Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy

Clinical and Experimental Allergy

Volumn 26, Issue 10, 1996, Pages 1142-1149

  Holloway, J W ^a   Doull, I ^c   Begishvili, B ^c   Beasley, R ^b   Holgate, S T ^c   Howell, W M ^d  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Atopy; HDM allergy; HLA

Indexed keywords

HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN E;

ADULT; ALLERGY; ARTICLE; CHILD; CONTROLLED STUDY; DERMATOPHAGOIDES PTERONYSSINUS; FEMALE; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ALLERGENS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; GLYCOPROTEINS; HLA-D ANTIGENS; HLA-DP ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LINKAGE (GENETICS); MITES; PEDIGREE; POLYMORPHISM, GENETIC;

EID: 0029831266     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1996.tb00500.x     Document Type: Article

References (45)

1. Cookson WO, Sharp PA, Faux JA, Hopkin JM. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1989; 1:1292-5.
2. Cookson WO, Young RP, Sandford AJ et al. Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet 1992; 340:381-4.
3. Shirakawa T, Li A, Dubowitz M et al. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nature Gen 1994; 7:125-9.
4. Shirakawa T, Hashimoto T, Furuyama J, Takeshita T, Morimoto K. Linkage between severe atopy and chromosome 11q13 in Japanese families. Clin Gen 1994; 46:228-32.
5. Hill MR, James AL, Faux JA et al. FceR1-B polymorphism and risk of atopy in a general population sample. Lancet 1995; 311:776-778.
6. Brereton HM, Ruffin RE, Thompson PJ, Turner DR. Familial atopy in Australian pedigrees: adventitious linkage to chromosome 8 is not confirmed nor is there evidence of linkage to the high affinity IgE receptor. Clin Exp Allergy 1994; 24:868-77.
7. Lympany P, Welsh K, MacCochrane G, Kemeny D, Lee T. Genetic analysis using DNA polymorphisim of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. J Allergy Clin Immunol 1992; 89:619-28.
8. Moffatt MF, Sharp PA, Faux JA, Young RP, Cookson WO, Hopkin JM. Factors confounding genetic linkage between atopy and 11q. Clin Exp Allergy 1992; 22:1046-51.
9. Rich SS, Roitman JB, Greenberg B, Roberts S, Blumenthal MN. Genetic analysis of atopy in three large kindreds: no evidence linkage to D11S97. Clin Exp Allergy 1992; 22:1070-6.
10. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich KE, Schou C, Krishnaswamy G, Beaty TH. Linkage analysis of IL4 and other chromosome 5q31.1 total serum immunoglobulin E concentrations. Science 1994; 264:1152-6.
11. Meyers DA, Postma DS, Panhuysen C, Xu J, Amelung PJ, Levitt RC, Bleecker ER. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994; 23:464-470.
12. Postma DS, Bleecker ER, Amelung PJ et al. Gentic susceptibility to asthma bronchial hyperresponsiveness coin-herited with a major gene for atopy. New Engl J Med 1995; 333:894-8.
13. Tiwari JL, Terasaki PI. HLA and disease associations. New York: Springer-Verlag, 1985.
14. Bodmer JG, Marsh S, Albert ED et al. Nomenclature for factors of the HLA system. 1995. Human Immunol 1995; 43:149-64.
15. Huang SK, Zwollo P, Marsh DG. Class II major histocompatibility complex restriction of human T cell responses to short ragweed allergen, Amb a V. Eur J Immunol 1991; 21:1469-73.
16. Goldstein R, Yang WH, Drouin MA, Karsh J. Studies of the HLA class II alleles involved in human responses to ragweed allergens Ambrosia artemisiifolia V (Ra5S) and Ambrosia trifida V (Ra5G). Tissue Antig 1992; 39:122-7.
17. Ansari A, Friedhoff L, Meyers D, Bias W, Marsh D. Human immune responsivness to Lolium perenne pollen allergen Lol p III * (Rye III) is associated with HLA-DR3 and DR5. Human Immunol 1989; 25:59-71.
18. Marsh DG, Hsu SH, Roebber M et al. HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure. J Exp Med 1982; 155:1439-51.
19. Marsh DG, Zwollo P, Huang SK. Molecular and cellular studies of human immune responsiveness to the short ragweed allergen. Amb a V. Eur Resp J 1991; 13:60s-67s.
20. O'Hehir RE, Mach B, Berte C et al. Direct evidence for a functional role of HLA-DRB1 and -DRB3 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T lymphocytes. Int Immunol 1990; 2:885-92.
21. Marsh DG, Blumenthal MN, Ishikawa T, Ruffilli A, Sparholt S, Friedhoff LR. HLA and specific immune responsiveness to allergens. In: Tsuji K, Aizawa M, Sasazuki T, eds. HLA 1991. Proceedings of the Eleventh International Histocompatability Workshop and Conference. Oxford: Oxford University Press, 765-71.
22. Cardaba B, Vilches C, Martin E et al. DR7 and DQ2 are positively associated with immunoglobulin-E response to the main antigen of olive pollen (Ole e I) in allergic patients. Human Immunol 1993; 38:293-9.
23. Sparholt SH, Georgsen J, Madsen HO, Svendse UG, Schou C. Association between HLA-DRB3*0101 and immunoglobulin-E responsiveness to Bet v 1. Human Immunol 1994; 39:76-8.
24. Young RP, Dekker JW, Wordsworth BP et al. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy 1994; 24:431-9.
25. Bignon JS, Aron Y, Ju LY et al. HLA class II alleles in isocyanate-induced asthma. Am J Resp Crit Care Med 1994; 149:71-5.
26. Young RP, Barker RD, Pile KD, Cookson WO, Taylor AJ. The association of HLA-DR3 with specific IgE to inhaled acid anhydrides. Am J Resp Crit Care Med 1995; 151:219-21.
27. Blumenthal M, Marcus BD, Awdeh Z et al. HLA-DR2. [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] distinguish subjects with asthma from those with rhinitis only ragweed pollen allergy. J Immunol 1992; 148:411-6.
28. Aron Y, Swierczewski E, Lockhart A. A simple and rapid micromethod for genomic DNA extraction from jugal epithelial cells. Application to human lymphocyte antigen typing in one large family of atopic asthmatic probands. Allergy 1994; 49:788-90.
29. Aron Y, Swierczewski E, Lockhart A. HLA class II haplotypes in atopic asthmatic and non-atopic control subjects. Clin Exp Allergy 1995; 25(Suppl 2):65-67.
30. Lawrence S, Beasley R, Doull I, Begishvili B, Lampe F, Holgate ST, Morton NE. Genetic analysis of atopy and asthma as quantitative traits and ordered polychotomies. Ann Hum Gene 1994; 48:359-68.
31. Burney PG, Laitinen LA, Perdrizet S et al. Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: an international comparison. Eur Resp J 1989; 2:940-5.
32. Pearce N, Weiland S, Keil U et al. Self-reported prevalence of asthma symptoms in children in Australia, England, Germany and New Zealand: an international comparison using the ISAAC protocol. Eur Resp J 1993; 6:1455-61.
33. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
34. Howell WM, Sage DA, Haegert DG, Evans PR, Smith JL. PCR-SSO typing for HLA-DPB alleles. Eur J Immunogen 1991; 18:81-95.
35. Kimura A, Sasazuki T. Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique. In: Tsuji K, Aizawa M, Sasazuki T. HLA 1991, Proceedings of the Eleventh International Histocompatability Workshop and Conference. Oxford: Oxford University Press. 1992:397-425.
36. Nevinny-Stickel C, Hinzpeter M, Andreas A, Albert ED. Non-radioactive oligotyping for HLA-DR1-DRw10 using polymerase chain reaction, digoxigenin-labelled oligonucleotides and chemiluminescence detection. Eur J Immunogen 1991; 18:323-32.
37. Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39:225-35.
38. Olerup O, Aldener A, Fogdell A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens 1993; 41:119-34.
39. Olerup O, Zetterguist H. DR 'low-resolution' PCR-SSP typing - a correction and an up-date. Tissue Antigens 1993; 41:55-6.
40. Versluis LF, Rozemuller E, Tonks S, Marsh SG, Bouwens AG, Bodmer JG, Tilanus MG. High-resolution HLA-DPB typing based upon computerized analysis of data obtained by fluorescent sequencing of the amplified polymorphic exon 2. Human Immunol 1993: 38:277-83.
41. Howell WM, Leung ST, Jones DB et al. HLA-DRB. -DQA, and -DQB polymorphism in celiac disease and enteropathy-associated T-cell lymphoma: common features and additional risk factors for malignancy. Human Immunol 1995;43:29-37.
42. Sage DA, Evans PR, Howell WM. HLA DPA1-DPB1 linkage disequilibrium in the British caucasoid population. Tissue Antigens 1994;44:335-8.
43. Cookson WO, Hopkin JM. Dominant inheritance of atopic immunoglobulin-E responsiveness. Lancet 1988; 1:86-8.
44. Lamb JR, Kay AB, O'Hehir RE. HLA class II restriction specificity of Dermatophagoides spp. reactive T lymphocyte clones that support IgE synthesis. Clin Exp Allergy 1989; 19:389-93.
45. O'Hehir RE, Eckels DD, Frew AJ, Kay AB, Lamb JR. MHC class II restriction specificity of cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite). Immunology 1988; 64:627-31.