Polymerized liposomes as potential oral vaccine carriers: Stability and bioavailability

Journal of Controlled Release

Volumn 42, Issue 3, 1996, Pages 263-272

  Chen, Hongming ^a   Torchilin, Vladimir ^b   Langer, Robert ^a  

^a USA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Bioavailability; Oral vaccine carriers; Peyer's patches; Polymerized liposomes; Stability

Indexed keywords

CALCEIN; DRUG CARRIER; LIPOSOME; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG RELEASE; DRUG STABILITY; FEMALE; GASTROINTESTINAL TRACT; HYDROPHOBICITY; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030560621     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(96)01459-9     Document Type: Article

References (23)

1. [1] J. Mestecky, The common mucosal immune system and current strategies for induction of immune responses in external secretions, J. Clin. Immunol. 7 (1987) 265-276.
2. [2] M.R. Neutra and J.P. Kraehenbuhl, Transepithelial transport and mucosal defence I: the role of M cells, Trends Cell Biol. 2 (1992) 134-138.
3. [3] D.T. O'Hagan, Oral immunization and the common mucosal immune system. in: D.T. O'Hagan (Ed.) Novel delivery systems for oral vaccines, Boca Raton, Florida: CRC Press, 1994, pp. 1-24.
4. [4] D.T. O'Hagan, N.M. Christy and S.S. Davis, Particulates and lymphatic drug delivery, in: W.N. Charman and V.J. Stella (Eds.) Lymphatic transport of drugs, Boca Raton, Florida: CRC Press, 1992, pp. 279-315.
5. [5] D.T. O'Hagan, Microparticles as oral vaccines, in: D.T. O'Hagan (Ed.) Novel delivery systems for oral vaccines, Boca Raton, Florida: CRC Press, 1994, pp. 175-205.
6. [6] N.K. Childers and S.M. Michalek, Liposomes, in: D.T. O'Hagan (Ed.) Novel delivery systems for oral vaccines, Boca Raton, Florida: CRC Press, 1994,.
7. [7] C.R. Alving, Liposomes as carriers for vaccines, in: M.J. Ostro (Ed.) Liposomes: from biophysics to therapeutics, New York: Marcel Dekker, 1987, pp. 195-218.
8. [8] J. Okada, S. Cohen and R. Langer, In vitro evaluation of polymerized liposomes as an oral drug delivery system, Pharm. Res. 12 (1995) 576-582.
9. [9] D.S. Deshmukh, W.D. Bear and H. Brockerhoff, Can intact liposomes be absorbed in the gut? Life Sci. 28 (1980) 239-242.
10. [10] P. Jani, G.W. Halbert, J. Langridge and A.T. Florence, The uptake and translocation of latex nanospheres and microspheres after oral administration to rats, J. Pharm. Pharmacol. 41 (1989) 809-812.
11. [11] P. Jani, G.W. Halbert, J. Langridge and A.T. Florence, Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency, J. Pharm. Pharmacol. 42 (1990) 821-826.
12. [12] J.H. Eldridge, J.K. Staas, J.A. Meulbroek, J.R. McGhee, T.R. Tice and R.M. Gilley, Biodegradable microspheres as a vaccine delivery system, Mol. Immunol. 28 (1991) 287-294.
13. [13] M.E. Lefevre and D.D. Joel, Intestinal absorption of particular matter, Life Sci. 21 (1977) 1403-1408.
14. [14] M.E. LeFevre, A.M. Boccio and D.D. Joel, Intestinal uptake of fluorescent microspheres in young and aged mice, Pro. Soc. Exp. Biol. Med. 190 (1989) 23-27.
15. [15] E. Sanders and C.T. Ashworth, A study of paniculate intestinal absorption and hepatocellular uptake, Exp. Cell Res. 22 (1961) 137-145.
16. [16] Y. Aramaki, H. Tomizawa, T. Hara, K. Yachi, H. Kikuchi and S. Tsuchiya, Stability of liposomes in vitro and their uptake by rat Peyer's patches following oral administration, Pharm. Res. 10 (1993) 1228-1231.
17. [17] J. Okada, S. Cohen and R. Langer, Intestinal uptake of polymerized liposomes in rats, J. Pharm. Sci. (submitted).
18. [18] P. Ralph, J, Prichard and M. Cohn, Reticulum cell sarcoma: an effector celt in antibody-dependent cell-mediated immunity, J. Immunol. 114 (1975) 898-905.
19. [19] P. Ralph and I. Nakoinz, Phagocytosis and cytolysis by a macrophage tumor and its cloned cell line, Nature 257 (1975) 393-394.
20. [20] H. Ohno, Y. Ogata and E. Tsuchida, Polymerization of liposomes composed of diene-containing lipids by UV and radical initiators: evidence for the different chemical environment of diene groups on 1-and 2-acyl chains. Macromolecules 20 (1987) 929-933.
21. [21] M. Edelbroek, M. Horowitz, A. Maddox and J. Bellen, Gastric emptying and intragastric distribution of oil in the presence of a liquid or a solid meal, J. Nuclear Med. 33 (1992) 1283-1290.
22. [22] R.M. Straubinger, K. Hong, D.S. Friend and D, Papahadjopoulos, Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesicles, Cell 32 (1983) 1069-1079.
23. [23] J. Connor and L. Huang, Efficient cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomes, J. Cell Biol. 101 (1985) 582-589.