Efficient mitomycin C coupling with stable p-nitrophenyl-benzyl carbonates using N-hydroxybenzotriazole as a catalytic additive

Tetrahedron Letters

Volumn 38, Issue 30, 1997, Pages 5261-5264

  Dubowchik, Gene M ^a   King, H Dalton ^a   Pham Kaplita, Kahnie ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOMYCIN C; MITOMYCIN C DERIVATIVE; PRODRUG;

ARTICLE; CATALYST; DRUG SYNTHESIS; TECHNIQUE;

EID: 0030805612     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01159-3     Document Type: Article

References (14)

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8. For details see the preceding communication in this issue.
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11. An equivalent amount of base is required since HOBt is acidic enough to remove the MMT protecting group. DIEA has been found to accelerate carbodiimide peptide couplings using HOBt as an additive: Beyermann, M.; Henklein, P.; Klose, A.; Sohr, R. and Bienert, M. Int. J. Pept. Protein Res. 1991, 37, 252-256.
12. All new compounds gave satisfactory NMR, mass spectral, microanalytical and/or HRMS data.
13. 13: 1224.5406. Found: 1224.5385.
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