Characterization of humoral immune responses induced by immunization with plasmid DNA expressing HIV-1 Nef accessory protein

Vaccine

Volumn 16, Issue 16, 1998, Pages 1523-1530

  Moynier, Marinette ^a   Kavsan, Vadim ^a   Gales, Céline ^a   Montagnier, Luc ^b   Bahraoui, Elmostafa ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

Anti Nef antibodies; DNA vaccination; HIV 1 Nef

Indexed keywords

ADJUVANT; ANTIBODY; EPITOPE; FREUND ADJUVANT; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; NEF PROTEIN; PEPTIDE; PLASMID DNA; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNIZATION; INTRADERMAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; EPITOPE MAPPING; EPITOPES, B-LYMPHOCYTE; FEMALE; GENE PRODUCTS, NEF; HIV ANTIBODIES; HIV-1; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PLASMIDS; VACCINATION; VACCINES, DNA;

EID: 0032192573     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00036-X     Document Type: Article

References (52)

1. 1 Franchini, G., Robert-Guroff, M., Ghrayeb, J., Chang, N.T. and Wong-Stall, F. Cytoplasmic localization of the HTLV-III 3′orf protein in cultured T cells. Virology 1986, 155, 593-599.
2. 2 Kaminchik, J., Margalit, R. and Yaish, S. et al. Cellular distribution of HIV type 1 Nef protein: identification of domains in Nef required for association with membrane and detergent-insoluble cellular matrix. AIDS Res. Hum. Retroviruses 1994, 10, 1003-1010.
3. 3 Robert-Guroff, M., Popovic, M., Gartner, S., Markham, P., Gallo, R.C. and Reitz, M.S. Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages. J. Virol. 1990, 64, 3391-3398.
4. 4 Miller, M.D., Warmerdam, M.T., Gaston, I., Greene, W.C. and Feinberg, M.B. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J.Exp. Med. 1994, 179, 101-103.
5. 5 Chowers, M.Y., Spina, C.A., Kwoh, T.J., Fitch, J.S., Richman, D.D. and Cuatelli, J.C. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol. 1994, 68, 2906-2914.
6. 6 Guy, B., Kieny, M.P. and Riviere, Y. et al. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 1987, 330, 266-269.
7. 7 Garcia, J.V. and Miller, A.D. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 1991, 350, 508-511.
8. 8 Benson, R.E., Sanfridson, A., Ottinger, J.S., Doyle, C. and Cullen, B.R. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus nef prevents viral super infection. J. Exp. Med. 1993, 177, 1561-1566.
9. 9 De, S.K. and Marsh, J.W. HIV-1 Nef inhibits a common activation pathway in NIH3T3 cells. J. Biol. Chem. 1994, 269, 6656-6660.
10. 10 Collette, Y., Chang, H.L. and Cerdan, C. et al. Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 nef gene-induced expression. J. Immunol. 1996, 156, 360-370.
11. 11 Skowronski, J., Parks, D. and Mariani, R. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J. 1993, 12, 703-713.
12. 12 Rhee, S.S. and Marsh, J.W. HIV-1 nef activity in murine T cells. CD4 modulation and positive enhancement. J. Immunol. 1994, 152, 5128-5134.
13. 13 Baur, A.S., Sawai, E.T., Dazin, P., Fantl, W.J., Chen-Mayer, C. and Peterlin, B.M. HIV-1 Nef leds to inhibition or activation of T cells depending on its intracellular localization. Immunity 1994, 1, 373-384.
14. 14 Kestler, H.W., Ringler, D.J. and Mori, K. et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991, 65, 651-662.
15. 15 Chakrabarti, L., Baptiste, V. and Khatissian, E. et al. Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus. Virology 1995, 213, 535-548.
16. 16 Deacon, N.J., Tsykin, A. and Solomon, A. et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 1995, 270, 988-991.
17. 17 Mariani, R., Kirchhoff, F., Greenough, T.C., Sullivan, J.L., Desrosiers, R.C. and Skowronski, J. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J. Virol. 1996, 70, 7752-7764.
18. 18 Fujii, Y., Nishino, Y., Nakaya, T., Tokunaga, K. and Ikuta, K. Expression of human immunodeficiency virus type 1 Nef antigen on the surface of acutely and persistently infected human T cells. Vaccine 1993, 11, 1240-1246.
19. + T cells. J. Immunol. 1994, 153, 5826-5837.
20. 20 Torres, B.A., Tanabe, T. and Johnson, H.M. Characterization of Nef-induced CD4 T cell proliferation. Biochem. Biophys. Res. Commun. 1996, 225, 54-61.
21. 21 Fujii, Y., Ito, M. and Ikuta, K. Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the nef function by anti-Nef antibodies. Vaccine 1989, 11, 837-847.
22. 22 Bachelerie, F., Alcami, J. and Hazan, U. et al. Constitutive expression of human immunodeficiency virus (HIV) Nef protein in human astrocytes does not influence basal or induced HIV long terminal repeat activity. J. Virol. 1990, 64, 3059-3062.
23. + T cells expressing the Nef protein. AIDS Res. Hum. Retroviruses 1992, 8, 545-551.
24. 24 Wolff, J.A., Williams, P., Acsadi, G., Jiao, S., Jani, A. and Chong, W. Conditions affecting direct gene transfer into roden muscle in vivo. Biotechniques 1991, 11, 474-485.
25. 25 Bodeus, M., Cardine, A.M., Bougeret, C., Ramos-Morales, F. and Benarous, R. In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/ threonine protein kinase. J. Gen. Virol. 1995, 76, 1337-1344.
26. 26 Merrifield, R.B. Solide phase peptide synthesis. Science 1989, 232, 341-347.
27. 27 Davis, H.L., Whalen, R.G. and Demenex, B.A. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum. Gene Ther. 1993, 4, 151-159.
28. 28 Major, M.E., Vitvitski, L. and Mink, M.A. et al. DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J. Virol. 1995, 69, 5798-5805.
29. 29 Deck, R.R., DeWitt, C.M., Donnelly, J.J., Liu, M.A. and Ulmer, J.B. Characterization of humoral immune responses induced by an influenza hemegglutinin DNA vaccine. Vaccine 1997, 15, 71-78.
30. 30 Davis, H.L., Mancini, M., Michel, M.L. and Whalens, R.G. DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost. Vaccine 1997, 14, 910-915.
31. 31 Wolff, J.A., Ludtke, J.J., Acsadi, G., Williams, P. and Jani, A. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Gen. 1992, 1, 363-369.
32. 32 Gray, D., Kosco, M. and Stockinger, B. Novel pathways of antigen presentation for the maintenance of memory. Int. Immunol. 1991, 3, 141-148.
33. 33 Estaquier, J., Boutillon, C. and Ameison, J.C. et al. Determination of B-cell epitopes of Nef HIV-1 protein: immunogenicity related to their structure. Mol. lmmunol. 1992, 29, 1337-1345.
34. 34 Hinkula, J., Svanholm, C. and Schwartz, S. et al. Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes. J. Virol. 1997, 71, 5528-5539.
35. 35 Bahraoui, E., Yagello, M. and Billaud, J.N. et al. Immunogenicity of the human immunodeficiency virus (HIV) recombinant nef gene product. Mapping of T-cell and B-cell epitopes in immunized chimpanzees. AIDS Res. Hum. Retroviruses 1990, 6, 1087-1098.
36. 36 Sabatier, J.M., Clerget-Raslain, B. and Fontan, G. et al. Use of synthetic peptides for the dection of antibodies against the Nef regulating protein in sera of HIV-infected patients. AIDS 1989, 3, 215-220.
37. 37 Leclerc, C., Charbit, A., Molla, A. and Hofnung, G.M. Antibody response to a foreign epitope expressed at the surface of recombinant bacteria: importance of the route of immunization. Vaccine 1989, 7, 242-248.
38. 38 Sutcliffe, J.G., Shinnick, T.M., Green, N. and Lerner, R.A. Antibodies that react with predetermined sites on proteins. Science 1983, 213, 660-665.
39. 39 Mabrouk, K., Benjouad, A., Gluckman, J.C., Rochat, H., Van Rietschoten, J. and Bahraoui, E. Specificity of anti-p25 antibodies produced against whole VIV-1 particles or soluble forms of the protein. Mol. Immunol. 1992, 29, 1309-1318.
40. 40 Feltquate, D.M., Heaney, S., Webster, R.G. and Robinson, H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 1997, 158, 2278-2284.
41. 41 Pertmer, T.M., Roberts, T.R. and Haynes, J.R. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicitated by DNA vaccination are dependant on the route of vector DNA delivery. J. Virol. 1996, 70, 6119-6125.
42. 42 Barry, M.A. and Johnston, S.A. Biological features of genetic immunization. Vaccine 1997, 15, 788-791.
43. 43 Kim, J.J., Ayyavoo, V. and Bagarazzi, M.L. et al. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J. Immunol. 1997, 158, 816-826.
44. 44 Finkelman, F.D., Holmes, J. and Katona, I.M. et al. Lymphokine control of in vivo immunoglobulin isotype selection. Ann. Rev. Immunol. 1990, 8, 303-333.
45. 45 Romagnani, S. Understanding the role of Th1/Th2 cells in infection. Trends in Microbiol. 1996, 4, 470-473.
46. 46 Donnelly, J.J., Ulmer, J.B., Shiver, J.W. and Liu, M.A. DNA vaccines. Ann. Rev. Immunol. 1997, 15, 617-648.
47. 47 Wang, B., Ungen, K.E. and Srikantan, V. et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. 1993, 90, 4156-4160.
48. 48 Wang, B., Boyer, J.D. and Srikantan, V. et al. Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation. Virology 1995, 211, 102-112.
49. 49 Boyer, J.D., Ugen, K.E. and Wang, B. et al. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat. Med. 1997, 3, 526-532.
50. 50 Ugen, K.E., Boyer, J.D. and Wang, B. et al. Nucleic acid immunization of chimpanzees as a prophylactic/immunotherapeutic vaccination model for HIV-1: prelude to a clinical trial. Vaccine 1997, 15, 927-930.
51. 51 Asakura, Y., Hamajima, K., Fukushima, J., Mohri, H., Okubo, T. and Okuda, K. Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by nef-expressing DNA vaccine. Am. J. Hematol. 1996, 53, 116-117.
52. 52 Tobery, T.W. and Siliciano, R.F. Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med. 1997, 185, 909-920.