Tropane-based amino acids for peptide structure-function studies: Inhibitors of platelet aggregation

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 19, 1998, Pages 2699-2704

  Thompson, Philip E ^a,b   Steer, David L ^a   Aguilar, Marie Isabel ^a   Hearn, Milton T W ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

7 (9 FLUORENYLMETHYLOXYCARBONYL) 7 AZABICYCLO[2.2.1]HEXANE 2 CARBOXYLIC ACID; AMINO ACID DERIVATIVE; ANTITHROMBOCYTIC AGENT; EPIBATIDINE; THROMBIN; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SYNTHESIS; ARTICLE; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

AMINO ACIDS; HUMANS; PEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 0032491224     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00493-4     Document Type: Article

References (19)

1. 1. Graf von Roedern, E.; Lohof, E.; Hessler, G.; Hoffmann, M.; Kessler, H. J. Am. Chem. Soc. 1996, 118, 10156.
2. 2. Pavia, M. P.; Sawyer, T. K.; Moos, W. H. Bioorg. Med. Chem. Lett. 1993, 3, 387.
3. 3. Ojima, I.; Chakravarty, S.; Dong, Q. Bioorg. Med. Chem. 1995, 3, 337. 4. Lefkovits, J.; Plow, E. F.; Topol, E. J. New England J. Med. 1995, 332, 1553.
4. 3. Ojima, I.; Chakravarty, S.; Dong, Q. Bioorg. Med. Chem. 1995, 3, 337. 4. Lefkovits, J.; Plow, E. F.; Topol, E. J. New England J. Med. 1995, 332, 1553.
5. 5. Craig, W. S.; Cheng, S.; Mullen, D. G.; Blevitt, J.; Pierschbacher, M. D. Biopolymers 1995, 37, 157.
6. 6. Kloczewiak, M.; Timmons, S.; Lukas, T. J.; Hawiger, J. Biochemistry 1984, 23, 1767.
7. 7. Fodor, G.; Dharanipragada, R. Nat. Prod. Rep. 1993, 10, 199.
8. 8. Thompson, P. E.; Hearn, M. T. W. Tetrahedron Lett. 1997, 38, 2907.
9. 9. Xu, R.; Chu, G.; Bai, D. Tetrahedron Lett. 1996, 37, 1463.
10. 10. (a) Hernández, A.; Marcos, M.; Rapoport, H. J. Org. Chem. 1995, 60, 2683.
11. (b) Zhang, C.; Trudell, M. L. J. Org. Chem. 1996, 61, 7189.
12. 3) δ 2.60 (dd (J = 4.9 Hz, 8.9 Hz), 1H, C2H endo).
13. 12. Hoekstra, W. J.; Beavers, M. P.; Andrade-Gordon, P.; Evangelisto, M. F.; Keane, P. M.; Press, J. B.; Tomko, K. A.; Fan, F.; Kloczewiak, M.; Mayo, K. H.; Durkin, K. A.; Liotta, D. C. J. Med. Chem. 1995, 38, 1582.
14. 13. Fields, G. B.; Noble, R. L. Int. J. Peptide Protein Res. 1990, 35, 161.
15. 14. King, D. S.; Fields, C. G., Fields, G. B. Int. J. Peptide Protein Res. 1990, 36, 255.
16. 15. Schoenwalder, S. M.; Jackson, S. P.; Yuan, Y.; Teasdale, M. S.; Salem, H. H.; Mitchell, C. A. J. Biol. Chem. 1994, 269, 32479.
17. 16. For example: Combs, A. P.; Kapoor, T. M.; Feng, S.; Chen, J. C.; Daudé-Snow, L. F.; Schreiber, S. L. J. Am. Chem. Soc. 1996, 118, 287.
18. 17. Klein, S. I.; Czejak, M.; Molino, B. F.; Chu, V. Bioorg. Med. Chem. Lett. 1997, 7, 1773.
19. 18. Hoekstra, W. J.; Maryanoff, B. E.; Andrade-Gordon, P.; Cohen, J. H.; Costanzo, M. J.; Damiano, B. P.; Haertlein, B. J.; Harris, B. D.; Kauffman, J. A.; Keane, P. M.; McComsey, D. F.; Villani Jr., F. J.; Yabut, S. C. Bioorg, Med. Chem. Lett. 1996, 6, 2371.