Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 401, Issue 1-2, 1998, Pages 39-53

  Greenwood, Susan K ^a   Armstrong, Michael J ^a   Hill, Rosina B ^a   Bradt, Carole I ^a   Johnson, Timothy E ^a   Hilliard, Catherine A ^a   Galloway, Sheila M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Apoptosis; Chromosome aberration; Genomic instability; P53

Indexed keywords

ALKYLATING AGENT; APHIDICOLIN; CYTARABINE; DNA TOPOISOMERASE INHIBITOR; ETHYLNITROSOUREA; ETOPOSIDE; GYRASE INHIBITOR; HYDROXYUREA; MESYLIC ACID METHYL ESTER; METHOTREXATE; MUTANT PROTEIN; PROTEIN P53; THYMIDINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL TYPE; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LYMPHOBLASTOID CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE;

ALKYLATING AGENTS; ANTINEOPLASTIC AGENTS; APHIDICOLIN; APOPTOSIS; B-LYMPHOCYTES; CELL DIVISION; CELL LINE; CHROMOSOME ABERRATIONS; CYTARABINE; DNA REPLICATION; DNA TOPOISOMERASES, TYPE II; ETOPOSIDE; HUMANS; HYDROXYUREA; METHOTREXATE; MUTAGENESIS; NUCLEIC ACID SYNTHESIS INHIBITORS; RADIATION, IONIZING; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0032486088     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00272-8     Document Type: Article

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