Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform

British Journal of Pharmacology

Volumn 118, Issue 7, 1996, Pages 1659-1668

  Szabó, Csaba ^a   Bryk, Ruslana ^b   Zingarelli, Basilia ^a   Southan, Garry J ^a   Gahman, Timothy C ^c   Bhat, Venkat ^c   Salzman, Andrew L ^a   Wolff, Donald J ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Calbiochem Novabiochem Corp   (United States)

Author keywords

Blood pressure; Endotoxin; Isothioureas; L arginine; Mercaptoalkylguanidines; Nitric oxide; Shock; Tetrahydrobiopterin; Vasoconstriction; Vasodilatation

Indexed keywords

ARGININE; BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; GUANIDINE DERIVATIVE; GUANYLATE CYCLASE; METHYLENE BLUE; NITRIC OXIDE SYNTHASE; NITRITE; NORADRENALIN; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BRAIN; CELL CULTURE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENDOTOXEMIA; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFLAMMATION; INTESTINE CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG ALVEOLUS EPITHELIUM; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; SURVIVAL RATE; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0029899544     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15589.x     Document Type: Article

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