Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 374, Issue 1, 1997, Pages 89-98

  Honma, Masamitsu ^a   Hayashi, Makoto ^a   Sofuni, Toshio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Genetic instability; Loss of heterozygosity (LOH); p53; Recombination; TK gene mutation

Indexed keywords

MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; MITOMYCIN C; PROTEIN P53; THYMIDINE KINASE;

ALLELE; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG SENSITIVITY; GENE CONVERSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC RECOMBINATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MUTAGENIC ACTIVITY; PRIORITY JOURNAL; SOUTHERN BLOTTING; SPONTANEOUS MUTATION; X IRRADIATION;

CELL LINE; CHROMOSOME BREAKAGE; CHROMOSOME DELETION; DNA FINGERPRINTING; ETHYL METHANESULFONATE; GENES, P53; HUMANS; LYMPHOCYTES; METHYL METHANESULFONATE; MITOMYCIN; MUTAGENS; X-RAYS;

EID: 0031052903     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00223-0     Document Type: Article

References (38)

1. Hollstein, M., D. Sidransky, B. Vogelstein and C.C. Harris (1991) p53 mutations in human cancers, Science, 253, 49-53.
2. Kuerbitz, S.J., B.S. Plunkett, W.V. Walsh and M.B. Kastan (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation, Proc. Natl. Acad. Sci. USA, 89, 7491-7495.
3. Selivanova, G. and K.G. Wilman (1995) p53: A cell cycle regulator activated by DNA damage, Adv. Cancer Res., 66, 143-180.
4. Lane, D.P. (1992) p53, guardian of the genome, Nature, 358, 15-16.
5. Lee, J.M. and A. Bernstein (1993) p53 mutations increase resistance to ionizing radiation, Proc. Natl. Acad. Sci. USA, 90, 5742-5746.
6. Kastan, M.B., O. Onyekwere, D. Sidransky, B. Vogelstein and R.W. Craig (1991) Participation of p53 protein in the cellular response to DNA damage, Cancer Res., 51, 6304-6311.
7. Amundson, S.A., F. Xia, K. Wolfson and H.L. Liber (1993) Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor, Mutation Res., 286, 233-241.
8. Liber, H.L. and W.G. Thilly (1982) Mutation assay at the thymidine kinase locus in diploid human lymphoblasts, Mutation Res., 94, 467-485.
9. Little, J.B., H. Nagasawa, P.C. Keng, Y. Yu and C.-Y. Li, C. (1995) Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status, J. Biol. Chem., 270, 11033-11036.
10. Xia, F., X. Wang, Y.-H. Wang, N.-M. Tsang, D.W. Yandell, K.T. Kelsey, K. and H.L. Liber (1995) Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines, Cancer Res., 55, 12-15.
11. Yandell, D.W., T.P. Dryja and J.B. Little (1986) Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations, Somat. Cell Mol. Genet., 12, 255-263.
12. Liber, H.L., D.W. Yandell and J.B. Little (1989) A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus, Mutatation Res., 216, 9-17.
13. Li, C.-Y., D.W. Yandell and J.B. Little (1992) Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro, Somat. Cell Mol. Genet., 18, 77-87.
14. Yandell, D.W., T.P. Dryja and J.B. Little (1990) Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells, Mutation Res., 229, 89-102.
15. Lasko, D. and W. Cavenee (1991) Loss of constitutional heterozygosity in human cancer, Annu. Rev. Genet., 25, 281-314.
16. Honma, M. and J.B. Little (1995) Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in human lymphoblastoid cells, Carcinogenesis, 16, 1717-1722.
17. Honma, M., H. Mizusawa, K. Sasaki, M. Hayashi, T. Ohno, N. Tanaka and T. Sofuni (1994) Demonstration by DNA fingerprint analysis of genomic instability in mouse BALB/3T3 cells during cell transformation, Mutatation Res., 304, 167-179.
18. Maniatis, T., E.F. Frisch and J. Sambrook (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Habor Laboratory Press, Cold Spring Harbor, New York.
19. Furth, E.E., W.G. Thilly, B.W. Penman, H.L. Liber and W.M. Rand (1981) Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates, Anal. Biochem., 110, 1-8.
20. Bradshaw, H.D.J. and P.L. Deninger (1984) Human thymidine kinase gene: Molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells. Mol. Cell. Biol., 4, 2316-2320.
21. Jenkins, J.R., P. Chumakov, C. Addison, H.W. Sturzbecher and A. Wade-Evans (1988) Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen, J. Virol., 62, 3903-3906.
22. Chowdary, D.R., J.J. Dermody, K.K. Jha and H.L. Ozer (1994) Accumulation of p53 in a mutant cell line defective in the ubiquitine pathway, Mol. Cell. Biol., 14, 1997-2003.
23. Bouffler, S.D., C.J. Kemp, A. Balmain and R. Cox (1995) Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice, Cancer Res., 55, 3883-3889.
24. Livingstone, L.R., A. White, J. Sprouse, E. Livanos, T. Jacks and T.D. Tlsty (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53, Cell, 70, 923-935.
25. Eryfjord, J.E., S. Thorlacius, M. Steinarsdottir, R. Valgardsdottir, H.M. Ogmundsdottir and K. Anamthawat-Jonsson (1995) p53 abnormalities and genomic instability in primary human breast carcinomas, Cancer Res., 55, 646-651.
26. Lin, J.-T., M.-S. Wu, C.-T. Shun, W.-J. Lee, J.-C. Sheu n and T.-H. Wang (1995) Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein, Cancer Res., 55, 1428-1430.
27. Sands, A.T., M.B. Surakar, A. Sanchez, J.E. Marth, L.A. Donehower and A. Bradley (1995) p53 deficiency does not affect the accumulation of point mutations in a transgenic target, Proc. Natl. Acad. Sci. USA, 92, 8517-8521.
28. Amundson, S.A. and H.L. Liber (1992) A comparison of induced mutations at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants, Mutatations Res., 267, 89-95.
29. Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi and M. Oren (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6, Nature, 352, 345-347.
30. Schwartz, J.L., R. Jordan, B.A. Sedita, M.J. Swenningson, J.P. Banath and P.L. Olive (1995) Different sensitivity to cell killing and chromosom mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis, Mutagenesis, 10, 227-233.
31. Zhen, W., C.M. Denault, K. Loviscek, S. Walter, L. Geng and A.T. Vaughan (1995) The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status, Mutatation Res., 346, 85-92.
32. Xia, F., S.A. Amundson, J.A. Nicolff and H.L. Liber (1994) Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation, Mol. Cell. Biol., 14, 5850-5857.
33. Wang, X.W., H. Yeh, L. Schaeffer, V. Moncollin, J.-M. Egly, Z. Wang, E.C. Freidberg, M.K. Evans, B.G. Taffe, V.A. Bohr, G. Weeda, J.H.J. Hoeijmaker, K. Forrester and C.C. Harris (1995) p53 modulation of TFIIH-associated nucleotide excision repair activity, Nature Genet., 10, 188-195.
34. Ford, J.M. and P.C. Hanawalt (1995) Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance, Proc. Natl. Acad. Sci. USA, 92, 8876-8880.
35. Oberosler, P., P. Hloch, U. Ramsperger and H. Stahl (1993) p53-catalyzed annealing of complementary single-stranded nucleic acid, EMBO J., 12, 2389-2396.
36. Bakalkin, G., T. Yakovleva, G. Selivanova, K. Magnusson, L. Szekely, E. Kiseleva, G. Klein, L. Terenius and K.G. Wiman (1994) p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer, Proc. Natl. Acad. Sci. USA, 91, 413-417.
37. Miyaki, M., M. Seki, M. Okamoto, A. Yamanaka, Y. Maeda, K. Tanaka, R. Kikuchi, T. Iwama, T. Ikeuchi, A. Tonomura, Y. Nakamura, R. White, Y. Miki, J. Utsunomiya and M. Koike (1990) Genetic changes and histopahological types in colorectal tumors from patients with familial adenomatous polyposis, Cancer Res., 50, 7166-7133.
38. Yokota, J. and T. Sugimura (1993) Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes, FASEB J., 7, 920-925.