The complement system and adaptive immunity

Seminars in Immunology

Volumn 10, Issue 5, 1998, Pages 355-361

  Fearon, Douglas T ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

B lymphocyte; CD19; CD21; CD22; Complement

Indexed keywords

CD19 ANTIGEN; CD22 ANTIGEN; COMPLEMENT COMPONENT C3D; COMPLEMENT RECEPTOR; FC RECEPTOR; PROTEIN TYROSINE PHOSPHATASE;

B LYMPHOCYTE; COMPLEMENT SYSTEM; CROSS LINKING; IMMUNITY; REVIEW;

EID: 0032192484     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1998.0137     Document Type: Article

References (74)

1. 1. Pepys MB (1972) Role of complement in induction of the allergic response. Nat New Biol 237:157-159
2. 2. Janeway CA Jr (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54:1-13
3. 3. Klickstein LB, Wong WW, Smith JA, Weis JH, Wilson JG, Fearon DT (1987) Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins. J Exp Med 165:1095-1112
4. 4. Moore MD, Cooper NR, Tack BF, Nemerow GR (1987) Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes. Proc Natl Acad Sci USA 84:9194-9198
5. 5. Weis JJ, Toothaker LE, Smith JA, Weis JH, Fearon DT (1988) Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins. J Exp Med 167:1047-1066
6. 6. Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (1997) A second serine protease associated with mannan-binding lectin that activates complement. Nature 386:506-510
7. 7. Carter RH, Spycher MO, Ng YC, Hoffman R, Fearon DT (1988) Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes. J Immunol 141:457-463
8. 8. Heyman B, Wiersma EJ, Kinoshita T (1990) In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody. J Exp Med 172:665-668
9. 9. Thyphronitis G, Kinoshita T, Inoue K, Schweinle JE, Tsokos GC, Metcalf ES, Finkelman FD, Balow JE (1991) Modulation of mouse complement receptors 1 and 2 suppresses antibody responses in vivo. J Immunol 147:224-230
10. 10. Hebell T, Ahearn JM, Fearon DT (1991) Suppression of the immune response by a soluble complement receptor of B lymphocytes. Science 254:102-105
11. 11. Croix DA, Ahearn, JM, Rosengard AM, Han S, Kelsoe G, Ma M, Carroll MC (1996) Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med 183:1857-1864
12. 12. Ahearn JM, Fischer MB, Croix D, Goerg S, Ma M, Xia J, Zhou X, Howard RG, Rothstein TL, Carroll MC (1996) Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4:251-262
13. 13. Molina H, Holers VM, Li B, Fung Y, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Chaplin DD (1996) Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci USA 93:3357-3361
14. 14. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT (1996) C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348-350
15. 15. Humphrey JH, Grennan D, Sundaram V (1984) The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them. Eur J Immunol 14:859-864
16. 16. Kroncke R, Loppnow H, Flad HD, Gerdes J (1996) Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol 26:2541-2544
17. 17. MacLennan IC, Liu YJ, Johnson GD (1992) Maturation and dispersal of B-cell clones during T cell-dependent antibody responses. Immunol Rev 126:143-161
18. 18. Tew JG, Wu J, Qin D, Helm S, Burton GF, Szakal AK (1997) Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol Rev 156:39-52
19. 19. Matsumoto M, Fu YX, Molina H, Chaplin DD (1997) Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. Immunol Rev 156:137-144
20. 20. Kosco-Vilbois MH, Bonnefoy JY, Chvatchko Y (1997) The physiology of murine germinal center reactions. Immunol Rev 156:127-136
21. 21. Matsumoto AK, Kopicky Burd-J, Carter RH, Tuveson DA, Tedder TF, Fearon DT (1991) Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. J Exp Med 173:55-64
22. 22. Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF (1992) The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol 149:2841-2850
23. 23. Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT (1993) Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. J Exp Med 178:1407-1417
24. 24. Bradbury LE, Goldmacher VS, Tedder TF (1993) The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. J Immunol 151:2915-2927
25. 25. Tedder TF, Isaacs CM (1989) Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. J Immunol 143:712-717
26. 26. Carter RH, Tuveson DA, Park DJ, Rhee SG, Fearon DT (1991) The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J Immunol 147:3663-3671
27. 27. Rickert RC, Rajewsky K, Roes J (1995) Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352-355
28. 28. Engel P, Zhou LJ, Ord DC, Sato S, Koller B, Tedder TF (1995) Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39-50
29. 29. Sato S, Steeber DA, Tedder TF (1995) The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci USA 92:11558-11562
30. 30. Tuveson DA, Carter RH, Soltoff SP, Fearon DT (1993) CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260:986-989
31. 31. Roifman CM, Ke S (1993) CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells. Biochem Biophys Res Commun 194:222-225
32. 32. Chalupny NJ, Kanner SB, Schieven GL, Wee SF, Gilliland LK, Aruffo A, Ledbetter JA (1993) Tyrosine phosphorylation of CD19 in pre-B and mature B cells. EMBO J 12:2691-2696
33. 33. Uckun FM, Burkhardt AL, Jarvis L, Jun X, Stealey B, Dibirdik I, Myers DE, Tuel-Ahlgren L, Bolen JB (1993) Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny. J Biol Chem 268:21172-21184
34. 34. Kitanaka A, Ito C, Coustan-Smith E, Campana D (1997) CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinase. J Immunol 159:184-192
35. 35. Lund FE, Yu N, Kim KM, Reth M, Howard MC (1996) Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression. J Immunol 157:1455-1467
36. 36. Chalupny NJ, Aruffo A, Esselstyn JM, Chan PY, Bajorath J, Blake J, Gilliland LK, Ledbetter JA, Tepper MA (1995) Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains. Eur J Immunol 25:2978-2984
37. 37. Weng WK, Jarvis L, LeBien TW (1994) Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J Biol Chem 269:32514-32521
38. 38. Han J, Luby-Phelps K, Das B, Shu X, Mosteller RD, Murali Krishna U, Falck JR, White MA, Broek D (1998) Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-560
39. 39. Zhang R, Alt FW, Davidson L, Orkin SH, Swat W (1995) Defective signalling through the T-and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470-473
40. 40. Tooze RM, Doody GM, Fearon DT (1997) Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin. Immunity 7:59-67
41. 41. Li X, Sandoval D, Freeberg L, Carter RH (1997) Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig. J Immunol 158:5649-5657
42. 42. Smith KGC, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT. Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med:in press
43. 43. Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT (1995) A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269:242-244
44. 44. Campbell MA, Klinman NR (1995) Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C. Eur J Immunol 25:1573-1579
45. 45. Lankester AC, van Schijndel GM, van Lier RA (1995) Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation. J Biol Chem 270:20305-20308
46. 46. Law CL, Sidorenko SP, Chandran KA, Zhao Z, Shen SH, Fischer EH, Clark EA (1996) CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. J Exp Med 183:547-560
47. 47. Nadler MJ, McLean PA, Neel BG, Wortis HH (1997) B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines. J Immunol 159:4233-4243
48. 48. Peaker CJ, Neuberger MS (1993) Association of CD22 with the B cell antigen receptor. Eur J Immunol 23:1358-1363
49. 49. Leprince C, Draves KE, Geahlen RL, Ledbetter JA, Clark EA (1993) CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci USA 90:3236-3240
50. 50. O'Keefe TL, Williams GT, Davies SL, Neuberger MS (1996) Hyperresponsive B cells in CD22-deficient mice. Science 274:798-801
51. 51. Otipoby KL, Andersson KB, Draves KE, Klaus SJ, Farr AG, Kerner JD, Perlmutter RM, Law CL, Clark EA (1996) CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384:634-637
52. 52. Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang ML, Tedder TF (1996) CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5:551-562
53. 53. Nitschke L, Carsetti R, Ocker B, Kohler G, Lamers MC (1997) CD22 is a negative regulator of B-cell receptor signalling. Curr Biol 7:133-143
54. 54. Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR (1995) Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301-311
55. 55. Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, Watanabe T, Yamamoto T (1995) Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3:549-560
56. 56. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA (1997) Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7:69-81
57. 57. Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig MC, Ravetch JV (1994) A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature 368:70-73
58. 58. D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC (1995) Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science 268:293-297
59. 59. Ono M, Bolland S, Tempst P, Ravetch JV (1997) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 383:263-266
60. 60. Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV (1997) Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90:293-301
61. 61. Nadler MJS, Chen B, Anderson JS, Wortis HH, Neel BG (1997) Protein-tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of B cell antigen receptor activation. J Biol Chem 272:20038-20043
62. 62. Tridandapani S, Kelley T, Pradhan M, Cooney D, Justement LB, Coggeshall KM (1997) Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif. Mol Cell Biol 17:4305-4311
63. 63. Gupta N, Scharenberg AM, Burshtyn DN, Wagtmann N, Lioubin MN, Rohrschneider LR, Kinet JP, Long EO (1997) Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases. J Exp Med 186:473-478
64. 64. Fong DC, Malbec O, Arock M, Gambier JC, Fridman WH, Daeron M (1996) Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol Lett 54:83-91
65. 65. D'Ambrosio D, Fong DC, Cambier JC (1996) The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling. Immunol Lett 54:77-82
66. 66. Kiener PA, Lioubin MN, Rohrschneider LR, Ledbetter JA, Nadler SG, Diegel ML (1997) Co-ligation of the antigen and Fc receptors gives rise to the selective modulation of intracellular signaling in B cells. Regulation of the association of phosphatidylinositol 3-kinase and inositol 5′-phosphatase with the antigen receptor complex. J Biol Chem 272:3838-3844
67. 2+ mobilization is integrated by CD19 dephosphorylation. Immunity 7:49-58
68. 68. Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, Scaife R, Margolis RL, Gigg R, Smith CI, Driscoll PC, Waterfield MD, Panayotou G (1996) Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J 15:6241-6250
69. 69. Carter RH, Doody GM, Bolen JB, Fearon DT (1997) Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex. J Immunol 158:3062-3069
70. 70. Thornton BP, Vetvicka V, Ross GD (1994) Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes. J Immunol 152:1727-1737
71. 71. Rey-Millet CA, Villiers CL, Gabert FM, Chesne S, Colomb MG (1994) C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells. Mol Immunol 31:1321-1327
72. 72. Jacquier-Sarlin MR, Gabert FM, Villiers MB, Colomb MG (1995) Modulation of antigen processing and presentation by covalently linked complement C3b fragment. Immunology 84:164-170
73. 73. Villiers MB, Villiers, CL, Jacquier-Sarlin MR, Gabert FM, Journet AM, Colomb MG (1996) Covalent binding of C3b to tetanus toxin: influence on uptake/internalization of antigen by antigen-specific and non-specific B cells. Immunology 89:348-355
74. 74. Gustavsson S, Kinoshita T, Heyman B (1995) Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction. J Immunol 154:6524-6528