Abnormal expression of a 170-kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infection

AIDS Research and Human Retroviruses

Volumn 12, Issue 15, 1996, Pages 1457-1462

  Andreana, A ^a,b   Aggarwal, S ^a   Gollapudi, S ^a   Wien, D ^a   Tsuruo, T ^c   Gupta, S ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; GLYCOPROTEIN P; RHODAMINE 123; ZIDOVUDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL; SUPPRESSOR CELL;

EID: 0029846735     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1996.12.1457     Document Type: Article

References (29)

1. Juranka PF, Zastawny RL, and Ling V: P-glycoprotein: Multidrug resistance and a superfamily of membrane associated transport protein. FASEB J 1989;3:2583-2592.
2. Roninson IB: The role of MDR-1 (P-glycoprotein) gene in multiple drug resistance in vitro and in vivo. Biochem Pharmacol 1992;43:95-102.
3. Gottesman MM and Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993;62:385-427.
4. Gros P and Shustik C: Multidrug resistance: A novel class of membrane-associated transport proteins is identified. Cancer Invest 1991;9:563-569.
5. Doige CA and Ames GF: ATP-dependent transport systems in bacteria and humans: Relevance to cystic fibrosis and multidrug resistance. Annu Rev Microbiol 1993;47:291-319.
6. Gros P, Croop J, and Housman D: Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 1986;47:371-380.
7. Hyde SC, Emsley P, Hartshorn MJ, et al.: Structural model of ATP-binding protein associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature (London) 1990;346:362-365.
8. Sharma RC, Inoue S, Roitelman J, et al.: Peptide transport by the multidrug resistance pump. J Biol Chem 1992;267:5731-5734.
9. Foote SJ, Thompson JK, Cowman AF, et al.: Amplification of multidrug resistant gene in some chloroquine-resistant isolates of P. falciparum. Cell 1989;57:921-930.
10. Wilson CM, Serrano AE, Wesley A, et al.: Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science 1989;244:1184-1186.
11. Gollapudi S and Gupta S: Human immunodeficiency virus 1 (HIV-1)-induced P-glycoprotein expression. Biochem Biophys Res Commun 1990;171:1002-1007.
12. Antonelli G, Turriziani O, Cainfriglia M, et al.: Resistance to AZT might also involve the cellular expression of multidrug resistance by P-glycoprotein. AIDS Res Hum Retroviruses 1992;8: 1839-1844.
13. Hamada H and Tsuruo T: Functional role for the 170-180 kDa glycoprotein specific to drug-resistant tumor cells as treated by monoclonal antibodies. Proc Natl Acad Sci USA 1986;83:7785-7789.
14. Kessel D, Beck WT, Kukuraga D, et al.: Characterization of multidrug resistance by fluorescent dyes. Cancer Res 1991;51: 4665-4670.
15. Tamai I and Safa A: Competitive interaction of cyclosporins with Vinca alkaloid-binding site of P-glycoprotein in multidrug resistant cells. J Biol Chem 1990;266:16509-16513.
16. Foxwell BMJ, Mackie A, Ling V, et al.: Identification of multidrug resistance related P-glycoprotein as a cyclosporin binding protein. Mol Pharmacol 1989;36:543-546.
17. Saeki T, Ueda K, Tanigawara Y, et al.: Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 1993; 268:6077-6080.
18. + T cells: A role in cytotoxic effector function. J Clin Immunol 1992; 12:451-458.
19. Young PR and Krasney PA: Stimulation of interleukin 1β secretion in monkey kidney cells by coexpression of the mammalian P-glycoprotein MDR 1. In: Pathophysiology and Pharmacology of Cytokines (Ghezzi P and Mantovani A, Eds.). Biomedical Press, Augusta, GA, 1992, pp. 21-27.
20. Gupta S, Tsuruo T, and Gollapudi S: Expression of multidrug resistance gene 1 (mdr 1) in human T cell subsets. Regulation by cyclosporin A and role of protein kinase C isoforms. Adv Exp Med Biol 1992;323:39-47.
21. Coon JS, Wang Y, Bines SD, et al.: Multidrug resistance activity in human lymphocytes. Hum Immunol 1991;32:134-140.
22. Drach D, Zhao S, Drach J, et al.: Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood 1992;80:2729-2734.
23. Chaudhary PM, Mechetner EB, and Robinson IB: Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 1992;80:2735-2739.
24. Neyfakh AA, Serpinskaya AS, Chevonsky AV, Aposov SG, and Kazarov AR: Multidrug resistant phenotype of a subpopulation of T lymphocytes without drug selection. Exp Cell Res 1989; 185:496-505.
25. Carlsen SV, Till JE, and Ling V: Modulation of drug permeability in Chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins. Biochim Biophys Acta 1977; 467:238-250.
26. Gollapudi S, Reddy M, Gangadharan P, et al.: Mycobacterium tuberculosis induces expression of P-glycoprotein in promonocytic U1 cells chronically infected with HIV-1. Biochem Biophys Res Commun 1994;199:1181-1187.
27. Andreana A, Gollapudi S, and Gupta S: Salmonella typhimurium induces expression of P-glycoprotein (mdr 1 gene product) in promonocytic cell line chronically infected with human immunodeficiency virus type 1. J Infect Dis 1994;169:493-496.
28. Chaudhary PM and Roninson I: Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst 1993;85:632-639.
29. Yusa K, Ohara T, Yamazaki A, et al.: Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells. Biochem Biophys Res Commun 1990;169:986-990.