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli
    • Hwang, J., FitzGerald, D.J., Adhya, S. and Pastan, I. (1987) Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli, Cell 48, 129-136
    • (1987) Cell , vol.48 , pp. 129-136
    • Hwang, J.1    FitzGerald, D.J.2    Adhya, S.3    Pastan, I.4
  • 8
    • 0028090446 scopus 로고
    • Selection of pseudomonas exotoxin-resistant cells with altered expression of α2MR/LRP
    • FitzGerald, D. et al. (1994) Selection of pseudomonas exotoxin-resistant cells with altered expression of α2MR/LRP, Ann. New York Acad. Sci. 737, 138-144
    • (1994) Ann. New York Acad. Sci. , vol.737 , pp. 138-144
    • FitzGerald, D.1
  • 9
    • 0028304478 scopus 로고
    • Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver
    • Chiron, M.F., Fryling, CM. and FitzGerald, D.J. (1994) Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver, J. Biol. Chem. 269, 18167-18176
    • (1994) J. Biol. Chem. , vol.269 , pp. 18167-18176
    • Chiron, M.F.1    Fryling, C.M.2    FitzGerald, D.J.3
  • 10
    • 0042048435 scopus 로고
    • Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of pseudomonas exotoxin
    • Batra, J.K. et al. (1989) Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of pseudomonas exotoxin, Proc. Natl. Acad. Sci. U. S. A. 86, 8545-8549
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 8545-8549
    • Batra, J.K.1
  • 11
    • 0026318613 scopus 로고
    • Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of pseudomonas exotoxin
    • Pai, L.H. et al. (1991) Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of pseudomonas exotoxin, Proc. Natl. Acad. Sci. U. S. A. 88, 3358-3362
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 3358-3362
    • Pai, L.H.1
  • 12
    • 0024349836 scopus 로고
    • A recombinant immunotoxin consisting of two antibody variable domains fused to pseudomonas exotoxin
    • Chaudhary, V.K. et al. (1989) A recombinant immunotoxin consisting of two antibody variable domains fused to pseudomonas exotoxin, Nature 339, 394-397
    • (1989) Nature , vol.339 , pp. 394-397
    • Chaudhary, V.K.1
  • 13
    • 0026005994 scopus 로고
    • B3(Fv)-PE38KDEL, a single chain immunotoxin that causes complete regression of a human carcinoma in mice
    • Brinkmann, U. et al. (1991) B3(Fv)-PE38KDEL, a single chain immunotoxin that causes complete regression of a human carcinoma in mice, Proc. Natl. Acad. Sci. U. S. A. 88, 8616-8620
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 8616-8620
    • Brinkmann, U.1
  • 14
    • 0026755810 scopus 로고
    • Recombinant anti-ErbB2 immunotoxins containing pseudomonas exotoxin
    • Batra, J.K. et al. (1992) Recombinant anti-ErbB2 immunotoxins containing pseudomonas exotoxin, Proc. Natl. Acad. Sci. U. S. A. 89, 5867-5871
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 5867-5871
    • Batra, J.K.1
  • 15
    • 0027473745 scopus 로고
    • Immunotoxins made with a recombinant form of pseudomonas exotoxin A that do not require proteolysis for activity
    • Theuer, C.P., Kreitman, R.J., FitzGerald, D.J. and Pastan, I. (1993) Immunotoxins made with a recombinant form of pseudomonas exotoxin A that do not require proteolysis for activity, Cancer Res. 53, 340-347
    • (1993) Cancer Res. , vol.53 , pp. 340-347
    • Theuer, C.P.1    Kreitman, R.J.2    FitzGerald, D.J.3    Pastan, I.4
  • 17
    • 0028790796 scopus 로고
    • Recombinant immunotoxins: From basic research to cancer therapy
    • Brinkmann, U. and Pastan, I. (1995) Recombinant immunotoxins: from basic research to cancer therapy, Methods Companion Methods Enzymol. 8, 143-158
    • (1995) Methods Companion Methods Enzymol. , vol.8 , pp. 143-158
    • Brinkmann, U.1    Pastan, I.2
  • 18
    • 0025162270 scopus 로고
    • A comparison of strategies to stabilize immunoglobulin Fv-fragments
    • Glockshuber, R., Malia, M., Pfitzinger, I. and Pluckthun, A. (1990) A comparison of strategies to stabilize immunoglobulin Fv-fragments, Biochemistry 29, 1362-1367
    • (1990) Biochemistry , vol.29 , pp. 1362-1367
    • Glockshuber, R.1    Malia, M.2    Pfitzinger, I.3    Pluckthun, A.4
  • 19
    • 0004198722 scopus 로고
    • Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analog produced in Escherichia coli
    • Huston, J.S. et al. (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analog produced in Escherichia coli, Proc. Natl. Acad. Sci. U. S. A. 85, 5879-5883
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 5879-5883
    • Huston, J.S.1
  • 20
    • 0024293979 scopus 로고
    • Single-chain antigen binding proteins
    • Bird, R.E. et al. (1988) Single-chain antigen binding proteins, Science 242, 423-426
    • (1988) Science , vol.242 , pp. 423-426
    • Bird, R.E.1
  • 21
    • 0027183934 scopus 로고
    • A recombinant immunotoxin containing a disulfide-stabilized Fv fragment
    • Brinkmann, U. et al. (1993) A recombinant immunotoxin containing a disulfide-stabilized Fv fragment, Proc. Natl. Acad. Sci. U. S. A. 90, 7538-7542
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 7538-7542
    • Brinkmann, U.1
  • 22
    • 0028285899 scopus 로고
    • Improved binding and antitumor activity of a recombinant anti-ErbB2 immunotoxin by disulfide stabilization of the Fv fragment
    • Reiter, Y. et al. (1994) Improved binding and antitumor activity of a recombinant anti-ErbB2 immunotoxin by disulfide stabilization of the Fv fragment, J. Biol. Chem. 269, 18327-18331
    • (1994) J. Biol. Chem. , vol.269 , pp. 18327-18331
    • Reiter, Y.1
  • 23
    • 0026510381 scopus 로고
    • Independent domain folding of pseudomonas exotoxin and single-chain immunotoxins: Influence of inter-domain connections
    • Brinkmann, U., Buchner, J. and Pastan, I. (1992) Independent domain folding of pseudomonas exotoxin and single-chain immunotoxins: influence of inter-domain connections, Proc. Natl. Acad. Sci. U. S. A. 89, 3075-3079
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 3075-3079
    • Brinkmann, U.1    Buchner, J.2    Pastan, I.3
  • 24
    • 0026792807 scopus 로고
    • A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies
    • Buchner, J., Pastan, I. and Brinkmann, U. (1992) A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies, Anal. Biochem. 205, 263-270
    • (1992) Anal. Biochem. , vol.205 , pp. 263-270
    • Buchner, J.1    Pastan, I.2    Brinkmann, U.3
  • 25
    • 0028205130 scopus 로고
    • Recombinant single-chain immunotoxins against T and B cell leukemias
    • Kreitman, R. and Pastan, I. (1994) Recombinant single-chain immunotoxins against T and B cell leukemias, Leukemia Lymphoma 13, 1-10
    • (1994) Leukemia Lymphoma , vol.13 , pp. 1-10
    • Kreitman, R.1    Pastan, I.2
  • 26
    • 0029383661 scopus 로고
    • Targeting pseudomonas exotoxin to hematologic malignancies
    • Kreitman, R. and Pastan, I. (1995) Targeting pseudomonas exotoxin to hematologic malignancies, Semin. Cancer Biol. 6, 297-306
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 297-306
    • Kreitman, R.1    Pastan, I.2
  • 27
    • 0029383734 scopus 로고
    • Targeting diphtheria toxin to growth factor receptors
    • Murphy, J.R. and VanderSpek, J.C. (1995) Targeting diphtheria toxin to growth factor receptors, Semin. Cancer Biol. 6, 259-267
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 259-267
    • Murphy, J.R.1    Vanderspek, J.C.2
  • 28
    • 0028230402 scopus 로고
    • In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats
    • Siegall, C. et al. ( 1994) In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats, J. Immunol. 152, 2377-2384
    • (1994) J. Immunol. , vol.152 , pp. 2377-2384
    • Siegall, C.1
  • 31
    • 0028313090 scopus 로고
    • Immunotoxins and recombinant toxins for cancer treatment
    • (DeVita, V., Hellman, S. and Rosenberg, S., eds), J.B. Lippincott
    • Pai, L. and Pastan, I. (1994) Immunotoxins and recombinant toxins for cancer treatment, in Important Advances in Oncology (DeVita, V., Hellman, S. and Rosenberg, S., eds), pp. 3-19, J.B. Lippincott
    • (1994) Important Advances in Oncology , pp. 3-19
    • Pai, L.1    Pastan, I.2
  • 32
    • 0027317693 scopus 로고
    • The use of immunotoxins for cancer therapy
    • Pai, L.H. and Pastan, I. (1993) The use of immunotoxins for cancer therapy, Eur. J. Cancer 11, 1606-1609
    • (1993) Eur. J. Cancer , vol.11 , pp. 1606-1609
    • Pai, L.H.1    Pastan, I.2
  • 33
    • 0027441541 scopus 로고
    • Immunotoxin therapy for cancer
    • Pai, L.H. and Pastan, I. (1993) Immunotoxin therapy for cancer, J. Am. Med. Assoc. 269, 78-81
    • (1993) J. Am. Med. Assoc. , vol.269 , pp. 78-81
    • Pai, L.H.1    Pastan, I.2
  • 34
    • 0028609356 scopus 로고
    • Cloning, expression and characterization of the Fv fragments of the anticarbohydrate monoclonal antibodies B1 and B5 as single-chain immunotoxins
    • Benhar, I. and Pastan, I. (1994) Cloning, expression and characterization of the Fv fragments of the anticarbohydrate monoclonal antibodies B1 and B5 as single-chain immunotoxins, Protein Eng. 7, 1509-1515
    • (1994) Protein Eng. , vol.7 , pp. 1509-1515
    • Benhar, I.1    Pastan, I.2
  • 35
    • 0028275863 scopus 로고
    • Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment
    • Reiter, Y. et al. (1994) Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment, Cancer Res. 54, 2714-2718
    • (1994) Cancer Res. , vol.54 , pp. 2714-2718
    • Reiter, Y.1
  • 36
    • 0029165134 scopus 로고
    • Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice
    • Benhar, I., Reiter, Y., Pai, L.H. and Pastan, I. (1995) Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice, Int. J. Cancer 62, 351-355
    • (1995) Int. J. Cancer , vol.62 , pp. 351-355
    • Benhar, I.1    Reiter, Y.2    Pai, L.H.3    Pastan, I.4
  • 37
    • 0028928499 scopus 로고
    • Intrathecal administration of single-chain immunotoxin, LMB-7 (B3(Fv)-PE38), produces cures of carcinomatous meningitis in a rat model
    • Pastan, I. et al. (1995) Intrathecal administration of single-chain immunotoxin, LMB-7 (B3(Fv)-PE38), produces cures of carcinomatous meningitis in a rat model, Proc. Natl. Acad. Sci. U. S. A. 92, 2765-2769
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 2765-2769
    • Pastan, I.1
  • 38
    • 0029925934 scopus 로고    scopus 로고
    • Treatment of advanced solid tumors with immunotoxin LMB-1: An antibody linked to pseudomonas exotoxin
    • Pai, L.H. et al. (1996) Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to pseudomonas exotoxin, Nat. Med. 1, 350-353
    • (1996) Nat. Med. , vol.1 , pp. 350-353
    • Pai, L.H.1
  • 39
    • 0024411071 scopus 로고
    • Phase I study of an anti-breast cancer immunotoxin by continuous infusion: Report of a targeted toxic effect not predicted by animal studies
    • Gould, B.J. et al (1989) Phase I study of an anti-breast cancer immunotoxin by continuous infusion: report of a targeted toxic effect not predicted by animal studies, J. Natl. Cancer Inst. 81, 775-781
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 775-781
    • Gould, B.J.1
  • 40
    • 0025826197 scopus 로고
    • Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas
    • Pastan, I. et al. (1991) Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas, Cancer Res. 51, 3781-3787
    • (1991) Cancer Res. , vol.51 , pp. 3781-3787
    • Pastan, I.1
  • 41
    • 0026211630 scopus 로고
    • Routes to active proteins from transformed microorganisms
    • Buchner, J. and Rudolph, R. (1991) Routes to active proteins from transformed microorganisms, Curr. Opin. Biotechnol. 2, 532-538
    • (1991) Curr. Opin. Biotechnol. , vol.2 , pp. 532-538
    • Buchner, J.1    Rudolph, R.2
  • 42
    • 0026486446 scopus 로고
    • Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the ErbB-2 receptor
    • Wels, W. et al. (1992) Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the ErbB-2 receptor, Cancer Res. 52, 6310-6317
    • (1992) Cancer Res. , vol.52 , pp. 6310-6317
    • Wels, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.