Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression

Immunology

Volumn 87, Issue 3, 1996, Pages 402-407

  Taplin, M E ^a   Frantz, M E ^a   Canning, C ^b   Ritz, J ^b   Blumberg, R S ^c   Balk, S P ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD8 ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE MUCOSA; LYMPHOCYTE DIFFERENTIATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029924603     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.496571.x     Document Type: Article

References (35)

1. SELBY W.S., JANOSSY G. & JEWELL D.P. (1981) Immunohistological characterization of intraepithelial lymphocytes of the human gastrointestinal tract. Gut 22, 169.
2. CERF-BENSUSSAN N., SCHNEEBERGER E.E. & BHAN, A.K. (1983) Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. J Immunol 130, 2615.
3. ERNST P.B., BEFUS A.D. & BIENENSTOCK J. (1985) Leukocytes in the intestinal epithelium: an unusual immunological compartment. Immunol Today 6, 50.
4. BRANDTZAEG P., BOSNES V., HALSTENSEN T.S. et al. (1989) T lymphocytes in human gut epithelium preferentially express the α/β antigen receptor and are often CD45/UCHL1-positive. Scand J Immunol 30, 123.
5. + lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 20, 1097.
6. TREJDOSIEWICZ L.K., SMART C.J., OAKES D.J. et al. (1989) Expression of T-cell receptors TcR1 (γ/δ) and TcR2 (α/β) in the human intestinal mucosa. Immunology 68, 7.
7. BALK S.P., EBERT E.C., BLUMENTHAL R.L. et al. (1991) Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253, 1411.
8. VAN KERCKHOVE C., RUSSELL G.J., DEUSCH K. et al. (1992) Oligoclonality of human intestinal intraepithelial T cells. J Exp Med 175, 57.
9. BLUMBERG R.S., YOCKEY C.E., GROSS G.G., EBERT E.C. & BALK S.P. (1993) Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple Vβ T cell receptor genes. J Immunol 150, 5144.
10. GROSS G.G., SCHWARTZ V.L., STEVENS C., EBERT E.C., BLUMBERG R.S. & Balk S.P. (1994) Distribution of dominant T cell receptor β chains in human intestinal mucosa. J Exp Med 180, 1337.
11. VINEY J.L., MACDONALD T.T. & KILSHAW P.J. (1989) T cell receptor expression in intestinal intraepithelial lymphocyte subpopulations of normal and athymic mice. Immunology 66, 583.
12. MOSLEY R.L., STYRE D. & KLEIN J.R. (1990) Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras. J Immunol 145, 1369.
13. LEFRANCOIS L., LECORRE R., MAYO J., BLUESTONE J.A. & GOODMAN T. (1990) Extrathymic selection of TCR γδ positive T cells by class II major histocompatibility complex molecules. Cell 63, 333.
14. DE GEUS B., VAN DEN ENDEN M., COOLEN C., NAGELKERKEN L., VAN DER HEIJDEN P. & ROZING J. (1990) Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3-associated γδ T cell receptor. Eur J Immunol 20, 291.
15. BANDEIRA A., ITOHARA S., BONNEVILLE M. et al. (1991) Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor γδ. Proc Natl Acad Sci USA 88, 43.
16. CARDING S.R., KYES S., JENKINSON E.J., BOTTOMLY K., OWEN J.J.T. & HAYDAY A.C. (1990) Developmentally regulated fetal thymic and extrathymic T-cell receptor γ/δ T-cell receptor repertoire. Genes Dev 4, 1304.
17. + lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 173, 471.
18. + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J Exp Med 173, 483.
19. POUSSIER P., EDOUARD P., LEE C., BINNIE M. & JULIUS M. (1992) Thymus-independent development and negative selection of T cells expressing T cell receptor α/β in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes. J Exp Med 176, 187.
20. ROCHA B., VON BOEHMER H. & GUY-GRAND D. (1992) Selection of intraepithelial lymphocytes with CD8 α/α co-receptors by self-antigen in the murine gut. Proc Natl Acad Sci USA 89, 5336.
21. MOSLEY R.L. & KLEIN J.R. (1992) Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine. J Exp Med 176, 1365.
22. SYDORA B.C., HABU S. & TANIGUCHI M. (1993) Intestinal intraepithelial lymphocytes preferentially repopulate the intestinal epithelium. Int Immunol 5, 743.
23. GUY-GRAND D., VANDEN BROECKE C., BRIOTTET C., MALASSIS-SERIS M., SELZ F. & VASSALLI P. (1992) Different expression of the recombination activity gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement. Eur J Immunol 22, 505.
24. DUNON D., COOPER M.D. & IMHOF B.A. (1993) Thymic origin of embryonic intestinal γ/δ T cells. J Exp Med 177, 257.
25. KOMORI T., OKADA A., STEWART V. & ALT F.W. (1993) Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261, 1171.
26. GILFILLAN S., DIERICH A., LEMEUR M., BENOIST C. & MATHIS D. (1993) Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261, 1175.
27. TAUNK J., ROBERTS A.I. & EBERT E.C. (1992) Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology 102, 69.
28. GUSSOW D., REIN, R., GINJAAR I. et al. (1987) The human β2-microglobulin gene: primary structure and definition of the transcriptional unit. J Immunol 139, 3132.
29. RILEY L.K., MORROW J.K., DANTON M.J. & COLEMAN M.S. (1988) Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5′ flanking region. Proc Natl Acad Sci USA 85, 2489.
30. SHIUE L., GORMAN S.D. & PARNES J.R. (1988) A second chain of human CD8 is expressed on peripheral blood lymphocytes. J Exp Med 168, 1993.
31. OI V., GLASER A.N. & STRYER L. (1982) Fluorescent phycobiliprotein conjugates for analysis of cells and molecules. J Cell Biol 93, 981.
32. OETTINGER M.A., SCHATZ D.G., GORKA C. & BALTIMORE D. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517.
33. LYNCH S., KELLEHER D., MCMANNUS R. & O'FARRELLY C. (1995) RAG1 and RAG2 expression in human intestinal epithlium: evidence of extrathymic T cell differentiation. Eur J Immunol 25, 1143.
34. LATTHE M., TERRY L. & MACDONALD T.T. (1994) High frequency of CD8αα homodimer-bearing T cells in human fetal intestine. Eur J Immunol 24, 1703.
35. KONINGSBERGER J.A., CHOTT A., LOGTENBERG T., BLUMBERG R.S. & BALK S.P. (1995) The TCRα/β repertoire in human intestinal fetal mucosa during gestation. Gastroenterology 108, A851.