Evaluation of behavioural effects of neural melanocortin receptor antagonists injected ICV and in VTA in rats

Neuropeptides

Volumn 32, Issue 6, 1998, Pages 573-580

  Klusa, V ^a   Svirskis, S ^a   Opmane, B ^a   Muceniece, R ^a,b   Skujins, A ^a   Mutulis, F ^b   Wikberg, J E S ^b   Schioth H B ^b  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; HS 964; MELANOCORTIN; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; GROOMING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; SCORING SYSTEM; VENTRAL TEGMENTUM;

EID: 0032422223     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4179(98)90088-9     Document Type: Article

References (35)

1. Eberle AN, The melanotropins In; Chemistry, physiology and mechanisms of action. Basel: S. Karger; 1988.
2. O'Donahue TL, Dorsa DM. The opiomelanotropinergic neuronal and endocrine systems. Peptides 1982; 3: 353-395.
3. Chhajlani V, Wikberg JES. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 1992; 309: 417-420.
4. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encode the melanocortin receptors. Science 1992; 257: 1248-1251.
5. Gantz I, Konda Y, Tashiro T et al. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 1993; 268: 8246-8250.
6. Gantz I, Miwa H, Konda Y et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 1993; 268: 15174-15179.
7. Chhajlani V, Muceniece R, Wikberg JES. Molecular cloning of a novel human melanocortin receptor. Biochem. Biophys. Res. Commun. 1993; 195: 866-873.
8. Xia Y Wikberg JES. Localization of ACTH receptor mRNA by in situ hybridization in mouse adrenal gland. Cell and Tissue Res 1996; 286, 63-68.
9. Schiöth HB, Chhajlani V, Muceniece R et al. Major pharmacological distinction of the ACTH receptor from the other melanocortic receptors. Life Sciences 1996; 59: 797-801.
10. Roselli-Rehfuss L, Mountjoy KG, Robbins LS et al. Identification of a receptor for g melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl. Acad. Sci. USA 1993; 90: 8856-8860.
11. Xia Y, Wikberg JES. Postnatal expression of melanocortin-3 receptor in rat diencephalon and mesencephalon. Neuropharmacology 1997; 36: 217-224.
12. Mountjoy KG, Mortrud MT, Low MJ et al. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 1994, 8: 1298-1308.
13. Huszar D, Lynch CA, Fairchild-Huntress V et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-141.
14. Chen W, Kelly MA, Optiz-Araya X et al. Exocrine gland dysfunction in MC5-R deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997; 91: 789-798.
15. Schiöth HB, Muceniece, R, Wikberg JES, Chhajlani V. Characterisation of melanocortin receptor subtypes by radioligand binding analysis. Eur J Pharmacol Mol Pharm Sect 1995; 288: 311-317
16. Schiöth HB, Muceniece R, Wikberg JES. Characterisation of melanocortin 4 receptor by radioligand binding analysis. Pharmacol. & Toxicol. 1996; 79: 161-165.
17. Schiöth HB, Muceniece R, Larsson M, Wikberg JES. The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of α-MSH. J Endocrinology 1997; 155: 73-78.
18. 2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J Med Chem 1995; 38: 3454-3461.
19. 7] substituted MSH analogues for the melanocortin receptors, Peptides 1997; 18: 1009-1013.
20. Schiöth HB, Mutulis F, Muceniece R et al. Discovery of novel melanocortin 4 receptor selective MSH analogues. Brit J. Pharmacology 1998; 124: 75-82.
21. Nordstedt C, Fredholm BB. A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid. Analytical Chemistry 1990; 189: 231-234.
22. Kask A, Rägo L, Mutulis F et al. Selective melanocortin 4 receptor antagonist (HS014) increases food intake in free-feeding rats, Biochem. Biophys Res Commun 1998; 245: 90-93.
23. Kask A, Rägo L, Korrovits P et al. Evidence that the orexigenic effects of melanocortin 4 receptor antagonist are mediated by NPY, Biochem Biophys Res Commun 1998. In press.
24. Spruijt BM, de Graan PNE, Eberle AN, Gispen WH. Comparison of structural requirements of α-MSH and ACTH for inducing exessive grooming and pigment dispersion. Peptides 1992; 6: 1185-1189.
25. Gispen WH, Wiegant VM, Greven HM, de Wied D. The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: structure-activity studies. Life Sci 1995; 17: 645-652.
26. Adan RAH, Oosterom J, Ludviksdottir G et al. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. Eur J Pharmacol 1994; 269: 331-337.
27. van Ree JM, Bohus B, Csontos KM et al. Behavioral profile of gamma-MSH: relationship with ACTH and beta-endorphin action. Life Sci 1981; 28: 2875-2878.
28. Von Frijtag JC, Croiset G, Gispen WH et al. The role of central melanocortin receptors in the activation of the hypothalamuspituitary-adrenal-axis and the induction of excessive grooming. Br J Pharmacol 1998; 123: 1503-1508.
29. Xia Y, Wikberg JE, Chhajlani V. Expression of melanocortin 1 receptor in periaqueductal gray matter Neuroreport 1995; 6: 2193-2196.
30. Rajora N, Boccoli G, Burns D et al. alpha-MSH modulates local and circulating tumor necrosis factor-alpha in experimental brain inflammation Neurosci 1997; 17: 2181-2186.
31. Labbé O, Desarnaud F, Eggerickx D et al. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry 1994; 33: 4543-4549.
32. Barrett P, MacDonald A, Helliwell R et al. Cloning and expression of a member of the melanocyte-stimulating hormone receptor family. J Mol Endocrinology 1994; 12: 203-213.
33. Gantz I, Shimoto Y, Konda Y et al. Molecular cloning, expression, and characterization of fifth melanocortin receptor. Biochem Biophys Res Commun 1994; 200: 1214-1220.
34. Griffon N, Mignon V, Facchinetti P et al. Molecular cloning and characterization of the fifth melanocortin receptor. Biochem Biophys Res Commun 1994; 200: 1007-1014.
35. Fathi Z, Iben LG, Parker EM. Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. Neurochem Res 1995; 20: 107-113.