Biased expression of T cell receptor genes characterizes activated T cells in multiple sclerosis cerebrospinal fluid

Journal of Neuroscience Research

Volumn 45, Issue 6, 1996, Pages 829-837

  Usuku, K ^a   Joshi, N ^a   Hatem Jr , C J ^b   Wong, M A ^a   Stein, M C ^b   Hauser, S L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

autoimmunity; cerebrospinal fluid; multiple sclerosis; myelin basic protein; T cell receptor

Indexed keywords

HLA ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; ARTICLE; AUTOIMMUNITY; CELL COMPARTMENTALIZATION; CEREBROSPINAL FLUID CYTOLOGY; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; ETIOLOGY; GENE EXPRESSION; HLA TYPING; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; MULTIGENE FAMILY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE;

ADULT; CELL DIVISION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HLA-DR ANTIGENS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MULTIGENE FAMILY; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL;

EID: 0029742518     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960915)45:6<829::AID-JNR20>3.0.CO;2-P     Document Type: Article

References (39)

1. Acha-Orbea, H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L (1988): Limited heterogeniety of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263-273.
2. Allen M, Sandberg-Wollheim M, Sjogren K, et al. (1994): Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles. Hum Immunol 39:41-48.
3. Beall SS, Biddison W, McFarlin DE, et al. (1993): Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TCR Vβ chain locus and HLA class Ii genes. J Neuroimmunol 45:53-60.
4. Ben-Nun A, Liblau RS, Cohen L, Lehmann D, Tournier-Lasserve E, Rosenzweig A, Zhang JW, Raus JC, Bach MA (1991): Restricted T-cell receptor Vβ gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: Predominant genes vary in individuals. Proc Natl Acad Sci USA 88:2466-2470.
5. Bourdette DN, Whitham WH, Chou YK, et al. (1994): Immunity to TCR peptides in multiple sclerosis 1 Successful immunization of patients with synthetic vβ52 and Vβ61 CDR2 peptides. J Immunol 152:2510-2519.
6. Bruns J, Littlefield K, Gill J, Trotter JL (1992): Bacterial toxin superantigens activate human T lymphocytes reactive with myelin autoantigens. Ann Neurol 32:352-357.
7. Chofflon M, Weiner HL, Morimoto C, Hafler DA (1989): Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Ann Neurol 25:494-499.
8. Choi YW, Kotzin B, Herron L, Callahan J, Marrack P, Kappler J (1989): Interaction of staphylococcus aureus toxin "superantigens" with human T cells. Proc Natl Acad Sci USA 86:8941-8945.
9. Chou YK, Bourdette DN, Offner H, Whitham R, Wang RY, Hashim GA, Vandenbard AA (1992): Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 38:105-113.
10. Critchield JM, Racke M, Zuniga-Pflucker JC, et al. (1994) T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139-1143.
11. Davies TF, Martin A, Concepcion ES, Graves P, Lahat N, Cohen WL, Ben-Nun A (1992): Evidence for selective accumulation of intrathyroid T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. J Clin Invest 89:157-162.
12. Fallis RJ, Powers ML, Sy M, Weiner HL (1987): Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis. J Neuroimmnol 14:205-219.
13. Hauser SL, Fleischnick E, Weiner HL, Marcus D, Awdeh A, Yunis EJ, Alper CA (1989): Extended major histocompatibility complex haplotypes in patients with Multiple Sclerosis. Neurology 39:275-277.
14. Hillert J, Olerup O (1993): Multiple sclerosis is associated with genes within or close to the HLA-DR-DQ subregion on a normal DR 15,DQ6,Dw2 haplotype. Neurology 43:163-168.
15. Howell MD, Diveley JP, Lundeen KA, Esty A, Winters ST, Carlo DJ, Brostoff SW (1991) Limited T-cell receptor B-chain heterogeniety among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci USA 88:10921-10925.
16. Kimura A, Dong R-P, Harada H, Sasazuki T (1992) DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA. Tissue Antigens 40:5-12.
17. Kotzin BL, Karuturi S, Chou YK, Lafferty J, Forrester JM, Better M, Nedwin GE, Offner H, Vandenbark AA (1991): Preferential T-cell receptor β-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proc Natl Acad Sci USA 88:9161-9165.
18. Lynch, SG, Rose JW, Petajan JH, et al (1991): Discordance of T-cell receptor beta-chain genes in familial multiple sclerosis. Ann Neurol 30:229-241.
19. Marrack P, Kappler JW (1990) The staphylococcal enterotoxins and their relatives. Science 248:705-711.
20. Martin R, McFarland HF, McFarlin DE (1992): Immunological aspects of demyelinating diseases. Annu Rev Immunol 10:153-187.
21. Moller DR, Konishi K, Kirby M, Balbi B, Crystal RG (1988): Bias toward use of a specific T cell receptor β-chain variable region in subgroup of individuals with sarcoidosis. J Clin Invest 82: 1183-1191.
22. Offner H, Buenafe AC, Vainiene M, Celnik B, Weinberg AD, Gold DP, Hashim G, Vandenbark AA (1993): Where, when, and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis. J Immunol 151:506-517.
23. Oksenberg JR, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard R, Bernard CCA, Steinmann L (1993): Selection of T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362:68-70.
24. Oksenberg J, Hauser SL (1996): Pathogenesis of multiple sclerosis relationship to therapeutic strategies In Goodkin, DE and Rudick RA (eds): "Treatment of Multiple Sclerosis: Trial Design, Results and Future Strategies." 2nd Ed. London: Springer-Verlag (in press).
25. Seboun E, Robinson MA, Doolittle TH, Ciulla TA, Kindt TJ, Hauser SL (1989): A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex. Cell 57:1095-1100.
26. Soderstrom M, Link H, Sun JB, Fredrikson S, Kostulas V, Hojeberg B, Li BL, Olsson T (1993): T cells recognizing multiple peptides of myelin basic protein are found in blood and enriched in cerebrospinal fluid in optic neuritis and multiple sclerosis. Scand J Immunol 37:355-368.
27. Spurkland A, Ronningen KS, Vandvik B, Thorsby E, Vartdal F (1991): HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis. Hum Immunol 30:69-75.
28. Tourtellote, WW (1985): The cerebrospinal fluid in multiple sclerosis. In "Handbook of Clinical Neurology," Revised Series, Vol 3. Vinken PJ, Bruyn GW, Klawans HL (eds): New York: Elsevier Science Publishing Co., Inc., pp 79-130.
29. Traugott U, Reinherz EL, Raine CS (1983): Multiple sclerosis: Distribution of T cell subsets within active chronic lesions. Science 219:308-310.
30. Urban J L, Kumar V, Kono DH, Gomez C, Horvath SJ, Clayton J, Ando DG, Sercarz EE, Hood L (1988) Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577-592.
31. Usuku K, Joshi N, Hatem CJ, Jr., Alper CA, Schoenfeld DA, Hauser SL (1993): The human T-cell receptor β-chain repertoire: Longitudinal fluctuations and assessment in MHC matched populations. Immunogenetics 38:193-198.
32. Waldmann, T A 1986 The structure, function, and expression of Il-2 receptors on normal and malignant lymnphocytes. Science 232: 727.
33. Walsh MJ, Tourtellotte WW (1986) Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J Exp Med 163:41-53.
34. Wei S, Charmley P, Birchfield RI, Concannon P (1995): Human T-cell receptor Vβ gene polymorphism and multiple sclerosis. Am J Hum Genet 56:963-969.
35. Wood, NW, SJ Sawcer, HF Kellar-Wood, et al (1995) The T-cell receptor β locus and susceptibility to multiple sclerosis. Neurology 45:1859-1863.
36. Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA (1990): Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248:9161-9165.
37. Wucherpfennig KW, Newcome J, Li H, Keddy C, Cuzner ML, Hafler DA (1992): T cell receptor Vα-Vβ repertoire and cytokine gene expression in active multiple sclerosis lesions. J Exp Med 175: 993-1002.
38. Zaller DM, Osman G, Kanagawa O, Hood L (1990): Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor Vβ-specific antibodies. J Exp Med 171: 1943-1955.
39. Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA (1994) Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179:973-984.