TCR repertoire and cytokine profiles of cerebrospinal fluid- and peripheral blood-derived T lymphocytes from patients with multiple sclerosis

Journal of Neuroscience Research

Volumn 51, Issue 6, 1998, Pages 759-770

  Birebent, Brigitte ^a,c   Semana, Gilbert ^a   Commeurec, Agnes ^a   Edan, Gilles ^b   Genetet, Bernard ^a   Genetet, Noelle ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^c WISTAR INSTITUTE   (United States)

Author keywords

Human CSF T cells; Multiple sclerosis; T cell receptor V genes

Indexed keywords

CYTOKINE; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MULTIPLE SCLEROSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE;

ADULT; CLONE CELLS; CYTOKINES; FEMALE; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0032521403     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19980315)51:6<759::AID-JNR9>3.0.CO;2-A     Document Type: Article

References (66)

1. Akolkar PN, Gulwani-Akolkar B, Pergolizzi R, Bigler RD, Silver J (1993): Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes. J Immunol 150:2761-2773.
2. Ando DG, Clayton J, Kono D, Urban JL, Sercaz E (1989): Encephalitogenic T cells in the B10-PL model of experimental allergic encephalomyelitis (EAE) are of the TH1 lymphokine subtype. Cell Immunol 124:132-143.
3. Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA (1993): Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med 177:57-68.
4. Barten DM, Ruddle NH (1994): Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis. J Neuroimmunol 51:123-133.
5. Ben-Nun A, Cohen IR (1982): Experimental autoimmune encephalomyelitis (EAE) mediated by cell lines: Process of selection of lines and characterization of the cells. J Immunol 129:303-308.
6. Benvenuto R, Paroli M, Buttinelli C, Franco A, Barnaba V, Fieschi C, Balsano F (1991): Tumor necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. Clin Exp Immunol 84:97-102.
7. Birnbaum G, Van Ness NB (1992): Quantitation of T-cell receptor V beta chain expression of lymphocytes from blood, brain and spinal fluid in patients with multiple sclerosis and other neurological diseases. Ann Neurol 32:24-40.
8. Bourdette DN, Whitham R, Chou YK, Morrison WJ, Atherton J, Kenny C, Liefeld D, Hashim GA, Offner H, Vandenbark AA (1994): Immunity to T cell receptor peptides in multiple sclerosis. I. Successful immunisation of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides. J Immunol 152:2510-2519.
9. Brod SA, Benjamin D, Hafler DA (1991): Restricted T cell expression of II-2/IFN-γ mRNA in human inflammatory disease. J Immunol 147:810-815.
10. Bucht A, Oksenberg JR, Lindblad S, Gronberg A, Steinman L, Klareskog L (1992): Characterization of T-cell receptor alpha beta repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand J Immunol 35:159-165.
11. Cannella BC, Raine CS (1995): The adhesion molecules and cytokine profile of multiple sclerosis lesion. Ann Neurol 37:424-435.
12. Chou Y, Bourdette D, Offner H, Whitham R, Wang R, Hashim G, Vandenbark AA (1992): Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and CSF in multiple sclerosis. J Neuroimmunol 28:105-114.
13. Chou YK, Buenafe AC, Dedrick R, Morrison WJ, Bourdette DN, Whitham R, Atherton J, Lane J, Spoor E, Hashim GA, Offner H, Vandenbark AA (1994): T cell receptor Vβ gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis. J Neurosci Res 37:169-181.
14. Chou YK, Weinberg AD, Buenafe A, Bourdette DN, Whitham R, Kaleeba JAR, Robey JF, Kavanagh DG, Offner H, Vandenbark AA (1996): MHC restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR Vβ CDR2 peptides: comparison with myelin-basic protein-specific T cells. J Neurosci Res 45:838-851.
15. Correale J, McMillan M, McCarthy K, Le BS, Weiner LP (1995): Patterns of cytokine secretion by autoreactive proteolipid protein peptide-specific T cell clones during the course of multiple sclerosis. J Immunol 154:2959-2968.
16. Dux R, Kindler-Rohrborn A, Annas M, Faustmann P, Lennartz K, Zimmermann CW (1994): A standardized protocol for flow cytometric analysis of cells isolated from cerebrospinal fluid. J Neurol Sci 121:74-78.
17. + T-cell population. Ann NY Acad Sci 756:19-27.
18. Grenier Y, Ruijs TC, Robitaille Y, Olivier A, Antel JP (1989): Immunohistochemical studies of adult human glial cells. J Neuroimmunol 21:103-115.
19. Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL (1988): Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 139:68-72
20. Hall BL, Finn OJ (1992): PCR-based analysis of the T-cell receptor Vβ multigene family: experimental parameters affecting its validity. BioTechniques 13:248-257.
21. Jason J, Inge KL (1996): The effects of mitogens, Il-2 and anti-CD3 antibody on the T-cell receptor Vβ repertoire. Scand J Immunol 43:652-661.
22. Jurewicz A, Biddison WE, Antel JP (1997): MHC Class I-restricted killing of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes. Neurology 48:A381.
23. Khoury SJ, Hancock WW, Weiner HL (1992): Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with down-regulation of inflammatory cytokines and differential upregulation of TGF-β, Il-4 and PGE expression in the brain. J Exp Med 176:1355-1364.
24. Khoruts A, Miller SD, Jenkins MK (1995): Neuroantigen-specific TH2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector TH1 cells. J Immunol 155:5011-5017.
25. Kotzin BL, Karuturi S, Chou YK, Lafferty J, Forrester JM, Better M, Nedwin GE, Offner H, Vandenbark AA (1991): Preferential T cell receptor Vβ gene usage in myelin basic protein reactive T cell clones from patients with multiple sclerosis. Proc Natl Acad Sci USA 88:9161-9165.
26. Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB (1991): Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology 59:305-312.
27. Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA (1991): Common T-cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol 29:33-40.
28. Linington C, Berger L, Perry S, Weeth S, Hinze-Selch D, Lu HC, Lassmann H, Wekerle H (1993): T cells specific for myelin/oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur J Immunol 23:1364-1372.
29. Link J, Soderstrom M, Olsson T, Hojeberg B, Ljungdahl A, Link H (1994): Increased transforming growth factor-β, interleukin-4 and interferon-γ in multiple sclerosis. Ann Neurol 36:379-386.
30. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J Immunol 148:1359-1366.
31. Meinl E, Weber F, Drexler K, Morelle C, Ott M, Saruhan-Direskeneli G, Goebels N, Ertl B, Jechart G, Giegerich G, Shonbeck S, Bannwarth W, Wekerle H, Hohlfeld R (1993): Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. J Clin Invest 92:2633-2643.
32. Mokhtarian F, Shi Y, Shirazian D, Morgante L, Miller A, Grob D (1994): Defective production of antiinflammatory cytokine. TGF-β by T cell lines of patients with active multiple sclerosis. J Immunol 152:6003-6010.
33. Morvan PY, Picot C, Dejour R, Gillot E, Genetet B, Genetet N (1994): In situ hybridization and cytofluorometric analysis of cytokine mRNA during in vitro activation of human T cells. Eur Cytokine Network 5:469-480.
34. Navikas V, He B, Link J, Haglund M, Soderstrom M, Fredrikson S, Hojeberg B, Qiao J, Olsson T, Link H (1996): Augmented expression of tumor necrosis factor-α and lymphotoxin mRNA in mononuclear cells in multiple sclerosis and optic neuritis. Brain 119:213-223.
35. Oksenberg JR, Panzara MA, Begovitch AB, Mitchell D, Ehrlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CCA, Steinman L (1993): Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in the brain lesions of multiple sclerosis. Nature 362:68-70.
36. Olsson T, Wang WZ, Hojeberg B, Kostulas V, Jiang YP, Andersson G, Ekre HP, Link H (1990): Autoreactive T lymphocytes in multiple sclerosis determined by antigen induced secretion of interferon gamma. J Clin Invest 86:981-985.
37. + T cell clones. J Immunol 141:849-855.
38. Panitch HS, Hirsch RL, Schindler J, Johnson KP (1987): Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology 37:1097-1102.
39. Racke MK, Bonomo A, Scott DE, Cannella B, Levine A, Raine CS, Schevach EM, Rocken M (1994): Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 180:1961-1966.
40. Raine CS (1994): The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion. Ann Neurol 36:S61-S72.
41. + T cells of the virus-positive twins. Proc Natl Acad Sci USA 91:1529-1533.
42. Richert JR, Robinson BS, Camphausen BS, Martin R, Voskhul RR, Faerber BA, McFarland HF, Hurley CK (1995): Diversity of T-cell receptor Vα, Vβ, and CDR3 expression by myelin basic protein-specific human T-cell clones. Neurology 45:1919-1922.
43. Rieckmann P, Albrecht M, Kitze B, Weber T, Tumani H, Brooks A, Luer W, Poser S (1994): Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 44:1523-1526.
44. Rieckmann P, Albrecht M, Kitze B, Weber T, Tumani H, Brooks A, Luer W, Helwig A, Poser S (1995): Tumor necrosis factor - a messenger RNA expression in patients with relapsing/remitting multiple sclerosis is associated with disease activity. Ann Neurol 37:82-88.
45. Selmaj K, Raine CS, Cannella B, Brosnan CF (1991): Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 87:949-954.
46. Sharief MK, Hentges R (1991): Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. New Engl J Med 325:467-472.
47. Shimonkevit R, Murray R, Kotzin B (1995): Characterization of T-cell receptor V beta usage in the brain of a subject with multiple sclerosis. Ann NY Acad Sci 756:305-306.
48. Street NE, Mosmann TR (1991): Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J 5:171-177.
49. Sun J, Link H, Olsson T, Xiao BG, Andersson G, Ekre HP, Linington C, Diener P (1991): T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 146:1490-1495.
50. Uurban JL, Kumar V, Kono DH, Gomez C, Horvath SJ, Clayton J, Ando DG, Sercax EE, Hood L (1988): Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577-592.
51. Usuku K, Joshi N, Hatem CJ, Wong MA, Stein MC, Hauser SL (1996): Biased expression of T cell receptor genes characterizes activated T cells in multiple sclerosis cerebrospinal fluid. J Neurosci Res 45:829-837.
52. Utz U, Biddison WE, McFarland HF, McFarlin DE, Flerlage M, Martin R (1993): Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature 364: 243-247.
53. Vandenbark AA, Hashim G, Offner H (1989): Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541-544.
54. Vandenbark AA, Chou YK, Whitham R, Mass M, Buenafe A, Liefeld D, Kavanagh D, Cooper S, Hashim GA, Offner H, Bourdette DN (1996): Treatment of multiple sclerosis with T cell receptor peptides: results of a double-blind pilot trial. Nature Med 2:1109-1115.
55. Van der Veen R, Kapp JA, Trotter JL (1993): Encephalitogenic TH1 cells are inhibited by TH2 cells with related peptide specificity: relative roles of interleukin-4 (Il-4) and Il-10. J Neuroimmunol 48:213-220.
56. Vartanian T, Li Y, Zhao M, Stefansson K (1995): Interferon-γ-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis. Mol Med 1:732-742.
57. Vassalli P (1992): The pathophysiology of tumor necrosis factors. Ann Rev Immunol 10:411-452.
58. Voskhul RR, Martin R, Bergam C, Dalal M, Ruddle NH, McFarland HF (1993): T helper 1 (TH1) functional phenotype of human myelin basic protein-specific T lymphocytes. Autoimmunity 15:137-143.
59. Waldor MK, Sriram S, Hardy R, Herzenberg LA, Lanier L, Lim M, Steinman L (1985): Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science 227:415-417.
60. Whitham RH, Bourdette DN, Hashim GA, Herndon RM, Ilg RC, Vandenbark AA, Hoffner H (1991): Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating EAE. J Immunol 146:101-107.
61. Wilson DB, Golding AB, Smith RA, Dafashy T, Nelson J, Smith L, Carlo DJ, Brostoff SW, Gold DP (1997): Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations. J Neuroimmunol 76:15-28.
62. Wong FS, Hibberd ML, Wen L, Millward BA, Demaine AG (1993): The human T cell receptor Vβ repertoire of normal peripheral blood lymphocytes before and after mitogen stimulation. Clin Exp Immunol 92:361-366.
63. Woodroofe MN, Cuzner ML (1993): Cytokine mRNA expression in inflammatory (MS) lesions: detection by non-radioactive in situ hybridization. Cytokine 5:583-588.
64. Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA (1990): Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248:1016-1019.
65. Zaller DM, Osman G, Kanagawa O, Hood L (1990): Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor Vβ-specific antibodies. J Exp Med 171: 1943-1955.
66. Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA (1994): Increased frequency of interleukin-2responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179:973-984.