Immunogenetic basis of environmental lung disease: Lessons from the berylliosis model

European Respiratory Journal

Volumn 12, Issue 6, 1998, Pages 1463-1475

  Saltini, C ^a   Amicosante, M ^a,b   Franchi, A ^a   Lombardi, G ^c   Richeldi, L ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Berylliosis; Environment; HLA; Immunogenetic; Lung disease

Indexed keywords

BERYLLIUM; HLA ANTIGEN CLASS 2;

ALLELE; ALLERGIC PNEUMONITIS; ASTHMA; BERYLLIOSIS; CHROMOSOME 6; CHRONIC INFLAMMATION; ENVIRONMENTAL FACTOR; HLA SYSTEM; HUMAN; LUNG DISEASE; LUNG FIBROSIS; LUNG GRANULOMATOSIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; BERYLLIOSIS; CHRONIC DISEASE; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HLA-DP ANTIGENS; HUMANS; INFLAMMATION; LUNG DISEASES; OCCUPATIONAL DISEASES;

EID: 0032437916     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12061463     Document Type: Review

References (123)

1. Saltini C, Kirby M, Bisetti A, Crystal RG. The lung epithelial immune system. J Immunol Res 1991; 3: 43-48.
2. Nemery B. Metal toxicity and the respiratory tract. Eur Respir J 1990; 3: 202-219.
3. Fine JM, Gordon T, Chen LC, Kinney P, Falcone G, Beckett WS. Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. J Occup Environ Med 1997; 39: 722-726.
4. Blanc PD, Boushey HA, Wong H, Wintermeyer SF, Bernstein MS. Cytokines in metal fume fever. Am Rev Respir Dis 1993; 147: 134-138.
5. Robinson DS, Richeldi L, Saltini C, duBois RM. Granulomatous processes. In: Crystal RG, West JB, Weibel ER, Barnes PJ, eds. The Lung: Scientific Foundations, 2nd Edn. New York, Raven Press, 1997; pp. 2395-2409.
6. Kreiss K, Miller F, Newman LS, Ojo-Amaize EA, Ross-man M, Saltini C. Chronic beryllium disease: from the work place to cellular immunology, molecular immunocenetics, and back. Cell Immunol Immunopathol 1994; 71: 123-129.
7. Bartter T, Irwin RS, Abraham JL, et al. Zirconium compound-induced pulmonary fibrosis. Arch Intern Med 1991; 151: 1197-1201.
8. Liippo KK, Anttila SL, Taikina-Aho O, Ruokonen E-L, Toivonen ST, Tuomi T. Hypersensitivity pneumonitis and exposure to zirconium silicate in a young ceramic tile worker. Am Rev Respir Dis 1993: 148: 1089-1092.
9. Romeo L, Cazzadori A, Bontempini L, Martini S. Interstitial lung granulomas as a possible consequence of exposure to zirconium dust. Med Lav 1994; 85: 219-222.
10. Redline S, Barna BP, Tomashefski JF, Abraham JL. Granulomatous disease associated with pulmonary deposition of titanium. Br J Ind Med 1986; 43: 652-656.
11. De Vuyst P, Dumortier P, Schandené L, Estenne M, Verhest A, Yernault J-C. Sarcoid-like lung granulomatosis induced by aluminium dusts. Am Rev Respir Dis 1987; 135:493-497.
12. Costabel U. The alveolitis of hypersensitivity pneumonitis. Eur Respir J 1988; 1: 5-9.
13. Shimazu K, Ando M, Sakata T, Yoshida K, Araki S. Hypersensitivity pneumonitis induced by Trichosporon cutaneum. Am Rev Respir Dis 1984; 130: 407-411.
14. Vandenplas O, Malo J-L, Dugas M, et al. Hypersensitivity pneumonitis-like reaction among workers exposed to piphenylmethane diisocyanate (MDI). Am Rev Respir Dis 1993; 147: 338-346.
15. Chan-Yeung M, Malo J. Occupational asthma. N Engt J Med 1995; 333: 107-112.
16. Shirakawa T, Kusaka Y, Nakano Y, et al. Both type I and IV allergic mechanisms specific to cobalt are involved in hard metal asthma? Am Rev Respir Dis 1988; 137: 299A.
17. Soyseth V, Kongerud J, Ekstrand J, Boe J. Relation between exposure to fluoride and bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms. Thorax 1994; 49: 984-989.
18. Benacerraf B, McDevitt HO. Histocompatibility-linked immune response genes. Science 1972; 175: 273-279.
19. Rammensee HG. Chemistry of peptides associated with MHC class I and class II molecules. Curr Opin Immunol 1995; 7: 85-96.
20. Pieters J. MHC class II restricted antigen presentation. Curr Opin Immunol 1997; 9: 89-96.
21. Brown JH, Jardetzky TS, Gorga JC, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993; 364: 33-39.
22. Jones EY. MHC class I and II structures. Curr Opin Immunol 1997; 9: 75-79.
23. Hunkapillar T, Hood L. Diversity of the immunoglobulin gene superfamily. Adv Immunol 1989; 44: 1-63.
24. Stern LJ, Brown JH, Jardetzky TS, et al. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994; 368: 215-221.
25. Sinigaglia F, Hammer J. Predicting major histocompatibility complex-binding sequence within protein antigens. Biochem Soc Trans 1995; 23: 675-677.
26. Cresswell P, Howard JC. Antigen recognition. Curr Opin Immunol 1997; 9: 71-74.
27. Saltini C, Pinkston P, Crystal RG. The specific immunity of chronic beryllium disease. In: Baggiolini M, Pozzi E, Semenzato G, eds. Neutrophils, Lymphocytes and Lung. Milan, Masson Italia, 1990; pp. 249-260.
28. Saltini C, Winestock K, Kirby M, Pinkston P, Crystal RG. Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T-cells. N Engl J Med 1989; 320: 1103-1109.
29. Rossman MD, Yang H-C, Murray RK, Williams WV, Weiner DB. Chronic beryllium disease: an immune response by restricted families of T-cells. Am Rev Respir Dis 1992; 145: A415.
30. Tinkle SS, Kittle LA, Schumacher BA, Newman LS. Beryllium induces IL-2 and IFN-γ in berylliosis. J Immunol 1997; 158:518-526.
31. Richeldi L, Sorrentino R, Saltini C. HLA-DPB1 Glutamate 69: a genetic marker of beryllium disease. Science 1993; 262: 242-244.
32. Richeldi L, Kreiss K, Mroz MM, Zhen B, Tartoni P, Saltini C. Interaction of genetic and exposure factors in the prevalence of chronic beryllium disease among beryllium ceramic workers. Am J Ind Med 1997; 32: 337-340.
33. Stubbs J, Argyris E, Lee CW, Monos D, Rossman MD. Genetic markers in beryllium hypersensitivity. Chest 1996; 109: 3 Suppl., 45s.
34. Lombardi G, Uren J, Jones-Williams W, Saltini C, Lechler R. Molecular basis of HLA-DP associated susceptibility to beryllium disease. In: Charron D, ed. Genetic Diversity of HLA. Functional and Medical Implications. Paris, EDK, 1997; pp. 709-711.
35. Sinigaglia F. The molecular basis of metal recognition by T-cells. J Invest Dermatol 1994; 102: 398-401.
36. Yao Z, Hartung K, Deicher HG, et al. DNA typing for HLA-DPB1 alleles in German patients with systemic lupus erythematosus using the polymerase chain reaction and DIG-ddUTP-labelled oligonucleotide probes. Eur J Immunogenet 1993; 20: 259-266.
37. Baisch JM, Capra JD. Linkage disequilibrium within the HLA complex does not extend into HLA-DP. Scand J Immunol 1993; 37: 499-503.
38. Potolicchio I, Mosconi G, Forni A, Nemery B, Seghizzi P, Sorrentino R. Susceptibility to hard metal lung disease is strongly associated with the presence of glutamate 69 in HLA-DPβ chain. Eur J Immunol 1997; 27: 2741-2743.
39. Newman LS, Lloyd J, Daniloff E. The natural history of beryllium sensitization and chronic beryllium disease. Environ Health Perspect 1996; 104: Suppl. 5, 937-943.
40. Shinbara M, Kondo N, Agata H, et al. T cell proliferation restricted by HLA class II molecules in patients with hen's egg allergy. Exp Clin Immunogenet 1995; 12: 103-110.
41. Lympany PA, Petrek M, Southcott AM, Newman-Taylor AJ, Welsh K, duBois RM. HLA-DPB polymorphisms: Glu 69 association with sarcoidosis. Eur J Immunogenet 1996; 23: 353-359.
42. Sorrentino R, Potolicchio I, D'Amato M, Tosi R. The HLA-DP locus in bone marrow transplantation: probeless genomic typing of the DPB1 alleles. Bone Marrow Transplant 1993; 11: Suppl. 1, 17-19.
43. Nakachi K, Imai K, Hayashi S-I, Kawajiri K. Polymorphisms of the CYTIAI and glutathione 5-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population. Cancer Res 1993; 53: 2994-2999.
44. Sandford A, Weir T, Paré P. The genetics of asthma. Am J Respir Crit Care Med 1996; 153: 1749-1765.
45. Rachelefsky G, Park MS, Siegel S, Terasaki PI, Katz R, Saito S. Strong association between B-lymphocyte group-2 specificity and asthma. Lancet 1976; ii: 1042-1044.
46. Turner MW, Brostoff J, Wells RS, Stokes CR, Soothill JF. HLA in eczema and hay fever. Clin Exp Immunol 1977; 27: 43-47.
47. Apostolakis J, Toumbis M, Kostantinopoulos K, et al. HLA and asthma in Greeks. Respir Med 1996; 90: 201-204.
48. Aron Y, Swierczewski E, Lockhart A. HLA class II haplo-types in atopic asthmatic and non-atopic control subjects. Clin Exp Allergy 1995; 25: 65-67.
49. Amelung PJ, Panhuysen CIM, Postnia DS, et al. Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosome 11q and 6p. Clin Exp Allergy 1992; 22: 1077-1084.
50. Li PKT, Lai CKW, Poon ASY, Ho ASS, Chan CHS, Lai KN. Lack of association between HLA-DQ and -DR genotypes and asthma in southern Chinese patients. Clin Exp Allergy 1995; 25: 323-331.
51. Holloway JW, Doull I, Begishvili B, Beasley R, Holgate ST, Howell WM. Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy. Clin Exp Allergy 1996; 26: 1142-1149.
52. Hakala M, Assendelft AH, Ilonen J, Jalava S, Tiilikainen A. Association of different HLA antigens with various toxic effects of gold salts in rheumatoid arthritis. Ann Rheum Dis 1986; 45: 177-182.
53. Partanen J, Assendelft AHW, Koskimies S, Forsberg S, Hakala M, Ilonem J. Patients with rheumatoid arthritis and gold-induced pneumonitis express two high-risk major histocompatibility complex patterns. Chest 1987; 92: 277-281.
54. Allen DH, Basten A, Woolcock AJ, Guinan J. HLA and bird breeder's hypersensitivity pneumonitis. Monogr Allergy 1977; 11: 45-54.
55. Sennekamp J, Rittner C, Vogel F, Tauberecht I. Distribution of the HLA antigens in patients with pigeon breeder's lung. Schweiz Med Wochenschr 1978; 108: 315-317.
56. Berrill WT, van Rood JJ. HLA-DW6 and avian hypersensitivity. Lancet 1977; ii: 248-249.
57. Muers MF, Faux JA, Ting A, Morris PJ. HLA-A, B, C and HLA-DR antigens in extrinsic allergic alveolitis (budgerigar fancier's lung disease). Clin Allergy 1982; 12: 47-53.
58. Rittner C, Sennekamp J, Mollenhauer E, et al. Pigeon breeder's lung: association with HLA-DR 3. Tissue Anti-gens 1983; 21: 374-379.
59. Selman M, Teran L, Mendoza A, et al. Increase of HLA-DR7 in pigeon breeder's lung in a Mexican population. Clin Immunol Immunopathol 1987; 44: 63-70.
60. Wahlstrom J, Berlin M, Lundgren R, et al. Lung and blood T-cell receptor repertoire in extrinsic allergic alveolitis. Eur Respir J 1997; 10: 772-779.
61. Khomenko AG, Pospelov LE, Malenko AF, Chukanova VP, Romanov VV. HLA antigens in lung diseases. Ter Arkh 1985; 57: 77-80.
62. Nowack D, Goebel KM. Genetic aspects of sarcoidosis. Class II histocompatibility antigens and a family study. Arch Intern Med 1987; 147: 481-483.
63. Huang S, Zwollo P, Marsh DG. Class II major histocompatibility complex restriction of human T cell responses to short ragweed allergen, Amb a V. Eur J Immunol 1991; 21: 1469-1473.
64. Blumenthal M, Marcus-Basley D, Awdeh Z, Johnson B, Yunis EJ, Alper C. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SCO1, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. J Immunol 1992; 148: 411-416.
65. Ansari AA, Friedhoff LR, Marsh DG. Molecular genetics of human immune responsiveness to Lolium perenne (rye) allergen Lol pIII. Int Arch Allergy Appl Immunol 1989; 88: 164-169.
66. O'Brien RM, Thomas WR, Nicholson I, Lamb JR, Tait BD. An immunogenetic analysis of the major house dust mite allergen Der p2: identification of high- and lowresponder HLA-DQ alleles and localization of T-cell epitopcs. Immunology 1995; 86: 176-182.
67. Van Neerven RJ, van t'Hof W, Ringrose JH, et al. T cell epitopes of house dust mite major allergen Der p II. J Immunol 1993; 151: 2326-2335.
68. Young RP, Barker RD, Pile KD, Cookson WO, Taylor AJ. The association of HLA-DR3 with specific IgE to inhaled acid anhydrides. Am J Respir Crit Med 1995; 151: 219-221.
69. Bignon JS, Aron Y, Ju LY, et al. HLA class II alleles in isocyanate-induced asthma. Am J Respir Crit Care Med 1994; 149: 71-75.
70. Balboni A, Baricordi OR, Fabbri LM, Gandini E, Ciaccia A, Mapp CE. Association between toluene diisocyanate-induced asthma and DQBI markers: a possible role for aspatic acid at position 57. Eur Respir J 1996; 9: 207-210.
71. Mullarkey MF, Thomas PS, Hansen JA, Webb DR, Nisperos B. Association of aspirin-sensitive asthma with HLA-DQw2.Am Rev Respir Dis 1986; 133: 261-263.
72. Lympany PA, Welsh KI, Christie PE, Scmitz-Schumann M, Keney M, Lee TH. An analysis with sequence specific oligonucleotide probes of the association between aspirin-induced asthma and antigens of the HLA system. J Allergy Clin Immunol 1993; 92: 114-123.
73. Brooks SM. Occupational and environmental asthma. In: Rom WN, ed. Environmental and Occupational Medicine. Boston, MA, Little Brown, 1992; pp. 393-446.
74. Merchant JA, Klouda PT, Soutar CA, Parkers WR, Lawler SD, Turner-Warwick M. The H-A system in asbestos workers. Br Med J 1975; i: 189-191.
75. Ferdoutsis M, Bouros D, Meletis G, Patsourakis G, Siafakas NM. Diffuse interstitial lung disease as an early manifestation of ankylosinc spondylitis. Respiration 1995; 62: 286-289.
76. Darke C, Wagner MM, McMillan GH. HLA-A and B antigen frequencies in an asbestos exposed population with normal and abnormal chest radiographs. Tissue Antigens 1979; 13: 228-232.
77. Evans CC, Lewinsohn HC, Evans JM. Frequency of HLA antigen in asbestos workers with and without pulmonary fibrosis. Br Med J 1997; i: 603-605.
78. Matej H, Lange A, Smolik R. HLA antigens in asbestosis. Arch Immunol Ther Exp Warsz 1977; 25: 489-491.
79. Huuskonen MS, Tiilikainen A, Alanko K, HLA-B18 antigens and protection from pulmonary fibrosis in asbestos workers. Br J Dis Chest 1979; 73: 253-259.
80. Begin R, Menard H, Decarie F, St Sauveur A. Immunogenetic factors as determinants of asbestosis. Lung 1987; 165: 159-163.
81. Shih JF, Hunnighake GW, Goeken NE, Galvin JR, Merchant JA, Schwartz DA. The relationship between HLA-A, B, DQ, and DR antigens and asbestos-induced lung disease. Chest 1993; 104: 26-31.
82. Al Jarad N, Uthayakumar S, Buckland EJ, et al. The histocompatibility anticen in asbestos related disease. Br J Ind Med 1992; 49: 826-831.
83. Heise ER, Mentnech MS, Olenchock SA, et al. HLA-A1 and coahvorker pneumoconiosis. Am Rev Respir Dis 1979; 119: 903-908.
84. Wahner MM, Darke C. HLA-A and B antigen frequencies in Welsh coalworkers with pneumoconiosis and Caplan's syndrome. Tissue Antigens 1979; 14: 165-168.
85. Darke C, Wagner MM, Nuki G, Dyer PA. HLA-A, B and DR antigens and properdin factor B allotypes in Caplan's syndrome. Br J Dis Chest 1983; 77: 235-342.
86. Koskinen H, Tiilikainen A, Nordman H. Increased prevalence of HLA-Aw 19 and of the phenogroup Aw 19,B18 in advanced silicosis. Chest 1983; 83: 848-852.
87. Kreiss K, Danilovs JA, Newman LS. Histocompalibility antigens in a population based silicosis series. Br J Ind Med 1989; 46: 364-369.
88. Rihs HP, Lipps P, May-Taube K, et al. Immunogenetic studies on HLA-DR in German coal miners with and without coal worker's pneumoconiosis. Lung 1994; 172: 347-354.
89. Honda K, Hiraynma K, Kikuchi I, Nagato H, Tamai H, Sazauki T. HLA and silicosis in Japan. N Engl J Med 1988; 318: 1610.
90. Honda K, Kimura A, Dong R-P, et al. Immunogenetic analysis of silicosis in Japan. Am J Respir Cell Mol Biol 1993; 8: 106-111.
91. Bernstein JA, Munson J, Lumrnus ZL, Balakrishnan K, Leikauf G. T-cell receptor Vβ gene segment expression in diisocyanate-induced occupational asthma. J Allergy Clin Immunol 1997; 99: 245-250.
92. Romagnoli P, Spinas GA, Sinigaglia F. Gold-specific T-cells in rheumatoid arthritis patients treated with gold. J Clin Invest 1992; 89: 2534-2558.
93. Ando M, Hirayama K, Soda K, Okubo R, Afaki S, Sasazuki T. HLA-DQw3 in Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum. Am Rev Respir Dis 1989; 140: 948-950.
94. Churg AM, Green FHY. Occupational lung disease. In: Thurlbeck WM, Churg AM, eds. Pathology of the Lung. 2nd Ed. New York, Thieme, 1995; pp. 851-930
95. Fisher T, Rystedt I, Safwenberg J. HLA-A, -B, -C and -DR antigens in individuals with sensitivity to cobalt. Acta Derm Venereal 1984; 64: 121-124.
96. Emtestam L, Zetterquist H, Olerup O. HLA-DR, -DQ and -DP alleles in nickel, chromium, and/or cobalt-sensitive individuals: genomic analysis based on restriction fragment length polymorphisms. J Invest Dermatol 1993; 100: 271-274.
97. Rolfe MW, Paine R, Davenport RB, Stricter RM. Hard metal pneumoconiosis and the association with tumor necrosis factor-alpha. Am Rev Respir Dis 1992; 146: 1600-1602.
98. Zone IJ, Rom WN. Circulating immune complexes in asbestos workers. Environ Res 1985; 37: 383-389.
99. Sluis-Cremer G, Maier G. HLA antigens of the A and B locus in relation to the development of silicosis. Br J Indust Med 1984; 41: 417-418.
100. Zhai R, Fransseen H, Schins RPF, Bonn PJA. TNF-α polymorphisms in ex-coal workers with and without coal worker's pneumoconiosis. Eur Respir J 1997; 10: 234s.
101. Bost TW, Riches DWH, Schumacher B, et al. Alveolar macrophages from patients with beryllium disease and sarcoidosis express increased levels of mRNA for tumor necrosis factor-α and interleukin-6 but not interleukin-1β. Am J Respir Cell Mol Biol 1994; 10: 506-513.
102. Muller-Quernheim J, Saltini C, Sondermeyer P, Crystal RG. Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis. J Immunol 1986; 137: 3475-3483.
103. Nowack D, Goebel KM. Genetic aspects of sarcoidosis. Class II histocompatibility antigens and a family study. Arch Intern Med 1983; 147: 481-483.
104. Abe S, Yamaguchi E, Makimura S, Okazaki N, Kunikane H, Kawakami Y. Association of HLA-DR with sarcoidosis. Correlation with clinical course. Chest 1987; 92: 488-490.
105. Ikeda T, Hayashi S, Kamikawaji N, Sasazuki T, Shige-matsu N. Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution. Chest 1992; 101: 758-762.
106. Hedfors E, Lindstrom F. HLA-B8/DR3 in sarcoidosis. Tissue Antigens 1983; 22: 200-203.
107. Gardner J, Kennedy HG, Hamblin A, Jones E. HLA association in sarcoidosis: a study of two ethnic groups. Thorax 1984; 39: 19-22.
108. Smith MJ, Turton CW, Mitchell DM, Turner-Warwick M, Morris LM, Lawler SD. Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax 1981; 36: 296-298.
109. Martinetti M, Tinelli C, Kolek V, et al. "The sarcoidosis map": a joint survey of clinical and immunogenetic findings in two European countries. Am J Respir Crit Care Med 1995; 152: 557-564.
110. Ishihara M, Ohno S, Ishida T, et al. Molecular genetic analyisis of HLA class II genes in sarcoidosis. Tissue Antigens 1994; 43: 238-241.
111. Grunewald J, Janson CH, Eklund A, et al. Restricted V alpha 2.3 gene usage by Cb4+T lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients correlates with HLA-DR3. Eur J Immunol 1992; 22: 129-135.
112. Grunewald J, Olerup O, Persson U, Olrn MB, Wigzell H, Eklund A. T-cell receptor variable region gene usage by CD4+ and Cb8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients. Proc Natl Acad Sci USA 1994; 91: 4965-4969.
113. Usui Y, Kohsaka H, Eishi Y, Saito I, Marumo F, Miyasaka N. Shared amino acid motifs in T-cell receptor beta junctional regions of bronchoalveolar T cells in patients with pulmonary sarcoidosis. Am J Respir Crit Care Med 1996; 154:50-56.
114. Ishihara M, Ohno S, Ishida T, et al. Genetic polymorphism of the TNFB and HSP70 genes located in the human major histocompatibility complex in sarcoidosis. Tissue Antigens 1995; 46: 59-62.
115. Richeldi L, Losi M, Pelori F, Luisetti M, Martinetti M, Saltini C. Role of the tumor necrosis factor α-308 polymorphism in pulmonary sarcoidosis. Eur Respir J 1997; 10: 98s.
116. Deng GY, Maclaren NK, Huang H-S, Zhang L-P, She J-X. No primary association between the 308 polymorophism in the tumor necrosis factor a promoter region and insulin dependent diabetes mellitus. Hum Immunol 1996; 45: 137-142.
117. Hillerdal G. Ankylosing spondylitis lung disease - an underdiagnosed entity? Eur J Respir Dis 1983; 64: 437-441.
118. Turton CWG, Morris LM, Lawler SD, Turner Warwick M. HLA in cryptogenic fibrosing alveolitis. Lancet 1978; 1: 507-508.
119. Varpela E, Tiilikainen A, Varpela M, Tukiainen P. High prevalences of HLA-B15 and HLA-Dw6 in patients with cryptogenic fibrosing alveolitis. Tissue Antigens 1979; 14: 68-71.
120. Fulmer JD, Sposovska MS, von Gal ER, Crystal RS, Mittal KK. Distribution of HLA antigens in idiopathic pulmonary fibrosis. Am Rev Respir Dis 1978; 118: 141-147.
121. Libby DM, Gibofsky A, Fotino M, Waters SJ, Smith JP. Immunogenetic and clinical findings in idiopathic pulmonary fibrosis. Association with the B-cell alloantigen HLA-DR2. Am Rev Respir Dis 1983; 127: 618-622.
122. Dorman JS, LaPorte R, Trucco M. Genes and environment. Baillière's Clin Endocrinol Metab 1991; 5: 229-245.
123. Hudson KL, Rothenberg KH, Andrews LB, Kahn MJ, Collins FS. Genetic discrimination and health insurance: an urgent need for reform. Science 1995; 270: 391-393.