Determinants of channel gating located in the N-terminal extracellular domain of nicotinic α7 receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 2, 1998, Pages 469-479

  Anand, René ^a   Nelson, Mark E ^c   Gerzanich, Volodymyr ^b   Wells, Gregg B ^c   Lindstrom, Jon ^c  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; ACETYLCHOLINE; CYTISINE; DECAMETHONIUM; ION CHANNEL; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; SUXAMETHONIUM;

AGONIST; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING COMPETITION; CHANNEL GATING; CHIMERA; ION CURRENT; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; DIMETHYLPHENYLPIPERAZINIUM IODIDE; ION CHANNEL GATING; KINETICS; NICOTINIC AGONISTS; RECEPTORS, NICOTINIC; XENOPUS;

EID: 0032456161     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Adams PR and Sakmann B (1978) Decamethonium both opens and blocks end plate channels. Proc Natl Acad Sci USA 75:2994-2998.
2. Auerbach A, Sigurdson W, Chen J and Akk G (1996) Voltage dependence of mouse acetylcholine receptor gating: Different charge movements in di, mono- and unliganded receptors. J Physiol (Lond) 494:155-170.
3. Barnard EA (1992) Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci 17:368-374.
4. Bertrand D, Bertrand S and Ballivet M (1992) Pharmacological properties of the homomeric α7 receptor. Neurosci Lett 146:87-90.
5. Betz H (1990) Homology and analogy in transmembrane channel design: lessons from synaptic membrane proteins. Biochemistry 29:3591-3599.
6. Castro NG and Albuquerque EX (1993) Brief-lifetime, fast-inactivating ion channels account for the α-bungarotoxin-sensitive nicotinic response in hippocampal neurons. Neurosci Lett 164:137-140.
7. Chabala LD (1992) Voltage dependence of acetylcholine receptor channel gating in rat myoballs. J Gen Physiol 100:729-748.
8. Changeux JP, Galzi JL, Devillers-Thiery A and Bertrand D (1992) The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis. Q Rev Biophys 25:395-432.
9. Chothia C and Pauling P (1978) The crystal and molecular structure of 1,1-dimethyl-4-phenylpiperazinium iodide. Acta Cryst B34:2986-2989.
10. Colquhoun D and Sigworth FJ (1983) Fitting and statistical analysis of single-channel records, in Single-Channel Recording (Sakmann B, Neher E, eds), pp 191-263, Plenum Press, New York.
11. Corringer JP, Galzi JP, Eisele JP, Bertrand S, Changeux JP and Bertrand D (1995) Identification of a new component of the agonist binding site of the nicotinic α7 homooligomeric receptor. J Biol Chem 270:11749-11752.
12. Couturier S, Bertrand D, Matter JM, Hernandez MC, Bertrand S, Millar N, Valera S, Barkas T and Ballivet M (1990) A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX. Neuron 5:847-856.
13. Devillers-Thiery A, Galzi JL, Bertrand S, Changeux JP and Bertrand D (1992) Stratified organization of the nicotinic acetylcholine receptor channel. Neuroreport 3:1001-1004.
14. Eisele JL, Bertrand S, Galzi JL, Devillers TA, Changeux JP and Bertrand D (1993) Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature 366:479-483.
15. Elgoyhen AB, Johnson DS, Boulter J, Vetter DE and Heinemann S (1994) α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705-715.
16. Galzi JL, Bertrand D, Devillers-Thiery A, Revah F, Bertrand S and Changeux JP (1991) Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS Lett 294:198-202.
17. Galzi JL, Bertrand S, Corringer PJ, Changeux JP and Bertrand D (1996) Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor. EMBO J 15:5824-5832.
18. Galzi JL, Devillers-Thiery TA, Hussy N, Bertrand S, Changeux JP and Bertrand D (1992) Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359:500-505.
19. Gerzanich V, Anand R and Lindstrom J (1994) Homomers of α8 and α7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties. Mol Pharmacol 45:212-220.
20. Gerzanich V, Peng X, Wang F, Wells G, Anand R, Fletcher S and Lindstrom J (1995) Comparative pharmacology of epibatidine: A potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol 48:774-782.
21. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch Eur J Physiol 391:85-100.
22. Hussy N, Ballivet M and Bertrand D (1994) Agonist and antagonist effects of nicotine on chick neuronal nicotinic receptors are denned by α and β subunits. J Neurophysiol 72:1317-1326.
23. Karlin A and Akabas MH (1995) Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231-1244.
24. Krause RM, Buisson BO, Bertrand S, Corringer PJ, Galzi JL, Changeux JP and Bertrand D (1998) Ivermectin: A positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 53:283-294.
25. Lindstrom J, Anand R, Gerzanich V, Peng X, Wang F and Wells G (1996) Structure and function of neuronal nicotinic acetylcholine receptors. Prog Brain Res 109: 125-137.
26. Liu Y and Dilger JP (1993) Decamethonium is a partial agonist at the nicotinic acetylcholine receptor. Synapse 13:57-62.
27. Marshall CG, Ogden D and Colquhoun D (1990) The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle. J Physiol (Lond) 428:155-174.
28. Methfessel C, Witzemann V, Takahashi T, Mishina M, Numa S and Sakmann B (1986) Patch clamp measurements on Xenopus laevis oocytes: Currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflügers Arch Eur J Physiol 407:577-588.
29. Papke RL (1993) The kinetic properties of neuronal nicotinic receptors genetic basis of functional diversity. Prog Neurobiol 41:509-531.
30. Papke RL and Heinemann SF (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol Pharmacol 45:142-149.
31. Revah F, Bertrand D, Galzi JL, Devillers-Thiery A, Mulle C, Hussy N, Bertrand S, Ballivet M and Changeux JP (1991) Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature 353:846-849.
32. Role LW and Berg DK (1996) Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16:1077-1085.
33. Sargent PB (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16:403-443.
34. Schoepfer R, Conroy WG, Whiting P, Gore M and Lindstrom J (1990) Brain αbungarotoxin binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. Neuron 5:35-48.
35. Sine SM, Claudio T and Sigworth FJ (1990) Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts: Single channel current kinetics reveal distinct agonist binding affinities. J Gen Physiol 96:395-437.
36. Sine SM and Steinbach JH (1986) Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by low concentrations of agonist. J Physiol (Lond) 373:129-162.
37. Tsigelny I, Sugiyama N, Sine SM and Taylor P (1997) A model of the nicotinic receptor extracellular domain based on sequence identity and residue location. Biophys J 73:52-66.
38. Wang F, Gerzanich V, Wells GB, Anand R, Peng X, Keyser K and Lindstrom J (1996) Assembly of human neuronal nicotinic receptor α5 subunits with α3, β2 and β4 subunits. J Biol Chem 271:17656-17665.
39. Zhang XZ, Strand A and White HD (1989) A general pre-steady-state solution to complex kinetic mechanisms. Anal Biochem 176:427-431.