Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex

Genes and Development

Volumn 10, Issue 24, 1996, Pages 3202-3215

  Hagstrom, Kirsten ^a   Muller, Martin ^a,b   Schedl, Paul ^a  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Bithorax complex; chromatin domain boundary; Fab 7; insulator; suppresor of Hairy wing

Indexed keywords

ARTICLE; CHROMATIN; DROSOPHILA; EYE COLOR; GENE CONTROL; GENE REPRESSION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0030463741     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.24.3202     Document Type: Article

References (46)

1. Bellen, H.J., C. O'Kane, C. Wilson, U. Grossniklaus, R.K. Pearson, and W.J. Gehring. 1989. P-element mediated enhancer detection: A versatile method to study development in Drosophila. Genes & Dev. 3: 1288-1300.
2. Bienz, M. 1992. Molecular mechanisms of determination in Droaophila. Curr. Opin. Cell Biol. 4: 955-961.
3. Busturia, A. and M. Bienz. 1993. Silencers in Abdominal-B, a homeotic Drosophila gene. EMBO J. 12: 1415-1425.
4. Casares, F. and E. Sanchez Herrero. 1995. Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes. Development 121: 1855-1866.
5. Celniker, S.E., S. Sharma, D.J. Keelan, and E.B. Lewis. 1990. The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J. 9: 4277-4286.
6. Chan, C.S., L. Rastelli, and V. Pirrotta. 1994. A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J. 13: 2553-2564.
7. Chung, J.H., M. Whiteley, and G. Felsenfeld. 1993. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74: 505-514.
8. Duncan, I. 1987. The bithorax complex. Annu. Rev. Genet. 21: 285-319.
9. Fauvarque, M.O. and J.M. Dura. 1993. polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes & Dev. 7: 1508-1520.
10. Galloni, M., H. Gyurkovics, P. Schedl, and F. Karch. 1993. The bluetail transposon: Evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex. EMBO J. 12: 1087-1097.
11. Gerasimova, T.I., D.A. Gdula, D.V. Gerasimov, O. Simonova, and V.G. Corces. 1995. A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82: 587-597.
12. Gindhart, J.G., Jr. and T.C. Kaufman. 1995. Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced. Genetics 139: 797-814.
13. Gyurkovics, H., J. Gausz, J. Kummer, and F. Karch. 1990. A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation. EMBO J. 9: 2579-2585.
14. Hiromi, Y. and W.J. Gehring. 1987. Regulation and function of the Drosophila segmentation gene fushi tarazu. Cell 50: 963-974.
15. Hiromi, Y., A. Kuriowa, and W.J. Gehring. 1985. Control elements of the Drosophila segmentation gene fushi tarazu. Cell 43: 603-613.
16. Karch, F., B. Weiffenbach, M. Peifer, W. Bender, I. Duncan, S. Celniker, M. Crosby, and E.B. Lewis. 1985. The abdominal region of the bithorax complex. Cell 43: 81-96.
17. Karch, F., M. Galloni, L. Sipos, J. Gausz, H. Gyurkovics, and P. Schedl. 1994. Mcp and Fab-7: Molecular analysis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster. Nucleic Acids Res. 22: 3138-3146.
18. Kassis, J.A., E.P. VanSickle, and S.M. Sensabaugh. 1991. A fragment of engrailed regulatory DNA can mediate transvection of the white gene in Drosophila. Genetics 128: 751-761.
19. Kellum, R. and P. Schedl. 1991. A position-effect assay for boundaries of higher order chromosomal domains. Cell 64: 941-950.
20. _. 1992. A group of ses elements function as domain boundaries in an enhancer-blocking assay. Mol. Cell. Biol. 12: 2424-2431.
21. Kennison, J.A. 1993. Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet. 9: 75-78.
22. Levis, R., T. Hazelrigg, and G.M. Rubin. 1985. Separable cis-acting control elements for expression of the white gene of Drosophila melanogaster. EMBO J 4: 3489-3499.
23. Lewis, E.B. 1978. A gene complex controlling segmentation in Drosophila. Nature 276: 565-570.
24. McCall, K., M.B. O'Connor, and W. Bender. 1994. Enhancer traps in the Drosophila bithorax complex mark parasegmental domains. Genetics 138: 387-399.
25. Modolell, J., W. Bender, and M. Meselson. 1983. D. melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3 kb mobile element. Proc. Natl. Acad. Sci. 80: 1678-1682.
26. Müller, J. and M. Bienz. 1992. Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein. EMBO J. 11: 3653-3661.
27. O'Hare, K., C. Murphy, R. Levis, and G. Rubin. 1984. DNA sequence of the white locus of Drosophila melanogaster. J. Mol. Biol. 180: 437-455.
28. Paro, R. 1990. Imprinting a determined state into the chromatin of Drosophila. Trends Genet. 6: 416-421.
29. Pcifer, M. and W. Bender. 1988. Sequences of the gypsy transposon of Drosophila necessary for its effects on adjacent genes. Proc. Natl. Acad. Sci. 85: 9650-9654.
30. Peifer, M., F. Karch, and W. Bender. 1987. The bithorax complex: Control of segmental identity. Genes & Dev. 1: 891-898.
31. Pirrotta, V. 1988. Vectors for P-mediated transformation in Drosophila. In Vectors: A survey of molecular cloning vectors and their uses (ed. R.L. Rodriguez and D.T. Denhardt), pp. 437-456. Butterworth, Boston, MA.
32. Roseman, R., V. Pirrotta, and P. Geyer. 1993. The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position effects. EMBO J. 12: 435-442.
33. Sanchez-Herrero, E. 1991. Control of the expression of the bithorax complex genes abdominal-A and abdominal-B by cis-regulatory regions in Drosophila embryos. Development 111: 437-449.
34. Schedl, P. and F. Grosveld. 1995. Boundaries and domains. In Chromatin structure and gene expression (ed. S.C.R. Elgin), pp. 172-196. IRL Press, New York, NY.
35. Scott, K. and P. Geyer. 1995. Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes. EMBO J. 14: 6258-6279.
36. Shimell, M.J., J. Simon, W. Bender, and M.B. O'Connor. 1994. Enhancer point mutation results in a homeotic transformation in Drosophila. Science 264: 968-971.
37. Simon, J. 1995. Locking in stable states of gene expression: Transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7: 376-385.
38. Simon, J.A., C.A. Sutton, R.B. Lobell, R.L. Glaser, and J.T. Lis. 1985. Determinants of heat shock induced chromosomal puffing. Cell 40: 805-817.
39. Simon, J., M. Peifer, W. Bender, and M. O'Connor. 1990. Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis. EMBO J. 9: 3945-3956.
40. Simon, J., A. Chiang, W. Bender, M.J. Shimell, and M. O'Connor. 1993. Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev. Biol. 158: 131-144.
41. Smith, P.A. and V.G. Corces. 1992. The su(Hw) binding region is required for gypsy mutagenesis. Mol. Gen. Genet. 233: 65-70.
42. Spana, C., D.A. Harrison, and V.G. Corces. 1988. The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon. Genes & Dev. 2: 1414-1423.
43. Suter, B., L. Romberg, and R. Steward. 1989. Bicaudal-D, a Drosophila gene involved in developmental asymmetry: Localized transcript accumulation in ovaries and sequence similarity to myosin heavy chain tail domains. Genes & Dev. 3: 1957-1968.
44. Vazquez, J. and P. Schedl. 1994. Sequences required for enhancer blocking activity of ses are located within two nuclease-hypersensitive regions. EMBO J. 13: 5984-5993.
45. Vazquez, J., G. Farkas, M. Gaszner, A. Udvardy, M. Muller, K. Hagstrom, H. Gyurkovics, L. Sipos, J. Gausz, M. Galloni, et al. 1993. Genetic and molecular analysis of chromatin domains. Cold Spring Harbor Symp. Quant. Biol. 58: 45-54.
46. Zink, D. and R. Paro. 1995. Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA. EMBO J. 14: 5660-5671.