Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization

Blood

Volumn 92, Issue 8, 1998, Pages 2802-2814

  Gokmen, Erhan ^b   Raaphorst, Frank M ^b   Boldt, David H ^b   Teale, Judy M ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION; DEVELOPMENTAL GENETICS; FEMALE; FETUS; FETUS DEVELOPMENT; GENE SEQUENCE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOGENETICS; MALE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0032532055     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.8.2802.420k18_2802_2814     Document Type: Article

References (68)

1. Antin, JH, Ault KA, Rappeport JM, Smith BR: B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes. J Clin Invest 80:325, 1987
2. Lum LG: The kinetics of immune reconstitution after human marrow transplantation. Blood 69:369, 1987
3. Velardi A, Cucciaioni S, Terenzi A, Quinti I, Aversa F, Grossi CE, Grignani F, Martelli MF: Acquisition of Ig isotype diversity after bone marrow transplantation in adults. A recapitulation of normal B cell ontogeny. J Immunol 141:815, 1988
4. Small TN, Keever CA, Weiner-Fedus S, Heller G, O'Reilly RJ, Flomenberg N: B-cell differentiation following autologous, conventional, or T-cell depleted bone marrow transplantation: A recapitulation of normal B-cell ontogeny. Blood 76:1647, 1990
5. Atkinson K: Reconstruction of the haemopoietic and immune systems after marrow transplantation. Bone Marrow Transplant 5:209, 1990
6. + B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein. Blood 79:3369, 1992
7. Storek J, Saxon A: Reconstitution of B cell immunity following bone marrow transplantation. Bone Marrow Transplant 9:395, 1992
8. Storek J, Ferrera S, Ku N, Giorgi JV, Champlin RE, Saxon A: B cell reconstitution after human bone marrow transplantation: Recapitulation of ontogeny? Bone Marrow Transplant 12:387, 1993
9. Fumoux F, Guigou V, Biaise D, Maraninchi D, Fougereau M, Schiff C: Reconstitution of human immunoglobulin VH repertoire after bone marrow transplantation mimics B-cell ontogeny. Blood 81:3153, 1993
10. Gerritsen EJA, van Tol MJD, Lankester AC, van der Weijden-Ragas CP, Jol-van der Zijde CM, Oudeman-Gruber NJ, Radl J, Vossen JM: Immunoglobulin levels and monoclonal gammopathies in children after bone marrow transplantation. Blood 82:3493, 1993
11. Storek J, King L, Ferrara S, Marcelo D, Saxon A, Braun J: Abundance of a restricted fetal B cell repertoire in marrow transplant recipients. Bone Marrow Transplant 14:783, 1994
12. Tonegawa S: Somatic generation of antibody diversity. Nature 302:575, 1983
13. H6 immunoglobulin genes in early human B-cell ontogeny. Scand J Immunol 30:493, 1989
14. Schroeder HW Jr, Hillson JL, Perlmutter RM: Early restriction of the human antibody repertoire. Science 238:791, 1987
15. Schroeder HW Jr, Wang JY: Preferential utilisation of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci USA 87:6146, 1990
16. H6 gene in immature B lymphoid cells. Eur J Immunol 21:1311, 1991
17. Hillson JL, Oppliger IR, Sasso EH, Milner ECB, Wener MH: Emerging human B cell repertoire. Influence of developmental stage and interindividual variation. J Immunol 149:3741, 1992
18. th week of gestation in fetal liver. Eur J Immunol 23:110, 1993
19. H6-encoded IgM antibodies in early ontogeny. J Immunol 150:161, 1993
20. Huang C, Stewart AK, Schwanz RS, Stollar BD: Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes. J Clin Invest 89:1331, 1992
21. H gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5+/IgM+ and CDS-/IgM + B cells. J Clin Invest 99:2488, 1997
22. Huang C, Stollar BD: A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies. J Immunol 151:5290, 1993
23. H3 genes and short diverse third complementarity-determining regions (CDR3) in fetal B lymphocyte immunoglobulin heavy chain rearrangements. Eur J Immunol 22:247, 1992
24. Pascual V, Verkruyse L, Casey ML, Capra JD: Analysis of Ig H chain gene segment utilization in human fetal liver. Revisiting the "proximal utilization hypothesis". J Immunol 151:4164, 1993
25. Sanz I: Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 147:1720, 1991
26. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 173:395, 1991
27. H amino acid sequences. Int Immunol 9:1503, 1997
28. Nuñez C, Nishimoto N, Gartland GL, Billips LG, Burrows PD, Kubagawa H, Cooper MD: B cells are generated throughout life in humans. J Immunol 156:866, 1996
29. Suzuki I, Milner ECB, Glas AM, Hufnagle WO, Rao SP, Pfister L, Nottenburg C: Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: Lack of somatic mutation indicates a maturational arrest. Blood 87:1873, 1996
30. H6-containing immunoglobulin repertoire during reconstitution after bone marrow transplantation. Blood 87:2795, 1996
31. Hawes GE, Struyk L, van den Elsen PJ: Differential usage of T Cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins. J Immunol 150:2033, 1993
32. Struyk L, Kurnick JT, Hawes GE, van Laar JM, Schipper R, Oksenberg JR, Steinman L, de Vries RR, Breedveld FC, van den Elsen P: T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis. Hum Immunol 37:237, 1993
33. Gorski J, Yassai M, Zhu X, Kissela B, Keever C, Flomenberg N: Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 spectratyping. J Immunol 152: 5109, 1994
34. Naumov YN, Naumova EN, Gorski J: CD4+ and CD8+ circulating α/β T-cell repertoires are equally complex and are characterized by different levels of steady-state TCR expression. Hum Immunol 48:52, 1996
35. Raaphorst FM, Tami J, Sanz I: Cloning of size-selected human immunoglobulin heavy chain rearrangements from third complementarity-determining region fingerprint profiles. Biotechniques 20:78, 1996
36. Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T: Detection of polymorphism of human DNA by gel electrophoresis as single-strand conformation polymorphism. Proc Natl Acad Sci USA 86:2766, 1989
37. Orita M, Suzuki Y, Sekiya T, Hayashi K: Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction. Genomics 5:874, 1989
38. Rabat EA, Wu TT, Perry HM, Gotesmann KS, Foeler C: Sequences of Proteins of Immunological Interest (ed 5). NIH Publication No. 91-3242. Bethesda, MD, US DHHS, NIH, 1991
39. Tomlinson IM, Williams SC, Corbett SJ, Cox JBL, Winter G: V BASE Sequence Directory. Cambridge, UK, MRC Centre for Protein Engineering, 1996
40. Sanz I, Wang SS, Meneses G, Fischbach M: Molecular characterization of human Ig heavy chain DIR genes. J Immunol 152:3958, 1994
41. Buluwela L, Albertson DG, Sherrington P, Rabbits PH, Spurr N, Rabbits TH: The use of chromosomal translocations to study human immunoglobulin gene organization: Mapping DH segments within 35 kb of the Cμ gene and identification of a new DH locus. EMBO J 7:2003, 1988
42. Ichihara Y, Abe M, Yasui H, Matsuoka H, Kurosawa Y: At least five DH genes of human immunoglobulin heavy chains are encoded in 9-kilobase DNA fragments. Eur J Immunol 18:649, 1988
43. Ichihara Y, Matsuoka H, Kurosawa Y: Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J 7:4141, 1988
44. Matsuda F, Shin EK, Hirabayashi Y, Nagaoka H, Yoshida MC, Zong SQ, Honjo T: Organization of variable region segments of the human immunoglobulin heavy chain: Duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. EMBO J 9:2501, 1990
45. H formation. Eur J Immunol 23:2365, 1993
46. Mattila PS, Schugk J, Wu H, Mäkela O: Extensive allelic sequence variation in the J region of the human heavy chain gene locus. Eur J Immunol 25:2578, 1995
47. Montari F, Wang JY, Schroeder HW Jr: Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed C alpha and C gamma repertoires. J Immunol 150:1348, 1993
48. H6 gene element by fetal B lymphocytes. Scand J Immunol 46:292, 1997
49. Li YS, Hayakawa K, Hardy RR: The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med 178:951, 1993
50. Landreth KS, Kincade PW, Lee G, Medlock ES: Phenotypic and functional characterization of murine B lymphocyte precursors isolated from fetal and adult tissues. J Immunol 131:572, 1983
51. Kincade PW: Experimental models for understanding B lymphocyte formation, Adv Immunol 41:181, 1987
52. H gene family repertoire of resting B cells. The preferential use of D-proximal families early in development may be due to distinct B cell subsets. J Immunol 143:2752, 1989
53. Ikuta K, Weissman IL: The junctional modifications of a T cell receptor γ chain are determined at the level of thymic precursors. J Exp Med 174:1279, 1991
54. Komagata Y, Weissman IL, Dcuta K: Heterogeneity of N insertion capacity in fetal hematopoietic stem cells. Int Immunol 8:837, 1996
55. Bogue M, Mossmann H, Stauffer U, Benoist C, Mathis D: The level of N-region diversity in T cell receptors is not pre-ordamed in the stem cell. Eur J Immunol 23:1185, 1993
56. + B cells. Blood 89:350, 1997 (letter)
57. Dilly SA, Sloane JP, Psalti ISM: The cellular composition of human lymph nodes after allogeneic bone marrow transplantation: An imrnunohistological study. J Pathol 150:213, 1986
58. Dilly SA, Sloane JP: Cellular composition of the spleen after human allogeneic bone marrow transplantation. J Pathol 155:151, 1988
59. Horny HP, Horst HA, Ehninger G, Kaiseling E: Lymph node morphology after allogeneic bone marrow transplantation for chronic myeloid leukemia: A histological and immunohistological study focusing on the phenotype of the recovering lymphoid cells. Blut 57:31, 1988
60. Horny HP, Ruck M, Kaiserling E, Ehninger G: Immunohistology of the human spleen after bone marrow transplantation for leukemia with special reference to the early post-transplant period. Path Res Pract 186:775, 1990
61. Lum LG, Seigneuret MC, Storb RF, Witherspoon RP, Thomas ED: In vitro regulation of immunoglobulin synthesis after marrow transplantation . I. T-cell and B-cell deficiencies in patients with and without chronic graft-versus-host disease. Blood 58:431, 1981
62. Korsmeyer SJ, Elfenbein GJ, Goldman JK, Marshall SL, Santos GW, Waldmann TA: B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. Transplantation 33: 184, 1982
63. Pahwa SG, Pahwa RN, Friedrich W, O'Reilly RJ, Good RA: Abnormal humoral immune responses in peripheral blood lymphocyte Cultures of bone marrow transplant recipients. Proc Natl Acad Sci USA 79:2663, 1982
64. Witherspoon RP, Lum LG, Storb R, Thomas ED: In vitro regulation of immunoglobulin synthesis after human marrow transplantation. II. Deficient T and non-T lymphocyte function within 3-4 months of allogeneic, syngeneic, or autologous marrow grafting for hematologie malignancy. Blood 59:844, 1982
65. Lum LG, Seigneuret MC, Orcutt-Thordarson N, Noges JE, Storb R: The regulation of immunoglobulin synthesis after HLA-identical bone marrow transplantation: VI. Differential rates of maturation of distinct functional groups within lymphoid subpopulations in patients after human marrow grafting. Blood 65:1422, 1985
66. Witherspoon RP, Goehle S, Kretschmer M, Storb R: Regulaton of immunoglobulin production after human marrow grafting. The role of helper and suppressor T cells in acute graft-versus-host disease. Transplantation 41:328, 1986
67. Ottinger HD, Beelen DW, Scheulen B, Schaefer UW. Grosse-Wilde H: Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow. Blood 88:2775, 1997
68. Storek J, Witherspoon RP, Maloney DG, Chauncey TR, Storb R: Improved reconstitution of CD4 T cells and B cells but worsened reconstitution of serum IgG levels after allogeneic transplantation of blood stem cells instead of marrow. Blood 89:3891, 1997 (letter)