The PML/RARα fusion protein inhibits tumor necrosis factor-α-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts

Journal of Clinical Investigation

Volumn 101, Issue 10, 1998, Pages 2278-2289

  Testa, Ugo ^a   Grignani, Francesco ^a,b   Samoggia, Paola ^a   Zanetti, Cristiana ^a   Riccioni, Roberta ^a   Lo Coco, Francesco ^c   Diverio, Daniela ^c   Felli, Nadia ^a   Passerini, Carlo Gambacorti ^d   Grell, Matthias ^e   Pelicci, Pier Giuseppe ^f   Peschle, Cesare ^a,g,h  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e UNIVERSITY OF STUTTGART   (Germany)

^f EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^g THOMAS JEFFERSON UNIVERSITY   (United States)

^h THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Apoptosis; Fusion protein; Leukemia; Tumor necrosis factor

Indexed keywords

FAS ANTIGEN; HYBRID PROTEIN; HYBRID PROTEIN PML RARALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; LEUKOCYTE ANTIGEN; MESSENGER RNA; NUCLEAR PROTEIN; PML PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; TRANSCRIPTION FACTOR; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ACUTE MYELOBLASTIC LEUKEMIA; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR BINDING; CELL CULTURE; CELL DIVISION; CELL SURVIVAL; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROMYELOCYTIC LEUKEMIA; PROTEIN BINDING;

ANTIGENS, CD; ANTIGENS, CD95; APOPTOSIS; CELL DIVISION; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; RECEPTORS, RETINOIC ACID; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEINS;

EID: 0032523245     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1332     Document Type: Article

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