Evidence for oligoclonal diversification of the VH6-containing immunoglobulin repertoire during reconstitution after bone marrow transplantation

Blood

Volumn 87, Issue 7, 1996, Pages 2795-2804

  Näsman, Ingrid ^a   Lundkvist, Inger ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN; MONOCLONAL ANTIBODY;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; B LYMPHOCYTE; BONE MARROW TRANSPLANTATION; CASE REPORT; CONTROLLED STUDY; DONOR; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECIPIENT;

ADULT; B-LYMPHOCYTES; BASE SEQUENCE; BONE MARROW TRANSPLANTATION; CLONE CELLS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS;

EID: 0029878662     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2795.bloodjournal8772795     Document Type: Article

References (50)

1. Storek J, Saxon A: Reconstitution of B cell immunity following bone marrow transplantation. Bone Marrow Transplant 9:395, 1992
2. Storek J, Ferrara S, Ku N, Giorgi JV, Champlin RE, Saxon A: B cell reconstitution after human bone marrow transplantation: Recapitulation of ontogeny? Bone Marrow Transplant 12:387, 1993
3. Velardi A, Cucciaioni S, Terenzi A, Quinti I, Aversa F, Grossi CE, Grignani F, Martelli MF: Acquisition of Ig isotype diversity after bone marrow transplantation in adults. A recapitulation of normal B cell ontogeny. J Immunol 141:815, 1988
4. Small TN, Keever CA, Weiner-Fedus S, Heller G, O'Reilly RJ, Flomenberg N: B-cell differentiation following autologous, conventional, or T-cell depleted bone marrow transplantation: A recapitulation of normal B-cell ontogeny. Blood 76:1647, 1990
5. Kagan JM, Champlin RE, Saxon A: B-cell dysfunction following human bone marrow transplantation: Functional-phenotypic dissociation in the early posttransplant period. Blood 74:777, 1989
6. Witherspoon RP, Storb R, Ochs HD, Fluornoy N, Kopecky KJ, Sullivan KM, Deeg JH, Sosa R, Noel DR, Atkinson K, Thomas ED: Recovery of antibody production in human allogeneic marrow graft recipients: Influence of time posttransplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatment. Blood 58:360, 1981
7. Korsmeyer SJ, Elfenbein GJ, Goldman CK, Marshall SL, Santos GW, Waldmann TA: B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. Transplantation 33:184, 1982
8. Ichihara Y, Matsuoka H, Kurosawa Y: Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J 7:4141, 1988
9. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P: Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell 27:583, 1981
10. Tonegawa S: Somatic generation of antibody diversity. Nature 302:575, 1983
11. Yancopoulos GD, Alt FW: Regulation of the assembly and expression of variable region genes. Annu Rev Immunol 4:339, 1986
12. Kodaira M, Kinashi T, Umemura I, Matsuda F, Noma T, Ono Y, Honjo T: Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J Molec Biol 190:529, 1986
13. Berman JE, Mellis SJ, Pollock R, Smith CL, Suh H, Heinke B, Kowal C, Surti U, Cantor CR, Alt FW: Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J 7:727, 1988
14. Buluwela L, Rabbits TH: A VH gene is located within 95 kb of the human immunoglobulin heavy chain constant region genes. Eur J Immun 18:1843, 1988
15. Kurosawa Y, Tonegawa S: Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. J Exp Med 155:201, 1982
16. Alt FW, Baltimore D: Joining of immunoglobulin heavy chain gene segments: Implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci USA 79:4118, 1982
17. Lafaille JJ, De Cloux A, Bonneville M, Takagaki Y, Tonegawa S: Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59:859, 1989
18. French DL, Laskov R, Scharff MD: The role of somatic hypermutation in the generation of antibody diversity. Science 244:1152, 1989
19. H clan and family identity predicts variable domain structure and may influence antigen binding. EMBO J 11:603, 1992
20. H locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 7:162, 1994
21. Cuisinier AM, Guigou V, Boubli L, Fougereau M, Tonnelle C: Preferential expression of VH5 and VH6 immunoglobulin genes in early human B-cell ontogeny. Scand J Immunol 30:493, 1989
22. Berman JE, Nickerson KG, Pollock RR, Barth JE, Schuurman RK, Knowles DM, Chess L, Alt FW: VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells. E J Immunol 21:1311, 1991
23. Schroeder HW Jr, Hillson JL, Perlmutter RM: Early restriction of the human antibody repertoire. Science 238:791, 1987
24. Schroeder HW Jr, Wang JY: Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci USA 87:6146, 1990
25. k repertoire revealed by in situ hybridisation. Mol Immunol 27:935, 1990
26. H gene-family utilization in human peripheral B cells by in situ hybridization. J Immunology 146:2855, 1991
27. Fumoux F, Guigou V, Blaise D, Maraninchi D, Fougereau M, Schiff C: Reconstitution of human immunoglobulin VH repertoire after bone marrow transplantation mimics B-cell ontogeny. Blood 81:3153, 1993
28. Storek J, King L, Ferrara S, Marcelo D, Saxon A, Braun J: Abundance of a restricted fetal B cell repertoire in marrow transplant recipients. Bone Marrow Transplant 14:783, 1994
29. Ringdén O, Pihlstedt P, Markling L, Aschan J, Båryd I, Ljungman P, Lönnqvist B, Tollemar J, Janossy G, Sundberg B: Prevention of graft-versus-host disease with T cell depletion or cyclosporin and metholrexate. A randomized trial in adult leukemic marrow recipients. Bone Marrow Transplant 7:221, 1991
30. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1988, 1988
31. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 173:395, 1991
32. Siebenlist U, Ravtech JV, Korsmeyer S, Waldmann T, Leder P: Human immunoglobulin D segments encoded in tandem multigenic families. Nature 294:631, 1981
33. Bakhshi A, Wright JJ, Graninger W, Seto M, Owens J, Cossman J, Jensen JP, Goldman P, Korsmeyer SJ: Mechanism of the t(14; 18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci USA 84:2396, 1987
34. Matsuda F, Shin EK, Hirabayashi Y, Nagaoka H, Yoshida MC, Zong SQ, Honjo T: Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. EMBO J 8:2501, 1990
35. Zong SQ, Nakai S, Matsuda F, Lee KH, Honjo T: Human immunoglobulin D segments: Isolation of a new D segment and polymorphic deletion of the D1 segment. Immunol Lett 17:329, 1988
36. Buluwela L, Albertson DG, Sherrington P, Rabbitts PH, Spurr N, Rabbitts TH: The use of chromosomal translocations to study human immunoglobulin gene organization: Mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus. EMBO J 7:2003, 1988
37. Betz AG, Neuberger MS, Milstein C: Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14:405, 1993
38. H) gene usage in the human IgH chain is established predominantly at the B precursor cell stage. J Immunol 149:511, 1992
39. Sanz I: Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 147:1720, 1991
40. Moore BB, Meek K: Recombination potential of the human DIR elements. J Immunol 154:2175, 1995
41. Varade WS, Marin E, Kittelberger AM, Insel RA: Use of the most JH-proximal human Ig H chain V region gene, VH6, in the expressed immune repertoire. J Immunol 150:4985, 1993
42. Mortari F, Newton JA, Wang JY, Schroeder H Jr: The human cord blood antibody repertoire. Frequent usage of the VH7 gene family. Eur J Immunol 22:241, 1992
43. Huang C, Stewart AK, Schwartz RS, Stollar BD: Immunoglobulin heavy chain gene expression in peripheral blood lymphocytes. J Clin Invest 89:1331, 1992
44. Mortari F, Wang JY, Schroeder HW Jr: Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed C alpha and C gamma repertoires. J Immunol 150:1348, 1993
45. Rathbun GA, Tucker PW: Conservation of sequences necessary for V gene recombination, in Kelsoe G, Schultz D (eds): Evolution of the Immune Response. New York, NY, Academic, 1986, p 75
46. Meek KD, Hasemann CA, Capra JD: Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity. J Exp Med 170:39, 1989
47. Krangel MS, Yssel H, Brocklehurst C, Spits H: A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: Evidence for controlled gene rearrangement and cytokine production. J Exp Med 172:847, 1990
48. Chaushu S, Chaushu G, Garfunkel AA, Slavin S, Or R, Yefenof E: Salivary immunoglobulins in recipients of bone marrow grafts. I. A longitudinal follow-up. Bone Marrow Transplant 14:871, 1994
49. Brenner MK, Wimperis JZ, Reittie JE, Patterson J, Asherson GL, Hoffbrand AV, Prentice HG: Recovery of immunoglobulin isotypes following T-cell depleted allogeneic bone marrow transplantation. Br J Haematol 64:125, 1986
50. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C: Sequences of proteins of immunological interest. Bethseda, MD, NIH Publication No. 91-3242, 1991