Chronic cardiac rejection in the LEW to F344 rat model: Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis

Journal of Clinical Investigation

Volumn 97, Issue 3, 1996, Pages 833-838

  Russell, Mary E ^a,b,c   Hancock, Wayne W ^b,d   Akalin, Enver ^b,c   Wallace, Africa F ^a   Glysing Jensen, Troels ^a   Willett, Theresa A ^c   Sayegh, Mohamed H ^b,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Arteriosclerosis; Cardiac transplantation; CD28; Macrophage activation

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GALACTOSAMINE; GALACTOSE; GAMMA INTERFERON; HYBRID PROTEIN; LECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOSCLEROSIS; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; ARTERIOSCLEROSIS; BASE SEQUENCE; CORONARY VESSELS; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOCONJUGATES; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MOLECULAR SEQUENCE DATA; RATS; RATS, INBRED F344; TRANSPLANTATION, HOMOLOGOUS; UP-REGULATION;

EID: 0030051268     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118483     Document Type: Article

References (27)

1. Paul, L.C., and B. Fellstrom. 1992. Chronic vascular rejection of the heart and the kidney: have rational treatment options emerged? Transplantation (Baltimore). 53:1169-1179.
2. Tullius, S.G., and N.L. Tilney 1995. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation (Baltimore). 59:313-318
3. Johnson, D.E., S.Z Gao, J.S Schroeder, W.M. DeCampli, and M.E. Billingham 1989. The spectrum of coronary artery pathologic findings in human cardiac allografts. J. Heart Transplant 8:349-359.
4. Russell, M.E., M. Fujita, MA. Masek, R.A. Rowan, and M.E, Billingham. 1993. Cardiac graft vascular disease. Nonselective involvement of large and small vessels. Transplantation (Baltimore). 56.1599-1601.
5. Adams, D.H., N.L. Tilney, J.J. Collins, and M.J. Karnovsky. 1992. Experimental graft arteriosclerosis. I. The Lewis-to-F-344 allograft model. Transplantation (Baltimore). 53:1115-1119.
6. Cramer, D.V. 1993. Graft Arteriosclerosis in Heart Transplantation. R. G. Landes Company, Austin, TX. 95.
7. Cramer, D.V , G.D. Wu, F.A. Chapman, E. Cajulis, H.K. Wang, and L. Makowka. 1992. Lymphocytic subsets and histopathologic changes associated with the development of heart transplant arteriosclerosis. J. Heart Lung Transplant. 11:458-466.
8. Adams, D.H., L.R Wyner, and M.J. Karnovsky. 1993. Experimental graft arteriosclerosis. II. Immunocytochemical analysis of lesion development. Transplantation (Baltimore). 56:794-799.
9. Russell, M.E., U. Utans, A.F. Wallace, P. Liang, R J. Arceci, M.J. Karnovsky, L.R. Wyner, Y. Yamashita, and C. Tarn. 1994. Identification and upregulation of galactose/N-acetylgalactosamine macrophage lectin in rat cardiac allografts with arteriosclerosis. J. Clin Invest. 94:722-730.
10. Russell, M.E., A.F. Wallace, W.W. Hancock, M.H. Sayegh, D.H. Adams, N.E.S. Sibinga, L.R. Wyner, and M.J. Karnovsky. 1995. Upregulation of cytokines associated with macrophage activation in the Lewis to F344 rat chronic cardiac rejection model. Transplantation (Baltimore). 59:572-578.
11. Russell, ME., A.F Wallace, J.B. Newell, L R Wyner, and M.J. Karnovsky. 1995. Upregulation and modulation of inducible nitric oxide synthesis in rat cardiac allografts with chrome rejection and transplant arteriosclerosis. Circulation. 92:457-464.
12. Watschinger, B., M.H. Sayegh, W.W. Hancock, and M.E Russell. 1995. Upregulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis. Am J. Pathol. 146:1065-1072.
13. Linsley, P.S , and J.A. Ledbetter. 1993. The role of CD28 receptor during T cell response to antigen. Ann. Rev. Immunol. 11:191-212.
14. Sayegh, M.H., and L A. Turka. 1995. T cell costimulatory pathways promising novel targets for immunosuppression and tolerance induction. J. Am Soc. Nephrol. 6:1143-1150.
15. Linsley, P.S., W. Brady, M. Urnes, L.S. Grosmaire, N.K. Damle, and J.A. Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7 J. Exp. Med. 174:561-569.
16. Sayegh, M.H., E. Akalin, W.W. Hancock, M.E. Russell, C.B. Carpenter, P S Linsley, and L A. Turka. 1995 CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181:1869-1874
17. Lin, H., S.F. Bolling, P.S. Linsley, R.Q. Wei, D. Gordon, C.B. Thompson, and L.A. Turka. 1993. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4 Ig plus donor-specific transfusion. J. Exp Med 178.1801-1806.
18. Russell, M.E., D.H. Adams, L.R. Wyner, Y Yamashita, N J. Halnon, and M.J. Karnovsky. 1993. Early and persistent induction of monocyte chemoattractant protein 1 in rat cardiac allografts. Proc. Natl Acad Sci. USA. 90:6086-6090.
19. Chapman, F.A., D.V. Cramer, and L. Makowka. 1994 Heterotopic Heart Transplantation in Rodents. In Handbook of Animal Models in Transplantation Research. D.V. Cramer, L. Podesta, and D.V. Makowka, editors. CRC Press, Inc., Boca Raton, FL. 149-160.
20. Qian, S.W., P Kondaiah, A.B. Roberts, and M.B. Sporn. 1990. cDNA cloning by PCR of rat transforming growth factor beta-1. Nucleic Acids Res. 18 3059.
21. Zhao, X M., W.H. Frist, T.K. Yeoh, and G.G. Miller. 1993. Expression of cytokine genes in human cardiac allografts: correlation of IL-6 and transforming growth factor-beta (TGF-beta) with histological rejection Clin. Exp. Immunol. 93.448-451.
22. Lemstrom, K.B., P.T. Aho, C.A. Hruggeman, and P.J. Hayry. 1994 Cytomegalovirus infection enhances mRNA expression of platelet-denved growth factor-BB and transforming growth factor-beta 1 in rat aortic allografts. Possible mechanism for cytomegalovirus-enhanced graft arteriosclerosis. Arterioscler. Thromb. 14:2043-2052.
23. Lenschow, D.J , Y. Zeng, J.R. Thistlethwaite, A. Montag, W. Brady, M.G. Gibson, P.S. Linsley, and J.A Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g. Science (Wash DC). 257: 789-792.
24. Pearson, T.C., D.Z. Alexander, K.J. Winn, P.S. Linsley, R.P Lowry, and C.P. Larsen. 1994. Transplantation tolerance induced by CTLA4-Ig. Transplantation (Baltimore). 57:1701-1706.
25. Orloff, M S., E M DeMara, M L. Coppage, N. Leong, M.A. Fallon J Sickel, X.J. Zuo, J. Prehn, and S.C. Jordan. 1995. Prevention of chronic rejection and graft arteriosclerosis by tolerance induction. Transplantation (Baltimore). 59:282-288
26. Shin, Y.T., D.H. Adams, L.R. Wyner, E Akalin, M.H. Sayegh, and M J Karnovsky. 1995. Intrathymic tolerance in the Lewis-to-F344 chronic cardiac allograft rejection model. Transplantation (Baltimore). 59.1647-1653.
27. Boussiotis, V.A., J.G Gribben, G J. Freeman, and L M. Nadler 1994 Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance Curr. Opin. Immunol. 6:797-807.