Interaction of thiocolchicoside with [3H]strychnine binding sites in rat spinal cord and brainstem

European Journal of Pharmacology

Volumn 318, Issue 1, 1996, Pages 201-204

  Cimino, Mauro ^a   Marini, Pietro ^b   Cattabeni, Flaminio ^b  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

3H Strychnine binding; Autoradiography; Glycine receptor, strychnine sensitive; Myorelaxant agent; Spinal cord, rat; Thiocolchicoside

Indexed keywords

GLYCINE; GLYCINE RECEPTOR; STRYCHNINE; THIOCOLCHICOSIDE; COLCHICINE; DRUG DERIVATIVE; STRYCHNINE RECEPTOR; TRITIUM;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; MATHEMATICAL MODEL; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; ANIMAL; BRAIN STEM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; RADIOASSAY;

ANIMALS; AUTORADIOGRAPHY; BINDING SITES; BRAIN STEM; COLCHICINE; RADIOLIGAND ASSAY; RATS; RECEPTORS, GLYCINE; SPINAL CORD; STRYCHNINE; TRITIUM;

EID: 0030604176     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00884-9     Document Type: Article

References (11)

1. Biziere, K., F. Huguet, G. Narcisse and M. Breteau, 1981a, Le thiocolchicoside, un agoniste des récepteurs GABAergiques, Thérapie 36, 95.
2. Biziere, K., F. Huguet, G. Narcisse and M. Breteau, 1981b, Affinity of thiocolchicoside and thiocolchicoside analogues for the postsynaptic GABA receptor site, Eur. J. Pharmacol. 75, 167.
3. 3H]strychnine binding sites in rat brain, Eur. J. Pharmacol. 126, 303.
4. 3H]strychnine binding sites, Brain Res. Bull. 15, 473.
5. Janbroers, J.M., 1987, Review of the toxicology, pharmacodynamics and pharmacokinetics of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions, Acta Ther. 13, 221.
6. Kuhse, J., H. Betz and J. Kirsch, 1995, The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex, Curr. Opin. Neurobiol. 5, 318.
7. Marvizon, J.C.G., J. Vazquez, M. Garcia Calvo, F. Mayor, A. Ruiz Gomez, F. Valdivieso and J. Benavides, 1986, The glycine receptor: pharmacological studies and mathematical modeling of the allosteric interaction between the glycine- and strychnine-binding sites, Mol. Pharmacol. 30, 590.
8. 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density, EMBO J. 13, 1318.
9. Van den Pol, A.N. and T. Gorcs, 1988, Glycine and glycine receptor immunoreactivity in brain and spinal cord, J. Neurosci. 8, 472.
10. Young, A.B. and S.H. Snyder, 1974, Strychnine binding in rat spinal cord membranes associated with the glycine synaptic receptor: cooperativity of glycine interactions, Mol. Pharmacol. 10, 790.
11. 3H]strychnine, J. Neurosci. 1, 532.