Under respiratory growth conditions, Bcl-x(L) and Bcl-2 are unable to overcome yeast cell death triggered by a mutant Bax protein lacking the membrane anchor

European Journal of Biochemistry

Volumn 258, Issue 1, 1998, Pages 19-28

  Clow, Angela ^a   Greenhalf, William ^a   Chaudhuri, Bhabatosh ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; Bax; Bcl 2; Bcl x(L); Membrane anchor

Indexed keywords

PROTEIN BAX;

APOPTOSIS; ARTICLE; CELL DEATH; GROWTH INHIBITION; GROWTH REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0032533976     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2580019.x     Document Type: Article

References (36)

1. Barr, P. J. & Tomei, L. D. (1994) Apoptosis and its role in human disease, Biotechnology 12, 487-493.
2. Thompson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease, Science 267, 1456-1462.
3. White, E. (1996) Life, death, and the pursuit of apoptosis, Genes and Devel. 10, 1-15.
4. Chao, D. T., Linette, G. P., Boise, L. H., White. L. S., Thompson, C. B. & Korsmeyer, S. J. (1995) Bcl-x(L) and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182, 821-828.
5. Korsmeyer, S. J. (1995) Regulators of cell death. Trends Genet. 11, 101-105.
6. Reed, J. C. (1994) Bcl-2 and the regulation of programmed cell death, J. Cell Biol. 124, 1 -6.
7. Oltvai, Z. N., Milliman, C. L. & Korsmeyer. S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog Bax, that accelerates programed cell death. Cell 74. 609-619.
8. Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise. L. H., Thompson, C. B., Golemis, E., Fong, L., Wang. H.-G. & Reed. J. C. (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl Acad. Sci. USA 91, 9238-9242.
9. Hanada, M., Aimé-Sempé, C., Sato, T. & Reed, J. C. (1995) Structure-function of Bcl-2 protein, J. Biol. Chem. 279. 11962-11 969.
10. Sedlak, T. W., Oltvai, Z. N., Yang, E., Wang, K., Boise, L. H., Thompson, C. B. & Korsmeyer, S. J. (1995) Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl Acad. Sci. USA 92, 7834-7838.
11. Zha, H., Aimé-Sempé. C., Sato, T. & Reed. J. C. (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem. 271. 7440-7444.
12. Hunter, J. J., Bond. B. L. & Parslow, T. G. ( 1996) Functional dissection of the human Bcl-2 protein: sequence requirements for inhibition of apoptosis, Mol. Cell. Biol. 16. 877-883.
13. Nguyen, M., Branton. P. E., Walton, P. A., Oltvai, Z. N., Korsmeyer, S. J. & Shore, G. C. ( 1994) Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by EIB-defective adenovirus, J. Biol. Chem. 269, 16521-16524.
14. Lithgow, T, van-Driel, R., Bertram. J. F. & Strasser, A. (1994) The protein product of the oncogene Bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ. 5, 411 -417.
15. González-Garcia, M., Perez-Ballestero. R., Ding, L., Duan, L., Boise, L. H., Thompson, C. B. & Nuñez. G. (1994) Bel-XL is the major Bcl-x mRNAform expressed during murine development and its product localizes to mitochondria. Development 120. 3033-3042.
16. Apte, S. S., Mattei, M.-G. & Olsen. B. R. (1995) Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta. Genomics 26. 592-594.
17. Zha. H., Fisk, H. A., Yaffe, M. P., Mahajan, N., Herman. B. & Reed. J. C. (1996) Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell. Biol. 16. 6494-6508.
18. Hsu. Y.-T, Wolter. K. G. & Youle, R. J. (1997) Cytosol-to-membrane redistribution of Bax and Bcl-x(L) during apoptosis. Proc. Natl Acad. Sci. USA 94, 3668-3672.
19. Wolter, K. G., HSU, Y. T., Smith, C. L., Nechushtan. A., Xi. X. G. & Youle, R. J. (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell. Biol. 139. 1281-1292.
20. Greenhalf, W., Stephan, C. & Chaudhuri, B. (1996) Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae, FEBS Lett. 380, 169-175.
21. Boise, L. H., González-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuñez, G. & Thompson, C. B. (1993) Bcl-x, a Bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608.
22. Croce, C. M. (1986) Analysis of the structure, transcripts, and protein products of Bcl-2, the gene involved in human follicular lymphoma, Proc. Natl Acad. Sci. USA 88, 1731-1735.
23. Guidot, D. M., Repine, J. E., Kitlowski, A. D., Flores, S. C., Nelson, S. K., Wright, R. M. & McCord. J. M. (1995) Mitochondrial respiration scavenges extramitochondrial Superoxide anion via a nonenzymatic mechanism, J. Clin. Invest. 96, 1131 -1136.
24. Gancedo. J. M. (1992) Carbon catabolite repression in yeast, Eur. J. Biochem. 206, 297-313.
25. Sonnleitner. B. & Hahnemann, U. (1994) Dynamics of the respiratory bottleneck of Saccharomyces cerevisiae, J. Biotechnol. 38, 63-79.
26. Gratzer, S., Lithgow, T., Bauer, R. E., Lamping. E., Paltauf, F., Kohlwein, S. P., Haucke. V., Junne, T., Schatz, S. & Horst, M. (1995) Mas37p, a novel receptor subunit for protein import into mitochondria, J. Cell Biol. 129, 25-34.
27. Newmeyer, D. D., Farschon, D. M. & Reed, J. C. (1994) Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria, Cell 79, 353-364.
28. Yang, J., Liu, X., Bhalla, K., Kirn, N., Ibrado, A. M., Cai, J., Peng, T., Jones, D. P. & Wang, X. (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science 275, 1129-1132.
29. Susin, S. A., Zanzami, N., Castedo, M., Hirsch, T., Marchetti, P., Macho, A., Daugas, E., Geuskens, M. & Kroemer, G. (1996) Bcl-2 inhibits the mitochondrial release of an apoptogenic protease, J. Exp. Med. 184, 1331-1341.
30. Nicotera, P. & Leist, M. (1997) Energy supply and the shape of death in neurons and lymphoid cells, Cell Death & Diff. 4, 435-442.
31. Shaham, S., Shuman, M. A. & Herskowitz, I. (1998) Death-defying yeast identify novel apoptosis genes, Cell 92, 425-427.
32. Manon, S., Chaudhuri, B. & Guérin, M. (1997) Release of cytochrome c and decrease of cytochrome c-oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL, FEBS Lett. 415, 29-32.
33. Kharbanda, S., Pandey, P., Schofield, L., Israels, S., Roncinske, R., Yoshida, K., Bharti, A., Yuan, Z. M., Saxena, S., Weichselbaum, R., Nalin, C. & Kufe, D. (1997) Role for Bcl-xL as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis, Proc. Natl Acad. Sci. USA 94, 6939-6942.
34. Pastorino, J. G., Chen. S. T., Tafani, M., Snyder, J. W. & Farber, J. L. (1998) The overexpression of bax produces cell death upon induction of the mitochondrial permeability transition, J. Biol. Chem. 273, 7770-7775.
35. Xiang, J. L., Chao, D. T. & Korsmeyer, S. J. (1996) Bax-induced cell death may not require interleukin 1-beta-converting enzyme-like proteases, Proc. Natl Acad. Sci. USA 93, 14559-14563.
36. Xu, Q. & Reed. J. C. (1998) Bax inhihitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell I, 337-346.