Resting B Cells from Autoimmune Lupus-Prone New Zealand Black and (New Zealand Black x New Zealand White)F 1 Mice Are Hyper-Responsive to T Cell-Derived Stimuli

Journal of Immunology

Volumn 159, Issue 12, 1997, Pages 5810-5820

  Jongstra Bilen, Jenny ^a,b   Vukusic, Brian ^a   Boras, Kata ^a   Wither, Joan E ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CROSS BREEDING; CYTOLOGY; DBA MOUSE; DISEASE PREDISPOSITION; DRUG EFFECT; FEMALE; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; INTERPHASE; INTRACELLULAR FLUID; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; METABOLISM; MOUSE; NEW ZEALAND BLACK MOUSE; SPLEEN; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; B-LYMPHOCYTE SUBSETS; CROSSES, GENETIC; CYTOKINES; DISEASE SUSCEPTIBILITY; FEMALE; IMMUNOGLOBULIN M; IMMUNOPHENOTYPING; INTERPHASE; INTRACELLULAR FLUID; LUPUS NEPHRITIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, INBRED NZB; SPLEEN; T-LYMPHOCYTES;

EID: 0031573510     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Theofilopoulos, A. N., and F. J. Dixon. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:269.
2. Diamond, B., J. B. Katz, E. Paul, C. Aranow, D. Lustgarten, and M. D. Scharff. 1992. The role of somatic mutation in the pathogenic anti-DNA response. Annu. Rev. Immunol. 10:731.
3. Datta, S. K., H. Patel, and D. Berry. 1987. Induction of a cationic shift in IgG anti-DNA autoantibodies: role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J. Exp. Med. 165:1252.
4. Wofsy, D., and W. E. Seaman. 1985. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J. Exp. Med. 161:378.
5. 1 mice: thymus-independent occurrence of a B cell abnormality and requirement for T cells in the development of autoimmune disease, as evidenced by an analysis of athymic nude individuals. J. Immunol. 141:85.
6. Kono, D. H., R. W. Burlingame, D. G. Owens, A. Kuramochi, R. S. Balderas, D. Balomenos, and A. N. Theofilopoulos. 1994. Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA 91:10168.
7. 1 mice. Proc. Natl. Acad. Sci. USA 91:4062.
8. Drake, C. G., S. J. Rozzo, H. F. Hirschfeld, N. P. Smamworawong, E. Palmer, and B. L. Kotzin. 1995. Analysis of the New Zealand Black contribution to lupus-like renal disease: multiple genes that operate in a threshold manner. J. Immunol. 154:2441.
9. Morel, L., Y. Yu, K. R. Blenman, R. A. Caldwell, and E. K. Wakeland. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived form the SLE-prone NZB2410 strain. Mamm. Genome 7:335.
10. Mohan, C., L. Morel, P. Yang, and E. K. Wakeland. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: sle-2 on murine chromosome 4 leads to B cell hyperactivity. J. Immunol. 159:454.
11. 1 mice. Int. Immunol. 6:1857.
12. Moutsopolous, H. M., M. Boehm-Truitt, S. S. Kassan, and T. N. Chusud. 1977. Demonstration of activation of B lymphocytes in New Zealand Black mice at birth by an immunoradiometric assay for murine IgM. J. Immunol. 119:1639.
13. 1 mice. J. Immunol. 119:1534.
14. Izui, S., P. J. McConahey, and F. J. Dixon. 1978. Increased spontaneous polyclonal activation of B lymphocytes in mice with spontaneous autoimmune disease. J. Immunol. 121:2213.
15. Manny, N., S. K. Datta, and R. S. Schwartz. 1979. Synthesis of IgM by cells in NZB and SWR mice and their crosses. J. Immunol. 122:1220.
16. Raveche, E. S., A. D. Steinberg, A. L. DeFranco, and J.-H. Tjio. 1982. Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice. J. Immunol. 129:1219.
17. - B cells. J. Immunol. 153:1847.
18. Minoda, M., K. Hamada, M. Higashikawa, H. Sugishima, M. Funauchi, and A. Horiuchi. 1989. Examination of the inhibitory effects of interferon-γ on interleukin-4-induced stimulation of resting B cells from NZB/NZWF1 mice. Clin. Exp. Immunol. 78:115.
19. 1 mice. J. Clin. Lab. Immunol. 35:57.
20. Umland, S. P., N. F. Go, J. E. Cupp, and M. Howard. 1989. Responses of B cells from autoimmune mice to IL-5. J. Immunol. 142:1528.
21. Prud'homme, G. J., R. S. Balderas, F. J. Dixon, and A. N. Theofilopoulos. 1983. B cell dependence on and response to accessory signals in murine lupus strains. J. Exp. Med. 157:1815.
22. Bishop, G. A., L. M. Ramirez, and T. J. Waldschmidt. 1994. Differential responses to Ig and class II-mediated signals in splenic B cell subsets from normal and autoimmune mice. Int. Immunol. 6:1049.
23. Alarcon-Riquelme, M. E., G. Moller, and C. Fernandez. 1991. The effects of interleukins 4 and 5 on the differentiation of B cells from (NZB X NZW)F1 mice. Scand. J. Immunol. 33:119.
24. - anti-DNA antibody-producing B cells in murine lupus. Autoimmunity 14:205.
25. Herron, L. R., R. L. Coffman, M. W. Bond, and B. L. Kotzin. 1988. Increased autoantibody production by NZB/NZW B cells in response to IL-5. J. Immunol. 141:842.
26. Mihara, M., H. Fukui, Y. Koishihara, M. Saito, and Y. Ohsugi. 1990. Immunologic abnormality in NZB/W F1 mice: thymus-independeny expansion of B cells responding to interleukin-6. Clin. Exp. Immunol. 82:533.
27. Arlarcon-Riquelme, M. E., G. Moller, and C. Fernandez. 1992. Age-dependent responsiveness to interleukin-6 in B lymphocytes from a systemic lupus erythematosus-prone (NZB X NZW)F1 hybrid. Clin. Immunol. Immunopathol. 62:264.
28. Merino, R., M. Iwamoto, L. Fossati, and S. Izui. 1993. Polyclonal B cell activation arises from different mechanisms in lupus-prone (NZB X NZW)F1 and MRL/MpJ-lpr/lpr mice. J. Immunol. 151:6509.
29. 1 pre-B cells. J. Exp. Med. 176:1343.
30. Reininger, L., T. H. Winkler, C. P. Kalberer, M. Jourdan, F. Melchers, and A. G. Rolink. 1996. Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB X NZW)F1 mice. J. Exp. Med. 184:853.
31. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of IL-2, 3, 4 or 5 using modified cDNA expression vectors. Ear. J. Immunol. 18:97.
32. Ratcliffe, M. J. H., and M. H. Julius. 1982. H-2-restricted T-B interactions involved in polyspecific B cell responses mediated by soluble antigen. Eur. J. Immunol. 12:634.
33. Hartwig, J. H., L. S. Jugloff, N. J. DeGroot, S. A. Grupp, and J. Jongstra-Bilen. 1995. The ligand-induced membrane IgM association with the cytoskelelal matrix of B cells is not mediated through the Ig αβ heterodimer. J. Immunol. 155: 3769.
34. Waldschmidt, T. J., F. G. M. Kroese, L. T. Tygrett, D. H. Conrad, and R. G. Lynch. 1991. The expression of B cell surface receptors. III. The murine low-affinity IgE Fc receptor is not expressed on Ly1 or 'Ly1-like' B cells. Int. Immunol. 3:305.
35. Hardy, R. R., and K. Hayakawa. 1994. CD5 B cells a fetal B cell lineage. Adv. Immunol. 55:297.
36. Ishida, H., R. Hastings, J. Kearney, and M. Howard. 1992. Continuous antiinterleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells. J. Exp. Med. 175:1213.
37. Pani, G., M. Kozlowski, J. C. Cambier, G. B. Mills, and K. A. Siminovitch. 1995. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J. Exp. Med. 181:2077.
38. Clark, E. A., and J. A. Ledbetter. 1994. How B and T cells talk to each other. Nature 367:425.
39. Lenschow, D. J., A. I. Sperling, M. P. Cooke, G. Freeman, L. Rhee, D. C. Decker, G. Gray, L. M. Nadler, C. C. Goodnow, and J. A. Bluestone. 1994. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J. Immunol. 153:1990.
40. Wortis, H. H., M. Teutsch, M. Higer, J. Zheng, and D. C. Parker. 1995. B-cell activation by cross-linking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. Proc. Natl. Acad. Sci. USA 92:3348.
41. Conrad, D. 1990. Fc epsilon RII/CD23: the low affinity receptor for IgE. Annu. Rev. Immunol. 9:623.
42. Yuan, D., and E. A. Goldings. 1988. Transient expression of pentameric IgM on the surface of NZB B cells. Mol. Immunol. 25:323.
43. Kaneko, Y., S. Hirose, A. Masaaki, H. Yagita, K. Okumura, and T. Shirai. 1996. CD40-mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus. Eur. J. Immunol. 26:3061.
44. Kehry, M. R. 1996. CD40-mediated signaling in B cells: balancing cell survival, growth, and death. J. Immunol. 156:2345.
45. Mohan, C., Y. Shi, J. D. Laman, and S. K. Datta. 1995. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J. Immunol. 154:1470.
46. Early, G. S., W. Zhao, and C. M. Burns. 1996. Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand Black X New Zealand White mice. J. Immunol. 157:3159.
47. Jaiswal, A. I., C. Dubey, S. L. Swain, and M. Croft. 1996. Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. Int. Immunol. 8:275.
48. + T lymphocytes from TCR transgenic mice. J. Immunol. 152:5220.
49. Nagata, S., and T. Suda. 1995. Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16:39.
50. Hibbs, M. L., D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S. A. Stacker, and A. R. Dunn. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301.
51. Wang, J., T. Koizumi, and T. Watanabe. 1996. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J. Exp. Med. 184:831.
52. Masuda, K., J. Wang, and T. Watanabe. 1997. Reduced susceptibility to Fas-mediated apoptosis in B-1 cells. Eur. J. Immunol. 27:449.