TCR Expression in Human Fetal Intestine and Identification of an Early T Cell Receptor β-Chain Transcript

Journal of Immunology

Volumn 159, Issue 4, 1997, Pages 1775-1782

  Koningsberger, Jacob C ^a   Chott, Andreas ^b   Logtenberg, Ton ^a   Wiegman, Lucietta J J M ^a   Blumberg, Richard S ^c   Van Berge Henegouwen, Gerard P ^a   Balk, Steven P ^d,e  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF VIENNA   (Austria)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA;

ARTICLE; FEMALE; FETUS; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOLOGY; INTESTINE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREGNANCY;

BASE SEQUENCE; FEMALE; FETUS; GENE REARRANGEMENT; HUMANS; INTESTINES; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PREGNANCY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA, MESSENGER;

EID: 0031571207     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Selby, W. S., G. Janossy, and D. P Jewell. 1981. Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract. Gut 22:169.
2. Cerf-Bensussan, N., E. E. Schneeberger, and A. K. Bhan. 1983. Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. J. Immunol. 130:2615.
3. Ernst, P. B., D. Befus, and J. Bienenstock. 1985. Leukocytes in the intestinal epithelium: an unusual immunological compartment. Immunol. Today 6:50.
4. Blumberg, R. S., and S. P. Balk. 1994. Intraepithelial lymphocytes and their recognition of nonclassical MHC molecules. Int. Rev. Immunol. 11:15.
5. Brandtzaeg, P., V. Bosnes, T. S. Halstensen, H. Scott, L. M. Sollid, and K. N. Vaines. 1989. T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1-positive. [Published erratum appears in 1989 Scand. J. Immunol. 30:653.] Scand. J. Immunol. 30:121.
6. - lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur. J. Immunol. 20: 1097.
7. Trejdosiewicz. L. K., C. J. Smart, D. J. Oakes, P. D. Howdle, G. Malizia, D. Campana, and A. W. Boylston. 1989. Expression of T-cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa. Immunology 68:7.
8. Balk, S. P., E. C. Ebert, R. L. Blumenthal, F. V. McDermott, K. W. Wucherpfennig, S. B. Landau, and R. S. Blumberg. 1991. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253: 1411.
9. Van Kearkhove, C., G. J. Russell, K. Deusch, K. Reich, A. K. Bhan, H. DerSimonian, and M. B. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57.
10. Blumberg, R. S., C. E. Yockey, G. G. Gross, E. C. Ebert, and S. P. Balk. 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes. J. Immunol. 150:5144.
11. Gross, G. G., V. L. Schwartz, C. Stevens, E. C. Ebert, R. S. Blumberg, and S. P. Balk. 1994. Distribution of dominant T cell receptor beta chains in human intestinal mucosa. J. Exp. Med 180:1337.
12. Chowers, Y., W. Holtmeier, J. Harwood, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1994. The V delta 1 T cell receptor repertoire in human small intestine and colon. J. Exp. Med. 180:183.
13. Mosley, R. L., D. Styre, and J. R. Klein. 1990. Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras. J. Immunol. 145:1369.
14. Lefrancois, L., R. LeCorre, J. Mayo, J. A. Bluestone, and T. Goodman. 1990. Extrathymic selection of TCR gamma delta + T cells by class II major histocompatibility complex molecules. Cell 63:333.
15. De Geus, B., M. Van den Enden, C. Coolen, L. Nagelkerken, P. Van der Heijden, and J. Rozing. 1990. Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells hearing a CD3-associated gamma delta T cell receptor. Eur. J. Immunol. 20:291.
16. Bandeira, A., S. Itohara, M. Bonneville, O. Burlen-Defranoux, T. Mota-Santos, A. Coutinho, and S. Tonegawa. 1991. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. Proc. Natl. Acad. Sci. USA 88:43.
17. Carding, S. R., S. Kyes, E. J. Jenkinson, R. Kingston, K. Bottomly, J. J. Owen, and A. C. Hayday. 1990. Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression. Genes Dev. 4:1304.
18. + lymphocyte populations with different T cell receptors: a role tor the gut epithelium in T cell differentiation. J. Exp. Med. 173:471.
19. Rocha, B., P. Vassalli, and D. Guy-Grand. 1991. The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173:483.
20. Mosley, R. L., and J. R. Klein. 1992. Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine. J. Exp. Med. 176:1365.
21. Guy-Grand, D., C. Vanden Broecke, C. Briottet, M. Malassis-Seris, F. Selz, and P. Vassalli. 1992. Different expression of the recombination activity gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement. Eur. J. Immunol. 22:505.
22. Lynch, S., D. Kelleher, R. McManus, and C. O'Farrelly. 1995. RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation. Eur. J. Immunol. 25:1143.
23. Lundqvist, C., V. Baranov, S. Hammarstrom, L. Athlin, and M. L. Hammarstrom. 1995. Intra-epithelial lymphocytes: evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int. Immunol. 7:1473.
24. Taplin, M.-E., M. E. Frantz, C. Canning, J. Ritz, R. S. Blumberg, and S. P. Balk. 1996. Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression. Immunology 87:402.
25. Itohara, S., A. G. Farr, J. J. Lafaille, M. Bonneville, Y. Takagaki, W. Haas, and S. Tonegawa. 1990. Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. Nature 343:754.
26. Havran, W. L., and J. P. Allison. 1988. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335:443.
27. Asarnow, D. M., T. Goodman, L. Lefrancois, and J. P. Allison. 1989. Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells. Nature 341:60.
28. Spencer, J., S. B. Dillon, P. G. Isaacson, and T. T. MacDonald. 1986. T cell subclasses in fetal human ileum. Clin. Exp. Immunol. 65:553.
29. Spencer, J., P. G. Isaacson, J. A. Walker-Smith, and T. T. MacDonald. 1989. Heterogeneity in intraepithelial lymphocyte subpopulations in fetal and postnatal human small intestine. J. Pediatr. Gastroenterol. Nutr. 9:173.
30. Latthe, M., L. Terry, and T. T. MacDonald. 1994. High frequency of CD8 alpha alpha homodimer-bearing T cells in human fetal intestine. Eur. J. Immunol. 24: 1703.
31. Chott, A., C. S. Probert, G. G. Gross, R. S. Blumberg, and S. P. Balk. 1996. A common TCR beta-chain expressed by CD8+ intestinal mucosa T cell in ulcerative colitis. J. Immunol. 156:3024.
32. Frohman, M. A., M. K. Dush, and G. R. Martin. 1988. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85:8998.
33. Loh, E. Y., J. F. Elliott, S. Cwirla, L. L. Lanier, and M. M. Davis. 1989. Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain. Science 243:217.
34. de Villartay, J. P., D. Lewis, R. Hockett, T. A. Waldmann, S. J. Korsmeyer, and D. I. Cohen. 1987. Deletional rearrangement in the human T-cell receptor alpha-chain locus. Proc. Natl. Acad. Sci. USA 84:8608.
35. Yoshikai, Y., N. Kimura, B. Toyonaga, and T. W. Mak. 1986. Sequences and repertoire of human T cell receptor alpha chain variable region genes in mature T lymphocytes. J. Eur. Med. 164:90.
36. Roman-Roman, S., L. Ferradini, J. Azocar, C. Genevee, T. Hercend, and F. Triebel. 1991. Studies on the human T cell receptor alpha/beta variable region genes. I. Identification of 7 additional V alpha subfamilies and 14 J alpha gene segments. Eur. J. Immunol. 21:927.
37. Ricken, G., G. Pluschke, and D. Krawinkel. 1992. T cell receptor alpha-chain germ line transcripts from activated lymphocytes. Immunol. Lett. 32:97.
38. Rowen, L., B. F. Koop, and L. Hood. 1996. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science 272:1755.
39. Thomas, R., G. Schurmann, P. Lionetti, S. L. F. Pender, and T. T. MacDonald. 1996. T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut. Gut 38:190.
40. Arden, B., S. P. Clark, D. Kabelitz, and T. W. Mak. 1995. Human T-cell receptor variable gene segment families. Immunogenetics 42:455.