Transgenic bioreactors

Biotechnology Annual Review

Volumn 4, Issue C, 1998, Pages 55-74

  Jänne, Juhani ^a   Alhonen, Leena ^a   Hyttinen, Juha Matti ^a   Peura, Teija ^a   Tolvanen, Minna ^a   Korhonen, Veli Pekka ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; RECOMBINANT PROTEIN;

ANIMAL; BIOREACTOR; BIOSYNTHESIS; CATTLE; HUMAN; MOUSE; PROTEIN SYNTHESIS; RABBIT; REVIEW; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOREACTORS; CATTLE; HUMANS; MICE; PROTEIN BIOSYNTHESIS; PROTEINS; RABBITS; RECOMBINANT PROTEINS;

EID: 0032246951     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(08)70067-X     Document Type: Article

References (86)

1. Palmiter R.D., and Brinster RL. Germ-line transformation of mice. Ann Rev Genet 20 (1986) 465-499
2. Jaenisch R. Transgenic animals. Science 240 (1988) 1468-1474
3. Gordon JW. Transgenic animals. Int Rev Cytol 115 (1989) 171-229
4. Wilmut I., Archibald A.L., Harris S., McClenaghan M., Simons J.P., Whitelaw C., and Clark AJ. Modification of milk composition. J Reprod Fertil 41 (1990) 135-146 (Suppl.)
5. Jänne J., Hyttinen J.-M., Peura T., Tolvanen M., Alhonen L., and Halmekytö M. Transgenic animals as bioproducers of therapeutic proteins. Ann Med 24 (1992) 273-280
6. Jänne J., Hyttinen J.-M., Peura T., Tolvanen M., Alhonen L., Sinervirta R., and Halmekytö M. Transgenic Bioreactors. Int J Biochem 26 (1994) 859-870
7. Wilmut I., and Whitelaw CBA. Strategies for production of pharmaceutical proteins in milk. Reprod Fertil Dev 6 (1994) 625-630
8. Hall L., Emery D.C., Davies M.S., Parker D., and Craig RK. Organization and sequence of the human a-lactalbumin gene. Biochem J 242 (1987) 735-742
9. Dale T.C., Krnacik M.J., Schmidhauser C., Yang C.-Q., Bissel M.J., and Rosen JM. High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3′ untranslated region. Molec Cell Biol 12 (1992) 905-914
10. Wall R.J., Pursel V.G., Shamay A., McKnight R.A., Pittius C.W., and Hennighausen L. High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine. Proc Natl Acad Sci USA 88 (1991) 1696-1700
11. Gordon K., Vitale J., Lee E., Westphal H., and Hennighausen L. Expression of human TPA in the milk of transgenic animals. Gene Transfer and Gene Ther. (1989), Alan R. Liss, Inc. 57-66
12. Meade H., Gates L., Lacy E., and Lonberg N. Bovine alphaS l-casein gene sequences direct high level expression of active human urokinase in mouse milk. Biotechnology 8 (1990) 443-446
13. Günzburg W.H., Salmons B., Zimmermann B., Müller M., Erfle V., and Brem G. A mammary-specific promoter directs expression of growth hormone not only to the mammary gland, but also to Bergman glia cells in transgenic mice. Molec Endocrinol 5 (1991) 123-133
14. Reddy V.B., Vitale J.A., Wei C., Montoya-Zavala M., Stice S.L., Balise J., and Robl JM. Expression of human growth hormone in the milk of transgenic mice. Anim Biotechnol 2 (1991) 15-29
15. Devinoy E., Thepot D., Stinnakre M.-G., Fontaine M.-L., Grabowski H., Puissant C., Pavirani A., and Houdebine LM. High level production of human growth hormone in the milk of transgenic mice: the upstream region of the rabbit whey acidic protein (WAP) gene targets transgene expression to the mammary gland. Transgenic Res 3 (1994) 79-89
16. Archibald A.L., McClenaghan M., Hornsey V., Simons J.P., and Clark AJ. High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice. Proc Natl Acad Sci USA 87 (1990) 5178-5182
17. Dobrovolsky V.N., Lagutin O.V., Vinogradova T.V., Frolova I.S., Kuznetso V.P., and Larionov OA. Human γ-interferon expression in the mammary gland of transgenic mice. FEBS Lett 319 (1993) 181-184
18. Platenburg G.J., Kootwijk E., Kooiman P.M., Woloshuk S.L., Nuijens J.H., Krimpenfort P., Pieper F.R., de Boer H.A., and Strijker R. Expression of human lactoferrin in milk of transgenic mice. Transgenic Res 3 (1994) 99-108
19. Uusi-Oukari M., Hyttinen J.-M., Korhonen V.-P., Västi A., Alhonen L., Jänne O.A., and Jänne J. Bovine alphaSl-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice. Transgenic Res 6 (1997) 75-84
20. Korhonen V.-P., Tolvanen M., Hyttinen J.-M., Uusi-Oukari M., Sinervirta R., Alhonen L., Jauhiainen M., Jänne O.A., and Jänne J. Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits. Eur J Biochem 245 (1997) 482-489
21. Bijvoet A., Pieper M.A., de Boer F.R., Reuser H.A., van der Ploeg A.T., and Verbeet MP. Expression of cDNA-encoded human acid alpha-glucosidase in milk of transgenic mice. Biochim Biophys Acta 1308 (1996) 93-96
22. Escalante R., Houdebine L.-M., and Pamblanco M. Transferrin gene expression in the mammary gland of the rat. The enhancing effect of 17β-oestradiol on the level of RNA is tissue-specific. J Mol Endocrinol 11 (1993) 151-159
23. Stinnakre M.-G., Devinoy E., Thepot D., Chene N., Bayat-Samardi M., Grabowski H., and Houdebine L.-M. Quantitative collection of milk and active recombinant proteins from the mammary glands of transgenic mice. Anim Biotechnol 3 (1992) 245-255
24. Bühler T.A., Bruyère T., Went D.F., Stranzinger G., and Bürki K. Rabbit β-casein promoter directs secretion of human interkeukin-2 into the milk of transgenic rabbits. Biotechnology 8 (1989) 140-143
25. Riego E., Limonta J., Auguilar A., Perez A., de Armas R., Solanto R., Ramos B., Castro F.O., and de la Fuente J. Production of transgenic mice and rabbits that carry and express human tissue plasminogen activator cDNA under the control of a bovine alpha Sl casein promoter. Theriogenology 39 (1993) 1173-1185
26. Brem G., Hartl P., Besenfelder U., Wolf E., Zinovieva N., and Pfaller R. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits. Gene 149 (1994) 351-355
27. Wolf E., Jehle P.M., Weber M.M., Sauerwein H., Daxenberger A., Breier B.H., Bessenfelder U., Frenyo L., and Brem G. Human insulin-like growth factor I (IGF-I) produced in the mammary gland of transgenic rabbits: yield, receptor binding, mitogenic activity, and effects on IGF-binding protein. Endocrinology 138 (1997) 307-313
28. Limonta J.M., Castro F.O., Martinez R., Puentes P., Ramos B., Aguilar A., Lleonart R.L., and de la Fuente J. Transgenic rabbits as bioreactors for the production of human growth hormone. J Biotechnol 40 (1995) 49-58
29. Stromqvist M., Houdebine M., Andersson J.O., Edlund A., Johansson T., Viglietta C., Puissant C., and Hansson L. Recombinant human extracellular superoxide dismutase produced in milk of transgenic rabbits. Transgenic Res 6 (1997) 271-278
30. Brem G., Besenfelder U., Aigner B., Müller M., Liebl I., Schütz G., and Montoliu L. YAC transgenesis in farm animals: rescue of albinism in rabbits. Molec Reprod Devel 44 (1996) 56-62
31. Fujiwara Y., Miwa M., Takahashi R., Hirabayashi M., Suzuki T., and Ueda M. Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA. Molec Reprod Dev 47 (1997) 157-163
32. Brem G., Basenfelder U., Castro F.O., and Müller M. Transgenesis in rabbits. In: Castro F.O., and Jänne J. (Eds). Mammary Gland Transgenesis in Laboratory and Farm Animals (1998), Landes Bioscience Publishers, Austin 107-141
33. Palmiter R.D., Brinster R.L., Hammer R.E., Trubaner M.E., Rosenfeld M.G., Birnberg N.C., and Evans MR. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300 (1982) 611-615
34. Pursel V.G., Hammer R.E., Bolt D.J., Palmiter R.D., and Brinster RL. Integration, expression and germline transmission of growth-related genes in pigs. J Reprod Fertil 41 (1990) 77-87 (Suppl.)
35. Wieghart M., Hoover J.L., McGrane M.M., Hanson R.W., Rottman F.M., Holzman S.H., Wagner T.E., and Pinkert CA. Production of transgenic pigs harbouring a rat phosphoenolpyruvate carboxykinase-bovine growth hormone fusion gene. J Reprod Fertil Suppl 41 (1990) 89-96
36. Murray J.D., Nancarrow C.D., Marshall J.T., Hazelton I.G., and Ward KA. Production of transgenic Merino sheep by microinjection of ovine metallothionein-ovine growth hormone fusion genes. Reprod Fertil Dev 1 (1989) 147-155
37. Rexroad C.E., Hammer R.E., Behringer R.R., Palmiter R.D., and Brinster RL. Insertion, expression and physiology of growth- regulating genes in ruminants. J Reprod Fertil 41 (1990) 119-124 (Suppl.)
38. Bowen R.A., Reed M.L., Schnieke A., Seidel Jr. G.E., Stacey A., Thomas W.K., and Kajikawa O. Transgenic cattle resulting from biopsied embryos: Expression of c-ski in a transgenic calf. Biol Reprod 50 (1993) 664-668
39. Damak S., Su H.Y., and Bullock D.W. Improved wool production in transgenic sheep expressing insulin-like growth factor I. Biotechnology 14 (1996) 185-188
40. Powell B.C., Walker S.K., Bawden C.S., Sivaprasad A.V., and Rogers GE. Transgenic sheep and wool growth: possibilities and current status. Reprod Fertil Dev 6 (1994) 615-623
41. Clements J.E., Wall R.J., Narayan O., Hauer D., Schoborg R., Sheffer D., Powell A., Carruth L.M., Zink M.C., and Rexroad CE. Development of transgenic sheep that express the visna virus envelope gene. Virology 200 (1994) 370-380
42. Martin P., and Groslaude F. Improvment of milk quality by gene technology. Livestock Prod Sci 35 (1993) 95-115
43. Maga E.A., Anderson G.B., and Murray JD. The effect of mammary gland expression of human lysozyme on the properties of milk from transgenic mice. J Dairy Sci 78 (1995) 2645-2652
44. Krimpenfort P., Rademakers A., Eyestone W., van der Schans A., van den Broek S., Kooiman P., Kootwijk E., Platenburg G., Pieper F., Strijker R., and de Boer H. Generation of transgenic dairy cattle using "in vitro" embryo production. Biotechnology 9 (1991) 844-847
45. Hill AR. Chemical species in cheese and their origin in milk composition. Adv Exp Med Biol 367 (1995) 43-58
46. Gutierrezadan A., Maga E.A., and Meade H. Alteration of the physical characteristics of milk from transgenic mice producing bovine kappa-casein. J Dairy Sci 79 (1996) 791-799
47. Persuy M.-A., Legrain S., Printz C., Stinnakre M.-G., Lepourry L., Brignon G., and Mercier J.-C. High-level, stage- and mammary-tissue-specific expression of a caprine κ-casein-encoding minigene driven by a β-casein promoter in transgenic mice. Gene 165 (1995) 291-296
48. Behringer R.R., Ryan T.M., Reilly M.P., Asakura T., Palmiter R.D., Brinster R.L., and Townes TM. Synthesis of functional human hemoglobin in transgenic mice. Science 245 (1989) 971-973
49. Grosveld F., van Assendelft G.B., Greaves D.R., and Kollias G. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51 (1987) 975-985
50. Swanson M.E., Martin M.J., O'Donnel J.K., Hoover K., Lago W., Huntress V., Parsons C.T., Pinkert C.A., Pilder S., and Logan JS. Production of functional human hemoglobin in transgenic swine. Biotechnology 10 (1992) 557-559
51. Sharma A., Martin M.J., Okabe J.F., Truglio R.A., Dhanjal N.K., Logan J.S., and Kumar R. An isologous porcine promoter permits high level expression of human hemoglobin in transgenic swine. Biotechnology 12 (1994) 55-59
52. Lo D., Pursel V., Linton P.J., Sandgren E., Behringer R., Rexroad C., Palmiter R.D., and Brinster RL. Expression of mouse IgA by transgenic mice, pigs and sheep. Eur J Immunol 21 (1991) 1001-1006
53. Wall R.J., Hawk H.W., and Nel N. Making transgenic livestock: Genetic engineering on a large scale. J Cell Biochem 49 (1992) 113-120
54. Simons J.P., Wilmut I., Clark A.J., Archibald A.L., Bishop J.O., and Lathe R. Gene transfer into sheep. Biotechnology 6 (1988) 179-183
55. Clark A.J., Bessos H., Bishop J.O., Brown P., Harris S., Lathe R., McClenaghan M., Prowse C., Simons J.P., Whitelaw C., and Wilmut I. Expression of human anti-hemophilic factor IX in the milk of transgenic sheep. Biotechnology 7 (1989) 487-492
56. Brinster R.L., Allen J., Behringer R.R., Gelinas R.E., and Palmiter RD. Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci USA 85 (1988) 836-840
57. Velander W.H., Johnson J.L., Page R.L., Russell C.G., Subramanian A., Wilkins T.D., Gwazdauskas F.C., Pittius C., and Drohan WN. High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C. Proc Natl Acad Sci USA. 89 (1992) 12003-12007
58. Wright G., Carver A., Cottom D., Reeves D., Scott A., Simons P., Wilmut I., Garner I., and Colman A. High level of expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Biotechnology 9 (1991) 830-834
59. Carver A., Wright G., Cottom D., Cooper J., Dalrymple M., Temperley S., Udell M., Reeves D., Percy J., Scott A., Barrass D., Gibson Y., Jeffrey Y., Samuel C., Colman A., and Garner I. Expression of human α 1-antitrypsin in transgenic sheep. Cytotechnology 9 (1992) 77-84
60. Carver A.S., Dalrymple M.A., Wright G., Cottom D.S., Reeves D.B., Gibson Y.H., Keenan J.L., Barrass J.D., Scott A.R., Colman A., and Garner I. Transgenic livestock as bioreactors: stable expression of human alpha-1-antirypsin by a flock of sheep. Biotechnology 11 (1993) 1263-1270
61. Ebert K.M., Selgrath J.P., DiTullio P., Denman J., Smith T.E., Memon M.A., Schindler J.E., Monastersky G.M., Vitale J.A., and Gordon K. Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression. Biotechnology 9 (1991) 835-838
62. Ebert K.M., and Schindler JES. Transgenic farm animals: progress report. Theriogenology 39 (1993) 121-135
63. Denman J., Hayes M., O'Day C., Edmunds T., Barlett C., Hirani S., Ebert K.M., Gordon K., and McPherson JM. Transgenic expression of a variant of human tissue-type plasminogen activator in goat milk: purification an characterization of the recombinant enzyme. Biotechnology 9 (1991) 839-843
64. Ebert K.M., DiTullio P., Barry C.A., Schindler J.E., Ayers S.L., Smith T.E., Pellerin L.J., Meade H.M., Denman J., and Roberts B. Induction of human tissue plasminogen activator in the mammary gland of transgenic goats. Biotechnology 12 (1994) 699-702
65. Archer J.S., Kennan W.S., Gould M.N., and Bremell RD. Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors. Proc Natl Acad Sci USA 91 (1994) 6840-6844
66. Eyestone WH. Challenges and progress in the production of transgenic cattle. Reprod Fert Dev 6 (1994) 647-652
67. Van Cott K.E., Lubon H., Russell C.G., Butler S.P., Gwazdauskas F.C., Knight J., Drohan W.N., and Velander WH. Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C. Transgenic Res 6 (1997) 203-212
68. Van Cott K.E., Williams B., Velander V.H., Gwazdauskas F., Lee T., Lubon H., and Drohan WN. Affinity purification of biologically active and inactive form of recombinant human protein C produced in porcine mammary gland. J Mol Recognit 9 (1996) 407-414
69. Dalton J.C., Bruley D.F., Kang K.A., and Drohan WN. Separation of recombinant human protein C from transgenic animal milk using immobilized metal affinity chromatography. Adv Exp Med Biol 411 (1997) 419-428
70. Paleyanda R.K., Velander W.H., Lee T.K., Scandella D.H., Gwazdauskas F.C., Knight J.W., Hoyer L.W., Drohn W.N., and Lubon H. Transgenic pigs produce functional human factor VIII in milk. Nature Biotechnol 15 (1997) 971-975
71. Peura T., Aalto J., Rainio V., and Vanha-Perttula T. Pregnancies of bovine oocyte matured and fertilized in vitro. Acta Vet Scand 30 (1989) 483-485
72. Peura T., Hyttinen J.-M., Tolvanen M., and Jänne J. Effects of microinjection-related treatments on the subsequent development of in vitro-produced bovine embryos. Theriogenology 42 (1994) 433-443
73. Hyttinen J.-M., Peura T., Tolvanen M., and Jänne J. Detection of microinjected genes in bovine preimplantation embryos with combined DNA digestion polymerase chain reaction. Molec Reprod Dev 43 (1996) 150-157
74. Hyttinen J.-M., Peura T., Tolvanen M., Aalto J., Alhonen L., Sinervirta R., Halmekytö M., Myöhänen S., and Jänne J. Generation of transgenic dairy cattle from transgene-analyzed and sexed embryos produced in vitro. Biotechnology 12 (1994) 606-608
75. Eyestone W.H., and First NL. Co-culture of early cattle embryos to the blastocyst stage with oviductal tissue or in conditioned medium. J Reprod Fert 85 (1991) 715-720
76. Peura T., Hyttinen J.-M., Turunen M., and Jänne J. A reliable sex determination assay for bovine preimplantation embryos using the polymerase chain reaction. Theriogenology 35 (1991) 547-555
77. Peura T., Hyttinen J.-M., Turunen M., Aalto J., Rainio V., and Jänne J. Birth of calves developed from embryos of predetermined sex. Acta Vet Scand 32 (1991) 283-286
78. Lacks S., and Greenberg B. A deoxyribonuclease of Diplococcus pneumoniae specific for methylated DNA. J Biol Chem 250 (1975) 4060-4066
79. King D., and Wall RJ. Identification of specific gene sequences in preimplantation embryos by genomic amplification: Detection of a transgene. Molec Reprod Dev 1 (1988) 57-62
80. Horvat S., Medrano J.F., Behboodi E., Anderson G.B., and Murray JD. Sexing and detection of gene construct in microinjected bovine blastocysts using the polymerase chain reaction. Transgenic Res 2 (1993) 134-140
81. Houdebine LM. Production of pharmaceutical proteins from transgenic animals. J Biotechnol 34 (1994) 269-287
82. Lee S.H., and de Boer HA. Production of biomedical proteins in the milk of transgenic dairy cows: The state of the art. J Control Rel 29 (1994) 213-221
83. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., and Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 385 (1997) 810-813
84. Ziomek CA. Minimization of viral contamination in human pharmaceuticals produced in the milk of transgenic goats. Dev Biol Stand 88 (1996) 265-268
85. Wall R.J., Rexroad C., Powell A., Shamay A., McKnight R., and Hennighausen L. Synthesis and secretion of mouse whey acidic protein in transgenic sheep. Transgenic Res 5 (1996) 67-72
86. Massoud M., and Attal J. Thepot D, Pointu H, Stinnakre MG, Theron MC, Lopez C, Houdebine LM. The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits. Reprod Nutr Devel 36 (1996) 555-563