'Reagent explosion': An efficient method to increase library size and diversity

Tetrahedron Letters

Volumn 39, Issue 24, 1998, Pages 4255-4258

  Bienayme H ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL; CYANOACRYLATE; IMIDAZOLE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; POLYMERIZATION; SYNTHESIS;

EID: 0032508081     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00696-0     Document Type: Article

References (24)

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2. Curr. Op. Chem. Biol. 1997, 1, 3-145. Hermkens, P.H.H. ; Ottenheijm, H.C.J. ; Rees, D.C. Tetrahedron, 1997, 53, 5643-5678. Balkenhohl, F. ; von den Bussche-Hünnefeld, C. ; Lansky, A. ; Zechel, C. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288-2337. Thompson, L.A. ; Ellman, J.A. Chem. Rev. 1996, 96, 555-600. Gordon, E.M. ; Barrett, R.W. ; Dower, W.J. ; Fodor, S.P.A. ; Gallop, M.A. J. Med. Chem. 1994, 37, 1233-1251 and 1385-1401.
3. Curr. Op. Chem. Biol. 1997, 1, 3-145. Hermkens, P.H.H. ; Ottenheijm, H.C.J. ; Rees, D.C. Tetrahedron, 1997, 53, 5643-5678. Balkenhohl, F. ; von den Bussche-Hünnefeld, C. ; Lansky, A. ; Zechel, C. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288-2337. Thompson, L.A. ; Ellman, J.A. Chem. Rev. 1996, 96, 555-600. Gordon, E.M. ; Barrett, R.W. ; Dower, W.J. ; Fodor, S.P.A. ; Gallop, M.A. J. Med. Chem. 1994, 37, 1233-1251 and 1385-1401.
4. Curr. Op. Chem. Biol. 1997, 1, 3-145. Hermkens, P.H.H. ; Ottenheijm, H.C.J. ; Rees, D.C. Tetrahedron, 1997, 53, 5643-5678. Balkenhohl, F. ; von den Bussche-Hünnefeld, C. ; Lansky, A. ; Zechel, C. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288-2337. Thompson, L.A. ; Ellman, J.A. Chem. Rev. 1996, 96, 555-600. Gordon, E.M. ; Barrett, R.W. ; Dower, W.J. ; Fodor, S.P.A. ; Gallop, M.A. J. Med. Chem. 1994, 37, 1233-1251 and 1385-1401.
5. Curr. Op. Chem. Biol. 1997, 1, 3-145. Hermkens, P.H.H. ; Ottenheijm, H.C.J. ; Rees, D.C. Tetrahedron, 1997, 53, 5643-5678. Balkenhohl, F. ; von den Bussche-Hünnefeld, C. ; Lansky, A. ; Zechel, C. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288-2337. Thompson, L.A. ; Ellman, J.A. Chem. Rev. 1996, 96, 555-600. Gordon, E.M. ; Barrett, R.W. ; Dower, W.J. ; Fodor, S.P.A. ; Gallop, M.A. J. Med. Chem. 1994, 37, 1233-1251 and 1385-1401.
6. 2 Armstrong, R.W. ; Combs, A.P. ; Tempest, P.A. ; Brown, S.D. ; Keating, T.A. Acc. Chem. Res. 1996, 29, 123-131.
7. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
8. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
9. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
10. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
11. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
12. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
13. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
14. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
15. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
16. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
17. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
18. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
19. 3. Ugi M-CC have been extensively used both in solution and on solid phase : Hulme, C. ; Morissette, M.M. ; Volz, F.A. ; Burns, C.J. Tetrahedron Lett. 1998, 39, 1113. Ugi, I. ; Goebel, M. ; Gruber, B. ; Heilingbrunner, M. ; Heiβ, C. ; Hörl, W. ; Kern, O. ; Starnecker, M. Res. Chem. Intermed. 1996, 22, 625. Harriman, G.C.B. Tetrahedron Lett. 1997, 38, 5591. Rossen, K. ; Sager, J. ; DiMichele, L.M. Tetrahedron Lett. 1997, 38, 3183. Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1997, 38, 359. Sutherlin, D.P. ; Stark, T.M. ; Hughes, R. ; Armstrong, R.W. J. Org. Chem 1996, 61, 8350. Ugi, I. ; Demharter, A. ; Hörl, W. ; Schmid, T. Tetrahedron 1996, 52, 11657. Demharter, A. ; Hörl, W. ; Eberhardt, H. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1996, 35, 173. Keating, T.A. ; Armstrong, R.W. J. Org. Chem. 1996, 61, 8935. Keating, T.A. ; Armstrong, R.W. J. Am. Chem. Soc. 1996, 118, 2574. Mjalli, A.M.M. ; Sarshar, S. ; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943. Strocker, A.M. ; Keating, T.A. ; Tempest, P.A. ; Armstrong, R.W. Tetrahedron Lett. 1996, 37, 1149. Zhang, C. ; Moran, E.J. ; Woiwode, T.F. ; Short, K.M. ; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
20. 4 Tempest, P.A. ; Brown, S.D. ; Armstrong, R.W. Angew. Chem. Int. Ed. Engl. 1996, 35, 640.
21. 5. Herdeis, C. ; Dimmerling, A. Arch. Pharm. 1986, 319, 473 Schöllkopf, U. ; Porsch, P-H. ; Lau, H-H. Liebigs Ann. Chem. 1979, 1444.
22. 5. Herdeis, C. ; Dimmerling, A. Arch. Pharm. 1986, 319, 473 Schöllkopf, U. ; Porsch, P-H. ; Lau, H-H. Liebigs Ann. Chem. 1979, 1444.
23. 6 Its preparation is straightforward from imidazole and trimethyl (or triethyl) orthoformate : Brown, R.S. J. Org. Chem. 1980, 45, 4038. N-Formyltriazole diethylacetal was also prepared and evaluated, but didn't proved superior to its imidazole analog.
24. 7. See for instance : Dömling, A. ; Ugi, I. Angew. Chem. Int. Ed. Engl. 1993, 32, 563.