Development of V(H)81X transgene-bearing B cells in fetus and adult: Sites for expansion and deletion in conventional and CD5/B1 cells

International Immunology

Volumn 9, Issue 4, 1997, Pages 493-505

  Martin, Flavius ^a   Chen, Xinjian ^a   Kearney, John F ^a,b  

^a The University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

5; B1 cells; Bone marrow; Fetal liver; V(H)81X

Indexed keywords

LEUKOSIALIN; STEM CELL FACTOR RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; LEUKOCYTE ANTIGEN; SIALOGLYCOPROTEIN; SPN PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL; CONTROLLED STUDY; DEVELOPMENT; FETUS LIVER; GENE EXPRESSION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TRANSGENIC MOUSE; AGING; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW CELL; C57BL MOUSE; CELL DIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; GENETICS; HYBRIDOMA; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LIVER; METABOLISM; NEWBORN; PHYSIOLOGY; PRENATAL DEVELOPMENT; RADIATION CHIMERA; TRANSGENE;

AGING; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD; ANTIGENS, CD43; B-LYMPHOCYTES; BONE MARROW; BONE MARROW CELLS; CELL DIFFERENTIATION; CLONAL DELETION; EMBRYONIC AND FETAL DEVELOPMENT; GENES, IMMUNOGLOBULIN; HYBRIDOMAS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-KIT; RADIATION CHIMERA; SIALOGLYCOPROTEINS; TRANSGENES;

EID: 0030612149     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.4.493     Document Type: Article

References (69)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
2. H gene segments in pre-B cell lines. Nature 311:727.
3. H genes. Science 227:1597.
4. Schroeder, H. W., Jr, Hilson, J. L. and Perlmutter, R. M. 1987. Early restriction of the human antibody repertoire. Science 238:791.
5. Dighiero, G., Lymberi, P., Holmberg, D., Lundquist, I, Coutinho, A. and Avrameas, S. 1985. High frequency of natural autoantibodies in normal newborn mice. J. Immunol. 134:765.
6. Levinson, A. I., Dalal, N. and Hardar, M. 1987. Prominent IgM rheumatoid factor production by human cord blood lymphocytes stimulated in vitro with Staphylococcus aureus Cowan I. J. Immunol. 139:2237.
7. Lehuen, A., Monteiro, R. C. and Kearney, J. F. 1992. Identification of a surface protein (p100) associated with two glycosylphosphatidylinositol-linked molecules (Thy-1 and ThB) by natural anti-lymphocyte autoantibodies. Eur. J. Immunol. 22:2373.
8. Holmberg, D., Forsgren, S., Ivars, F. and Coutinho, A. 1984. Reactions among IgM antibodies derived from normal, neonatal mice. Eur. J. Immunol. 14:435.
9. Vakil, M. and Kearney, J. F. 1986. Functional characterization of monoclonal auto-anti-idiotype antibodies isolated from the early B cell repertoire of BALB/c mice. Eur. J. Immunol. 16:1151.
10. Kearney, J. F. 1993. Idiotypic networks. In W. E. Paul, ed., Fundamental Immunology, Vol. 3, p. 887. Raven Press, New York.
11. Sigal, N. H., Gearhart, P. J., Press, J. L. and Klinman, N. R. 1976. Late acquisition of a germline antibody specificity. Nature 259:51.
12. Stohrer, R. and Kearney, J. F. 1984 Ontogeny of B cell precursors responding to α1-3 dextran in BALB/c mice. J. Immunol. 133:2323.
13. Stein, K. E. 1992. Thymus-independent and thymus-dependent response to polysaccharide antigens. J. Infect. Dis. 165 (Suppl. 1):S49.
14. Lawler, A. M., Lin, P. S. and Gearhart, P. J. 1987, Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells. Proc. Natl Acad. Sci. USA 84:2454.
15. H7183 genes and evidence for stage-specific somatic diversification. Eur. J. Immunol. 22:71.
16. H81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. J. Immunol. 147:1406.
17. Huetz, F., Carlsson, L., Tornberg, U. and Holmberg, D. 1993. V-region directed selection in differentiating B lymphocytes. EMBO J. 12:1819.
18. H81X usage during B cell development - initial decline in usage is independent of Ig heavy chain cell surface expression. J. Immunol. 156:2077.
19. Alt, F. W., Blackwell, T. K. and Yancopoulos, G. D. 1987. Development of the primary antibody repertoire. Science 238:1079.
20. H families. Int. Immunol. 2:41.
21. Tutter, A. and Riblet, R. 1989. Conservation of an immunoglobulin variable-region gene family indicates a specific, noncoding function. Proc. Natl Acad. Sci. USA 86:7460.
22. H81X in newborns but not in adults. Mol. Immunol. 30:1473.
23. Kearney, J. F., Radbruch, A., Liesegang, B. and Rajewsky, K. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody secreting hybrid cell lines. J. Immunol. 123:1548.
24. Burrows, P. D., LeJeune, M. and Kearney, J. F. 1979. Evidence that murine pre-B cells synthesize μ heavy chain but no light chains. Nature 280:838.
25. Hamilton, A. M., Lehuen, A. and Kearney, J. F. 1994. Immunofluorescence analysis of B-1 B cell ontogeny in the mouse. Int. Immunol. 6:355.
26. Hamilton, A. M. and Kearney, J. F. 1994. Effects of IgM allotype suppression on serum IgM levels, B-1 and B-2 cells, and antibody responses in allotype heterozygous F1 mice. Dev. Immunol. 4:27.
27. Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
28. Chang, Y., Paige, C. J. and Wu, G. 1992. Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J. 11:1891.
29. Chen, X., Martin, F., Forbush, K. A., Perlmutter, R. M. and Kearney, J. F. 1997. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. Int. Immunol. 9:27.
30. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
31. Li, Y.-S., Hayakawa, K. and Hardy, R. R., 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
32. Rolink, A. and Melchers, F. 1993. B lymphopoiesis in the mouse. Adv. Immunol. 53:123.
33. Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H. and Melchers, F. 1994. IL-2 receptor a chain (CD25,TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257.
34. Melchers, F., Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H., Ghia, P. and Andersson, J. 1995. Positive and negative selection events during B lymphopoiesis. Curr. Opin. Immunol. 7:214.
35. Rolink, A., Ten Boekel, E., Melchers, F., Fearon, D. T., Krop, I. and Anderson, J. 1996, A subpopulation of B220 positive cells in murine bone marrow does not express CD 19 and contains NK progenitors. J. Exp. Med. 183:187.
36. Ehlich, A., Martin, V., Muller, W. and Rajewsky, K. 1994. Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4:573.
37. Spanopoulou, E., Roman, C. A., Corcoran, L. M., Schlissel, M. S., Silver, D. P., Nemazee, D., Nussenzweig, M. C., Shinton, S. A., Hardy, R. R. and Baltimore, D. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in rag-1-deficient mice. Genes Dev. 8:1030.
38. Keyna, U., Beck-Engeser, G. B., Jongstra, J., Applequist, S. E. and Jack, H.-M. 1995. Surrogate light chain-dependent selection of Ig heavy chain V regions. J. Immunol. 155:5536.
39. Cook, J. L., Ikle, D. N. and Routes, B. A. 1995. Natural killer cell ontogeny in the athymic rat. J. Immunol. 155:5512.
40. Storb, U., Pinkert, C., Art, B., Engler, P., Gollahon, K., Manz, J., Brady, W. and Brinster, R. L. 1986. Transgenic mice with μ and κ genes encoding antiphosphorylcholine antibodies. J. Exp. Med. 164:627.
41. Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smithgill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., Trent, R. J. and Basten, A. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
42. Cyster, J. G., Hartley, S. B. and Goodnow, C. G. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B cell repertoire. Nature 371:389.
43. Kenny, J. . J., O'Connell, C., Sieckmann, D. G., Fischer, R. T. and Longo, D. L. 1991. Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-μ heavy chain gene. J. Exp. Med. 174:1189.
44. Kearney, J. F., Cooper, M. D., Klein, J., Abney, E. R., Parkhouse, R. M. E. and Lawton, A. R. 1977. Ontogeny of Ia and IgD on IgM-bearing lymphocytes in mice. J. Exp. Med. 146:297.
45. Hayakawa, K., Tarlinton, D. and Hardy, R. R. 1994. Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. J. Immunol. 152:4801.
46. Lam, K.-P. and Stall, A. M. 1994. Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny. J. Exp. Med. 180:507.
47. Oltz, E. M., Yancopoulos, G. D., Morrow, M. A., Rolink, A., Lee, G., Wong, F., Kaplan, K., Gillis, S., Melchers, F. and Alt, F. W. 1992. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J. 11:2759.
48. Wells, S. M., Kantor, A. and Stall, A. M. 1994. CD43 (S7) expression identifies peripheral B cell subsets. J. Immunol. 153:5503.
49. MacLennan, I. C. and Gray, D. 1986. Antigen driven selection of virgin and memory B cells. Immunol. Rev. 91:61.
50. Waldschmidt, T., Snapp, K., Foy, T., Tygrett, L. and Carpenter, C. 1992. B-cell subsets defined by the Fc epsilon R. Ann. NY Acad. Sci. 651:84.
51. Cyster, J. C. and Goodnow, C. C. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection, Immunity 2:13.
52. Nemazee, D. A. and Burki, K. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.
53. Erikson, J., Radic, M. Z., Camper, S. A., Hardy, R. R., Carmack, C. and Weigert, M. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349:331.
54. Hartley, S. B., Cooke, M. P., Fulcher, D, A., Harris, A. W., Cory, S., Basten, A. and Goodnow, C. C. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72:325.
55. Martin, F., Chen, X., Shu, F. and Kearney, J. F. 1995. Development of the mouse B cell repertoire Ann. NY Acad. Sci. 764:207.
56. Fulcher, D. A. and Basten, A. 1994. Reduced life span of anergic self-reactive B cells in a double-transgenic model. J. Exp. Med. 179:125.
57. Chang, Y., Bosma, G. C. and Bosma, M. J. 1995. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity 2:607.
58. Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T. K., Mendelsohn, M., Rolink, A., Melchers, F. and Alt, F. W. 1994. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev. 8:1043.
59. ten Boekel, E., Melchers, F. and Rolink, A. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013.
60. Decker, D. J., Kline, G. H., Hayden, T. A., Zaharevitz, S. N. and Klinman, N. R. 1995 Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition. J. Immunol. 154:4924.
61. Freitas, A. A., Rosando, M. M., Viale, A.-C. and Grandien, A. 1995. The role of cellular competition in B cell survival and selection of B cell repertoires. Eur. J. Immunol. 25:1729.
62. Lortan, J. E., Roobottom, C. A., Oldfield, S. and MacLennan, I. C. 1987. Newly produced virgin B cells migrate to secondary lymphoid organs but their capacity to enter follicles is restricted. Eur. J. Immunol. 17:1311.
63. Schlissel, M. S. and Morrow, T. 1994. Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153:1645.
64. Lamers, M. C., Vakil, M., Kearney, J. F., Langhorne, J., Paige, C. J., Julius, M. H., Mossmann, H., Carsetti, R. and Kohler, G. 1989. Immune status of a μ,κ transgenic mouse line. Deficient response to bacterially related antigens. Eur. J. Immunol. 19:459.
65. Arnold, L. W., Pennell, C. A., McCray, S. K. and Clarke, S. H. 1994. Development of B-1 cells: Segregation of phosphatidylcholine specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179:1585.
66. Herzenberg, L. A., Stall, A. M., Braun, J., Weaver, D., Baltimore, D., Herzenberg, L. A. and Grosschedl, R. 1987. Depletion of the predominant B cell population in immunoglobulin mu heavy chain transgenic mice. Nature 329:71.
67. Iacomini, J. and Imanishi-Kari, T. 1992. The effect of an immunoglobulin mu transgene on B cell maturation. Eur. J. Immunol. 22:745.
68. H repertoires formed at different stages of ontogeny and under different selection pressures, EMBO J. 14:1680.
69. Kantor, A. B., Merrill, C. E., MacKenzie, J. D., Herzenberg, L. A. and Hillson, J. L., 1995. Development of the antibody repertoire as revealed by single-cell PCR of FACS-sorted B-cell subsets. Ann. NY Acad. Sci. 764:224.